메뉴 건너뛰기




Volumn 235, Issue 2, 2015, Pages 368-380

The role of Kaposi sarcoma-associated herpesvirus in the pathogenesis of Kaposi sarcoma

Author keywords

Aberrant angiogenesis; Atypical differentiation; Inflammation; Invasiveness; Kaposi sarcoma; KSHV; Oncogenesis

Indexed keywords

VIRUS PROTEIN;

EID: 84917690896     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4441     Document Type: Article
Times cited : (84)

References (163)
  • 1
    • 0020213971 scopus 로고
    • Classics in oncology. Idiopathic multiple pigmented sarcoma of the skin by Kaposi
    • Braun M. Classics in oncology. Idiopathic multiple pigmented sarcoma of the skin by Kaposi. CA Cancer J Clin 1982; 32: 340-347.
    • (1982) CA Cancer J Clin , vol.32 , pp. 340-347
    • Braun, M.1
  • 2
    • 0014322390 scopus 로고
    • Kaposi's sarcoma. Present concept of clinical course and treatment
    • Davis J. Kaposi's sarcoma. Present concept of clinical course and treatment. N Y State J Med 1968; 68: 2067-2073.
    • (1968) N y State J Med , vol.68 , pp. 2067-2073
    • Davis, J.1
  • 3
    • 73849168257 scopus 로고
    • Medical research in Africa. Geographic pathology Kaposi's sarcoma and cutaneous physiology of pachyderms
    • Rothman S. Medical research in Africa. Geographic pathology, Kaposi's sarcoma, and cutaneous physiology of pachyderms. Arch Dermatol 1962; 85: 311-324.
    • (1962) Arch Dermatol , vol.85 , pp. 311-324
    • Rothman, S.1
  • 4
    • 0015449433 scopus 로고
    • Herpes-type virus particles in tissue culture of Kaposi's sarcoma from different geographic regions
    • Giraldo G, Beth E, Haguenau F. Herpes-type virus particles in tissue culture of Kaposi's sarcoma from different geographic regions. J Natl Cancer Inst 1972; 49: 1509-1526.
    • (1972) J Natl Cancer Inst , vol.49 , pp. 1509-1526
    • Giraldo, G.1    Beth, E.2    Haguenau, F.3
  • 5
    • 0027486166 scopus 로고
    • Detection of human immunodefciency virus type 1 and human papillomavirus type 16 in acquired immunodefciency syndrome-related and classic Kaposi's sarcoma
    • Fujiwara H, Hashimoto K, Fujiwara K, et al. Detection of human immunodefciency virus type 1 and human papillomavirus type 16 in acquired immunodefciency syndrome-related and classic Kaposi's sarcoma. Arch Dermatol 1993; 129: 1620-1622.
    • (1993) Arch Dermatol , vol.129 , pp. 1620-1622
    • Fujiwara, H.1    Hashimoto, K.2    Fujiwara, K.3
  • 6
    • 0024492257 scopus 로고
    • The role of opportunistic viruses in Kaposi's sarcoma (KS) evolution
    • Giraldo G, Buonaguro FM, Beth-Giraldo E. The role of opportunistic viruses in Kaposi's sarcoma (KS) evolution. APMIS Suppl 1989; 8: 62-70.
    • (1989) APMIS Suppl , vol.8 , pp. 62-70
    • Giraldo, G.1    Buonaguro, F.M.2    Beth-Giraldo, E.3
  • 7
    • 0022877365 scopus 로고
    • Kaposi's sarcoma and HTLV-III, a study in Nigerian adult males
    • Otu AA. Kaposi's sarcoma and HTLV-III, a study in Nigerian adult males. J R Soc Med 1986; 79: 510-514.
    • (1986) J R Soc Med , vol.79 , pp. 510-514
    • Otu, A.A.1
  • 8
    • 0026829889 scopus 로고
    • Cytomegalovirus, angiomatosis, and Kaposi's sarcoma; New observations of a debated relationship
    • Ioachim HL, Dorsett B, Melamed J, et al. Cytomegalovirus, angiomatosis, and Kaposi's sarcoma; new observations of a debated relationship. Mod Pathol 1992; 5: 169-178.
    • (1992) Mod Pathol , vol.5 , pp. 169-178
    • Ioachim, H.L.1    Dorsett, B.2    Melamed, J.3
  • 9
    • 0020507962 scopus 로고
    • National case-control study of Kaposi's sarcoma and Pneumocystis carinii pneumonia in homosexual men, part 1. Epidemiologic results
    • Jaffe HW, Choi K, Thomas PA, et al. National case-control study of Kaposi's sarcoma and Pneumocystis carinii pneumonia in homosexual men, part 1. Epidemiologic results. Ann Intern Med 1983; 99: 145-151.
    • (1983) Ann Intern Med , vol.99 , pp. 145-151
    • Jaffe, H.W.1    Choi, K.2    Thomas, P.A.3
  • 10
    • 0026799562 scopus 로고
    • AIDS-associated malignant lymphoma
    • Levine AM. AIDS-associated malignant lymphoma. Med Clin N Am 1992; 76: 253-268.
    • (1992) Med Clin N Am , vol.76 , pp. 253-268
    • Levine, A.M.1
  • 11
    • 0025096694 scopus 로고
    • Kaposi's sarcoma among persons with AIDS; A sexually transmitted infection?
    • Beral V, Peterman TA, Berkelman RL, et al. Kaposi's sarcoma among persons with AIDS; a sexually transmitted infection? Lancet 1990; 335: 123-128.
    • (1990) Lancet , vol.335 , pp. 123-128
    • Beral, V.1    Peterman, T.A.2    Berkelman, R.L.3
  • 12
    • 0029001821 scopus 로고
    • Cancer and HIV infection in Rwanda
    • Newton R, Grulich A, Beral V, et al. Cancer and HIV infection in Rwanda. Lancet 1995; 345: 1378-1379.
    • (1995) Lancet , vol.345 , pp. 1378-1379
    • Newton, R.1    Grulich, A.2    Beral, V.3
  • 13
    • 0028588064 scopus 로고
    • Identifcation of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma
    • Chang Y, Cesarman E, Pessin MS, et al. Identifcation of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 1994; 266: 1865-1869.
    • (1994) Science , vol.266 , pp. 1865-1869
    • Chang, Y.1    Cesarman, E.2    Pessin, M.S.3
  • 14
    • 0029812632 scopus 로고    scopus 로고
    • Detection of herpesvirus-like DNA by nested PCR on archival skin biopsy specimens of various forms of Kaposi sarcoma
    • Cathomas G, McGandy CE, Terracciano LM, et al. Detection of herpesvirus-like DNA by nested PCR on archival skin biopsy specimens of various forms of Kaposi sarcoma. J Clin Pathol 1996; 49: 631-633.
    • (1996) J Clin Pathol , vol.49 , pp. 631-633
    • Cathomas, G.1    McGandy, C.E.2    Terracciano, L.M.3
  • 15
    • 0029163617 scopus 로고
    • Detection of Kaposi's sarcoma associated herpesvirus in peripheral blood of HIV-infected individuals and progression to Kaposi's sarcoma
    • Whitby D, Howard MR, Tenant-Flowers M, et al. Detection of Kaposi's sarcoma associated herpesvirus in peripheral blood of HIV-infected individuals and progression to Kaposi's sarcoma. Lancet 1995; 346: 799-802.
    • (1995) Lancet , vol.346 , pp. 799-802
    • Whitby, D.1    Howard, M.R.2    Tenant-Flowers, M.3
  • 16
    • 0007607941 scopus 로고    scopus 로고
    • Evidence for concurrent epidemics of human herpesvirus 8 and human immunodefciency virus type 1 in US homosexual men, rates, risk factors, and relationship to Kaposi's sarcoma
    • O'Brien TR, Kedes D, Ganem D, et al. Evidence for concurrent epidemics of human herpesvirus 8 and human immunodefciency virus type 1 in US homosexual men, rates, risk factors, and relationship to Kaposi's sarcoma. J Infect Dis 1999; 180: 1010-1017.
    • (1999) J Infect Dis , vol.180 , pp. 1010-1017
    • O'Brien, T.R.1    Kedes, D.2    Ganem, D.3
  • 17
    • 0029069445 scopus 로고
    • Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas
    • Cesarman E, Chang Y, Moore PS, et al. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N Engl J Med 1995; 332: 1186-1191.
    • (1995) N Engl J Med , vol.332 , pp. 1186-1191
    • Cesarman, E.1    Chang, Y.2    Moore, P.S.3
  • 18
    • 0029166033 scopus 로고
    • Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castle-man's disease
    • Soulier J, Grollet L, Oksenhendler E, et al. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castle-man's disease. Blood 1995; 86: 1276-1280.
    • (1995) Blood , vol.86 , pp. 1276-1280
    • Soulier, J.1    Grollet, L.2    Oksenhendler, E.3
  • 19
    • 84871907133 scopus 로고    scopus 로고
    • Biological agents. Volume 100 B. A review of human carcinogens
    • Biological agents. Volume 100 B. A review of human carcinogens. IARC Monogr Eval Carcinog Risks Hum 2012; 100: 1-441.
