-
1
-
-
79960652801
-
Molecular chaperones in protein folding and proteostasis
-
Hartl FU, Bracher A, Hayer-Hartl M (2011) Molecular chaperones in protein folding and proteostasis. Nature 475(7356):324-332.
-
(2011)
Nature
, vol.475
, Issue.7356
, pp. 324-332
-
-
Hartl, F.U.1
Bracher, A.2
Hayer-Hartl, M.3
-
2
-
-
32944457929
-
Amyloidosis
-
Pepys MB (2006) Amyloidosis. Annu Rev Med 57:223-241.
-
(2006)
Annu Rev Med
, vol.57
, pp. 223-241
-
-
Pepys, M.B.1
-
3
-
-
78651252910
-
Molecular pathology of human prion disease
-
Wadsworth JDF, Collinge J (2011) Molecular pathology of human prion disease. Acta Neuropathol 121(1):69-77.
-
(2011)
Acta Neuropathol
, vol.121
, Issue.1
, pp. 69-77
-
-
Wadsworth, J.D.F.1
Collinge, J.2
-
4
-
-
67650410543
-
Biological and chemical approaches to diseases of proteostasis deficiency
-
Powers ET, Morimoto RI, Dillin A, Kelly JW, Balch WE (2009) Biological and chemical approaches to diseases of proteostasis deficiency. Annu Rev Biochem 78:959-991.
-
(2009)
Annu Rev Biochem
, vol.78
, pp. 959-991
-
-
Powers, E.T.1
Morimoto, R.I.2
Dillin, A.3
Kelly, J.W.4
Balch, W.E.5
-
5
-
-
84863988708
-
A molecular history of the amyloidoses
-
10.1016/jmb.2012.01.024
-
Buxbaum JN, Linke RP (2012) A molecular history of the amyloidoses. J Mol Biol 421(2-3):142-159, 10.1016/jmb.2012.01.024.
-
(2012)
J Mol Biol
, vol.421
, Issue.2-3
, pp. 142-159
-
-
Buxbaum, J.N.1
Linke, R.P.2
-
6
-
-
79959887638
-
A diversity of assembly mechanisms of a generic amyloid fold
-
Eichner T, Radford SE (2011) A diversity of assembly mechanisms of a generic amyloid fold. Mol Cell 43(1):8-18.
-
(2011)
Mol Cell
, vol.43
, Issue.1
, pp. 8-18
-
-
Eichner, T.1
Radford, S.E.2
-
7
-
-
80054752317
-
Molecular basis for amyloid-beta polymorphism
-
Colletier JP, et al. (2011) Molecular basis for amyloid-beta polymorphism. Proc Natl Acad Sci USA 108(41):16938-16943.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, Issue.41
, pp. 16938-16943
-
-
Colletier, J.P.1
-
8
-
-
33750365052
-
Are amyloid diseases caused by protein aggregates that mimic bacterial pore-forming toxins?
-
DOI 10.1017/S0033583506004422, PII S0033583506004422
-
Lashuel HA, Lansbury PT, Jr. (2006) Are amyloid diseases caused by protein aggregates that mimic bacterial pore-forming toxins? Q Rev Biophys 39(2):167-201. (Pubitemid 44711851)
-
(2006)
Quarterly Reviews of Biophysics
, vol.39
, Issue.2
, pp. 167-201
-
-
Lashuel, H.A.1
Lansbury Jr., P.T.2
-
9
-
-
33344463679
-
Common mechanisms of amyloid oligomer pathogenesis in degenerative disease
-
Glabe CG (2006) Common mechanisms of amyloid oligomer pathogenesis in degenerative disease. Neurobiol Aging 27(4):570-575.
-
(2006)
Neurobiol Aging
, vol.27
, Issue.4
, pp. 570-575
-
-
Glabe, C.G.1
-
10
-
-
84855750207
-
2+) imaging implicates Aβ1-42 amyloid pores in Alzheimer's disease pathology
-
2+) imaging implicates Aβ1-42 amyloid pores in Alzheimer's disease pathology. J Cell Biol 195(3):515-524.
