-
1
-
-
84865300719
-
Metabolism and autophagy in the immune system: immunometabolism comes of age
-
Rathmell J.C. Metabolism and autophagy in the immune system: immunometabolism comes of age. Immunol. Rev. 2012, 249:5-13.
-
(2012)
Immunol. Rev.
, vol.249
, pp. 5-13
-
-
Rathmell, J.C.1
-
2
-
-
84859416933
-
Regulatory T cells: mechanisms of differentiation and function
-
Josefowicz S.Z., et al. Regulatory T cells: mechanisms of differentiation and function. Annu. Rev. Immunol. 2012, 30:531-564.
-
(2012)
Annu. Rev. Immunol.
, vol.30
, pp. 531-564
-
-
Josefowicz, S.Z.1
-
3
-
-
76749133610
-
Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate
-
Zheng Y., et al. Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature 2010, 463:808-812.
-
(2010)
Nature
, vol.463
, pp. 808-812
-
-
Zheng, Y.1
-
4
-
-
84869148187
-
T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development
-
Ohkura N., et al. T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development. Immunity 2012, 37:785-799.
-
(2012)
Immunity
, vol.37
, pp. 785-799
-
-
Ohkura, N.1
-
5
-
-
84881192927
-
MTORC1 couples immune signals and metabolic programming to establish T-cell function
-
Zeng H., et al. mTORC1 couples immune signals and metabolic programming to establish T-cell function. Nature 2013, 499:485-490.
-
(2013)
Nature
, vol.499
, pp. 485-490
-
-
Zeng, H.1
-
6
-
-
79953172571
-
+ T cell subsets
-
+ T cell subsets. J. Immunol. 2011, 186:3299-3303.
-
(2011)
J. Immunol.
, vol.186
, pp. 3299-3303
-
-
Michalek, R.D.1
-
7
-
-
79960369458
-
HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
-
Shi L.Z., et al. HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J. Exp. Med. 2011, 208:1367-1376.
-
(2011)
J. Exp. Med.
, vol.208
, pp. 1367-1376
-
-
Shi, L.Z.1
-
8
-
-
84919617295
-
Editorial Effects of nutrition on growth and resistance to infection
-
Editorial Effects of nutrition on growth and resistance to infection. Am. J. Public Health 1926, 16:2.
-
(1926)
Am. J. Public Health
, vol.16
, pp. 2
-
-
-
9
-
-
0037224876
-
The history of nutrition: malnutrition, infection and immunity
-
Keusch G.T. The history of nutrition: malnutrition, infection and immunity. J. Nutr. 2003, 133:336S-3340S.
-
(2003)
J. Nutr.
, vol.133
, pp. 336S-3340S
-
-
Keusch, G.T.1
-
10
-
-
84878785347
-
Immunological goings-on in visceral adipose tissue
-
Mathis D. Immunological goings-on in visceral adipose tissue. Cell Metab. 2013, 17:851-859.
-
(2013)
Cell Metab.
, vol.17
, pp. 851-859
-
-
Mathis, D.1
-
11
-
-
50249179101
-
Vitamin effects on the immune system: vitamins A and D take centre stage
-
Mora J.R., et al. Vitamin effects on the immune system: vitamins A and D take centre stage. Nat. Rev. Immunol. 2008, 8:685-698.
-
(2008)
Nat. Rev. Immunol.
, vol.8
, pp. 685-698
-
-
Mora, J.R.1
-
12
-
-
5644300399
-
Retinoic acid imprints gut-homing specificity on T cells
-
Iwata M., et al. Retinoic acid imprints gut-homing specificity on T cells. Immunity 2004, 21:527-538.
-
(2004)
Immunity
, vol.21
, pp. 527-538
-
-
Iwata, M.1
-
13
-
-
79952740974
-
+ T cell effector responses via retinoic acid receptor alpha
-
+ T cell effector responses via retinoic acid receptor alpha. Immunity 2011, 34:435-447.
-
(2011)
Immunity
, vol.34
, pp. 435-447
-
-
Hall, J.A.1
-
14
-
-
33751223544
-
Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells
-
Mora J.R., et al. Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells. Science 2006, 314:1157-1160.
-
(2006)
Science
, vol.314
, pp. 1157-1160
-
-
Mora, J.R.1
-
15
-
-
84892928571
-
Adaptation of innate lymphoid cells to a micronutrient deficiency promotes type 2 barrier immunity
-
Spencer S.P., et al. Adaptation of innate lymphoid cells to a micronutrient deficiency promotes type 2 barrier immunity. Science 2014, 343:432-437.
