Tissue damage in the amyloidoses: Transthyretin monomers and nonnative oligomers are the major cytotoxic species in tissue culture

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 9, 2004, Pages 2817-2822

  Reixach, Natàlia ^a   Deechongkit, Songpon ^a   Jiang, Xin ^a   Kelly, Jeffery W ^a   Buxbaum, Joel N ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; MONOMER; OLIGOMER; PREALBUMIN;

AMYLOIDOSIS; ARTICLE; CROSS LINKING; CYTOTOXICITY; FLUORESCENCE MICROSCOPY; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; TISSUE CULTURE; TISSUE INJURY;

AMYLOIDOSIS; CELL LINE, TUMOR; CELL SURVIVAL; CHROMATOGRAPHY, GEL; HUMANS; KINETICS; MACROMOLECULAR SUBSTANCES; NEUROBLASTOMA; PREALBUMIN; PROTEIN STRUCTURE, QUATERNARY; VARIATION (GENETICS);

EID: 1542357685     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0400062101     Document Type: Article

References (23)

1. Buxbaum, J. N. & Tagoe, C. E. (2000) Annu. Rev. Med. 51, 543-569.
2. Merlini, G. & Bellotti, V. (2003) N. Engl. J. Med. 349, 583-596.
3. Sacchettini, J. C. & Kelly, J. W. (2002) Nat. Rev. Drug Discov. 1, 267-275.
4. Kelly, J. W. (1998) Curr. Opin. Struct. Biol. 8, 101-106.
5. Damas, A. M. & Saraiva, M. J. (2000) J. Struct. Biol. 130, 290-299.
6. Jacobson, D. R., Pastore, R. D., Yaghoubian, R., Kane, I., Gallo, G., Buck, F. S. & Buxbaum, J. N. (1997) N. Engl. J. Med. 336, 466-473.
7. Eriksson, L. & Westermark, P. (1990) Acta Neuropathol. 80, 597-603.
8. Quintas, A., Vaz, D. C., Cardoso, I., Saraiva, M. J. & Brito, R. M. (2001) J. Biol. Chem. 276, 27207-27213.
9. Hammarstrom, P., Wiseman, R. L., Powers, E. T. & Kelly, J. W. (2003) Science 299, 713-716.
10. White, J. T. & Kelly, J. W. (2001) Proc. Natl. Acad. Sci. USA 98, 13019-13024.
11. Jiang, X., Smith, C. S., Petrassi, H. M., Hammarstrom, P., White, J. T., Sacchettini, J. C. & Kelly, J. W. (2001) Biochemistry 40, 11442-11452.
12. Hammarstrom, P., Sekijima, Y., White, J. T., Wiseman, R. L., Lim, A., Costello, C. E., Altland, K., Garzuly, F., Budka, H. & Kelly, J. W. (2003) Biochemistry 42, 6656-6663.
13. Hammarström, P., Jiang, X., Hurshman, A. R., Powers, E. T. & Kelly, J. W. (2002) Proc. Natl. Acad. Sci. USA 99, 16427-16432.
14. Lashuel, H. A., Wurth, C., Woo, L. & Kelly, J. W. (1999) Biochemistry 38, 13560-13573.
15. Oza, V. B., Petrassi, H. M., Purkey, H. E. & Kelly, J. W. (1999) Bioorg. Med. Chem. Lett. 9, 1-6.
16. Hammarstrom, P., Jiang, X., Deechongkit, S. & Kelly, J. W. (2001) Biochemistry 40, 11453-11459.
17. Klabunde, T., Petrassi, H. M., Oza, V. B., Raman, P., Kelly, J. W. & Sacchettini, J. C. (2000) Nat. Struct. Biol. 7, 312-321.
18. Cardoso, I., Goldsbury, C. S., Muller, S. A., Olivieri, V., Wirtz, S., Damas, A. M., Aebi, U. & Saraiva, M. J. (2002) J. Mol. Biol. 317, 683-695.
19. Kayed, R., Head, E., Thompson, J. L., McIntire, T. M., Milton, S. C., Cotman, C. W. & Glabe, C. G. (2003) Science 300, 486-489.
20. Andersson, K., Olofsson, A., Nielsen, E. H., Svehag, S. E. & Lundgren, E. (2002) Biochem. Biophys. Res. Commun. 294, 309-314.
21. Sousa, M. M., Cardoso, I., Fernandes, R., Guimaraes, A. & Saraiva, M. J. (2001) Am. J. Pathol. 159, 1993-2000.
22. Taylor, B. M., Sarver, R. W., Fici, G., Poorman, R. A., Lutzke, B. S., Molinari, A., Kawabe, T., Kappenman, K., Buhl, A. E. & Epps, D. E. (2003) J. Protein Chem. 22, 31-40.
23. Buxbaum, J. N. (2003) Trends Biochem. Sci. 28, 585-592.