메뉴 건너뛰기




Volumn 45, Issue 7, 2012, Pages 1005-1013

Polymers for siRNA delivery: Inspired by viruses to be targeted, dynamic, and precise

Author keywords

[No Author keywords available]

Indexed keywords

NANOPARTICLE; POLYMER; SMALL INTERFERING RNA;

EID: 84862902835     PISSN: 00014842     EISSN: 15204898     Source Type: Journal    
DOI: 10.1021/ar2002232     Document Type: Article
Times cited : (274)

References (74)
  • 1
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir, S. M.; Harborth, J.; Lendeckel, W.; Yalcin, A.; Weber, K.; Tuschl, T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells Nature 2001, 411, 494-498
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 4
    • 79960963683 scopus 로고    scopus 로고
    • MicroRNA Replacement Therapy for miR-145 and miR-33a Is Efficacious in a Model of Colon Carcinoma
    • Ibrahim, A. F.; Weirauch, U.; Thomas, M.; Grunweller, A.; Hartmann, R. K.; Aigner, A. MicroRNA Replacement Therapy for miR-145 and miR-33a Is Efficacious in a Model of Colon Carcinoma Cancer Res. 2011, 71, 5214-24
    • (2011) Cancer Res. , vol.71 , pp. 5214-5224
    • Ibrahim, A.F.1    Weirauch, U.2    Thomas, M.3    Grunweller, A.4    Hartmann, R.K.5    Aigner, A.6
  • 5
    • 79955604155 scopus 로고    scopus 로고
    • Poly(I:C)-mediated tumor growth suppression in EGF-receptor overexpressing tumors using EGF-polyethylene glycol-linear polyethylenimine as carrier
    • Schaffert, D.; Kiss, M.; Rodl, W.; Shir, A.; Levitzki, A.; Ogris, M.; Wagner, E. Poly(I:C)-mediated tumor growth suppression in EGF-receptor overexpressing tumors using EGF-polyethylene glycol-linear polyethylenimine as carrier Pharm. Res. 2011, 28, 731-741
    • (2011) Pharm. Res. , vol.28 , pp. 731-741
    • Schaffert, D.1    Kiss, M.2    Rodl, W.3    Shir, A.4    Levitzki, A.5    Ogris, M.6    Wagner, E.7
  • 9
    • 34249890562 scopus 로고    scopus 로고
    • Gene therapy for severe combined immunodeficiency: Are we there yet?
    • Cavazzana-Calvo, M.; Fischer, A. Gene therapy for severe combined immunodeficiency: are we there yet? J. Clin. Invest 2007, 117, 1456-1465
    • (2007) J. Clin. Invest , vol.117 , pp. 1456-1465
    • Cavazzana-Calvo, M.1    Fischer, A.2
  • 10
    • 33845728507 scopus 로고    scopus 로고
    • Optimizing targeted gene delivery: Chemical modification of viral vectors and synthesis of artificial virus vector systems
    • Boeckle, S.; Wagner, E. Optimizing targeted gene delivery: chemical modification of viral vectors and synthesis of artificial virus vector systems AAPS J. 2006, 8, E731-E742
    • (2006) AAPS J. , vol.8
    • Boeckle, S.1    Wagner, E.2
  • 11
    • 37549072604 scopus 로고    scopus 로고
    • Converging Paths of Viral and Non-viral Vector Engineering
    • Wagner, E. Converging Paths of Viral and Non-viral Vector Engineering Mol. Ther. 2008, 16, 1-2
    • (2008) Mol. Ther. , vol.16 , pp. 1-2
    • Wagner, E.1
  • 13
    • 0026655684 scopus 로고
    • Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: Toward a synthetic virus-like gene-transfer vehicle
    • Wagner, E.; Plank, C.; Zatloukal, K.; Cotten, M.; Birnstiel, M. L. Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene-transfer vehicle Proc. Natl. Acad. Sci. U.S.A 1992, 89, 7934-7938
    • (1992) Proc. Natl. Acad. Sci. U.S.A , vol.89 , pp. 7934-7938
    • Wagner, E.1    Plank, C.2    Zatloukal, K.3    Cotten, M.4    Birnstiel, M.L.5
  • 15
    • 1642579669 scopus 로고    scopus 로고
    • Strategies to improve DNA polyplexes for in vivo gene transfer: Will artificial viruses be the answer?