    • (2012) IARC Monogr Eval Carcinog Risks Hum , vol.100 , pp. 1-441
  • 20
    • 0037434413 scopus 로고    scopus 로고
    • Review of the distribution of Kaposi's sarcoma-associated herpesvirus (KSHV) in Africa in relation to the incidence of Kaposi's sarcoma
    • Dedicoat M, Newton R. Review of the distribution of Kaposi's sarcoma-associated herpesvirus (KSHV) in Africa in relation to the incidence of Kaposi's sarcoma. Br J Cancer 2003; 88: 1-3.
    • (2003) Br J Cancer , vol.88 , pp. 1-3
    • Dedicoat, M.1    Newton, R.2
  • 21
    • 0033910466 scopus 로고    scopus 로고
    • Kaposi's sarcoma and transplantation
    • Mendez JC, Paya CV. Kaposi's sarcoma and transplantation. Herpes 2000; 7: 18-23.
    • (2000) Herpes , vol.7 , pp. 18-23
    • Mendez, J.C.1    Paya, C.V.2
  • 22
    • 60649117353 scopus 로고    scopus 로고
    • The malignant potential of HIV-associated Kaposi sarcoma
    • Wood NH, Feller L. The malignant potential of HIV-associated Kaposi sarcoma. Cancer Cell Int 2008; 8: 14.
    • (2008) Cancer Cell Int , vol.8 , pp. 14
    • Wood, N.H.1    Feller, L.2
  • 23
    • 0026656394 scopus 로고
    • Spindle cell ploidy and proliferation in endemic and epidemic African Kaposi's sarcoma
    • Kaaya EE, Parravicini C, Sundelin B, et al. Spindle cell ploidy and proliferation in endemic and epidemic African Kaposi's sarcoma. Eur J Cancer 1992; 28A: 1890-1894.
    • (1992) Eur J Cancer , vol.28 A , pp. 1890-1894
    • Kaaya, E.E.1    Parravicini, C.2    Sundelin, B.3
  • 24
    • 55049139641 scopus 로고    scopus 로고
    • Ultrastructure of Kaposi sarcoma
    • Orenstein JM. Ultrastructure of Kaposi sarcoma. Ultrastruct Pathol 2008; 32: 211-220.
    • (2008) Ultrastruct Pathol , vol.32 , pp. 211-220
    • Orenstein, J.M.1
  • 25
    • 0035024652 scopus 로고    scopus 로고
    • Spindle cell conversion by Kaposi's sarcoma-associated herpesvirus, formation of colonies and plaques with mixed lytic and latent gene expression in infected primary dermal microvascular endothelial cell cultures
    • Ciufo DM, Cannon JS, Poole LJ, et al. Spindle cell conversion by Kaposi's sarcoma-associated herpesvirus, formation of colonies and plaques with mixed lytic and latent gene expression in infected primary dermal microvascular endothelial cell cultures. J Virol 2001; 75: 5614-5626.
    • (2001) J Virol , vol.75 , pp. 5614-5626
    • Ciufo, D.M.1    Cannon, J.S.2    Poole, L.J.3
  • 26
    • 84901823376 scopus 로고    scopus 로고
    • Manipulation of endothelial cells by KSHV; Implications for angiogenesis and aberrant vascular differentiation
    • Ojala PM, Schulz TF. Manipulation of endothelial cells by KSHV; implications for angiogenesis and aberrant vascular differentiation. Semin Cancer Biol 2014; 26: 69-77.
    • (2014) Semin Cancer Biol , vol.26 , pp. 69-77
    • Ojala, P.M.1    Schulz, T.F.2
  • 27
    • 85048034669 scopus 로고    scopus 로고
    • HHV-8 and multistep tumorigenesis
    • Ensoli B, Sturzl M. HHV-8 and multistep tumorigenesis. Trends Microbiol 1999; 7: 310-312.
    • (1999) Trends Microbiol , vol.7 , pp. 310-312
    • Ensoli, B.1    Sturzl, M.2
  • 28
    • 0024603567 scopus 로고
    • Depletion of PDGF from serum inhibits growth of AIDS-related and sporadic Kaposi's sarcoma cells in culture
    • Roth WK, Werner S, Schirren CG, et al. Depletion of PDGF from serum inhibits growth of AIDS-related and sporadic Kaposi's sarcoma cells in culture. Oncogene 1989; 4: 483-487.
    • (1989) Oncogene , vol.4 , pp. 483-487
    • Roth, W.K.1    Werner, S.2    Schirren, C.G.3
  • 29
    • 0033762395 scopus 로고    scopus 로고
    • Cytokine-mediated growth promotion of Kaposi's sarcoma and primary effusion lymphoma
    • Ensoli B, Sturzl M, Monini P. Cytokine-mediated growth promotion of Kaposi's sarcoma and primary effusion lymphoma. Semin Cancer Biol 2000; 10: 367-381.
    • (2000) Semin Cancer Biol , vol.10 , pp. 367-381
    • Ensoli, B.1    Sturzl, M.2    Monini, P.3
  • 30
    • 0024294008 scopus 로고
    • Angiogenic properties of Kaposi's sarcoma-derived cells after long-term culture in vitro
    • Salahuddin SZ, Nakamura S, Biberfeld P, et al. Angiogenic properties of Kaposi's sarcoma-derived cells after long-term culture in vitro. Science 1988; 242: 430-433.
    • (1988) Science , vol.242 , pp. 430-433
    • Salahuddin, S.Z.1    Nakamura, S.2    Biberfeld, P.3
  • 31
    • 0031950270 scopus 로고    scopus 로고
    • Limited transmission of Kaposi's sarcoma-associated herpesvirus in cultured cells
    • Renne R, Blackbourn D, Whitby D, et al. Limited transmission of Kaposi's sarcoma-associated herpesvirus in cultured cells. J Virol 1998; 72: 5182-5188.
    • (1998) J Virol , vol.72 , pp. 5182-5188
    • Renne, R.1    Blackbourn, D.2    Whitby, D.3
  • 33
    • 3042780203 scopus 로고    scopus 로고
    • Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus
    • Hong YK, Foreman K, Shin JW, et al. Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus. Nat Genet 2004; 36: 683-685.
    • (2004) Nat Genet , vol.36 , pp. 683-685
    • Hong, Y.K.1    Foreman, K.2    Shin, J.W.3
  • 34
    • 3042738138 scopus 로고    scopus 로고
    • Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma
    • Wang HW, Trotter MW, Lagos D, et al. Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma. Nat Genet 2004; 36: 687-693.
    • (2004) Nat Genet , vol.36 , pp. 687-693
    • Wang, H.W.1    Trotter, M.W.2    Lagos, D.3
  • 35
    • 83655190739 scopus 로고    scopus 로고
    • KSHV-initiated notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition
    • Cheng F, Pekkonen P, Laurinavicius S, et al. KSHV-initiated notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition. Cell Host Microbe 2011; 10: 577-590.
    • (2011) Cell Host Microbe , vol.10 , pp. 577-590
    • Cheng, F.1    Pekkonen, P.2    Laurinavicius, S.3
  • 36
    • 84857708955 scopus 로고    scopus 로고
    • Kaposi sarcoma herpesvirus promotes endothelial-to-mesenchymal transition through Notch-dependent signaling
    • Gasperini P, Espigol-Frigole G, McCormick PJ, et al. Kaposi sarcoma herpesvirus promotes endothelial-to-mesenchymal transition through Notch-dependent signaling. Cancer Res 2012; 72: 1157-1169.
    • (2012) Cancer Res , vol.72 , pp. 1157-1169
    • Gasperini, P.1    Espigol-Frigole, G.2    McCormick, P.J.3
  • 37
    • 84867096020 scopus 로고    scopus 로고
    • Instigation of Notch signaling in the pathogenesis of Kaposi's sarcoma-associated herpesvirus and other human tumor viruses
    • Cheng F, Pekkonen P, Ojala PM. Instigation of Notch signaling in the pathogenesis of Kaposi's sarcoma-associated herpesvirus and other human tumor viruses. Future Microbiol 2012; 7: 1191-1205.
    • (2012) Future Microbiol , vol.7 , pp. 1191-1205
    • Cheng, F.1    Pekkonen, P.2    Ojala, P.M.3
  • 38
    • 80053940482 scopus 로고    scopus 로고
    • Deletion of Kaposi's sarcoma-associated herpesvirus FLICE inhibitory protein, v FLIP, from the viral genome compromises the activation of STAT1-responsive cellular genes and spindle cell formation in endothelial cells
    • Alkharsah KR, Singh VV, Bosco R, et al. Deletion of Kaposi's sarcoma-associated herpesvirus FLICE inhibitory protein, v FLIP, from the viral genome compromises the activation of STAT1-responsive cellular genes and spindle cell formation in endothelial cells. J Virol 2011; 85: 10375-10388.
