Lipids revert inert Aβ amyloid fibrils to neurotoxic protofibrils that affect learning in mice

EMBO Journal

Volumn 27, Issue 1, 2008, Pages 224-233

  Martins, Ivo Cristiano ^a   Kuperstein, Inna ^b   Wilkinson, Hannah ^a   Maes, Elke ^b   Vanbrabant, Mieke ^b   Jonckheere, Wim ^a   Van Gelder, Patrick ^a   Hartmann, Dieter ^b   D'Hooge, Rudi ^c   De Strooper, Bart ^b   Schymkowitz, Joost ^a   Rousseau, Frederic ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^c UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Alzheimer's disease; Amyloid fibril; Amyloidosis; Lipid

Indexed keywords

AMYLOID BETA PROTEIN; LIPID; MONOMER; TAU PROTEIN;

ALZHEIMER DISEASE; AMYLOIDOSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL REACTION KINETICS; COMPARATIVE STUDY; CONTROLLED STUDY; EQUILIBRIUM CONSTANT; EXPERIMENTAL MOUSE; LEARNING; LIPID ANALYSIS; MEMORY DISORDER; MOLECULAR STABILITY; MOUSE; NERVE CELL; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; BRAIN; CELLS, CULTURED; G(M1) GANGLIOSIDE; INJECTIONS, INTRAVENTRICULAR; LEARNING; LIPIDS; MICE; NEUROTOXINS; PEPTIDE FRAGMENTS; SPHINGOLIPIDS;

MUS;

EID: 38049056730     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/sj.emboj.7601953     Document Type: Article

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