-
(2014)
Science
, vol.343
, pp. 432-437
-
-
Spencer, S.P.1
-
16
-
-
84897480560
-
Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity
-
van de Pavert S.A., et al. Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity. Nature 2014, 508:123-127.
-
(2014)
Nature
, vol.508
, pp. 123-127
-
-
van de Pavert, S.A.1
-
17
-
-
84880095109
-
+ dendritic cells
-
+ dendritic cells. J. Immunol. 2013, 191:650-659.
-
(2013)
J. Immunol.
, vol.191
, pp. 650-659
-
-
Huang, G.1
-
18
-
-
43449135305
-
H17 cell differentiation by antagonizing RORgammat function
-
H17 cell differentiation by antagonizing RORgammat function. Nature 2008, 453:236-240.
-
(2008)
Nature
, vol.453
, pp. 236-240
-
-
Zhou, L.1
-
19
-
-
46749138596
-
Molecular antagonism and plasticity of regulatory and inflammatory T cell programs
-
Yang X.O., et al. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 2008, 29:44-56.
-
(2008)
Immunity
, vol.29
, pp. 44-56
-
-
Yang, X.O.1
-
20
-
-
34447503805
-
Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid
-
Mucida D., et al. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 2007, 317:256-260.
-
(2007)
Science
, vol.317
, pp. 256-260
-
-
Mucida, D.1
-
21
-
-
55549084247
-
hi Cells
-
hi Cells. Immunity 2008, 29:758-770.
-
(2008)
Immunity
, vol.29
, pp. 758-770
-
-
Hill, J.A.1
-
22
-
-
34547788180
-
+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism
-
+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J. Exp. Med. 2007, 204:1757-1764.
-
(2007)
J. Exp. Med.
, vol.204
, pp. 1757-1764
-
-
Coombes, J.L.1
-
23
-
-
34547757390
-
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
-
Sun C.M., et al. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J. Exp. Med. 2007, 204:1775-1785.
-
(2007)
J. Exp. Med.
, vol.204
, pp. 1775-1785
-
-
Sun, C.M.1
-
24
-
-
35748934494
-
+ regulatory T cells
-
+ regulatory T cells. J. Immunol. 2007, 179:3724-3733.
-
(2007)
J. Immunol.
, vol.179
, pp. 3724-3733
-
-
Kang, S.G.1
-
25
-
-
79954511312
-
Oral tolerance
-
Weiner H.L., et al. Oral tolerance. Immunol. Rev. 2011, 241:241-259.
-
(2011)
Immunol. Rev.
, vol.241
, pp. 241-259
-
-
Weiner, H.L.1
-
26
-
-
27744595600
-
+ regulatory T cells by 1,25-dihydroxyvitamin D3
-
+ regulatory T cells by 1,25-dihydroxyvitamin D3. Blood 2005, 106:3490-3497.
-
(2005)
Blood
, vol.106
, pp. 3490-3497
-
-
Penna, G.1
-
27
-
-
38449101546
-
+ cells in the draining lymph nodes
-
+ cells in the draining lymph nodes. J. Immunol. 2007, 179:6273-6283.
-
(2007)
J. Immunol.
, vol.179
, pp. 6273-6283
-
-
Gorman, S.1
-
28
-
-
37349104972
-
Immune modulatory treatment of trinitrobenzene sulfonic acid colitis with calcitriol is associated with a change of a T helper (Th) 1/Th17 to a Th2 and regulatory T cell profile
-
Daniel C., et al. Immune modulatory treatment of trinitrobenzene sulfonic acid colitis with calcitriol is associated with a change of a T helper (Th) 1/Th17 to a Th2 and regulatory T cell profile. J. Pharmacol. Exp. Ther. 2008, 324:23-33.
-
(2008)
J. Pharmacol. Exp. Ther.
, vol.324
, pp. 23-33
-
-
Daniel, C.1
-
29
-
-
77951253745
-
1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3
-
Jeffery L.E., et al. 1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3. J. Immunol. 2009, 183:5458-5467.
-
(2009)
J. Immunol.
, vol.183
, pp. 5458-5467
-
-
Jeffery, L.E.1
-
30
-
-
0037302966
-
Tolerogenic dendritic cells induced by vitamin D receptor ligands enhance regulatory T cells inhibiting allograft rejection and autoimmune diseases
-
Adorini L., et al. Tolerogenic dendritic cells induced by vitamin D receptor ligands enhance regulatory T cells inhibiting allograft rejection and autoimmune diseases. J. Cell. Biochem. 2003, 88:227-233.