-
(2011)
J Cell Biol
, vol.195
, Issue.3
, pp. 515-524
-
-
Demuro, A.1
Smith, M.2
Parker, I.3
-
11
-
-
77955312210
-
Amyloidogenic protein-membrane interactions: Mechanistic insight from model systems
-
Butterfield SM, Lashuel HA (2010) Amyloidogenic protein-membrane interactions: mechanistic insight from model systems. Angew Chem Int Ed Engl 49(33):5628-5654.
-
(2010)
Angew Chem Int Ed Engl
, vol.49
, Issue.33
, pp. 5628-5654
-
-
Butterfield, S.M.1
Lashuel, H.A.2
-
12
-
-
82555170657
-
Mechanism of membrane interaction and disruption by α-synuclein
-
Reynolds NP, et al. (2011) Mechanism of membrane interaction and disruption by α-synuclein. J Am Chem Soc 133(48):19366-19375.
-
(2011)
J Am Chem Soc
, vol.133
, Issue.48
, pp. 19366-19375
-
-
Reynolds, N.P.1
-
13
-
-
78049290389
-
Biochemical and biophysical features of both oligomer/fibril and cell membrane in amyloid cytotoxicity
-
Stefani M (2010) Biochemical and biophysical features of both oligomer/fibril and cell membrane in amyloid cytotoxicity. FEBS J 277(22):4602-4613.
-
(2010)
FEBS J
, vol.277
, Issue.22
, pp. 4602-4613
-
-
Stefani, M.1
-
14
-
-
38049072191
-
Islet amyloid polypeptide forms rigid lipid-protein amyloid fibrils on supported phospholipid bilayers
-
Domanov YA, Kinnunen PKJ (2008) Islet amyloid polypeptide forms rigid lipid-protein amyloid fibrils on supported phospholipid bilayers. J Mol Biol 376(1):42-54.
-
(2008)
J Mol Biol
, vol.376
, Issue.1
, pp. 42-54
-
-
Domanov, Y.A.1
Kinnunen, P.K.J.2
-
15
-
-
43149118349
-
Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane
-
DOI 10.1073/pnas.0708354105
-
Engel MFM, et al. (2008) Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane. Proc Natl Acad Sci USA 105(16):6033-6038. (Pubitemid 351758394)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.16
, pp. 6033-6038
-
-
Engel, M.F.M.1
Khemtemourian, L.2
Kleijer, C.C.3
Meeldijk, H.J.D.4
Jacobs, J.5
Verkleij, A.J.6
De Kruijff, B.7
Killian, J.A.8
Hoppener, J.W.M.9
-
16
-
-
84856545963
-
Toxic effects of amyloid fibrils on cell membranes: The importance of ganglioside GM1
-
Bucciantini M, et al. (2012) Toxic effects of amyloid fibrils on cell membranes: The importance of ganglioside GM1. FASEB J 26(2):818-831.
-
(2012)
FASEB J
, vol.26
, Issue.2
, pp. 818-831
-
-
Bucciantini, M.1
-
17
-
-
33744961169
-
Amyloid fibrils of mammalian prion protein are highly toxic to cultured cells and primary neurons
-
DOI 10.1074/jbc.M511174200
-
Novitskaya V, Bocharova OV, Bronstein I, Baskakov IV (2006) Amyloid fibrils of mammalian prion protein are highly toxic to cultured cells and primary neurons. J Biol Chem 281(19):13828-13836. (Pubitemid 43855298)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.19
, pp. 13828-13836
-
-
Novitskaya, V.1
Bocharova, O.V.2
Bronstein, I.3
Baskakov, I.V.4
-
18
-
-
77957243833
-
The non-core regions of human lysozyme amyloid fibrils influence cytotoxicity
-
Mossuto MF, et al. (2010) The non-core regions of human lysozyme amyloid fibrils influence cytotoxicity. J Mol Biol 402(5):783-796.