    • (2011) J Virol , vol.85 , pp. 10375-10388
    • Alkharsah, K.R.1    Singh, V.V.2    Bosco, R.3
  • 39
    • 33745781669 scopus 로고    scopus 로고
    • Activation of NF-κB by the latent vFLIP gene of Kaposi's sarcoma-associated herpesvirus is required for the spindle shape of virus-infected endothe-lial cells and contributes to their proinfammatory phenotype
    • Grossmann C, Podgrabinska S, Skobe M, et al. Activation of NF-κB by the latent vFLIP gene of Kaposi's sarcoma-associated herpesvirus is required for the spindle shape of virus-infected endothe-lial cells and contributes to their proinfammatory phenotype. J Virol 2006; 80: 7179-7185.
    • (2006) J Virol , vol.80 , pp. 7179-7185
    • Grossmann, C.1    Podgrabinska, S.2    Skobe, M.3
  • 40
    • 0030800478 scopus 로고    scopus 로고
    • Interleukin-1 induces major phenotypic changes in human skin microvascular endothelial cells
    • Romero LI, Zhang DN, Herron GS, et al. Interleukin-1 induces major phenotypic changes in human skin microvascular endothelial cells. J Cell Physiol 1997; 173: 84-92.
    • (1997) J Cell Physiol , vol.173 , pp. 84-92
    • Romero, L.I.1    Zhang, D.N.2    Herron, G.S.3
  • 41
    • 80054976356 scopus 로고    scopus 로고
    • Infammation-induced endothelial-to-mesenchymal transition, a novel mechanism of intestinal fbrosis
    • Rieder F, Kessler SP, West GA, et al. Infammation-induced endothelial-to-mesenchymal transition, a novel mechanism of intestinal fbrosis. Am J Pathol 2011; 179, 2660-2673.
    • (2011) Am J Pathol , vol.179 , pp. 2660-2673
    • Rieder, F.1    Kessler, S.P.2    West, G.A.3
  • 42
    • 55249126800 scopus 로고    scopus 로고
    • The role of endothelial-to-mesenchymal transition in cancer progression
    • Potenta S, Zeisberg E, Kalluri R. The role of endothelial-to-mesenchymal transition in cancer progression. Br J Cancer 2008; 99: 1375-1379.
    • (2008) Br J Cancer , vol.99 , pp. 1375-1379
    • Potenta, S.1    Zeisberg, E.2    Kalluri, R.3
  • 43
    • 35948945337 scopus 로고    scopus 로고
    • Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fbroblasts
    • Zeisberg EM, Potenta S, Xie L, et al. Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fbroblasts. Cancer Res 2007; 67: 10123-10128.
    • (2007) Cancer Res , vol.67 , pp. 10123-10128
    • Zeisberg, E.M.1    Potenta, S.2    Xie, L.3
  • 44
    • 34547676391 scopus 로고    scopus 로고
    • Endothelial-to-mesenchymal transition contributes to cardiac fbrosis
    • Zeisberg EM, Tarnavski O, Zeisberg M, et al. Endothelial-to-mesenchymal transition contributes to cardiac fbrosis. Nat Med 2007; 13: 952-961.
    • (2007) Nat Med , vol.13 , pp. 952-961
    • Zeisberg, E.M.1    Tarnavski, O.2    Zeisberg, M.3
  • 45
    • 84865345444 scopus 로고    scopus 로고
    • The role of endothelial-mesenchymal transition in development and pathological process
    • Lin F, Wang N, Zhang TC. The role of endothelial-mesenchymal transition in development and pathological process. IUBMB Life 2012; 64: 717-723.
    • (2012) IUBMB Life , vol.64 , pp. 717-723
    • Lin, F.1    Wang, N.2    Zhang, T.C.3
  • 46
    • 80054976356 scopus 로고    scopus 로고
    • Infammation-induced endothelial-to-mesenchymal transition, a novel mechanism of intestinal fbrosis
    • Rieder F, Kessler SP, West GA, et al. Infammation-induced endothelial-to-mesenchymal transition, a novel mechanism of intestinal fbrosis. Am J Pathol 2011; 179: 2660-2673.
    • (2011) Am J Pathol , vol.179 , pp. 2660-2673
    • Rieder, F.1    Kessler, S.P.2    West, G.A.3
  • 47
    • 0034600309 scopus 로고    scopus 로고
    • Monoclonality or oligo-clonality of human herpesvirus 8 terminal repeat sequences in Kaposi's sarcoma and other diseases
    • Judde JG, Lacoste V, Briere J, et al. Monoclonality or oligo-clonality of human herpesvirus 8 terminal repeat sequences in Kaposi's sarcoma and other diseases. J Natl Cancer Inst 2000; 92: 729-736.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 729-736
    • Judde, J.G.1    Lacoste, V.2    Briere, J.3
  • 48
    • 0032493448 scopus 로고    scopus 로고
    • Evidence for multiclonality in multicentric Kaposi's sarcoma
    • Gill PS, Tsai YC, Rao AP, et al. Evidence for multiclonality in multicentric Kaposi's sarcoma. Proc Natl Acad Sci USA 1998; 95: 8257-8261.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 8257-8261
    • Gill, P.S.1    Tsai, Y.C.2    Rao, A.P.3
  • 49
    • 0030776745 scopus 로고    scopus 로고
    • Molecular analysis of clonality in Kaposi's sarcoma
    • Delabesse E, Oksenhendler E, Lebbe C, et al. Molecular analysis of clonality in Kaposi's sarcoma. J Clin Pathol 1997; 50: 664-668.
    • (1997) J Clin Pathol , vol.50 , pp. 664-668
    • Delabesse, E.1    Oksenhendler, E.2    Lebbe, C.3
  • 50
    • 84863274559 scopus 로고    scopus 로고
    • Direct and effcient cellular transformation of primary rat mesenchymal precursor cells by KSHV
    • Jones T, Ye F, Bedolla R, et al. Direct and effcient cellular transformation of primary rat mesenchymal precursor cells by KSHV. J Clin Invest 2012; 122: 1076-1081.
    • (2012) J Clin Invest , vol.122 , pp. 1076-1081
    • Jones, T.1    Ye, F.2    Bedolla, R.3
  • 51
    • 33847619373 scopus 로고    scopus 로고
    • In vivo-restricted and reversible malignancy induced by human herpesvirus-8 KSHV: A cell and animal model of virally induced Kaposi's sarcoma
    • Mutlu AD, Cavallin LE, Vincent L, et al. In vivo-restricted and reversible malignancy induced by human herpesvirus-8 KSHV: a cell and animal model of virally induced Kaposi's sarcoma. Cancer Cell 2007; 11: 245-258.
    • (2007) Cancer Cell , vol.11 , pp. 245-258
    • Mutlu, A.D.1    Cavallin, L.E.2    Vincent, L.3
  • 52
    • 33646440294 scopus 로고    scopus 로고
    • Long-term-infected telomerase-immortalized endothelial cells, a model for Kaposi's sarcoma-associated herpesvirus latency in vitro and in vivo
    • An FQ, Folarin HM, Compitello N, et al. Long-term-infected telomerase-immortalized endothelial cells, a model for Kaposi's sarcoma-associated herpesvirus latency in vitro and in vivo. J Virol 2006; 80: 4833-4846.
    • (2006) J Virol , vol.80 , pp. 4833-4846
    • An, F.Q.1    Folarin, H.M.2    Compitello, N.3
  • 53
    • 10544236112 scopus 로고    scopus 로고
    • Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells
    • Staskus KA, Zhong W, Gebhard K, et al. Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells. J Virol 1997; 71: 715-719.
    • (1997) J Virol , vol.71 , pp. 715-719
    • Staskus, K.A.1    Zhong, W.2    Gebhard, K.3
  • 54
    • 0029843883 scopus 로고    scopus 로고
    • Use of antiherpes drugs and the risk of Kaposi's sarcoma, data from the Multicenter AIDS Cohort Study
    • Glesby MJ, Hoover DR, Weng S, et al. Use of antiherpes drugs and the risk of Kaposi's sarcoma, data from the Multicenter AIDS Cohort Study. J Infect Dis 1996; 173: 1477-1480.
    • (1996) J Infect Dis , vol.173 , pp. 1477-1480
    • Glesby, M.J.1    Hoover, D.R.2    Weng, S.3
  • 55
    • 0029812506 scopus 로고    scopus 로고
    • Anti-herpesvirus treatment and risk of Kaposi's sarcoma in HIV infection. Royal Free/Chelsea and Westminster Hospitals Collaborative Group
    • Mocroft A, Youle M, Gazzard B, et al. Anti-herpesvirus treatment and risk of Kaposi's sarcoma in HIV infection. Royal Free/Chelsea and Westminster Hospitals Collaborative Group. AIDS 1996; 10: 1101-1105.
