β2-microglobulin amyloid fibrils are nanoparticles that disrupt lysosomal membrane protein trafficking and inhibit protein degradation by lysosomes

Journal of Biological Chemistry

Volumn 289, Issue 52, 2014, Pages 35781-35794

  Jakhria, Toral ^a   Hellewell, Andrew L ^a,b   Porter, Morwenna Y ^a   Jackson, Matthew P ^a   Tipping, Kevin W ^a   Xue, Wei Feng ^a,c   Radford, Sheena E ^a   Hewitt, Eric W ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c UNIVERSITY OF KENT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CELL DEATH; GLYCOPROTEINS; NANOTECHNOLOGY;

AMYLOID DISEASE; ASSEMBLY REACTIONS; BETA-2-MICROGLOBULIN; CELL VIABILITY; LYSOSOMAL MEMBRANES; MODEL PROTEINS; MOLECULAR ARCHITECTURE; PROTEIN DEGRADATION;

PROTEINS;

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; AMYLOID; BETA 2 MICROGLOBULIN; CD63 ANTIGEN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; NANOPARTICLE; MEMBRANE PROTEIN;

AMYLOIDOSIS; ARTICLE; ATOMIC FORCE MICROSCOPY; BIOACCUMULATION; CELL DEATH; CELL MEMBRANE PERMEABILITY; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; INTERNALIZATION; LYSOSOME; LYSOSOME MEMBRANE; PROTEIN DEFECT; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS INHIBITION; PROTEIN TRANSPORT; CELL SURVIVAL; HUMAN; INTRACELLULAR MEMBRANE; METABOLISM; OXIDATION REDUCTION REACTION; PERMEABILITY; PHYSIOLOGY; TUMOR CELL LINE;

AMYLOID; BETA 2-MICROGLOBULIN; CELL LINE, TUMOR; CELL SURVIVAL; HUMANS; INTRACELLULAR MEMBRANES; LYSOSOMES; MEMBRANE PROTEINS; NANOPARTICLES; OXIDATION-REDUCTION; PERMEABILITY; PROTEIN TRANSPORT; PROTEOLYSIS;

EID: 84919799070     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.586222     Document Type: Article

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