-
(2003)
J. Cell. Biochem.
, vol.88
, pp. 227-233
-
-
Adorini, L.1
-
31
-
-
84862093116
-
1,25-Dihyroxyvitamin D3 promotes FOXP3 expression via binding to vitamin D response elements in its conserved noncoding sequence region
-
Kang S.W., et al. 1,25-Dihyroxyvitamin D3 promotes FOXP3 expression via binding to vitamin D response elements in its conserved noncoding sequence region. J. Immunol. 2012, 188:5276-5282.
-
(2012)
J. Immunol.
, vol.188
, pp. 5276-5282
-
-
Kang, S.W.1
-
32
-
-
77949873898
-
Vitamin D controls T cell antigen receptor signaling and activation of human T cells
-
von Essen M.R., et al. Vitamin D controls T cell antigen receptor signaling and activation of human T cells. Nat. Immunol. 2010, 11:344-349.
-
(2010)
Nat. Immunol.
, vol.11
, pp. 344-349
-
-
von Essen, M.R.1
-
33
-
-
58549118947
-
Failure of T cell homing, reduced CD4/CD8alphaalpha intraepithelial lymphocytes, and inflammation in the gut of vitamin D receptor KO mice
-
Yu S., et al. Failure of T cell homing, reduced CD4/CD8alphaalpha intraepithelial lymphocytes, and inflammation in the gut of vitamin D receptor KO mice. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:20834-20839.
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 20834-20839
-
-
Yu, S.1
-
34
-
-
0346219142
-
A crucial role for the vitamin D receptor in experimental inflammatory bowel diseases
-
Froicu M., et al. A crucial role for the vitamin D receptor in experimental inflammatory bowel diseases. Mol. Endocrinol. 2003, 17:2386-2392.
-
(2003)
Mol. Endocrinol.
, vol.17
, pp. 2386-2392
-
-
Froicu, M.1
-
35
-
-
3142774934
-
Physiology of folate and vitamin B12 in health and disease
-
Stover P.J. Physiology of folate and vitamin B12 in health and disease. Nutr. Rev. 2004, 62:S3-S12.
-
(2004)
Nutr. Rev.
, vol.62
, pp. S3-S12
-
-
Stover, P.J.1
-
36
-
-
34447643405
-
Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor
-
Yamaguchi T., et al. Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor. Immunity 2007, 27:145-159.
-
(2007)
Immunity
, vol.27
, pp. 145-159
-
-
Yamaguchi, T.1
-
37
-
-
84866166162
-
+ regulatory T cells in the colon
-
+ regulatory T cells in the colon. J. Immunol. 2012, 189:2869-2878.
-
(2012)
J. Immunol.
, vol.189
, pp. 2869-2878
-
-
Kinoshita, M.1
-
38
-
-
84857419586
-
A pivotal role of vitamin B9 in the maintenance of regulatory T cells in vitro and in vivo
-
Kunisawa J., et al. A pivotal role of vitamin B9 in the maintenance of regulatory T cells in vitro and in vivo. PloS ONE 2012, 7:e32094.
-
(2012)
PloS ONE
, vol.7
, pp. e32094
-
-
Kunisawa, J.1
-
39
-
-
0842325192
-
Pellagra: dermatitis, dementia, and diarrhea
-
Hegyi J., et al. Pellagra: dermatitis, dementia, and diarrhea. Int. J. Dermatol. 2004, 43:1-5.
-
(2004)
Int. J. Dermatol.
, vol.43
, pp. 1-5
-
-
Hegyi, J.1
-
40
-
-
84892449521
-
Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis
-
Singh N., et al. Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis. Immunity 2014, 40:128-139.
-
(2014)
Immunity
, vol.40
, pp. 128-139
-
-
Singh, N.1
-
41
-
-
33847312289
-
A key role of leptin in the control of regulatory T cell proliferation
-
De Rosa V., et al. A key role of leptin in the control of regulatory T cell proliferation. Immunity 2007, 26:241-255.
-
(2007)
Immunity
, vol.26
, pp. 241-255
-
-
De Rosa, V.1
-
42
-
-
78650188983
-
An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness
-
Procaccini C., et al. An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness. Immunity 2010, 33:929-941.