    • (1996) AIDS , vol.10 , pp. 1101-1105
    • Mocroft, A.1    Youle, M.2    Gazzard, B.3
  • 56
    • 72949087815 scopus 로고    scopus 로고
    • Human tumor-associated viruses and new insights into the molecular mechanisms of cancer
    • Martin D, Gutkind JS. Human tumor-associated viruses and new insights into the molecular mechanisms of cancer. Oncogene 2008; 27(suppl 2), S31-42.
    • (2008) Oncogene , vol.27 , pp. S31-42
    • Martin, D.1    Gutkind, J.S.2
  • 57
    • 41049098677 scopus 로고    scopus 로고
    • Host transcript accumulation during lytic KSHV infection reveals several classes of host responses
    • Chandriani S, Ganem D. Host transcript accumulation during lytic KSHV infection reveals several classes of host responses. PLoS One 2007; 2: e811.
    • (2007) PLoS One , vol.2 , pp. e811
    • Chandriani, S.1    Ganem, D.2
  • 58
    • 33645744610 scopus 로고    scopus 로고
    • KSHV infection and the pathogenesis of Kaposi's sarcoma
    • Ganem D. KSHV infection and the pathogenesis of Kaposi's sarcoma. Annu Rev Pathol 2006; 1: 273-296.
    • (2006) Annu Rev Pathol , vol.1 , pp. 273-296
    • Ganem, D.1
  • 59
    • 0030834122 scopus 로고    scopus 로고
    • The 222-234 kDa latent nuclear protein (LNA) of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) is encoded by orf73 and is a component of the latency-associated nuclear antigen
    • Rainbow L, Platt GM, Simpson GR, et al. The 222-234 kDa latent nuclear protein (LNA) of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) is encoded by orf73 and is a component of the latency-associated nuclear antigen. J Virol 1997; 71: 5915-5921.
    • (1997) J Virol , vol.71 , pp. 5915-5921
    • Rainbow, L.1    Platt, G.M.2    Simpson, G.R.3
  • 60
    • 0035100879 scopus 로고    scopus 로고
    • Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 mediates episome persistence through cis-acting terminal repeat (TR) sequence and specifcally binds TR DNA
    • Ballestas ME, Kaye KM. Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 mediates episome persistence through cis-acting terminal repeat (TR) sequence and specifcally binds TR DNA. J Virol 2001; 75: 3250-3258.
    • (2001) J Virol , vol.75 , pp. 3250-3258
    • Ballestas, M.E.1    Kaye, K.M.2
  • 61
    • 0033604613 scopus 로고    scopus 로고
    • The latency-associated nuclear antigen tethers the Kaposi's sarcoma-associated herpesvirus genome to host chromosomes in body cavity-based lymphoma cells
    • Cotter MA, 2nd, Robertson ES. The latency-associated nuclear antigen tethers the Kaposi's sarcoma-associated herpesvirus genome to host chromosomes in body cavity-based lymphoma cells. Virol og y 1999; 264: 254-264.
    • (1999) Virol Og y , vol.264 , pp. 254-264
    • Cotter, M.A.1    Robertson, E.S.2
  • 62
    • 0037321704 scopus 로고    scopus 로고
    • The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus permits replication of terminal repeat-containing plasmids
    • Grundhoff A, Ganem D. The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus permits replication of terminal repeat-containing plasmids. J Virol 2003; 77: 2779-2783.
    • (2003) J Virol , vol.77 , pp. 2779-2783
    • Grundhoff, A.1    Ganem, D.2
  • 63
    • 33749243937 scopus 로고    scopus 로고
    • Recruitment of the de novo DNA methyltransferase Dnmt3a by Kaposi's sarcoma-associated herpesvirus LANA
    • Shamay M, Krithivas A, Zhang J, et al. Recruitment of the de novo DNA methyltransferase Dnmt3a by Kaposi's sarcoma-associated herpesvirus LANA. Proc Natl Acad Sci USA 2006; 103: 14554-14559.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 14554-14559
    • Shamay, M.1    Krithivas, A.2    Zhang, J.3
  • 64
    • 0034749459 scopus 로고    scopus 로고
    • Modulation of cellular and viral gene expression by the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus
    • Renne R, Barry C, Dittmer D, et al. Modulation of cellular and viral gene expression by the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus. J Virol 2001; 75: 458-468.
    • (2001) J Virol , vol.75 , pp. 458-468
    • Renne, R.1    Barry, C.2    Dittmer, D.3
  • 65
    • 0033767391 scopus 로고    scopus 로고
    • Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) binds ATF4/CREB2 and inhibits its transcriptional activation activity
    • Lim C, Sohn H, Gwack Y, et al. Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) binds ATF4/CREB2 and inhibits its transcriptional activation activity. J Gen Virol 2000; 81: 2645-2652.
    • (2000) J Gen Virol , vol.81 , pp. 2645-2652
    • Lim, C.1    Sohn, H.2    Gwack, Y.3
  • 66
    • 0033599006 scopus 로고    scopus 로고
    • P53 inhibition by the LANA protein of KSHV protects against cell death
    • Friborg J, Jr., Kong W, Hottiger MO, et al. p53 inhibition by the LANA protein of KSHV protects against cell death. Nature 1999; 402: 889-894.
    • (1999) Nature , vol.402 , pp. 889-894
    • Friborg, J.1    Kong, W.2    Hottiger, M.O.3
  • 67
    • 0033782793 scopus 로고    scopus 로고
    • The latent nuclear antigen of Kaposi sarcoma-associated herpesvirus targets the retinoblastoma-E2F pathway and with the oncogene Hras transforms primary rat cells
    • Radkov SA, Kellam P, Boshoff C. The latent nuclear antigen of Kaposi sarcoma-associated herpesvirus targets the retinoblastoma-E2F pathway and with the oncogene Hras transforms primary rat cells. Nat Med 2000; 6: 1121-1127.
    • (2000) Nat Med , vol.6 , pp. 1121-1127
    • Radkov, S.A.1    Kellam, P.2    Boshoff, C.3
  • 68
    • 0038365381 scopus 로고    scopus 로고
    • Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen prolongs the life span of primary human umbilical vein endothelial cells
    • Watanabe T, Sugaya M, Atkins AM, et al. Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen prolongs the life span of primary human umbilical vein endothelial cells. J Vi ro l 2003; 77: 6188-6196.
    • (2003) J Vi Ro L , vol.77 , pp. 6188-6196
    • Watanabe, T.1    Sugaya, M.2    Atkins, A.M.3
  • 69
    • 34547425829 scopus 로고    scopus 로고
    • Deregulation of c-Myc in primary effusion lymphoma by Kaposi's sarcoma herpesvirus latency-associated nuclear antigen
    • Bubman D, Guasparri I, Cesarman E. Deregulation of c-Myc in primary effusion lymphoma by Kaposi's sarcoma herpesvirus latency-associated nuclear antigen. Oncogene 2007; 26: 4979-4986.
    • (2007) Oncogene , vol.26 , pp. 4979-4986
    • Bubman, D.1    Guasparri, I.2    Cesarman, E.3
  • 70
    • 34648827798 scopus 로고    scopus 로고
    • The Kaposi's sarcoma-associated herpesvirus LANA protein stabilizes and activates c-Myc
    • Liu J, Martin HJ, Liao G, et al. The Kaposi's sarcoma-associated herpesvirus LANA protein stabilizes and activates c-Myc. J Virol 2007; 81: 10451-10459.
    • (2007) J Virol , vol.81 , pp. 10451-10459
    • Liu, J.1    Martin, H.J.2    Liao, G.3
  • 71
    • 0031041308 scopus 로고    scopus 로고
    • Kaposi's sarcoma-associated herpesvirus encodes a functional cyclin
    • Li M, Lee H, Yoon DW, et al. Kaposi's sarcoma-associated herpesvirus encodes a functional cyclin. J Virol 1997; 71: 1984-1991.
    • (1997) J Virol , vol.71 , pp. 1984-1991
    • Li, M.1    Lee, H.2    Yoon, D.W.3
  • 72
    • 1642556785 scopus 로고    scopus 로고
    • The role of p53 in suppression of KSHV cyclin-induced lymphomagenesis
    • Verschuren EW, Hodgson JG, Gray JW, et al. The role of p53 in suppression of KSHV cyclin-induced lymphomagenesis. Cancer Res 2004; 64: 581-589.
    • (2004) Cancer Res , vol.64 , pp. 581-589
    • Verschuren, E.W.1    Hodgson, J.G.2    Gray, J.W.3
  • 73
    • 0035136288 scopus 로고    scopus 로고
    • Mechanisms governing expression of the v-FLIP gene of Kaposi's sarcoma-associated herpesvirus
    • Grundhoff A, Ganem D. Mechanisms governing expression of the v-FLIP gene of Kaposi's sarcoma-associated herpesvirus. J Virol 2001; 75: 1857-1863.