-
(2010)
J Mol Biol
, vol.402
, Issue.5
, pp. 783-796
-
-
Mossuto, M.F.1
-
19
-
-
84862701723
-
Fibrillar α-synuclein and huntingtin exon 1 assemblies are toxic to the cells
-
Pieri L, Madiona K, Bousset L, Melki R (2012) Fibrillar α-synuclein and huntingtin exon 1 assemblies are toxic to the cells. Biophys J 102(12):2894-2905.
-
(2012)
Biophys J
, vol.102
, Issue.12
, pp. 2894-2905
-
-
Pieri, L.1
Madiona, K.2
Bousset, L.3
Melki, R.4
-
20
-
-
68149162581
-
Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction
-
Tomic JL, Pensalfini A, Head E, Glabe CG (2009) Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction. Neurobiol Dis 35(3):352-358.
-
(2009)
Neurobiol Dis
, vol.35
, Issue.3
, pp. 352-358
-
-
Tomic, J.L.1
Pensalfini, A.2
Head, E.3
Glabe, C.G.4
-
21
-
-
51249115821
-
Formation of toxic Abeta(1-40) fibrils on GM1 ganglioside-containing membranes mimicking lipid rafts: Polymorphisms in Abeta(1-40) fibrils
-
Okada T, Ikeda K, Wakabayashi M, Ogawa M, Matsuzaki K (2008) Formation of toxic Abeta(1-40) fibrils on GM1 ganglioside-containing membranes mimicking lipid rafts: Polymorphisms in Abeta(1-40) fibrils. J Mol Biol 382(4):1066-1074.
-
(2008)
J Mol Biol
, vol.382
, Issue.4
, pp. 1066-1074
-
-
Okada, T.1
Ikeda, K.2
Wakabayashi, M.3
Ogawa, M.4
Matsuzaki, K.5
-
22
-
-
38949123792
-
Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease
-
DOI 10.1038/nature06616, PII NATURE06616
-
Meyer-Luehmann M, et al. (2008) Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease. Nature 451(7179):720-724. (Pubitemid 351220570)
-
(2008)
Nature
, vol.451
, Issue.7179
, pp. 720-724
-
-
Meyer-Luehmann, M.1
Spires-Jones, T.L.2
Prada, C.3
Garcia-Alloza, M.4
De Calignon, A.5
Rozkalne, A.6
Koenigsknecht-Talboo, J.7
Holtzman, D.M.8
Bacskai, B.J.9
Hyman, B.T.10
-
23
-
-
77952711519
-
Prion induction involves an ancient system for the sequestration of aggregated proteins and heritable changes in prion fragmentation
-
Tyedmers J, et al. (2010) Prion induction involves an ancient system for the sequestration of aggregated proteins and heritable changes in prion fragmentation. Proc Natl Acad Sci USA 107(19):8633-8638.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, Issue.19
, pp. 8633-8638
-
-
Tyedmers, J.1
-
24
-
-
23144459082
-
Molecular recycling within amyloid fibrils
-
DOI 10.1038/nature03986
-
Carulla N, et al. (2005) Molecular recycling within amyloid fibrils. Nature 436(7050):554-558. (Pubitemid 41112928)
-
(2005)
Nature
, vol.436
, Issue.7050
, pp. 554-558
-
-
Carulla, N.1
Caddy, G.L.2
Hall, D.R.3
Zurdo, J.4
Gairi, M.5
Feliz, M.6
Giralt, E.7
Robinson, C.V.8
Dobson, C.M.9
-
25
-
-
72149118250
-
An analytical solution to the kinetics of breakable filament assembly
-
Knowles TPJ, et al. (2009) An analytical solution to the kinetics of breakable filament assembly. Science 326(5959):1533-1537.