    • Wagner, E. Strategies to improve DNA polyplexes for in vivo gene transfer: will artificial viruses be the answer? Pharm. Res. 2004, 21, 8-14
    • (2004) Pharm. Res. , vol.21 , pp. 8-14
    • Wagner, E.1
  • 16
    • 14044252938 scopus 로고    scopus 로고
    • Toward synthetic viruses: Endosomal pH-triggered deshielding of targeted polyplexes greatly enhances gene transfer in vitro and in vivo
    • Walker, G. F.; Fella, C.; Pelisek, J.; Fahrmeir, J.; Boeckle, S.; Ogris, M.; Wagner, E. Toward synthetic viruses: endosomal pH-triggered deshielding of targeted polyplexes greatly enhances gene transfer in vitro and in vivo Mol. Ther. 2005, 11, 418-425
    • (2005) Mol. Ther. , vol.11 , pp. 418-425
    • Walker, G.F.1    Fella, C.2    Pelisek, J.3    Fahrmeir, J.4    Boeckle, S.5    Ogris, M.6    Wagner, E.7
  • 17
    • 78650476432 scopus 로고    scopus 로고
    • The proton sponge: A trick to enter cells the viruses did not exploit
    • Behr, J. P. The proton sponge: A trick to enter cells the viruses did not exploit Chimia 1997, 51, 34-36
    • (1997) Chimia , vol.51 , pp. 34-36
    • Behr, J.P.1
  • 18
    • 0031105393 scopus 로고    scopus 로고
    • Poly(Ethylene Glycol) Grafted Liposomes with Oligopeptide or Oligosaccharide Ligands Appended to the Termini of the Polymer Chains
    • Zalipsky, S.; Mullah, N.; Harding, J. A.; Gittelman, J.; Guo, L.; Defrees, S. A. Poly(Ethylene Glycol) Grafted Liposomes With Oligopeptide or Oligosaccharide Ligands Appended to the Termini Of the Polymer Chains Bioconjugate Chem. 1997, 8 (2) 111-118
    • (1997) Bioconjugate Chem. , vol.8 , Issue.2 , pp. 111-118
    • Zalipsky, S.1    Mullah, N.2    Harding, J.A.3    Gittelman, J.4    Guo, L.5    Defrees, S.A.6
  • 19
    • 75149141385 scopus 로고    scopus 로고
    • Targeting of the prostacyclin specific IP1 receptor in lungs with molecular conjugates comprising prostaglandin I2 analogues
    • Geiger, J.; Aneja, M. K.; Hasenpusch, G.; Yuksekdag, G.; Kummerlowe, G.; Luy, B.; Romer, T.; Rothbauer, U.; Rudolph, C. Targeting of the prostacyclin specific IP1 receptor in lungs with molecular conjugates comprising prostaglandin I2 analogues Biomaterials 2010, 31, 2903-2911
    • (2010) Biomaterials , vol.31 , pp. 2903-2911
    • Geiger, J.1    Aneja, M.K.2    Hasenpusch, G.3    Yuksekdag, G.4    Kummerlowe, G.5    Luy, B.6    Romer, T.7    Rothbauer, U.8    Rudolph, C.9
  • 20
    • 0034821014 scopus 로고    scopus 로고
    • Accelerated discovery of synthetic transfection vectors: Parallel synthesis and screening of a degradable polymer library
    • Lynn, D. M.; Anderson, D. G.; Putnam, D.; Langer, R. Accelerated discovery of synthetic transfection vectors: parallel synthesis and screening of a degradable polymer library J. Am. Chem. Soc. 2001, 123, 8155-8156
    • (2001) J. Am. Chem. Soc. , vol.123 , pp. 8155-8156
    • Lynn, D.M.1    Anderson, D.G.2    Putnam, D.3    Langer, R.4
  • 21
    • 0042311016 scopus 로고    scopus 로고
    • Semi-Automated Synthesis and Screening of a Large Library of Degradable Cationic Polymers for Gene Delivery
    • Anderson, D. G.; Lynn, D. M.; Langer, R. Semi-Automated Synthesis and Screening of a Large Library of Degradable Cationic Polymers for Gene Delivery Angew. Chem., Int. Ed. 2003, 42, 3153-3158
    • (2003) Angew. Chem., Int. Ed. , vol.42 , pp. 3153-3158
