β2-microglobulin amyloid fibril-induced membrane disruption is enhanced by endosomal lipids and acidic pH

PLoS ONE

Volumn 9, Issue 8, 2014, Pages

  Goodchild, Sophia C ^a   Sheynis, Tania ^a   Thompson, Rebecca ^a   Tipping, Kevin W ^a   Xue, Wei Feng ^a,b   Ranson, Neil A ^a   Beales, Paul A ^a   Hewitt, Eric W ^a   Radford, Sheena E ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b UNIVERSITY OF KENT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 OLEOYL 1 PALMITOYLPHOSPHATIDYLGLYCEROL; 2 OLEOYL 1 PALMITOYLPHOSPHATIDYLSERINE; AMYLOID; BETA 2 MICROGLOBULIN; LIPID; LIPOSOME; LYSOBISPHOSPHATIDIC ACID; TRYPTOPHAN; UNCLASSIFIED DRUG; ARTIFICIAL MEMBRANE;

ACIDITY; AMYLOIDOSIS; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DIALYSIS RELATED AMYLOIDOSIS; ENDOCYTOSIS; ENDOSOME; HEMODIALYSIS; LIPID BILAYER; LIPID COMPOSITION; LIPID VESICLE; MEMBRANE DAMAGE; MOLECULAR MECHANICS; OSTEOARTHROPATHY; PATHOPHYSIOLOGY; PH; PHOTOCHEMICAL QUENCHING; PROTEIN INTERACTION; TISSUE INJURY; ADVERSE EFFECTS; ARTIFICIAL MEMBRANE; CHEMISTRY; GENETICS; HUMAN; INTRACELLULAR MEMBRANE; METABOLISM; RENAL REPLACEMENT THERAPY;

AMYLOID; AMYLOIDOSIS; BETA 2-MICROGLOBULIN; ENDOSOMES; HUMANS; HYDROGEN-ION CONCENTRATION; INTRACELLULAR MEMBRANES; MEMBRANES, ARTIFICIAL; RENAL DIALYSIS;

EID: 84905457722     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0104492     Document Type: Article

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