    • (2001) J Virol , vol.75 , pp. 1857-1863
    • Grundhoff, A.1    Ganem, D.2
  • 75
    • 0030697223 scopus 로고    scopus 로고
    • Herpes viral cyclin/Cdk6 complexes evade inhibition by CDK inhibitor proteins
    • Swanton C, Mann DJ, Fleckenstein B, et al. Herpes viral cyclin/Cdk6 complexes evade inhibition by CDK inhibitor proteins. Nature 1997; 390: 184-187.
    • (1997) Nature , vol.390 , pp. 184-187
    • Swanton, C.1    Mann, D.J.2    Fleckenstein, B.3
  • 76
    • 2942679275 scopus 로고    scopus 로고
    • The cell cycle and how it is steered by Kaposi's sarcoma-associated herpesvirus cyclin
    • Verschuren EW, Jones N, Evan GI. The cell cycle and how it is steered by Kaposi's sarcoma-associated herpesvirus cyclin. J Gen Vi ro l 2004; 85: 1347-1361.
    • (2004) J Gen Vi Ro L , vol.85 , pp. 1347-1361
    • Verschuren, E.W.1    Jones, N.2    Evan, G.I.3
  • 77
    • 0033081619 scopus 로고    scopus 로고
    • Degradation of p27(Kip) cdk inhibitor triggered by Kaposi's sarcoma virus cyclin-cdk6 complex
    • Ellis M, Chew YP, Fallis L, et al. Degradation of p27(Kip) cdk inhibitor triggered by Kaposi's sarcoma virus cyclin-cdk6 complex. EMBO J 1999; 18: 644-653.
    • (1999) EMBO J , vol.18 , pp. 644-653
    • Ellis, M.1    Chew, Y.P.2    Fallis, L.3
  • 78
    • 84857247666 scopus 로고    scopus 로고
    • Subversion of autophagy by Kaposi's sarcoma-associated herpesvirus impairs oncogene-induced senescence
    • Leidal AM, Cyr DP, Hill RJ, et al. Subversion of autophagy by Kaposi's sarcoma-associated herpesvirus impairs oncogene-induced senescence. Cell Host Microbe 2012; 11: 167-180.
    • (2012) Cell Host Microbe , vol.11 , pp. 167-180
    • Leidal, A.M.1    Cyr, D.P.2    Hill, R.J.3
  • 79
    • 34848918826 scopus 로고    scopus 로고
    • Viral oncogene-induced DNA damage response is activated in Kaposi sarcoma tumorigenesis
    • Koopal S, Furuhjelm JH, Jarviluoma A, et al. Viral oncogene-induced DNA damage response is activated in Kaposi sarcoma tumorigenesis. PLoS Pathog 2007; 3: 1348-1360.
    • (2007) PLoS Pathog , vol.3 , pp. 1348-1360
    • Koopal, S.1    Furuhjelm, J.H.2    Jarviluoma, A.3
  • 80
    • 0035134520 scopus 로고    scopus 로고
    • Kaposi's sarcoma-associated herpesvirus vCyclin open reading frame contains an internal ribosome entry site
    • Bieleski L, Talbot SJ. Kaposi's sarcoma-associated herpesvirus vCyclin open reading frame contains an internal ribosome entry site. J Virol 2001; 75: 1864-1869.
    • (2001) J Virol , vol.75 , pp. 1864-1869
    • Bieleski, L.1    Talbot, S.J.2
  • 81
    • 47949101732 scopus 로고    scopus 로고
    • Kaposi's sarcoma-associated herpesvirus confers a survival advantage to endothelial cells
    • Wang L, Damania B. Kaposi's sarcoma-associated herpesvirus confers a survival advantage to endothelial cells. Cancer Res 2008; 68: 4640-4648.
    • (2008) Cancer Res , vol.68 , pp. 4640-4648
    • Wang, L.1    Damania, B.2
  • 82
    • 0032937799 scopus 로고    scopus 로고
    • Differential expression of p53 and Ki-67 proteins in classic and iatrogenic Kaposi's sarcoma
    • Hodak E, Hammel I, Feinmesser M, et al. Differential expression of p53 and Ki-67 proteins in classic and iatrogenic Kaposi's sarcoma. Am J Dermatopathol 1999; 21: 138-145.
    • (1999) Am J Dermatopathol , vol.21 , pp. 138-145
    • Hodak, E.1    Hammel, I.2    Feinmesser, M.3
  • 83
    • 77953799148 scopus 로고    scopus 로고
    • Induction of the Warburg effect by Kaposi's sarcoma herpesvirus is required for the maintenance of latently infected endothelial cells
    • Delgado T, Carroll PA, Punjabi AS, et al. Induction of the Warburg effect by Kaposi's sarcoma herpesvirus is required for the maintenance of latently infected endothelial cells. Proc Natl Acad Sci USA 2010; 107: 10696-10701.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 10696-10701
    • Delgado, T.1    Carroll, P.A.2    Punjabi, A.S.3
  • 84
    • 0001221508 scopus 로고
    • On respiratory impairment in cancer cells
    • Warburg O. On respiratory impairment in cancer cells. Science 1956; 124: 269-270.
    • (1956) Science , vol.124 , pp. 269-270
    • Warburg, O.1
  • 85
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O. On the origin of cancer cells. Science 1956; 123: 309-314.
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 86
    • 79960029992 scopus 로고    scopus 로고
    • Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release
    • Goetze K, Walenta S, Ksiazkiewicz M, et al. Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release. Int J Oncol 2011; 39: 453-463.
    • (2011) Int J Oncol , vol.39 , pp. 453-463
    • Goetze, K.1    Walenta, S.2    Ksiazkiewicz, M.3
  • 88
    • 34347323902 scopus 로고    scopus 로고
    • Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: A meta-analysis
    • Grulich AE, van Leeuwen MT, Falster MO, et al. Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: a meta-analysis. Lancet 2007; 370: 59-67.
    • (2007) Lancet , vol.370 , pp. 59-67
    • Grulich, A.E.1    Van Leeuwen, M.T.2    Falster, M.O.3
  • 89
    • 50849135475 scopus 로고    scopus 로고
    • Histological variants of cutaneous Kaposi sarcoma
    • Grayson W, Pantanowitz L. Histological variants of cutaneous Kaposi sarcoma. Diagn Pathol 2008; 3: 31.
    • (2008) Diagn Pathol , vol.3 , pp. 31
    • Grayson, W.1    Pantanowitz, L.2
  • 90
    • 0026346825 scopus 로고
    • Vascular endothelium, a potential role in HIV infection and the pathogenesis of Kaposi's sarcoma, observations and speculations
    • Kaul A, Pearson JD, Petty R, et al. Vascular endothelium, a potential role in HIV infection and the pathogenesis of Kaposi's sarcoma, observations and speculations. Mol Aspects Med 1991; 12: 297-312.
    • (1991) Mol Aspects Med , vol.12 , pp. 297-312
    • Kaul, A.1    Pearson, J.D.2    Petty, R.3
  • 91
    • 0025219921 scopus 로고
    • Growth patterns, infammatory cells and prognosis in AIDS-associated Kaposi's sarcoma
    • Muller H, Kaya S, Stutte HJ. Growth patterns, infammatory cells and prognosis in AIDS-associated Kaposi's sarcoma. Res Virol 1990; 141: 201-207.
    • (1990) Res Virol , vol.141 , pp. 201-207
    • Muller, H.1    Kaya, S.2    Stutte, H.J.3
  • 92
    • 0027220944 scopus 로고
    • The Tat proteinof human immunodefciency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence
    • Barillari G, Gendelman R, Gallo RC, et al. The Tat proteinof human immunodefciency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence. Proc Natl Acad Sci USA 1993; 90: 7941-7945.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 7941-7945
    • Barillari, G.1    Gendelman, R.2    Gallo, R.C.3
  • 93
    • 0033564367 scopus 로고    scopus 로고
    • Reactivation and persistence of human herpesvirus-8 infection in B cells and monocytes by Th-1 cytokines increased in Kaposi's sarcoma
    • Monini P, Colombini S, Sturzl M, et al. Reactivation and persistence of human herpesvirus-8 infection in B cells and monocytes by Th-1 cytokines increased in Kaposi's sarcoma. Blood 1999; 93: 4044-4058.
    • (1999) Blood , vol.93 , pp. 4044-4058
    • Monini, P.1    Colombini, S.2    Sturzl, M.3
  • 94
    • 0032923485 scopus 로고    scopus 로고
    • α-Interferon inhibits human herpesvirus 8 (HHV-8) reactivation in primary effusion lymphoma cells and reduces HHV-8 load in cultured peripheral blood mononu-clear cells
    • Monini P, Carlini F, Sturzl M, et al. α-Interferon inhibits human herpesvirus 8 (HHV-8) reactivation in primary effusion lymphoma cells and reduces HHV-8 load in cultured peripheral blood mononu-clear cells. J Virol 1999; 73: 4029-4041.
    • (1999) J Virol , vol.73 , pp. 4029-4041
    • Monini, P.1    Carlini, F.2    Sturzl, M.3
  • 95
    • 63449097051 scopus 로고    scopus 로고
    • KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANA
    • Cheng F, Weidner-Glunde M, Varjosalo M, et al. KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANA. PLoS Pathog 2009; 5: e1000324.
