Odd-even effect of repeating aminoethylene units in the side chain of N-substituted polyaspartamides on gene transfection profiles

Journal of the American Chemical Society

Volumn 133, Issue 39, 2011, Pages 15524-15532

  Uchida, Hirokuni ^a   Miyata, Kanjiro ^b   Oba, Makoto ^b   Ishii, Takehiko ^a   Suma, Tomoya ^a   Itaka, Keiji ^b   Nishiyama, Nobuhiro ^b   Kataoka, Kazunori ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO GROUP; BUFFERING CAPACITIES; CELL LINES; ENDOSOMAL MEMBRANE; ENDOSOMAL PH; GENE CARRIER; GENE TRANSFECTION; MEMBRANE INTEGRITY; NONVIRAL; ODD-EVEN EFFECTS; POLYASPARTAMIDES; POLYCATIONS; POLYMER SIDE-CHAINS; POLYPLEXES; PROTONATED; SIDE-CHAINS; TRANSFECTION EFFICIENCY; TRANSFECTION REAGENTS;

CELL CULTURE; CYTOTOXICITY; GENE TRANSFER; GENES; MOLECULAR BIOLOGY; OSMIUM; PH EFFECTS; SUBSTITUTION REACTIONS;

POLYMERS;

AMIDE; DRUG CARRIER; ETHYLENE DERIVATIVE; POLY[N (2 AMINOETHYL)ASPARTAMIDE]; POLY[N [N' [N'' (2 AMINOETHYL) 2 AMINOETHYL] 2 AMINOETHYL]ASPARTAMIDE]; POLY[N [N' [N'' [N'' (2 AMINOETHYL) 2 AMINOETHYL] 2 AMINOETHYL] 2 AMINOETHYL]ASPARTAMIDE]; POLYMER; UNCLASSIFIED DRUG;

ARTICLE; CELL LINE; CELL MEMBRANE; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; ENDOSOME; GENE TARGETING; GENETIC TRANSFECTION; PH; PROTON TRANSPORT; SYNTHESIS;

BIOLOGICAL TRANSPORT; CELL LINE, TUMOR; CELL MEMBRANE; DRUG CARRIERS; ENDOSOMES; ETHYLENES; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; NITROGEN; PEPTIDES; PROTONS; REPETITIVE SEQUENCES, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 80053330706     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja204466y     Document Type: Article

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