    • Anderson, D.G.1    Lynn, D.M.2    Langer, R.3
  • 22
    • 53849102257 scopus 로고    scopus 로고
    • Tailor-Made Poly(amidoamine)s for Controlled Complexation and Condensation of DNA
    • Hartmann, L.; Hafele, S.; Peschka-Suss, R.; Antonietti, M.; Borner, H. G. Tailor-Made Poly(amidoamine)s for Controlled Complexation and Condensation of DNA Chemistry 2008, 14, 2025-2033
    • (2008) Chemistry , vol.14 , pp. 2025-2033
    • Hartmann, L.1    Hafele, S.2    Peschka-Suss, R.3    Antonietti, M.4    Borner, H.G.5
  • 25
    • 0025891831 scopus 로고
    • Transferrin-polycation-DNA complexes: The effect of polycations on the structure of the complex and DNA delivery to cells
    • Wagner, E.; Cotten, M.; Foisner, R.; Birnstiel, M. L. Transferrin-polycation-DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells Proc. Natl. Acad. Sci. U.S.A. 1991, 88, 4255-4259
    • (1991) Proc. Natl. Acad. Sci. U.S.A. , vol.88 , pp. 4255-4259
    • Wagner, E.1    Cotten, M.2    Foisner, R.3    Birnstiel, M.L.4
  • 28
    • 41449109039 scopus 로고    scopus 로고
    • Breathing life into polycations: Functionalization with pH-responsive endosomolytic peptides and polyethylene glycol enables siRNA delivery
    • Meyer, M.; Philipp, A.; Oskuee, R.; Schmidt, C.; Wagner, E. Breathing life into polycations: functionalization with pH-responsive endosomolytic peptides and polyethylene glycol enables siRNA delivery J. Am. Chem. Soc. 2008, 130, 3272-3273
    • (2008) J. Am. Chem. Soc. , vol.130 , pp. 3272-3273
    • Meyer, M.1    Philipp, A.2    Oskuee, R.3    Schmidt, C.4    Wagner, E.5
  • 29
    • 47749100430 scopus 로고    scopus 로고
    • Simple Modifications of Branched PEI Lead to Highly Efficient siRNA Carriers with Low Toxicity
    • Zintchenko, A.; Philipp, A.; Dehshahri, A.; Wagner, E. Simple Modifications of Branched PEI Lead to Highly Efficient siRNA Carriers with Low Toxicity Bioconjugate Chem. 2008, 19, 1448-1455
    • (2008) Bioconjugate Chem. , vol.19 , pp. 1448-1455
    • Zintchenko, A.1    Philipp, A.2    Dehshahri, A.3    Wagner, E.4
  • 30
    • 0035408714 scopus 로고    scopus 로고
    • Different behavior of branched and linear polyethylenimine for gene delivery in vitro and in vivo
    • Wightman, L.; Kircheis, R.; Rossler, V.; Carotta, S.; Ruzicka, R.; Kursa, M.; Wagner, E. Different behavior of branched and linear polyethylenimine for gene delivery in vitro and in vivo J. Gene Med. 2001, 3, 362-372
    • (2001) J. Gene Med. , vol.3 , pp. 362-372
    • Wightman, L.1    Kircheis, R.2    Rossler, V.3    Carotta, S.4    Ruzicka, R.5    Kursa, M.6    Wagner, E.7
  • 31
    • 3242707528 scopus 로고    scopus 로고
    • In situ single cell observation by fluorescence resonance energy transfer reveals fast intra-cytoplasmic delivery and easy release of plasmid DNA complexed with linear polyethylenimine
    • Itaka, K.; Harada, A.; Yamasaki, Y.; Nakamura, K.; Kawaguchi, H.; Kataoka, K. In situ single cell observation by fluorescence resonance energy transfer reveals fast intra-cytoplasmic delivery and easy release of plasmid DNA complexed with linear polyethylenimine J. Gene Med. 2004, 6, 76-84
    • (2004) J. Gene Med. , vol.6 , pp. 76-84
    • Itaka, K.1    Harada, A.2    Yamasaki, Y.3    Nakamura, K.4    Kawaguchi, H.5    Kataoka, K.6
  • 32
