Viscosity behavior of high-concentration monoclonal antibody solutions: Correlation with interaction parameter and electroviscous effects

Journal of Pharmaceutical Sciences

Volumn 101, Issue 3, 2012, Pages 998-1011

  Yadav, Sandeep ^a,b   Shire, Steven J ^b   Kalonia, Devendra S ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b GENENTECH INC   (United States)

Author keywords

Electroviscous effects; High concentration monoclonal antibody formulation; Interaction parameter; Light scattering; Rheology; Viscosity

Indexed keywords

MONOCLONAL ANTIBODY;

ARTICLE; CIRCULAR DICHROISM; CONCENTRATION (PARAMETERS); CONFORMATIONAL TRANSITION; ELECTROPHORETIC MOBILITY; FLOW KINETICS; IONIC STRENGTH; ISOELECTRIC FOCUSING; LIGHT SCATTERING; MOLECULAR INTERACTION; PH; SURFACE CHARGE; VISCOSITY; ZETA POTENTIAL;

EID: 84855891967     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22831     Document Type: Article

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