-
(2010)
Immunity
, vol.33
, pp. 929-941
-
-
Procaccini, C.1
-
43
-
-
43549114292
-
Mechanisms of leptin action and leptin resistance
-
Myers M.G., et al. Mechanisms of leptin action and leptin resistance. Annu. Rev. Physiol. 2008, 70:537-556.
-
(2008)
Annu. Rev. Physiol.
, vol.70
, pp. 537-556
-
-
Myers, M.G.1
-
44
-
-
0037241113
-
Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses
-
Sanna V., et al. Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses. J. Clin. Invest. 2003, 111:241-250.
-
(2003)
J. Clin. Invest.
, vol.111
, pp. 241-250
-
-
Sanna, V.1
-
45
-
-
3042661014
-
Leptin receptor expression on T lymphocytes modulates chronic intestinal inflammation in mice
-
Siegmund B., et al. Leptin receptor expression on T lymphocytes modulates chronic intestinal inflammation in mice. Gut 2004, 53:965-972.
-
(2004)
Gut
, vol.53
, pp. 965-972
-
-
Siegmund, B.1
-
46
-
-
0035873418
-
Requirement for leptin in the induction and progression of autoimmune encephalomyelitis
-
Matarese G., et al. Requirement for leptin in the induction and progression of autoimmune encephalomyelitis. J. Immunol. 2001, 166:5909-5916.
-
(2001)
J. Immunol.
, vol.166
, pp. 5909-5916
-
-
Matarese, G.1
-
47
-
-
0034058378
-
Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity: role of tumor necrosis factor alpha and IL-18
-
Faggioni R., et al. Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity: role of tumor necrosis factor alpha and IL-18. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:2367-2372.
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 2367-2372
-
-
Faggioni, R.1
-
48
-
-
84862986986
-
PPAR-gamma is a major driver of the accumulation and phenotype of adipose tissue Treg cells
-
Cipolletta D., et al. PPAR-gamma is a major driver of the accumulation and phenotype of adipose tissue Treg cells. Nature 2012, 486:549-553.
-
(2012)
Nature
, vol.486
, pp. 549-553
-
-
Cipolletta, D.1
-
49
-
-
68349148211
-
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
-
Feuerer M., et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat. Med. 2009, 15:930-939.
-
(2009)
Nat. Med.
, vol.15
, pp. 930-939
-
-
Feuerer, M.1
-
50
-
-
84876032463
-
Hunger-promoting hypothalamic neurons modulate effector and regulatory T-cell responses
-
Matarese G., et al. Hunger-promoting hypothalamic neurons modulate effector and regulatory T-cell responses. Proc. Natl. Acad. Sci. U.S.A. 2013, 110:6193-6198.
-
(2013)
Proc. Natl. Acad. Sci. U.S.A.
, vol.110
, pp. 6193-6198
-
-
Matarese, G.1
-
51
-
-
84897138296
-
Role of the microbiota in immunity and inflammation
-
Belkaid Y., Hand T.W. Role of the microbiota in immunity and inflammation. Cell 2014, 157:121-141.
-
(2014)
Cell
, vol.157
, pp. 121-141
-
-
Belkaid, Y.1
Hand, T.W.2
-
52
-
-
84877742439
-
Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota
-
Cebula A., et al. Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota. Nature 2013, 497:258-262.
-
(2013)
Nature
, vol.497
, pp. 258-262
-
-
Cebula, A.1
-
53
-
-
84862777225
-
Extrathymically generated regulatory T cells control mucosal TH2 inflammation
-
Josefowicz S.Z., et al. Extrathymically generated regulatory T cells control mucosal TH2 inflammation. Nature 2012, 482:395-399.
-
(2012)
Nature
, vol.482
, pp. 395-399
-
-
Josefowicz, S.Z.1
-
54
-
-
80054020840
-
Peripheral education of the immune system by colonic commensal microbiota
-
Lathrop S.K., et al. Peripheral education of the immune system by colonic commensal microbiota. Nature 2011, 478:250-254.
-
(2011)
Nature
, vol.478
, pp. 250-254
-
-
Lathrop, S.K.1
-
55
-
-
85027947787
-
Induction of colonic regulatory T cells by indigenous Clostridium species
-
Atarashi K., et al. Induction of colonic regulatory T cells by indigenous Clostridium species. Science 2011, 331:337-341.
-
(2011)
Science
, vol.331
, pp. 337-341
-
-
Atarashi, K.1
-
56
-
-
14844349149
-
Probiotics ameliorate recurrent Th1-mediated murine colitis by inducing IL-10 and IL-10-dependent TGF-beta-bearing regulatory cells
-
Di Giacinto C., et al. Probiotics ameliorate recurrent Th1-mediated murine colitis by inducing IL-10 and IL-10-dependent TGF-beta-bearing regulatory cells. J. Immunol. 2005, 174:3237-3246.