-
(2009)
Science
, vol.326
, Issue.5959
, pp. 1533-1537
-
-
Knowles, T.P.J.1
-
26
-
-
48249092311
-
Systematic analysis of nucleation-dependent polymerization reveals new insights into the mechanism of amyloid self-assembly
-
Xue WF, Homans SW, Radford SE (2008) Systematic analysis of nucleation-dependent polymerization reveals new insights into the mechanism of amyloid self-assembly. Proc Natl Acad Sci USA 105(26):8926-8931.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.26
, pp. 8926-8931
-
-
Xue, W.F.1
Homans, S.W.2
Radford, S.E.3
-
27
-
-
71749089460
-
Fibril fragmentation enhances amyloid cytotoxicity
-
Xue WF, et al. (2009) Fibril fragmentation enhances amyloid cytotoxicity. J Biol Chem 284(49):34272-34282.
-
(2009)
J Biol Chem
, vol.284
, Issue.49
, pp. 34272-34282
-
-
Xue, W.F.1
-
28
-
-
67349152747
-
2)-microglobulin assemble into elaborate amyloid fibrils
-
2)- microglobulin assemble into elaborate amyloid fibrils. J Mol Biol 389(1):48-57.
-
(2009)
J Mol Biol
, vol.389
, Issue.1
, pp. 48-57
-
-
White, H.E.1
-
29
-
-
77952759080
-
2-microglobulin in amyloid fibrils revealed by site-directed spin labeling and chemical labeling
-
2-microglobulin in amyloid fibrils revealed by site-directed spin labeling and chemical labeling. J Biol Chem 285(22):17137-17147.
-
(2010)
J Biol Chem
, vol.285
, Issue.22
, pp. 17137-17147
-
-
Ladner, C.L.1
-
30
-
-
78650159249
-
Griffin RG Intermolecular alignment in beta(2)-microglobulin amyloid fibrils
-
Debelouchina GT, Platt GW, Bayro MJ, Radford SE (2010) Griffin RG Intermolecular alignment in beta(2)-microglobulin amyloid fibrils. J Am Chem Soc 132:17077-17079.
-
(2010)
J Am Chem Soc
, vol.132
, pp. 17077-17079
-
-
Debelouchina, G.T.1
Platt, G.W.2
Bayro, M.J.3
Radford, S.E.4
-
31
-
-
33144471714
-
2-microglobulin amyloid formation at neutral pH
-
2-microglobulin amyloid formation at neutral pH. Biochemistry 45(7):2311-2321.
-
(2006)
Biochemistry
, vol.45
, Issue.7
, pp. 2311-2321
-
-
Myers, S.L.1
-
32
-
-
33645978129
-
The mechanism of pore formation by bacterial toxins
-
Tilley SJ, Saibil HR (2006) The mechanism of pore formation by bacterial toxins. Curr Opin Struct Biol 16(2):230-236.
-
(2006)
Curr Opin Struct Biol
, vol.16
, Issue.2
, pp. 230-236
-
-
Tilley, S.J.1
Saibil, H.R.2
-
34
-
-
67650325176
-
The interplay of catalysis and toxicity by amyloid intermediates on lipid bilayers: Insights from type II diabetes
-
Hebda JA, Miranker AD (2009) The interplay of catalysis and toxicity by amyloid intermediates on lipid bilayers: insights from type II diabetes. Annu Rev Biophys 38:125-152.
