On-off multivalent recognition: Degradable dendrons for temporary high-affinity DNA binding

Angewandte Chemie - International Edition

Volumn 48, Issue 22, 2009, Pages 4047-4051

  Welsh, Daniel J ^a   Jones, Simon P ^a   Smith, David K ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

Author keywords

Biodegradable compounds; Biological activity; Dendrons; DNA; Supramolecular chemistry

Indexed keywords

BIODEGRADABLE COMPOUNDS; BIOLOGICAL ACTIVITY; BIOLOGICAL PATHWAYS; BIOLOGICAL TARGETS; CHEMICAL DEGRADATION; DENDRONS; DNA BINDING; HIGH AFFINITY; MULTIVALENT INTERACTIONS; SYNTHETIC SYSTEMS;

BIOACTIVITY; DENDRIMERS; DNA; GENES; MACROMOLECULES; NUCLEIC ACIDS; SUPRAMOLECULAR CHEMISTRY;

DEGRADATION;

CALF THYMUS DNA; DENDRIMER; DNA;

ANIMAL; BOVINAE; CHEMISTRY;

ANIMALS; CATTLE; DENDRIMERS; DNA;

EID: 70349785062     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200900401     Document Type: Article

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55. In their own right, these dendrons (e.g. G2-amide)are unable to effectively transfect cells, primarily owing to inefficient escape from endosomal vesicles. However, we recently reported (Ref. [7a]) that modification of the dendron focal point of G2-amidewith hydrophobic groups can significantly enhance the gene delivery profile. We are therefore currently in the process of synthetically modifying these new degradable dendrons in an analogous manner, so that their gene delivery characteristics can be fully investigated.