    • (2009) PLoS Pathog , vol.5 , pp. e1000324
    • Cheng, F.1    Weidner-Glunde, M.2    Varjosalo, M.3
  • 96
    • 19244368329 scopus 로고    scopus 로고
    • γ-Interferon production in peripheral blood mononuclear cells and tumor infltrating lymphocytes from Kaposi's sarcoma patients, correlation with the presence of human herpesvirus-8 in peripheral blood mononuclear cells and lesional macrophages
    • Sirianni MC, Vincenzi L, Fiorelli V, et al. γ-Interferon production in peripheral blood mononuclear cells and tumor infltrating lymphocytes from Kaposi's sarcoma patients, correlation with the presence of human herpesvirus-8 in peripheral blood mononuclear cells and lesional macrophages. Blood 1998; 91: 968-976.
    • (1998) Blood , vol.91 , pp. 968-976
    • Sirianni, M.C.1    Vincenzi, L.2    Fiorelli, V.3
  • 97
    • 10344244491 scopus 로고    scopus 로고
    • Immunological activation markers in the serum of African and European HIV-seropositive and seronegative individuals
    • Rizzardini G, Piconi S, Ruzzante S, et al. Immunological activation markers in the serum of African and European HIV-seropositive and seronegative individuals. AIDS 1996; 10: 1535-1542.
    • (1996) AIDS , vol.10 , pp. 1535-1542
    • Rizzardini, G.1    Piconi, S.2    Ruzzante, S.3
  • 99
    • 15144349979 scopus 로고    scopus 로고
    • A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus
    • Kledal TN, Rosenkilde MM, Coulin F, et al. A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus. Science 1997; 277: 1656-1659.
    • (1997) Science , vol.277 , pp. 1656-1659
    • Kledal, T.N.1    Rosenkilde, M.M.2    Coulin, F.3
  • 100
    • 0034857404 scopus 로고    scopus 로고
    • Selective recruitment of Th2-type cells and evasion from a cytotoxic immune response mediated by viral macrophage inhibitory protein-II
    • Weber KS, Grone HJ, Rocken M, et al. Selective recruitment of Th2-type cells and evasion from a cytotoxic immune response mediated by viral macrophage inhibitory protein-II. Eur J Immunol 2001; 31: 2458-2466.
    • (2001) Eur J Immunol , vol.31 , pp. 2458-2466
    • Weber, K.S.1    Grone, H.J.2    Rocken, M.3
  • 101
    • 18344398654 scopus 로고    scopus 로고
    • KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells
    • Stine JT, Wood C, Hill M, et al. KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells. Blood 2000; 95: 1151-1157.
    • (2000) Blood , vol.95 , pp. 1151-1157
    • Stine, J.T.1    Wood, C.2    Hill, M.3
  • 102
    • 0026761179 scopus 로고
    • Prostanoid biosynthesis and mechanisms of action
    • Smith WL. Prostanoid biosynthesis and mechanisms of action. Am J Physiol 1992; 263: F181-191.
    • (1992) Am J Physiol , vol.263 , pp. F181-191
    • Smith, W.L.1
  • 103
    • 0029924110 scopus 로고    scopus 로고
    • Prostaglandin endoperoxide synthase, why two isoforms?
    • Williams CS, DuBois RN. Prostaglandin endoperoxide synthase, why two isoforms? Am J Physiol 1996; 270: G393-400.
    • (1996) Am J Physiol , vol.270 , pp. G393-400
    • Williams, C.S.1    Dubois, R.N.2
  • 104
    • 0032542763 scopus 로고    scopus 로고
    • Expression of cyclooxygenase-1 and cyclooxygenase-2 in human breast cancer
    • Hwang D, Scollard D, Byrne J, et al. Expression of cyclooxygenase-1 and cyclooxygenase-2 in human breast cancer. J Natl Cancer Inst 1998; 90: 455-460.
    • (1998) J Natl Cancer Inst , vol.90 , pp. 455-460
    • Hwang, D.1    Scollard, D.2    Byrne, J.3
  • 105
    • 0030952695 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential
    • Tsujii M, Kawano S, DuBois RN. Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential. Proc Natl Acad Sci USA 1997; 94: 3336-3340.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 3336-3340
    • Tsujii, M.1    Kawano, S.2    Dubois, R.N.3
  • 106
    • 0033106051 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer
    • Tucker ON, Dannenberg AJ, Yang EK, et al. Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer. Cancer Res 1999; 59: 987-990.
    • (1999) Cancer Res , vol.59 , pp. 987-990
    • Tucker, O.N.1    Dannenberg, A.J.2    Yang, E.K.3
  • 107
    • 0035126879 scopus 로고    scopus 로고
    • Cyclooxygenase-2 is over-expressed in human cervical cancer
    • Kulkarni S, Rader JS, Zhang F, et al. Cyclooxygenase-2 is over-expressed in human cervical cancer. Clin Cancer Res 2001; 7: 429-434.
    • (2001) Clin Cancer Res , vol.7 , pp. 429-434
    • Kulkarni, S.1    Rader, J.S.2    Zhang, F.3
  • 108
    • 7244234090 scopus 로고    scopus 로고
    • Increased intra-hepatic cyclooxygenase 2, matrix metalloproteinase 2, and matrix metalloproteinase 9 expression is associated with progressive liver disease in chronic hepatitis C virus infection, role of viral core and NS5A proteins
    • Nunez O, Fernandez-Martinez A, Majano PL, et al. Increased intra-hepatic cyclooxygenase 2, matrix metalloproteinase 2, and matrix metalloproteinase 9 expression is associated with progressive liver disease in chronic hepatitis C virus infection, role of viral core and NS5A proteins. Gut 2004; 53: 1665-1672.
    • (2004) Gut , vol.53 , pp. 1665-1672
    • Nunez, O.1    Fernandez-Martinez, A.2    Majano, P.L.3
  • 109
    • 77649258068 scopus 로고    scopus 로고
    • Kaposi's sarcoma-associated herpesvirus (KSHV)-induced COX-2, a key factor in latency, infammation, angiogenesis, cell survival and invasion
    • Sharma-Walia N, Paul AG, Bottero V, et al. Kaposi's sarcoma-associated herpesvirus (KSHV)-induced COX-2, a key factor in latency, infammation, angiogenesis, cell survival and invasion. PLoS Pathog 2010; 6: e1000777.
    • (2010) PLoS Pathog , vol.6 , pp. e1000777
    • Sharma-Walia, N.1    Paul, A.G.2    Bottero, V.3
  • 110
    • 84868269793 scopus 로고    scopus 로고
    • COX-2/PGE2, molecular ambassadors of Kaposi's sarcoma-associated herpes virus oncoprotein-v-FLIP
    • Sharma-Walia N, Patel K, Chandran K, et al. COX-2/PGE2, molecular ambassadors of Kaposi's sarcoma-associated herpes virus oncoprotein-v-FLIP. Oncogenesis 2012; 1: e5.
    • (2012) Oncogenesis , vol.1 , pp. e5
    • Sharma-Walia, N.1    Patel, K.2    Chandran, K.3
  • 111
    • 84888236296 scopus 로고    scopus 로고
    • The infammatory kinase MAP4K4 promotes reactivation of Kaposi's sarcoma herpesvirus and enhances the invasiveness of infected endothelial cells
    • Haas DA, Bala K, Busche G, et al. The infammatory kinase MAP4K4 promotes reactivation of Kaposi's sarcoma herpesvirus and enhances the invasiveness of infected endothelial cells. PLoS Pa t h o g 2013; 9: e1003737.
    • (2013) PLoS Pa T H O G , vol.9 , pp. e1003737
    • Haas, D.A.1    Bala, K.2    Busche, G.3
  • 112
    • 36348942822 scopus 로고    scopus 로고
    • Kaposi's sarcoma, a model of both malignancy and chronic infammation
    • Douglas JL, Gustin JK, Dezube B, et al. Kaposi's sarcoma, a model of both malignancy and chronic infammation. Panminerva Med 2007; 49: 119-138.
    • (2007) Panminerva Med , vol.49 , pp. 119-138
    • Douglas, J.L.1    Gustin, J.K.2    Dezube, B.3
  • 113
    • 33645741486 scopus 로고    scopus 로고
    • Immortalization of primary endothelial cells by the K1 protein of Kaposi's sarcoma-associated herpesvirus
    • Wang L, Dittmer DP, Tomlinson CC, et al. Immortalization of primary endothelial cells by the K1 protein of Kaposi's sarcoma-associated herpesvirus. Cancer Res 2006; 66: 3658-3666.