    • 79952765801 scopus 로고    scopus 로고
    • Comparative structural and functional studies of nanoparticle formulations for DNA and siRNA delivery
    • Kwok, A.; Hart, S. L. Comparative structural and functional studies of nanoparticle formulations for DNA and siRNA delivery Nanomedicine 2011, 7, 210-219
    • (2011) Nanomedicine , vol.7 , pp. 210-219
    • Kwok, A.1    Hart, S.L.2
  • 34
    • 77249154018 scopus 로고    scopus 로고
    • Multimeric small interfering ribonucleic acid for highly efficient sequence-specific gene silencing
    • Mok, H.; Lee, S. H.; Park, J. W.; Park, T. G. Multimeric small interfering ribonucleic acid for highly efficient sequence-specific gene silencing Nat. Mater. 2010, 9, 272-278
    • (2010) Nat. Mater. , vol.9 , pp. 272-278
    • Mok, H.1    Lee, S.H.2    Park, J.W.3    Park, T.G.4
  • 35
    • 79955772881 scopus 로고    scopus 로고
    • Co-delivery of small interfering RNA and plasmid DNA using a polymeric vector incorporating endosomolytic oligomeric sulfonamide
    • Chang Kang, H.; Bae, Y. H. Co-delivery of small interfering RNA and plasmid DNA using a polymeric vector incorporating endosomolytic oligomeric sulfonamide Biomaterials 2011, 32, 4914-4924
    • (2011) Biomaterials , vol.32 , pp. 4914-4924
    • Chang Kang, H.1    Bae, Y.H.2
  • 40
    • 71249151558 scopus 로고    scopus 로고
    • Hydrophobically modified oligoethylenimines as highly efficient transfection agents for siRNA delivery
    • Philipp, A.; Zhao, X.; Tarcha, P.; Wagner, E.; Zintchenko, A. Hydrophobically modified oligoethylenimines as highly efficient transfection agents for siRNA delivery Bioconjugate Chem. 2009, 20, 2055-2061
    • (2009) Bioconjugate Chem. , vol.20 , pp. 2055-2061
    • Philipp, A.1    Zhao, X.2    Tarcha, P.3    Wagner, E.4    Zintchenko, A.5
  • 44
    • 79960369477 scopus 로고    scopus 로고
    • To be targeted: Is the magic bullet concept a viable option for synthetic nucleic acid therapeutics?
    • Ogris, M.; Wagner, E. To be targeted: is the magic bullet concept a viable option for synthetic nucleic acid therapeutics? Hum. Gene Ther. 2011, 22, 799-807
    • (2011) Hum. Gene Ther. , vol.22 , pp. 799-807
    • Ogris, M.1    Wagner, E.2
  • 47
    • 79958081671 scopus 로고    scopus 로고
    • Dual-targeted polyplexes: One step towards a synthetic virus for cancer gene therapy
    • Nie, Y.; Schaffert, D.; Rodl, W.; Ogris, M.; Wagner, E.; Gunther, M. Dual-targeted polyplexes: One step towards a synthetic virus for cancer gene therapy J. Controlled Release 2011, 152, 127-134
    • (2011) J. Controlled Release , vol.152 , pp. 127-134
    • Nie, Y.1    Schaffert, D.2    Rodl, W.3    Ogris, M.4    Wagner, E.5    Gunther, M.6
  • 48
    • 0029789793 scopus 로고    scopus 로고
    • Activation of the complement system by synthetic DNA complexes: A potential barrier for intravenous gene delivery
    • Plank, C.; Mechtler, K.; Szoka, F. C., Jr.; Wagner, E. Activation of the complement system by synthetic DNA complexes: a potential barrier for intravenous gene delivery Hum. Gene Ther. 1996, 7, 1437-1446
    • (1996) Hum. Gene Ther. , vol.7 , pp. 1437-1446
    • Plank, C.1    Mechtler, K.2    Szoka Jr., F.C.3    Wagner, E.4
  • 49
    • 67651202350 scopus 로고    scopus 로고