-
(2005)
J. Immunol.
, vol.174
, pp. 3237-3246
-
-
Di Giacinto, C.1
-
57
-
-
34047197836
-
Probiotic-induced suppression of allergic sensitization and airway inflammation is associated with an increase of T regulatory-dependent mechanisms in a murine model of asthma
-
Feleszko W., et al. Probiotic-induced suppression of allergic sensitization and airway inflammation is associated with an increase of T regulatory-dependent mechanisms in a murine model of asthma. Clin. Exp. Allergy 2007, 37:498-505.
-
(2007)
Clin. Exp. Allergy
, vol.37
, pp. 498-505
-
-
Feleszko, W.1
-
58
-
-
61449199478
-
Lactobacillus reuteri-induced regulatory T cells protect against an allergic airway response in mice
-
Karimi K., et al. Lactobacillus reuteri-induced regulatory T cells protect against an allergic airway response in mice. Am. J. Respir. Crit. Care. Med. 2009, 179:186-193.
-
(2009)
Am. J. Respir. Crit. Care. Med.
, vol.179
, pp. 186-193
-
-
Karimi, K.1
-
59
-
-
77950962146
-
+ T regulatory cells is protective in murine allergy models
-
+ T regulatory cells is protective in murine allergy models. Clin. Exp. Allergy 2010, 40:811-819.
-
(2010)
Clin. Exp. Allergy
, vol.40
, pp. 811-819
-
-
Lyons, A.1
-
60
-
-
84893370250
-
Identifying gut microbe-host phenotype relationships using combinatorial communities in gnotobiotic mice
-
220ra11
-
Faith J.J., et al. Identifying gut microbe-host phenotype relationships using combinatorial communities in gnotobiotic mice. Sci. Transl. Med. 2014, 6:220ra11.
-
(2014)
Sci. Transl. Med.
, vol.6
-
-
Faith, J.J.1
-
61
-
-
79956315886
-
Intestinal bacterial colonization induces mutualistic regulatory T cell responses
-
Geuking M.B., et al. Intestinal bacterial colonization induces mutualistic regulatory T cell responses. Immunity 2011, 34:794-806.
-
(2011)
Immunity
, vol.34
, pp. 794-806
-
-
Geuking, M.B.1
-
62
-
-
84881477044
-
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota
-
Atarashi K., et al. Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. Nature 2013, 500:232-236.
-
(2013)
Nature
, vol.500
, pp. 232-236
-
-
Atarashi, K.1
-
63
-
-
84901065053
-
The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells
-
Obata Y., et al. The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells. Nat. Immunol. 2014, 15:571-579.
-
(2014)
Nat. Immunol.
, vol.15
, pp. 571-579
-
-
Obata, Y.1
-
64
-
-
22144490199
-
An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system
-
Mazmanian S.K., et al. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell 2005, 122:107-118.
-
(2005)
Cell
, vol.122
, pp. 107-118
-
-
Mazmanian, S.K.1
-
65
-
-
44449106055
-
A microbial symbiosis factor prevents intestinal inflammatory disease
-
Mazmanian S.K., et al. A microbial symbiosis factor prevents intestinal inflammatory disease. Nature 2008, 453:620-625.
-
(2008)
Nature
, vol.453
, pp. 620-625
-
-
Mazmanian, S.K.1
-
66
-
-
77954738601
-
+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota
-
+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:12204-12209.
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 12204-12209
-
-
Round, J.L.1
Mazmanian, S.K.2
-
67
-
-
79956311926
-
The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota
-
Round J.L., et al. The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science 2011, 332:974-977.
-
(2011)
Science
, vol.332
, pp. 974-977
-
-
Round, J.L.1
-
68
-
-
77958119730
-
Central nervous system demyelinating disease protection by the human commensal Bacteroides fragilis depends on polysaccharide A expression
-
Ochoa-Reparaz J., et al. Central nervous system demyelinating disease protection by the human commensal Bacteroides fragilis depends on polysaccharide A expression. J. Immunol. 2010, 185:4101-4108.
