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Volumn 20, Issue 45, 2014, Pages 14705-14714

Degradable hybrid materials based on cationic acylhydrazone dynamic covalent polymers promote dna complexation through multivalent interactions

Author keywords

Dna recognition; Dynamic polymers; Multivalency; PH sensitive materials; Self assembly

Indexed keywords

BIOLOGICAL MATERIALS; ELECTROPHORESIS; ETHYLENE; GENE THERAPY; GENE TRANSFER; MONOMERS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OLIGONUCLEOTIDES; POLYMERS; SELF ASSEMBLY;

EID: 84919346598     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.201403695     Document Type: Article
Times cited : (44)

References (132)
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    • DMSO was found to be the best solvent for all combinations of monomers across a wide range of concentrations
    • DMSO was found to be the best solvent for all combinations of monomers across a wide range of concentrations.
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    • Poly(EI-EG) and poly(Gua-EG) were added from a concentrated (200 mm) stock solution to avoid constitutional reorganization of the material upon dilution. To assess whether small macrocycles or openchain oligomers are responsible for ct-DNA complexation, a diluted solution (1 mm) of Poly(Gua-EG), containing mostly macrocyclic species (HPLC), was tested and found to display weaker complexation to ct-DNA (CE50 > 4), which indicates that open-chain oligomers rather than small macrocyclic species promote complexation through multivalent interactions
    • Poly(EI-EG) and poly(Gua-EG) were added from a concentrated (200 mm) stock solution to avoid constitutional reorganization of the material upon dilution. To assess whether small macrocycles or openchain oligomers are responsible for ct-DNA complexation, a diluted solution (1 mm) of Poly(Gua-EG), containing mostly macrocyclic species (HPLC), was tested and found to display weaker complexation to ct-DNA (CE50 > 4), which indicates that open-chain oligomers rather than small macrocyclic species promote complexation through multivalent interactions.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.