Polyspermine imidazole-4,5-imine, a chemically dynamic and biologically responsive carrier system for intracellular delivery of siRNA

Angewandte Chemie - International Edition

Volumn 51, Issue 32, 2012, Pages 7938-7941

  Duan, Shiyue ^a   Yuan, Weien ^a   Wu, Fei ^a   Jin, Tuo ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

biodegradable polymers; cytotoxicity; drug delivery; siRNA; spermine

Indexed keywords

CARRIER SYSTEMS; ENDOSOMES; IN-VIVO; INTRACELLULAR DELIVERY; PH-RESPONSIVE; SIRNA; SPERMINE; TARGET GENES;

BIODEGRADABLE POLYMERS; CYTOTOXICITY; DRUG DELIVERY; GENES;

NITROGEN COMPOUNDS;

DRUG CARRIER; DRUG DERIVATIVE; IMIDAZOLE DERIVATIVE; POLYSPERMINE IMIDAZOLE 4,5 IMINE; POLYSPERMINE IMIDAZOLE-4,5-IMINE; SMALL INTERFERING RNA; SPERMINE;

ANIMAL; ARTICLE; CANCER TRANSPLANTATION; CELL PROLIFERATION; CELL STRAIN COS1; CELL SURVIVAL; CERCOPITHECUS; CHEMISTRY; DOSE RESPONSE; DRUG DELIVERY SYSTEM; DRUG EFFECT; METHODOLOGY; MOUSE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; CELL PROLIFERATION; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; COS CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; IMIDAZOLES; MICE; NEOPLASM TRANSPLANTATION; RNA, SMALL INTERFERING; SPERMINE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84864754074     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201201793     Document Type: Article

References (14)

1. A. Fire, S. Q. Xu, M. K. Montgomery, S. A. Kostas, S. E. Driver, C. C. Mello, Nature 1998, 391, 806-811
2. A. Z. Fire, Angew. Chem. 2007, 119, 7094-7113
3. Angew. Chem. Int. Ed. 2007, 46, 6966-6984
4. S. M. Elbashir, J. Harborth, W. Lendeckel, A. Yalcin, K. Weber, T. Tuschl, Nature 2001, 411, 494-498.
5. A. Khvorova, A. Reynolds, S. D. Jayasena, Cell 2003, 115, 209-216
6. A. Reynolds, D. Leake, Q. Boese, S. Scaringe, W. S. Marshall, A. Khvorova, Nat. Biotechnol. 2004, 22, 326-330
7. E. M. Anderson, A. Birmingham, S. Baskerville, A. Reynolds, E. Maksimova, D. Leake, Y. Fedorov, J. Karpilow, A. Khvorova, RNA 2008, 14, 853-861.
8. K. A. Whitehead, R. Langer, D. G. Anderson, Nat. Rev. Drug Discovery 2009, 8, 129-138.
9. D. W. Pack, A. S. Hoffman, S. Pun, P. S. Stayton, Nat. Rev. Drug Discovery 2005, 4, 581-593.
10. E. Novak, D. B. Lakings, L. M. Paxton, Antimicrob. Agents Chemother. 1987, 31, 1706-1710.
11. J. P. Behr, Chimia 1997, 51, 34-36.
12. D. W. Pack, D. Putnam, R. Langer, Biotechnol. Bioeng. 2000, 67, 217-223.
13. D. B. Rozema, K. Ekena, D. L. Lewis, A. G. Loomis, J. A. Wolff, Bioconjugate Chem. 2003, 14, 51-57.
14. Y. Zhang, F. Wu, W. Yuan, T. Jin, J. Controlled Release 2010, 147, 413-419.