-
(2010)
J. Immunol.
, vol.185
, pp. 4101-4108
-
-
Ochoa-Reparaz, J.1
-
69
-
-
77249096486
-
Role of gut commensal microflora in the development of experimental autoimmune encephalomyelitis
-
Ochoa-Reparaz J., et al. Role of gut commensal microflora in the development of experimental autoimmune encephalomyelitis. J. Immunol. 2009, 183:6041-6050.
-
(2009)
J. Immunol.
, vol.183
, pp. 6041-6050
-
-
Ochoa-Reparaz, J.1
-
70
-
-
77955913743
-
A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease
-
Ochoa-Reparaz J., et al. A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease. Mucosal Immunol. 2010, 3:487-495.
-
(2010)
Mucosal Immunol.
, vol.3
, pp. 487-495
-
-
Ochoa-Reparaz, J.1
-
71
-
-
70350343544
-
Induction of intestinal Th17 cells by segmented filamentous bacteria
-
Ivanov, et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 2009, 139:485-498.
-
(2009)
Cell
, vol.139
, pp. 485-498
-
-
Ivanov1
-
72
-
-
53349173070
-
Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine
-
Ivanov I.I., et al. Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe 2008, 4:337-349.
-
(2008)
Cell Host Microbe
, vol.4
, pp. 337-349
-
-
Ivanov, I.I.1
-
73
-
-
77953913586
-
Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells
-
Wu H.J., et al. Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity 2010, 32:815-827.
-
(2010)
Immunity
, vol.32
, pp. 815-827
-
-
Wu, H.J.1
-
74
-
-
53649100675
-
H17 cell differentiation
-
H17 cell differentiation. Nature 2008, 455:808-812.
-
(2008)
Nature
, vol.455
, pp. 808-812
-
-
Atarashi, K.1
-
75
-
-
84898679249
-
Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation
-
Goto Y., et al. Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation. Immunity 2014, 40:594-607.
-
(2014)
Immunity
, vol.40
, pp. 594-607
-
-
Goto, Y.1
-
76
-
-
84898685253
-
Segmented filamentous bacterium uses secondary and tertiary lymphoid tissues to induce gut IgA and specific T helper 17 cell responses
-
Lecuyer E., et al. Segmented filamentous bacterium uses secondary and tertiary lymphoid tissues to induce gut IgA and specific T helper 17 cell responses. Immunity 2014, 40:608-620.
-
(2014)
Immunity
, vol.40
, pp. 608-620
-
-
Lecuyer, E.1
-
77
-
-
84901979873
-
H17 cells towards commensal bacterial antigens
-
H17 cells towards commensal bacterial antigens. Nature 2014, 510:152-156.
-
(2014)
Nature
, vol.510
, pp. 152-156
-
-
Yang, Y.1
-
78
-
-
32944466887
-
Ecological and evolutionary forces shaping microbial diversity in the human intestine
-
Ley R.E., et al. Ecological and evolutionary forces shaping microbial diversity in the human intestine. Cell 2006, 124:837-848.
-
(2006)
Cell
, vol.124
, pp. 837-848
-
-
Ley, R.E.1
-
79
-
-
0023276469
-
Short chain fatty acids in human large intestine, portal, hepatic and venous blood
-
Cummings J.H., et al. Short chain fatty acids in human large intestine, portal, hepatic and venous blood. Gut 1987, 28:1221-1227.
-
(1987)
Gut
, vol.28
, pp. 1221-1227
-
-
Cummings, J.H.1
-
80
-
-
84890550163
-
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
-
Arpaia N., et al. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature 2013, 504:451-455.
-
(2013)
Nature
, vol.504
, pp. 451-455
-
-
Arpaia, N.1
-
81
-
-
84881068658
-
The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis
-
Smith P.M., et al. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science 2013, 341:569-573.
-
(2013)
Science
, vol.341
, pp. 569-573
-
-
Smith, P.M.1
-
82
-
-
84890564250
-
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
-
Furusawa Y., et al. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature 2013, 504:446-450.
-
(2013)
Nature
, vol.504
, pp. 446-450
-
-
Furusawa, Y.1
-
83
-
-
70350666634
-
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
-
Maslowski K.M., et al. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature 2009, 461:1282-1286.
-
(2009)
Nature
, vol.461
, pp. 1282-1286
-
-
Maslowski, K.M.1
-
84
-
-
84888167311
-
Transporters and receptors for short-chain fatty acids as the molecular link between colonic bacteria and the host
-
Ganapathy V., et al. Transporters and receptors for short-chain fatty acids as the molecular link between colonic bacteria and the host. Curr. Opin. Pharmacol. 2013, 13:869-874.
