A pivotal role of vitamin B9 in the maintenance of regulatory T cells in vitro and in vivo

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Kunisawa, Jun ^a,b   Hashimoto, Eri ^a   Ishikawa, Izumi ^a   Kiyono, Hiroshi ^a,b,c  

^a UNIVERSITY OF TOKYO   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FOLATE RECEPTOR; FOLATE RECEPTOR 4; INTERLEUKIN 2; PROTEIN BCL 2; UNCLASSIFIED DRUG; VITAMIN B GROUP; VITAMIN B9; CARRIER PROTEIN; FOLIC ACID; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL COUNT; CELL SURVIVAL; CONTROLLED STUDY; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SMALL INTESTINE; T LYMPHOCYTE; VITAMIN DEFICIENCY; VITAMIN METABOLISM; ANIMAL; BAGG ALBINO MOUSE; CYTOLOGY; DIET SUPPLEMENTATION; DRUG EFFECT; IMMUNOLOGY; METABOLISM; SIGNAL TRANSDUCTION;

ANIMALS; CARRIER PROTEINS; CELL SURVIVAL; DIETARY SUPPLEMENTS; FEMALE; FOLIC ACID; FORKHEAD TRANSCRIPTION FACTORS; INTERLEUKIN-2; INTESTINE, SMALL; MICE; MICE, INBRED BALB C; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, REGULATORY;

EID: 84857419586     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032094     Document Type: Article

References (41)