    • Stability of siRNA polyplexes from poly(ethylenimine) and poly(ethylenimine)-g-poly(ethylene glycol) under in vivo conditions: Effects on pharmacokinetics and biodistribution measured by Fluorescence Fluctuation Spectroscopy and Single Photon Emission Computed Tomography (SPECT) imaging
    • Merkel, O. M.; Librizzi, D.; Pfestroff, A.; Schurrat, T.; Buyens, K.; Sanders, N. N.; De Smedt, S. C.; Behe, M.; Kissel, T. Stability of siRNA polyplexes from poly(ethylenimine) and poly(ethylenimine)-g-poly(ethylene glycol) under in vivo conditions: effects on pharmacokinetics and biodistribution measured by Fluorescence Fluctuation Spectroscopy and Single Photon Emission Computed Tomography (SPECT) imaging J. Controlled Release 2009, 138, 148-159
    • (2009) J. Controlled Release , vol.138 , pp. 148-159
    • Merkel, O.M.1    Librizzi, D.2    Pfestroff, A.3    Schurrat, T.4    Buyens, K.5    Sanders, N.N.6    De Smedt, S.C.7    Behe, M.8    Kissel, T.9
  • 50
    • 0034993240 scopus 로고    scopus 로고
    • The enhanced permeability and retention (EPR) effect in tumor vasculature: The key role of tumor-selective macromolecular drug targeting
    • Maeda, H. The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting Adv. Enzyme Regul. 2001, 41, 189-207
    • (2001) Adv. Enzyme Regul. , vol.41 , pp. 189-207
    • Maeda, H.1
  • 52
    • 77954298422 scopus 로고    scopus 로고
    • Targeted intracellular delivery of antisense oligonucleotides via conjugation with small-molecule ligands
    • Nakagawa, O.; Ming, X.; Huang, L.; Juliano, R. L. Targeted intracellular delivery of antisense oligonucleotides via conjugation with small-molecule ligands J. Am. Chem. Soc. 2010, 132, 8848-8849
    • (2010) J. Am. Chem. Soc. , vol.132 , pp. 8848-8849
    • Nakagawa, O.1    Ming, X.2    Huang, L.3    Juliano, R.L.4
  • 53
    • 0028852342 scopus 로고
    • Rhinovirus-mediated endosomal release of transfection complexes
    • Zauner, W.; Blaas, D.; Kuechler, E.; Wagner, E. Rhinovirus-mediated endosomal release of transfection complexes J. Virol. 1995, 69, 1085-1092
    • (1995) J. Virol. , vol.69 , pp. 1085-1092
    • Zauner, W.1    Blaas, D.2    Kuechler, E.3    Wagner, E.4
  • 55
    • 33646152349 scopus 로고    scopus 로고
    • Melittin analogs with high lytic activity at endosomal pH enhance transfection with purified targeted PEI polyplexes
    • Boeckle, S.; Fahrmeir, J.; Roedl, W.; Ogris, M.; Wagner, E. Melittin analogs with high lytic activity at endosomal pH enhance transfection with purified targeted PEI polyplexes J. Controlled Release 2006, 112, 240-248
    • (2006) J. Controlled Release , vol.112 , pp. 240-248
    • Boeckle, S.1    Fahrmeir, J.2    Roedl, W.3    Ogris, M.4    Wagner, E.5
  • 57
    • 49049118656 scopus 로고    scopus 로고
    • An artificial virus-like nano carrier system: Enhanced endosomal escape of nanoparticles via synergistic action of pH-sensitive fusogenic peptide derivatives
    • Sasaki, K.; Kogure, K.; Chaki, S.; Nakamura, Y.; Moriguchi, R.; Hamada, H.; Danev, R.; Nagayama, K.; Futaki, S.; Harashima, H. An artificial virus-like nano carrier system: enhanced endosomal escape of nanoparticles via synergistic action of pH-sensitive fusogenic peptide derivatives Anal. Bioanal. Chem. 2008, 391, 2717-2727
    • (2008) Anal. Bioanal. Chem. , vol.391 , pp. 2717-2727