-
(2013)
Curr. Opin. Pharmacol.
, vol.13
, pp. 869-874
-
-
Ganapathy, V.1
-
85
-
-
84893859801
-
The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition
-
Chang P.V., et al. The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc. Natl. Acad. Sci. U.S.A. 2014, 111:2247-2252.
-
(2014)
Proc. Natl. Acad. Sci. U.S.A.
, vol.111
, pp. 2247-2252
-
-
Chang, P.V.1
-
86
-
-
84866562625
-
Metabolic checkpoints in activated T cells
-
Wang R., Green D.R. Metabolic checkpoints in activated T cells. Nat. Immunol. 2012, 13:907-915.
-
(2012)
Nat. Immunol.
, vol.13
, pp. 907-915
-
-
Wang, R.1
Green, D.R.2
-
87
-
-
84879195658
-
MTOR and lymphocyte metabolism
-
Zeng H., Chi H. mTOR and lymphocyte metabolism. Curr. Opin. Immunol. 2013, 25:347-355.
-
(2013)
Curr. Opin. Immunol.
, vol.25
, pp. 347-355
-
-
Zeng, H.1
Chi, H.2
-
88
-
-
84890137621
-
T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming
-
Yang K., et al. T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming. Immunity 2013, 39:1043-1056.
-
(2013)
Immunity
, vol.39
, pp. 1043-1056
-
-
Yang, K.1
-
89
-
-
84860237060
-
Regulation and function of mTOR signalling in T cell fate decisions
-
Chi H. Regulation and function of mTOR signalling in T cell fate decisions. Nat. Rev. Immunol. 2012, 12:325-338.
-
(2012)
Nat. Rev. Immunol.
, vol.12
, pp. 325-338
-
-
Chi, H.1
-
90
-
-
84859778293
-
MTOR signaling in growth control and disease
-
Laplante M., Sabatini D.M. mTOR signaling in growth control and disease. Cell 2012, 149:274-293.
-
(2012)
Cell
, vol.149
, pp. 274-293
-
-
Laplante, M.1
Sabatini, D.M.2
-
92
-
-
77958151145
-
reg cells
-
reg cells. Nat. Immunol. 2010, 11:1047-1056.
-
(2010)
Nat. Immunol.
, vol.11
, pp. 1047-1056
-
-
Liu, G.1
-
93
-
-
45549098562
-
T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and Mtor
-
Sauer S., et al. T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and Mtor. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:7797-7802.
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 7797-7802
-
-
Sauer, S.1
-
94
-
-
67749091321
-
Infectious tolerance via the consumption of essential amino acids and mTOR signaling
-
Cobbold S.P., et al. Infectious tolerance via the consumption of essential amino acids and mTOR signaling. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:12055-12060.
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 12055-12060
-
-
Cobbold, S.P.1
-
95
-
-
67649185215
-
The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR
-
Liu G., et al. The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR. Nat. Immunol. 2009, 10:769-777.
-
(2009)
Nat. Immunol.
, vol.10
, pp. 769-777
-
-
Liu, G.1
-
96
-
-
66949173728
-
The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment
-
Delgoffe G.M., et al. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity 2009, 30:832-844.
-
(2009)
Immunity
, vol.30
, pp. 832-844
-
-
Delgoffe, G.M.1
-
97
-
-
80052277906
-
reg balance by hypoxia-inducible factor 1
-
reg balance by hypoxia-inducible factor 1. Cell 2011, 146:772-784.
-
(2011)
Cell
, vol.146
, pp. 772-784
-
-
Dang, E.V.1
-
98
-
-
79952985551
-
The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
-
Delgoffe G.M., et al. The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nat. Immunol. 2011, 12:295-303.
-
(2011)
Nat. Immunol.
, vol.12
, pp. 295-303
-
-
Delgoffe, G.M.1
-
99
-
-
79551529432
-
Visceral adipose inflammation in obesity is associated with critical alterations in tregulatory cell numbers
-
Deiuliis J., et al. Visceral adipose inflammation in obesity is associated with critical alterations in tregulatory cell numbers. PloS ONE 2011, 6:e16376.
-
(2011)
PloS ONE
, vol.6
, pp. e16376
-
-
Deiuliis, J.1
-
100
-
-
80755168875
-
Potential role of regulatory T cells in reversing obesity-linked insulin resistance and diabetic nephropathy
-
Eller K., et al. Potential role of regulatory T cells in reversing obesity-linked insulin resistance and diabetic nephropathy. Diabetes 2011, 60:2954-2962.
