Leptin receptor expression on T lymphocytes modulates chronic intestinal inflammation in mice

Gut

Volumn 53, Issue 7, 2004, Pages 965-972

  Siegmund, B ^b   Sennello, J A ^c   Jones Carson, J ^c   Gamboni Robertson, F ^c   Lehr, H A ^d   Batra, A ^b   Fedke, I ^b   Zeitz, M ^b   Fantuzzi, G ^a,c  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c UNIVERSITY OF COLORADO   (United States)

^d JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN RECEPTOR;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL ISOLATION; CHRONIC DISEASE; COLITIS; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE MODEL; ENTERITIS; LAMINA PROPRIA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCID MOUSE; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD45; CHRONIC DISEASE; COLITIS; CORTICOSTERONE; CYTOKINES; DISEASE PROGRESSION; DISEASE SUSCEPTIBILITY; IMMUNITY, MUCOSAL; LEPTIN; LYMPHOCYTE TRANSFUSION; MALE; MICE; MICE, INBRED C57BL; MICE, SCID; RECEPTORS, CELL SURFACE; T-LYMPHOCYTES; TH1 CELLS;

EID: 3042661014     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2003.027136     Document Type: Article

References (27)

1. Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature 1998;395:763-70.
2. Fantuzzi G, Faggioni R. Leptin in the regulation of immunity, inflammation and hematopoiesis. J Leukoc Biol 2000;68:437-46.
3. Sanna V, Di Giacomo A, La Cava A, et al. Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses. J Clin Invest 2003;111:241-50.
4. Faggioni R, Jones-Carson J, Reed DA, et al. Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepototoxicily: role of tumor necrosis factor-α and IL-18. Proc Natl Acad Sci U S A 2000;97:2367-72.
5. Busso N, So A, Choboz-Peclat V, et al. Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis J Immunol 2002;168:875-82.
6. Matarese G, Di Giacomo A, Sanna V, et al. Requirement for leptin in the induction of autoimmune encephalomyelitis. J Immunol 2001;166:5909-16.
7. Siegmund B, Lehr HA, Fantuzzi G. Leptin: a pivotal mediator of intestinal inflammation. Gastroenterology 2002;122:2011-25.
8. Mykoniatis A, Anton PM, Wlk M, et al. Leptin mediates Clostridium difficile toxinA-induced enteritis in mice. Gastroenterology 2003;124:683-91.
9. Cohen P, Zhao C, Cai X, et al. Selective deletion of leptin receptor in neurons leads to obesity. J Clin Invest 2001;108:1113-21.
10. Lord GM, Matarese G, Howard JK, et al. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 1998;394:897-901.
11. Martin-Romero C, Santos-Alvarez J, Goberna R, et al. Human leptin enhances activation and proliferation of human circulating T lymphocytes. Cell Immunol 2000;199:15-24.
12. Zarkesh-Esfahani H, Pockley G, Metcalfe RA, et al. High-dose leptin activates human leukocytes via receptor expression on monocytes. J Immunol 2001;167:4593-9.
13. + cells. Immunity 1994;1:553-62.
14. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 1997;389:737-42.
15. Siegmund B, Fantuzzi G, Rieder F, et al. Neutralization of IL-18 reduces severity in murine colitis and intestinal IFN-γ and TNF-α production. Am J Physiol 2001;281:R1264-73.
16. Siegmund B, Lehr HA, Fantuzzi G, et al. IL-1β-converting enzyme (caspose-1) in intestinal inflammation. Proc Nat Acad Sci U S A 2001;98:13249-54.
17. Fantuzzi G, Reed DA, Dinarello CA. Interleukin (IL)-12-induced interferon-gamma is dependent on caspose-1 processing of the IL-18 precursor. J Clin Invest 1999;104:761-7.
18. Melnikov VY, Ecder T, Fantuzzi G, et al. Protection against ischemic acute renal failure in caspose-1 deficient mice: role of interleukin-18. J Clin Invest 2001;107:1145-52.
19. Saito M, Bray GA. Diurnal rhythm far corticosterone in obese (ob/ob) diabetes (db/db) and gold-thioglucose-induced obesity in mice. Endocrinology 1983;113:2181-5.
20. high T cells to SCID recipients. J Immunol 1997;158:3464-73.
21. Wada K, Nakajima A, Blumberg RS. PPARγ and inflammatory bowel disease: a new therapeutic target far ulcerative colitis and Crohn's disease. Trends Mol Med 2001;7:329-31.
22. Szabo SJ, Tim ST, Costa GL, et al. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 2000;100:655-69.
23. Groux H, Powrie F. Regulatory T cells and inflammatory bowel disease. Immunol Today 1999;20:442-5.
24. Vidal-Pluig A, Jimenez-Linan M, Lowell BB, et al. Regulation of PPARγ gene expression by nutrition and obesity in rodents. J Clin Invest 1996;97:2553-61.
25. Neuroth M, Finotto S, Fuss IJ, et al. Regulation of T-cell apoptosis in inflammatory bowel disease: to die or not to die, that is the mucosal question. Trends Immunol 2001;22:21-6.
26. Fujita Y, Murakami M, Ogawa Y, et al. Leptin inhibits stress-induced apoptosis of T lymphocytes. Clin Exp Immunol 2002;128:21-6.
27. Neuroth MF, Weigmann B, Finotto S, et al. The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease. J Exp Med 2002;195:1129-43.