-
(2009)
Annu Rev Biophys
, vol.38
, pp. 125-152
-
-
Hebda, J.A.1
Miranker, A.D.2
-
35
-
-
0037041420
-
Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases
-
DOI 10.1038/416507a
-
Bucciantini M, et al. (2002) Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases. Nature 416(6880):507-511. (Pubitemid 34288846)
-
(2002)
Nature
, vol.416
, Issue.6880
, pp. 507-511
-
-
Bucciantini, M.1
Giannoni, E.2
Chiti, F.3
Baroni, F.4
Formigli, L.5
Zurdo, J.6
Taddei, N.7
Ramponi, G.8
Dobson, C.M.9
Stefani, M.10
-
36
-
-
38049056730
-
Lipids revert inert Abeta amyloid fibrils to neurotoxic protofibrils that affect learning in mice
-
Martins IC, et al. (2008) Lipids revert inert Abeta amyloid fibrils to neurotoxic protofibrils that affect learning in mice. EMBO J 27(1):224-233.
-
(2008)
EMBO J
, vol.27
, Issue.1
, pp. 224-233
-
-
Martins, I.C.1
-
37
-
-
77950684398
-
Effect of lipid type on the binding of lipid vesicles to islet amyloid polypeptide amyloid fibrils
-
Sasahara K, Hall D, Hamada D (2010) Effect of lipid type on the binding of lipid vesicles to islet amyloid polypeptide amyloid fibrils. Biochemistry 49(14):3040-3048.
-
(2010)
Biochemistry
, vol.49
, Issue.14
, pp. 3040-3048
-
-
Sasahara, K.1
Hall, D.2
Hamada, D.3
-
38
-
-
34548291359
-
Surface structure of amyloid-beta fibrils contributes to cytotoxicity
-
DOI 10.1021/bi700455c
-
Yoshiike Y, Akagi T, Takashima A (2007) Surface structure of amyloid-beta fibrils contributes to cytotoxicity. Biochemistry 46(34):9805-9812. (Pubitemid 47328586)
-
(2007)
Biochemistry
, vol.46
, Issue.34
, pp. 9805-9812
-
-
Yoshiike, Y.1
Akagi, T.2
Takashima, A.3
-
39
-
-
4143094106
-
Phospholipid catalysis of diabetic amyloid assembly
-
DOI 10.1016/j.jmb.2004.06.086, PII S0022283604007983
-
Knight JD, Miranker AD (2004) Phospholipid catalysis of diabetic amyloid assembly. J Mol Biol 341(5):1175-1187. (Pubitemid 39099208)
-
(2004)
Journal of Molecular Biology
, vol.341
, Issue.5
, pp. 1175-1187
-
-
Knight, J.D.1
Miranker, A.D.2
-
40
-
-
84859175662
-
Membrane fission is promoted by insertion of amphipathic helices and is restricted by crescent BAR domains
-
Boucrot E, et al. (2012) Membrane fission is promoted by insertion of amphipathic helices and is restricted by crescent BAR domains. Cell 149(1):124-136.
-
(2012)
Cell
, vol.149
, Issue.1
, pp. 124-136
-
-
Boucrot, E.1
-
41
-
-
75349097530
-
A causative link between the structure of aberrant protein oligomers and their toxicity
-
Campioni S, et al. (2010) A causative link between the structure of aberrant protein oligomers and their toxicity. Nat Chem Biol 6(2):140-147.
-
(2010)
Nat Chem Biol
, vol.6
, Issue.2
, pp. 140-147
-
-
Campioni, S.1
-
42
-
-
79952742454
-
In vivo demonstration that alpha-synuclein oligomers are toxic
-
Winner B, et al. (2011) In vivo demonstration that alpha-synuclein oligomers are toxic. Proc Natl Acad Sci USA 108(10):4194-4199.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, Issue.10
, pp. 4194-4199
-
-
Winner, B.1
-
43
-
-
84861563520
-
Direct observation of the interconversion of normal and toxic forms of α-synuclein
-
Cremades N, et al. (2012) Direct observation of the interconversion of normal and toxic forms of α-synuclein. Cell 149(5):1048-1059.