    • (2006) Cancer Res , vol.66 , pp. 3658-3666
    • Wang, L.1    Dittmer, D.P.2    Tomlinson, C.C.3
  • 114
    • 34250811336 scopus 로고    scopus 로고
    • Kaposi's sarcoma-associated herpesvirus infection promotes invasion of primary human umbilical vein endothelial cells by inducing matrix metalloproteinases
    • Qian LW, Xie J, Ye F, et al. Kaposi's sarcoma-associated herpesvirus infection promotes invasion of primary human umbilical vein endothelial cells by inducing matrix metalloproteinases. J Virol 2007; 81: 7001-7010.
    • (2007) J Virol , vol.81 , pp. 7001-7010
    • Qian, L.W.1    Xie, J.2    Ye, F.3
  • 115
    • 84863969631 scopus 로고    scopus 로고
    • Cancer angiogenesis induced by Kaposi sarcoma-associated herpesvirus is mediated by EZH2
    • He M, Zhang W, Bakken T, et al. Cancer angiogenesis induced by Kaposi sarcoma-associated herpesvirus is mediated by EZH2. Cancer Res 2012; 72: 3582-3592.
    • (2012) Cancer Res , vol.72 , pp. 3582-3592
    • He, M.1    Zhang, W.2    Bakken, T.3
  • 116
    • 77952858493 scopus 로고    scopus 로고
    • Direct activation of emmprin and associated pathogenesis by an oncogenic herpesvirus
    • Qin Z, Dai L, Slomiany MG, et al. Direct activation of emmprin and associated pathogenesis by an oncogenic herpesvirus. Cancer Res 2012; 70: 3884-3889.
    • (2012) Cancer Res , vol.70 , pp. 3884-3889
    • Qin, Z.1    Dai, L.2    Slomiany, M.G.3
  • 117
    • 84862531262 scopus 로고    scopus 로고
    • KSHV activation of VEGF secretion and invasion for endothelial cells is mediated through viral upregulation of emmprin-induced signal transduction
    • Dai L, Bratoeva M, Toole BP, et al. KSHV activation of VEGF secretion and invasion for endothelial cells is mediated through viral upregulation of emmprin-induced signal transduction. Int J Cancer 2010; 131: 834-843.
    • (2010) Int J Cancer , vol.131 , pp. 834-843
    • Dai, L.1    Bratoeva, M.2    Toole, B.P.3
  • 118
    • 84897389369 scopus 로고    scopus 로고
    • Latency-associated nuclear antigen of Kaposi sarcoma-associated herpesvirus promotes angiogenesis through targeting Notch signaling effector Hey1
    • Wang X, He Z, Xia T, et al. Latency-associated nuclear antigen of Kaposi sarcoma-associated herpesvirus promotes angiogenesis through targeting Notch signaling effector Hey1. Cancer Res 2014; 74: 2026-2037.
    • (2014) Cancer Res , vol.74 , pp. 2026-2037
    • Wang, X.1    He, Z.2    Xia, T.3
  • 119
    • 0029074938 scopus 로고
    • Identifcation of interleukin-1 and platelet-derived growth factor-B as major mitogens for the spindle cells of Kaposi's sarcoma, a combined in vitro and in vivo analysis
    • Sturzl M, Brandstetter H, Zietz C, et al. Identifcation of interleukin-1 and platelet-derived growth factor-B as major mitogens for the spindle cells of Kaposi's sarcoma, a combined in vitro and in vivo analysis. Oncogene 1995; 10: 2007-2016.
    • (1995) Oncogene , vol.10 , pp. 2007-2016
    • Sturzl, M.1    Brandstetter, H.2    Zietz, C.3
  • 120
    • 0026780550 scopus 로고
    • Expression of platelet-derived growth factor and its receptor in AIDS-related Kaposi sarcoma in vivo suggests paracrine and autocrine mechanisms of tumor maintenance
    • Sturzl M, Roth WK, Brockmeyer NH, et al. Expression of platelet-derived growth factor and its receptor in AIDS-related Kaposi sarcoma in vivo suggests paracrine and autocrine mechanisms of tumor maintenance. Proc Natl Acad Sci USA 1992; 89: 7046-7050.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 7046-7050
    • Sturzl, M.1    Roth, W.K.2    Brockmeyer, N.H.3
  • 121
    • 84884687082 scopus 로고    scopus 로고
    • Proteomic screening of human targets of viral microRNAs reveals functions associated with immune evasion and angiogenesis
    • Gallaher AM, Das S, Xiao Z, et al. Proteomic screening of human targets of viral microRNAs reveals functions associated with immune evasion and angiogenesis. PLoS Pathog 2013; 9: e1003584.
    • (2013) PLoS Pathog , vol.9 , pp. e1003584
    • Gallaher, A.M.1    Das, S.2    Xiao, Z.3
  • 122
    • 77954688337 scopus 로고    scopus 로고
    • The epigenetic landscape of latent Kaposi sarcoma-associated herpesvirus genomes
    • Gunther T, Grundhoff A. The epigenetic landscape of latent Kaposi sarcoma-associated herpesvirus genomes. PLoS Pathog 2010; 6: e1000935.
    • (2010) PLoS Pathog , vol.6 , pp. e1000935
    • Gunther, T.1    Grundhoff, A.2
  • 123
    • 77951996351 scopus 로고    scopus 로고
    • Array-based transcript profling and limiting-dilution reverse transcription-PCR analysis identify additional latent genes in Kaposi's sarcoma-associated herpesvirus
    • Chandriani S, Ganem D. Array-based transcript profling and limiting-dilution reverse transcription-PCR analysis identify additional latent genes in Kaposi's sarcoma-associated herpesvirus. J Virol 2010; 84: 5565-5573.
    • (2010) J Virol , vol.84 , pp. 5565-5573
    • Chandriani, S.1    Ganem, D.2
  • 124
    • 0032775720 scopus 로고    scopus 로고
    • Identifcation of a spliced gene from Kaposi's sarcoma-associated herpesvirus encoding a protein with similarities to latent membrane proteins 1 and 2A of Epstein-Barr virus
    • Glenn M, Rainbow L, Aurade F, et al. Identifcation of a spliced gene from Kaposi's sarcoma-associated herpesvirus encoding a protein with similarities to latent membrane proteins 1 and 2A of Epstein-Barr virus. J Virol 1999; 73: 6953-6963.
    • (1999) J Virol , vol.73 , pp. 6953-6963
    • Glenn, M.1    Rainbow, L.2    Aurade, F.3
  • 125
    • 0033901248 scopus 로고    scopus 로고
    • Differential viral protein expression in Kaposi's sarcoma-associated herpesvirus-infected diseases, Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease
    • Parravicini C, Chandran B, Corbellino M, et al. Differential viral protein expression in Kaposi's sarcoma-associated herpesvirus-infected diseases, Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. Am J Pathol 2000; 156: 743-749.
    • (2000) Am J Pathol , vol.156 , pp. 743-749
    • Parravicini, C.1    Chandran, B.2    Corbellino, M.3
  • 126
    • 0034630323 scopus 로고    scopus 로고
    • Expression and localization of human herpesvirus 8-encoded proteins in primary effusion lymphoma, Kaposi's sarcoma, and multicentric Castleman's disease
    • Katano H, Sato Y, Kurata T, et al. Expression and localization of human herpesvirus 8-encoded proteins in primary effusion lymphoma, Kaposi's sarcoma, and multicentric Castleman's disease. Virology 2000; 269: 335-344.
    • (2000) Virology , vol.269 , pp. 335-344
    • Katano, H.1    Sato, Y.2    Kurata, T.3
  • 127
    • 25144462103 scopus 로고    scopus 로고
    • Characterization of the Kaposi's sarcoma-associated herpesvirus K1 signalosome
    • Lee BS, Lee SH, Feng P, et al. Characterization of the Kaposi's sarcoma-associated herpesvirus K1 signalosome. J Virol 2005; 79: 12173-12184.
    • (2005) J Virol , vol.79 , pp. 12173-12184
    • Lee, B.S.1    Lee, S.H.2    Feng, P.3
  • 128
    • 84869010521 scopus 로고    scopus 로고
    • Sirolimus for the treatment of Kaposi sarcoma after renal transplantation, a series of 10 cases
    • Yaich S, Charfeddine K, Zaghdane S, et al. Sirolimus for the treatment of Kaposi sarcoma after renal transplantation, a series of 10 cases. Transpl Proc 2012; 44: 2824-2826.
    • (2012) Transpl Proc , vol.44 , pp. 2824-2826
    • Yaich, S.1    Charfeddine, K.2    Zaghdane, S.3
  • 129
    • 0032786533 scopus 로고    scopus 로고
    • Comparison of genetic variability at multiple loci across the genomes of the major subtypes of Kaposi's sarcoma-associated herpesvirus reveals evidence for recombination and for two distinct types of open reading frame K15 alleles at the right-hand end
    • Poole LJ, Zong JC, Ciufo DM, et al. Comparison of genetic variability at multiple loci across the genomes of the major subtypes of Kaposi's sarcoma-associated herpesvirus reveals evidence for recombination and for two distinct types of open reading frame K15 alleles at the right-hand end. J Virol 1999; 73: 6646-6660.