1. Kiyono H, Kunisawa J, McGhee JR, Mestecky J, (2008) The mucosal immune system. In: Paul WE, editors. Fundamental Immunology Philadelphia Lippincott-Raven pp. 983-1030.
2. Littman DR, Rudensky AY, (2010) Th17 and regulatory T cells in mediating and restraining inflammation. Cell 140: 845-858.
3. Cebra JJ, Jiang HQ, Boiko NV, Tlaskalva-Hogenova H, (2005) The role of mucosal microbiota in the development, maintenance, and pathologies of the mucosal immune system. In: Mestecky J, Lamm ME, Strober W, Bienenstock J, McGhee JR, editors. Mucosal Immunology. 3rd ed San Diego Academic Press pp. 335-368.
4. Ivanov II, Atarashi K, Manel N, Brodie EL, Shima T, et al. (2009) Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 139: 485-498.
5. Atarashi K, Tanoue T, Shima T, Imaoka A, Kuwahara T, et al. (2011) Induction of colonic regulatory T cells by indigenous Clostridium species. Science 331: 337-341.
6. Geuking MB, Cahenzli J, Lawson MA, Ng DC, Slack E, et al. (2011) Intestinal bacterial colonization induces mutualistic regulatory T cell responses. Immunity 34: 794-806.
7. Hanson LA, Robertson A, Bjersing J, Herias MV, (2005) Undernutrition, Immunodeficiency, and Mucosal Infections. In: Mestecky J, Lamm ME, Strober W, Bienenstock J, McGhee JR, editors. Mucosal Immunology. 3rd ed San Diego Academic Press pp. 1159-1178.
8. Wintergerst ES, Maggini S, Hornig DH, (2007) Contribution of selected vitamins and trace elements to immune function. Ann Nutr Metab 51: 301-323.
9. Iwata M, Hirakiyama A, Eshima Y, Kagechika H, Kato C, et al. (2004) Retinoic acid imprints gut-homing specificity on T cells. Immunity 21: 527-538.
10. Mora JR, Iwata M, Eksteen B, Song SY, Junt T, et al. (2006) Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells. Science 314: 1157-1160.
11. Coombes JL, Siddiqui KR, Arancibia-Carcamo CV, Hall J, Sun CM, et al. (2007) A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β and retinoic acid-dependent mechanism. J Exp Med 204: 1757-1764.
12. Sun CM, Hall JA, Blank RB, Bouladoux N, Oukka M, et al. (2007) Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 Treg cells via retinoic acid. J Exp Med 204: 1775-1785.
13. Benson MJ, Pino-Lagos K, Rosemblatt M, Noelle RJ, (2007) All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation. J Exp Med 204: 1765-1774.
14. Mucida D, Park Y, Kim G, Turovskaya O, Scott I, et al. (2007) Reciprocal Th17 and regulatory T cell differentiation mediated by retinoic acid. Science 317: 256-260.
15. Rivera J, Proia RL, Olivera A, (2008) The alliance of sphingosine-1-phosphate and its receptors in immunity. Nat Rev Immunol 8: 753-763.
16. Miller LT, Kerkvliet NI, (1990) Effect of vitamin B6 on immunocompetence in the elderly. Ann N Y Acad Sci 587: 49-54.
17. Schwab SR, Pereira JP, Matloubian M, Xu Y, Huang Y, et al. (2005) Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science 309: 1735-1739.
18. Kunisawa J, Kurashima Y, Higuchi M, Gohda M, Ishikawa I, et al. (2007) Sphingosine 1-phosphate dependence in the regulation of lymphocyte trafficking to the gut epithelium. J Exp Med 204: 2335-2348.
19. Iyer R, Tomar SK, (2009) Folate: a functional food constituent. J Food Sci 74: R114-122.
20. Stover PJ, (2004) Physiology of folate and vitamin B12 in health and disease. Nutr Rev 62: S3-12 discussion S13.
21. Gangjee A, Jain HD, Kurup S, (2008) Recent advances in classical and non-classical antifolates as antitumor and antiopportunistic infection agents: Part II. Anticancer Agents Med Chem 8: 205-231.
22. Bourre-Tessier J, Haraoui B, (2010) Methotrexate drug interactions in the treatment of rheumatoid arthritis: a systematic review. J Rheumatol 37: 1416-1421.
23. Courtemanche C, Elson-Schwab I, Mashiyama ST, Kerry N, Ames BN, (2004) Folate deficiency inhibits the proliferation of primary human CD8+ T lymphocytes in vitro. J Immunol 173: 3186-3192.
24. Troen AM, Mitchell B, Sorensen B, Wener MH, Johnston A, et al. (2006) Unmetabolized folic acid in plasma is associated with reduced natural killer cell cytotoxicity among postmenopausal women. J Nutr 136: 189-194.
25. Yamaguchi T, Hirota K, Nagahama K, Ohkawa K, Takahashi T, et al. (2007) Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor. Immunity 27: 145-159.
26. Gohda M, Kunisawa J, Miura F, Kagiyama Y, Kurashima Y, et al. (2008) Sphingosine 1-phosphate regulates the egress of IgA plasmablasts from Peyer's patches for intestinal IgA responses. J Immunol 180: 5335-5343.
27. Zhao R, Matherly LH, Goldman ID, (2009) Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues. Expert Rev Mol Med 11: e4.
28. Jansen G, Westerhof GR, Jarmuszewski MJ, Kathmann I, Rijksen G, et al. (1990) Methotrexate transport in variant human CCRF-CEM leukemia cells with elevated levels of the reduced folate carrier. Selective effect on carrier-mediated transport of physiological concentrations of reduced folates. J Biol Chem 265: 18272-18277.
29. Biswal BK, Verma RS, (2009) Differential usage of the transport systems for folic acid and methotrexate in normal human T-lymphocytes and leukemic cells. J Biochem 146: 693-703.
30. Takahashi T, Kuniyasu Y, Toda M, Sakaguchi N, Itoh M, et al. (1998) Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol 10: 1969-1980.
31. Setoguchi R, Hori S, Takahashi T, Sakaguchi S, (2005) Homeostatic maintenance of natural Foxp3+ CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J Exp Med 201: 723-735.
32. D'Cruz LM, Klein L, (2005) Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling. Nat Immunol 6: 1152-1159.
33. Fontenot JD, Rasmussen JP, Gavin MA, Rudensky AY, (2005) A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol 6: 1142-1151.
34. Matherly LH, Hou Z, Deng Y, (2007) Human reduced folate carrier: translation of basic biology to cancer etiology and therapy. Cancer Metastasis Rev 26: 111-128.
35. Salazar MD, Ratnam M, (2007) The folate receptor: what does it promise in tissue-targeted therapeutics? Cancer Metastasis Rev 26: 141-152.
36. Low PS, Kularatne SA, (2009) Folate-targeted therapeutic and imaging agents for cancer. Curr Opin Chem Biol 13: 256-262.
37. Jia Z, Zhao R, Tian Y, Huang Z, Tian Z, et al. (2009) A novel splice variant of FR4 predominantly expressed in CD4+CD25+ regulatory T cells. Immunol Invest 38: 718-729.
38. Said HM, Mohammed ZM, (2006) Intestinal absorption of water-soluble vitamins: an update. Curr Opin Gastroenterol 22: 140-146.
39. Aufreiter S, Gregory JF 3rd, Pfeiffer CM, Fazili Z, Kim YI, et al. (2009) Folate is absorbed across the colon of adults: evidence from cecal infusion of (13)C-labeled [6S]-5-formyltetrahydrofolic acid. Am J Clin Nutr 90: 116-123.
40. Said HM, (2011) Intestinal absorption of water-soluble vitamins in health and disease. Biochem J 437: 357-372.
41. Pompei A, Cordisco L, Amaretti A, Zanoni S, Matteuzzi D, et al. (2007) Folate production by bifidobacteria as a potential probiotic property. Appl Environ Microbiol 73: 179-185.