    • Sasaki, K.1    Kogure, K.2    Chaki, S.3    Nakamura, Y.4    Moriguchi, R.5    Hamada, H.6    Danev, R.7    Nagayama, K.8    Futaki, S.9    Harashima, H.10
  • 58
    • 0038402594 scopus 로고    scopus 로고
    • Design and synthesis of pH-responsive polymeric carriers that target uptake and enhance the intracellular delivery of oligonucleotides
    • Murthy, N.; Campbell, J.; Fausto, N.; Hoffman, A. S.; Stayton, P. S. Design and synthesis of pH-responsive polymeric carriers that target uptake and enhance the intracellular delivery of oligonucleotides J. Controlled Release 2003, 89, 365-374
    • (2003) J. Controlled Release , vol.89 , pp. 365-374
    • Murthy, N.1    Campbell, J.2    Fausto, N.3    Hoffman, A.S.4    Stayton, P.S.5
  • 59
    • 25444518193 scopus 로고    scopus 로고
    • Membrane activity and transfection ability of amphipathic polycations as a function of alkyl group size
    • Wakefield, D. H.; Klein, J. J.; Wolff, J. A.; Rozema, D. B. Membrane activity and transfection ability of amphipathic polycations as a function of alkyl group size Bioconjugate Chem. 2005, 16, 1204-1208
    • (2005) Bioconjugate Chem. , vol.16 , pp. 1204-1208
    • Wakefield, D.H.1    Klein, J.J.2    Wolff, J.A.3    Rozema, D.B.4
  • 60
    • 0025313130 scopus 로고
    • Transferrin-polycation-mediated introduction of DNA into human leukemic cells: Stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels
    • Cotten, M.; Langle-Rouault, F.; Kirlappos, H.; Wagner, E.; Mechtler, K.; Zenke, M.; Beug, H.; Birnstiel, M. L. Transferrin-polycation-mediated introduction of DNA into human leukemic cells: stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels Proc. Natl. Acad. Sci. U.S.A. 1990, 87, 4033-4037
    • (1990) Proc. Natl. Acad. Sci. U.S.A. , vol.87 , pp. 4033-4037
    • Cotten, M.1    Langle-Rouault, F.2    Kirlappos, H.3    Wagner, E.4    Mechtler, K.5    Zenke, M.6    Beug, H.7    Birnstiel, M.L.8
  • 61
    • 73949092713 scopus 로고    scopus 로고
    • Understanding the protonation behavior of linear polyethylenimine in solutions through Monte Carlo simulations
    • Ziebarth, J. D.; Wang, Y. Understanding the protonation behavior of linear polyethylenimine in solutions through Monte Carlo simulations Biomacromolecules 2010, 11, 29-38
    • (2010) Biomacromolecules , vol.11 , pp. 29-38
    • Ziebarth, J.D.1    Wang, Y.2
  • 62
    • 0242414440 scopus 로고    scopus 로고
    • Chloride Accumulation and Swelling in Endosomes Enhances DNA Transfer by Polyamine-DNA Polyplexes
    • Sonawane, N. D.; Szoka, F. C., Jr.; Verkman, A. S. Chloride Accumulation and Swelling in Endosomes Enhances DNA Transfer by Polyamine-DNA Polyplexes J. Biol. Chem. 2003, 278, 44826-44831
    • (2003) J. Biol. Chem. , vol.278 , pp. 44826-44831
    • Sonawane, N.D.1    Szoka Jr., F.C.2    Verkman, A.S.3
  • 63
    • 0033137012 scopus 로고    scopus 로고
    • Efficient gene transfer by histidylated polylysine/pDNA complexes
    • Midoux, P.; Monsigny, M. Efficient gene transfer by histidylated polylysine/pDNA complexes Bioconjugate Chem. 1999, 10, 406-411
    • (1999) Bioconjugate Chem. , vol.10 , pp. 406-411
    • Midoux, P.1    Monsigny, M.2
  • 66
    • 56649086656 scopus 로고    scopus 로고
    • Oligoethylenimine-grafted polypropylenimine dendrimers as degradable and biocompatible synthetic vectors for gene delivery
