Distinct conformations of in vitro and in vivo amyloids of huntingtin-exon1 show different cytotoxicity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 24, 2009, Pages 9679-9684

  Nekooki Machida, Yoko ^a   Kurosawa, Masaru ^a   Nukina, Nobuyuki ^a   Ito, Kazuki ^b   Oda, Toshiro ^b   Tanaka, Motomasa ^a,c  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^b RIKEN SPring 8 Center ^*  (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Aggregation; Huntington disease; Polyglutamine misfolding

Indexed keywords

AMYLOID; HUNTINGTIN; POLYGLUTAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; CYTOTOXICITY; EXON; HIPPOCAMPUS; HUNTINGTON CHOREA; MAMMAL CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FOLDING; TEMPERATURE;

AMYLOID; ANIMALS; BRAIN; CELL SURVIVAL; EXONS; MICE; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PROTEIN CONFORMATION; TEMPERATURE;

MAMMALIA; MUS;

EID: 67649856863     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0812083106     Document Type: Article

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