-
(2012)
Cell
, vol.149
, Issue.5
, pp. 1048-1059
-
-
Cremades, N.1
-
44
-
-
28444476999
-
Membrane curvature and mechanisms of dynamic cell membrane remodelling
-
DOI 10.1038/nature04396
-
McMahon HT, Gallop JL (2005) Membrane curvature and mechanisms of dynamic cell membrane remodelling. Nature 438(7068):590-596. (Pubitemid 41740562)
-
(2005)
Nature
, vol.438
, Issue.7068
, pp. 590-596
-
-
McMahon, H.T.1
Gallop, J.L.2
-
45
-
-
77950528480
-
Architecture of a nascent viral fusion pore
-
Lee K-K (2010) Architecture of a nascent viral fusion pore. EMBO J 29(7):1299-1311.
-
(2010)
EMBO J
, vol.29
, Issue.7
, pp. 1299-1311
-
-
Lee, K.-K.1
-
46
-
-
77749234000
-
Kinesin motor activation: Microtubules pull the switches
-
Fourniol F, Moores CA (2010) Kinesin motor activation: Microtubules pull the switches. Proc Natl Acad Sci USA 107(9):3949-3950.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, Issue.9
, pp. 3949-3950
-
-
Fourniol, F.1
Moores, C.A.2
-
47
-
-
13444280218
-
Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain
-
DOI 10.1038/nature03251
-
Otomo T, et al. (2005) Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain. Nature 433(7025):488-494. (Pubitemid 40204299)
-
(2005)
Nature
, vol.433
, Issue.7025
, pp. 488-494
-
-
Otomo, T.1
Tomchick, D.R.2
Otomo, C.3
Panchal, S.C.4
Machius, M.5
Rosen, M.K.6
-
48
-
-
23444445907
-
2-microglobulin into amyloid
-
2-microglobulin into amyloid. J Mol Biol 351(4):850-864.
-
(2005)
J Mol Biol
, vol.351
, Issue.4
, pp. 850-864
-
-
Gosal, W.S.1
-
50
-
-
78649499176
-
Mutual modulation between membrane-embedded receptor clustering and ligand binding in lipid membranes
-
Tomas S, Milanesi L (2010) Mutual modulation between membrane-embedded receptor clustering and ligand binding in lipid membranes. Nat Chem 2(12):1077-1083.
-
(2010)
Nat Chem
, vol.2
, Issue.12
, pp. 1077-1083
-
-
Tomas, S.1
Milanesi, L.2
-
51
-
-
0029957224
-
Rapid preparation of giant unilamellar vesicles
-
DOI 10.1073/pnas.93.21.11443
-
Moscho A, Orwar O, Chiu DT, Modi BP, Zare RN (1996) Rapid preparation of giant unilamellar vesicles. Proc Natl Acad Sci USA 93(21):11443-11447. (Pubitemid 26347140)
-
(1996)
Proceedings of the National Academy of Sciences of the United States of America
, vol.93
, Issue.21
, pp. 11443-11447
-
-
Moscho, A.1
Orwar, O.2
Chiu, D.T.3
Modi, B.P.4
Zare, R.N.5
-
52
-
-
0029879295
-
Computer visualization of three-dimensional image data using IMOD
-
DOI 10.1006/jsbi.1996.0013
-
Kremer JR, Mastronarde DN, McIntosh JR (1996) Computer visualization of three-dimensional image data using IMOD. J Struct Biol 116(1):71-76. (Pubitemid 26093126)
-
(1996)
Journal of Structural Biology
, vol.116
, Issue.1
, pp. 71-76
-
-
Kremer, J.R.1
Mastronarde, D.N.2
McIntosh, J.R.3
-
53
-
-
0035783287
-
Noise reduction in electron tomographic reconstructions using nonlinear anisotropic diffusion
-
Frangakis AS, Hegerl R (2001) Noise reduction in electron tomographic reconstructions using nonlinear anisotropic diffusion. J Struct Biol 135(3):239-250.
-
(2001)
J Struct Biol
, vol.135
, Issue.3
, pp. 239-250
-
-
Frangakis, A.S.1
Hegerl, R.2
|