    • Russ, V.; Gunther, M.; Halama, A.; Ogris, M.; Wagner, E. Oligoethylenimine-grafted polypropylenimine dendrimers as degradable and biocompatible synthetic vectors for gene delivery J. Controlled Release 2008, 132, 131-140
    • (2008) J. Controlled Release , vol.132 , pp. 131-140
    • Russ, V.1    Gunther, M.2    Halama, A.3    Ogris, M.4    Wagner, E.5
  • 67
    • 57149087678 scopus 로고    scopus 로고
    • Polyplexes from poly(aspartamide) bearing 1,2-diaminoethane side chains induce pH-selective, endosomal membrane destabilization with amplified transfection and negligible cytotoxicity
    • Miyata, K.; Oba, M.; Nakanishi, M.; Fukushima, S.; Yamasaki, Y.; Koyama, H.; Nishiyama, N.; Kataoka, K. Polyplexes from poly(aspartamide) bearing 1,2-diaminoethane side chains induce pH-selective, endosomal membrane destabilization with amplified transfection and negligible cytotoxicity J. Am. Chem. Soc. 2008, 130, 16287-16294
    • (2008) J. Am. Chem. Soc. , vol.130 , pp. 16287-16294
    • Miyata, K.1    Oba, M.2    Nakanishi, M.3    Fukushima, S.4    Yamasaki, Y.5    Koyama, H.6    Nishiyama, N.7    Kataoka, K.8
  • 68
    • 34248136491 scopus 로고    scopus 로고
    • Programmed drug delivery: Nanosystems for tumor targeting
    • Wagner, E. Programmed drug delivery: nanosystems for tumor targeting Expert Opin. Biol. Ther. 2007, 7, 587-593
    • (2007) Expert Opin. Biol. Ther. , vol.7 , pp. 587-593
    • Wagner, E.1
  • 69
    • 34547153677 scopus 로고    scopus 로고
    • An acetal-based PEGylation reagent for pH-sensitive shielding of DNA polyplexes
    • Knorr, V.; Allmendinger, L.; Walker, G. F.; Paintner, F. F.; Wagner, E. An acetal-based PEGylation reagent for pH-sensitive shielding of DNA polyplexes Bioconjugate Chem. 2007, 18, 1218-1225
    • (2007) Bioconjugate Chem. , vol.18 , pp. 1218-1225
    • Knorr, V.1    Allmendinger, L.2    Walker, G.F.3    Paintner, F.F.4    Wagner, E.5
  • 70
    • 47249130263 scopus 로고    scopus 로고
    • Amine-reactive pyridylhydrazone-based PEG reagents for pH-reversible PEI polyplex shielding
    • Fella, C.; Walker, G. F.; Ogris, M.; Wagner, E. Amine-reactive pyridylhydrazone-based PEG reagents for pH-reversible PEI polyplex shielding Eur. J. Pharm. Sci. 2008, 34, 309-320
    • (2008) Eur. J. Pharm. Sci. , vol.34 , pp. 309-320
    • Fella, C.1    Walker, G.F.2    Ogris, M.3    Wagner, E.4
  • 73
    • 79953173288 scopus 로고    scopus 로고
    • Novel Fmoc-polyamino acids for solid-phase synthesis of defined polyamidoamines
    • Schaffert, D.; Badgujar, N.; Wagner, E. Novel Fmoc-polyamino acids for solid-phase synthesis of defined polyamidoamines Org. Lett. 2011, 13, 1586-1589
    • (2011) Org. Lett. , vol.13 , pp. 1586-1589
    • Schaffert, D.1    Badgujar, N.2    Wagner, E.3
  • 74
    • 77954383445 scopus 로고    scopus 로고
    • Tuning the mechanical properties of bioreducible multilayer films for improved cell adhesion and transfection activity
    • Blacklock, J.; Vetter, A.; Lankenau, A.; Oupicky, D.; Mohwald, H. Tuning the mechanical properties of bioreducible multilayer films for improved cell adhesion and transfection activity Biomaterials 2010, 31, 7167-7174
    • (2010) Biomaterials , vol.31 , pp. 7167-7174
    • Blacklock, J.1    Vetter, A.2    Lankenau, A.3    Oupicky, D.4    Mohwald, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.