Design of monodisperse and well-defined polypeptide-based polyvalent inhibitors of anthrax toxin

Angewandte Chemie - International Edition

Volumn 53, Issue 31, 2014, Pages 8037-8040

  Patke, Sanket ^a   Boggara, Mohan ^b   Maheshwari, Ronak ^b   Srivastava, Sunit K ^b   Arha, Manish ^b   Douaisi, Marc ^b   Martin, Jacob T ^a   Harvey, Ian B ^b   Brier, Matthew ^a   Rosen, Tania ^a   Mogridge, Jeremy ^c   Kane, Ravi S ^a,b  

^a RENSSELAER POLYTECHNIC INSTITUTE   (United States)

^b RENSSELAER POLYTECHNIC INSTITUTE   (United States)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

anthrax toxin; multivalency; periodic polypeptides; protein engineering; structure activity relationships

Indexed keywords

DESIGN; DISEASES; LIGANDS; METABOLITES; MOLECULES; PEPTIDES; POLYPEPTIDES; STEM CELLS;

ANTHRAX TOXINS; CELLULAR RECEPTORS; MULTIVALENCY; NANO-SCALE ORGANIZATION; ORDERS OF MAGNITUDE; PROTEIN ENGINEERING; RATIONAL DESIGN; STRUCTURE ACTIVITY RELATIONSHIPS;

TOXIC MATERIALS;

ANTHRAX TOXIN; BACTERIAL ANTIGEN; BACTERIAL TOXIN; PEPTIDE;

AMINO ACID SEQUENCE; ANTAGONISTS AND INHIBITORS; CHEMISTRY; THERMODYNAMICS;

AMINO ACID SEQUENCE; ANTIGENS, BACTERIAL; BACTERIAL TOXINS; PEPTIDES; THERMODYNAMICS;

EID: 84905389108     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201400870     Document Type: Article

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