Viscosity of concentrated therapeutic protein compositions

Advanced Drug Delivery Reviews

Volumn 63, Issue 13, 2011, Pages 1107-1117

  Jezek, Jan ^a   Rides, Martin ^b   Derham, Barry ^a   Moore, Jonathan ^b   Cerasoli, Elenora ^b   Simler, Robert ^c   Perez Ramirez, Bernardo ^c  

^a Arecor Limited   (United Kingdom)

^b NATIONAL PHYSICAL LABORATORY   (United Kingdom)

^c GENZYME CORPORATION   (United States)

Author keywords

Antibody; Formulation; Rheology; Shear; Surfactant

Indexed keywords

ANTIBODIES; CHEMICAL STABILITY; ELASTICITY; MONOCLONAL ANTIBODIES; RHEOLOGY; SHEARING; SURFACE ACTIVE AGENTS; VISCOSITY;

CONCENTRATED SOLUTION; DEVELOPMENT STRATEGIES; FORMULATION; LIQUID FORMULATIONS; RHEOLOGICAL CHARACTERISTICS; RHEOLOGY MEASUREMENT; THERAPEUTIC AGENTS; THERAPEUTIC PROTEIN;

CONCENTRATION (PROCESS);

IMMUNOGLOBULIN G1; MONOCLONAL ANTIBODY; NONIONIC SURFACTANT; POLYSORBATE 20; SODIUM CHLORIDE; SODIUM SULFITE; THIOCYANATE;

CALIBRATION; CONCENTRATION (PARAMETERS); DRUG FORMULATION; DRUG RELEASE; FLOW KINETICS; FLOW MEASUREMENT; FLOW RATE; FLUID TRANSPORT; INSTRUMENT VALIDATION; IONIC STRENGTH; MOLECULAR MECHANICS; PH; PRIORITY JOURNAL; PROTEIN ANALYSIS; REVIEW; SHEAR RATE; VISCOMETRY; VISCOSITY;

EID: 80054726708     PISSN: 0169409X     EISSN: 18728294     Source Type: Journal    
DOI: 10.1016/j.addr.2011.09.008     Document Type: Review

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