-
(2011)
Diabetes
, vol.60
, pp. 2954-2962
-
-
Eller, K.1
-
101
-
-
84876461373
-
Circulating regulatory T cells are reduced in obesity and may identify subjects at increased metabolic and cardiovascular risk
-
Wagner N.M., et al. Circulating regulatory T cells are reduced in obesity and may identify subjects at increased metabolic and cardiovascular risk. Obesity 2013, 21:461-468.
-
(2013)
Obesity
, vol.21
, pp. 461-468
-
-
Wagner, N.M.1
-
102
-
-
84904384753
-
+ T cells regulate immunoglobulin a selection and facilitate diversification of bacterial species responsible for immune homeostasis
-
+ T cells regulate immunoglobulin a selection and facilitate diversification of bacterial species responsible for immune homeostasis. Immunity 2014, 41:152-165.
-
(2014)
Immunity
, vol.41
, pp. 152-165
-
-
Kawamoto, S.1
-
103
-
-
37649015079
-
+ regulatory T cells induce alternative activation of human monocytes/macrophages
-
+ regulatory T cells induce alternative activation of human monocytes/macrophages. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:19446-19451.
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 19446-19451
-
-
Tiemessen, M.M.1
-
104
-
-
0346119234
-
Modulation of tryptophan catabolism by regulatory T cells
-
Fallarino F., et al. Modulation of tryptophan catabolism by regulatory T cells. Nat. Immunol. 2003, 4:1206-1212.
-
(2003)
Nat. Immunol.
, vol.4
, pp. 1206-1212
-
-
Fallarino, F.1
-
105
-
-
84890050252
-
A special population of regulatory T cells potentiates muscle repair
-
Burzyn D., et al. A special population of regulatory T cells potentiates muscle repair. Cell 2013, 155:1282-1295.
-
(2013)
Cell
, vol.155
, pp. 1282-1295
-
-
Burzyn, D.1
-
106
-
-
84863619688
-
Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict
-
Samstein R.M., et al. Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict. Cell 2012, 150:29-38.
-
(2012)
Cell
, vol.150
, pp. 29-38
-
-
Samstein, R.M.1
-
107
-
-
84865559289
-
Compartmentalized control of skin immunity by resident commensals
-
Naik S., et al. Compartmentalized control of skin immunity by resident commensals. Science 2012, 337:1115-1119.
-
(2012)
Science
, vol.337
, pp. 1115-1119
-
-
Naik, S.1
-
108
-
-
68349137821
-
Normalization of obesity-associated insulin resistance through immunotherapy
-
Winer S., et al. Normalization of obesity-associated insulin resistance through immunotherapy. Nat. Med. 2009, 15:921-929.
-
(2009)
Nat. Med.
, vol.15
, pp. 921-929
-
-
Winer, S.1
-
109
-
-
77953897189
-
Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways
-
Lee K., et al. Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways. Immunity 2010, 32:743-753.
-
(2010)
Immunity
, vol.32
, pp. 743-753
-
-
Lee, K.1
-
110
-
-
84861134382
-
PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi1 expression and nuclear translocation of RORgamma
-
Kurebayashi Y., et al. PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi1 expression and nuclear translocation of RORgamma. Cell Rep. 2012, 1:360-373.
-
(2012)
Cell Rep.
, vol.1
, pp. 360-373
-
-
Kurebayashi, Y.1
-
111
-
-
84871861969
-
+ T cells
-
+ T cells. J. Exp. Med. 2012, 209:2441-2453.
-
(2012)
J. Exp. Med.
, vol.209
, pp. 2441-2453
-
-
Finlay, D.K.1
-
112
-
-
67650096912
-
Enhancing CD8 T-cell memory by modulating fatty acid metabolism
-
Pearce E.L., et al. Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature 2009, 460:103-107.
-
(2009)
Nature
, vol.460
, pp. 103-107
-
-
Pearce, E.L.1
-
113
-
-
67650074206
-
MTOR regulates memory CD8 T-cell differentiation
-
Araki K., et al. mTOR regulates memory CD8 T-cell differentiation. Nature 2009, 460:108-112.
-
(2009)
Nature
, vol.460
, pp. 108-112
-
-
Araki, K.1
-
114
-
-
74649085700
-
+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin
-
+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin. Immunity 2010, 32:67-78.
-
(2010)
Immunity
, vol.32
, pp. 67-78
-
-
Rao, R.R.1
|