    • (1999) J Virol , vol.73 , pp. 6646-6660
    • Poole, L.J.1    Zong, J.C.2    Ciufo, D.M.3
  • 130
    • 0033989865 scopus 로고    scopus 로고
    • Identifcation of the novel K15 gene at the rightmost end of the Kaposi's sarcoma-associated herpesvirus genome
    • Choi JK, Lee BS, Shim SN, et al. Identifcation of the novel K15 gene at the rightmost end of the Kaposi's sarcoma-associated herpesvirus genome. J Virol 2000; 74: 436-446.
    • (2000) J Virol , vol.74 , pp. 436-446
    • Choi, J.K.1    Lee, B.S.2    Shim, S.N.3
  • 131
    • 0041387452 scopus 로고    scopus 로고
    • Activation of mitogen-activated protein kinase and NF-κB pathways by a Kaposi's sarcoma-associated herpesvirus K15 membrane protein
    • Brinkmann MM, Glenn M, Rainbow L, et al. Activation of mitogen-activated protein kinase and NF-κB pathways by a Kaposi's sarcoma-associated herpesvirus K15 membrane protein. J Virol 2003; 77: 9346-9358.
    • (2003) J Virol , vol.77 , pp. 9346-9358
    • Brinkmann, M.M.1    Glenn, M.2    Rainbow, L.3
  • 132
    • 33845736881 scopus 로고    scopus 로고
    • Modulation of host gene expression by the K15 protein of Kaposi's sarcoma-associated herpesvirus
    • Brinkmann MM, Pietrek M, Dittrich-Breiholz O, et al. Modulation of host gene expression by the K15 protein of Kaposi's sarcoma-associated herpesvirus. J Virol 2007; 81: 42-58.
    • (2007) J Virol , vol.81 , pp. 42-58
    • Brinkmann, M.M.1    Pietrek, M.2    Dittrich-Breiholz, O.3
  • 133
    • 77954990257 scopus 로고    scopus 로고
    • Role of the Kaposi's sarcoma-associated herpesvirus K15 SH3 binding site in infammatory signaling and B-cell activation
    • Pietrek M, Brinkmann MM, Glowacka I, et al. Role of the Kaposi's sarcoma-associated herpesvirus K15 SH3 binding site in infammatory signaling and B-cell activation. J Virol 2010; 84: 8231-8240.
    • (2010) J Virol , vol.84 , pp. 8231-8240
    • Pietrek, M.1    Brinkmann, M.M.2    Glowacka, I.3
  • 134
    • 34249810339 scopus 로고    scopus 로고
    • Functional characterization of the M-type K15-encoded membrane protein of Kaposi's sarcoma-associated herpesvirus
    • Wang L, Brinkmann MM, Pietrek M, et al. Functional characterization of the M-type K15-encoded membrane protein of Kaposi's sarcoma-associated herpesvirus. J Gen Virol 2007; 88: 1698-1707.
    • (2007) J Gen Virol , vol.88 , pp. 1698-1707
    • Wang, L.1    Brinkmann, M.M.2    Pietrek, M.3
  • 135
    • 84866910260 scopus 로고    scopus 로고
    • Kaposi's sarcoma herpesvirus K15 protein contributes to virus-induced angiogenesis by recruiting PLCγ1 and activating NFAT1-dependent RCAN1 expression
    • Bala K, Bosco R, Gramolelli S, et al. Kaposi's sarcoma herpesvirus K15 protein contributes to virus-induced angiogenesis by recruiting PLCγ1 and activating NFAT1-dependent RCAN1 expression. PLoS Pa t h o g 2012; 8: e1002927.
    • (2012) PLoS Pa T H O G , vol.8 , pp. e1002927
    • Bala, K.1    Bosco, R.2    Gramolelli, S.3
  • 136
    • 0033564349 scopus 로고    scopus 로고
    • Angiogenesis and hematopoiesis induced by Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6
    • Aoki Y, Jaffe ES, Chang Y, et al. Angiogenesis and hematopoiesis induced by Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6. Blood 1999; 93: 4034-4043.
    • (1999) Blood , vol.93 , pp. 4034-4043
    • Aoki, Y.1    Jaffe, E.S.2    Chang, Y.3
  • 137
    • 84899424160 scopus 로고    scopus 로고
    • Synergy between Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6 and HIV-1 Nef protein in promotion of angiogenesis and oncogenesis: Role of the AKT signaling pathway
    • Zhu X, Guo Y, Yao S, et al. Synergy between Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6 and HIV-1 Nef protein in promotion of angiogenesis and oncogenesis: role of the AKT signaling pathway. Oncogene 2013; 33, 1986-1996.
    • (2013) Oncogene , vol.33 , pp. 1986-1996
    • Zhu, X.1    Guo, Y.2    Yao, S.3
  • 138
    • 45749111435 scopus 로고    scopus 로고
    • Autocrine and paracrine promotion of cell survival and virus replication by human herpesvirus 8 chemokines
    • Choi YB, Nicholas J. Autocrine and paracrine promotion of cell survival and virus replication by human herpesvirus 8 chemokines. J Virol 2008; 82: 6501-6513.
    • (2008) J Virol , vol.82 , pp. 6501-6513
    • Choi, Y.B.1    Nicholas, J.2
  • 139
    • 84899424160 scopus 로고    scopus 로고
    • Synergy between Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6 and HIV-1 Nef protein in promotion of angiogenesis and oncogenesis, role of the AKT signaling pathway
    • Zhu X, Guo Y, Yao S, et al. Synergy between Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6 and HIV-1 Nef protein in promotion of angiogenesis and oncogenesis, role of the AKT signaling pathway. Oncogene 2013; 33: 1986-1996.
    • (2013) Oncogene , vol.33 , pp. 1986-1996
    • Zhu, X.1    Guo, Y.2    Yao, S.3
  • 140
    • 0034080072 scopus 로고    scopus 로고
    • Human herpesvirus 8-encoded interleukin-6 homologue (viral IL-6) induces endogenous human IL-6 secretion
    • Mori Y, Nishimoto N, Ohno M, et al. Human herpesvirus 8-encoded interleukin-6 homologue (viral IL-6) induces endogenous human IL-6 secretion. J Med Virol 2000; 61: 332-335.
    • (2000) J Med Virol , vol.61 , pp. 332-335
    • Mori, Y.1    Nishimoto, N.2    Ohno, M.3
  • 141
    • 0030852894 scopus 로고    scopus 로고
    • A Kaposi's sarcoma-associated herpesvirus-encoded cytokine homolog (vIL-6) activates signaling through the shared gp130 receptor subunit
    • Molden J, Chang Y, You Y, et al. A Kaposi's sarcoma-associated herpesvirus-encoded cytokine homolog (vIL-6) activates signaling through the shared gp130 receptor subunit. J Biol Chem 1997; 272: 19625-19631.
    • (1997) J Biol Chem , vol.272 , pp. 19625-19631
    • Molden, J.1    Chang, Y.2    You, Y.3
  • 142
    • 0342264579 scopus 로고    scopus 로고
    • IL-6 receptor independent stimulation of human gp130 by viral IL-6
    • Mullberg J, Geib T, Jostock T, et al. IL-6 receptor independent stimulation of human gp130 by viral IL-6. J Immunol 2000; 164: 4672-4677.
    • (2000) J Immunol , vol.164 , pp. 4672-4677
    • Mullberg, J.1    Geib, T.2    Jostock, T.3
  • 143
    • 10644253485 scopus 로고    scopus 로고
    • Kaposi's sarcoma-associated herpesvirus-encoded viral interleukin-6 is secreted and modifed differently than human interleukin-6, evidence for a unique autocrine signaling mechanism
    • Meads MB, Medveczky PG. Kaposi's sarcoma-associated herpesvirus-encoded viral interleukin-6 is secreted and modifed differently than human interleukin-6, evidence for a unique autocrine signaling mechanism. J Biol Chem 2004; 279: 51793-51803.
    • (2004) J Biol Chem , vol.279 , pp. 51793-51803
    • Meads, M.B.1    Medveczky, P.G.2
  • 144
    • 67449107492 scopus 로고    scopus 로고
    • Determinants of secretion and intracellular localization of human herpesvirus 8 interleukin-6
    • Chen D, Choi YB, Sandford G, et al. Determinants of secretion and intracellular localization of human herpesvirus 8 interleukin-6. J Vi ro l 2009; 83: 6874-6882.
    • (2009) J Vi Ro L , vol.83 , pp. 6874-6882
    • Chen, D.1    Choi, Y.B.2    Sandford, G.3
  • 145
    • 58149526804 scopus 로고    scopus 로고
    • Intracellular signaling mechanisms and activitiesofhuman herpesvirus8interleukin-6
    • Chen D, Sandford G, Nicholas J. Intracellular signaling mechanisms and activitiesofhuman herpesvirus8interleukin-6. J Virol 2009; 83: 722-733.
    • (2009) J Virol , vol.83 , pp. 722-733
    • Chen, D.1    Sandford, G.2    Nicholas, J.3
  • 146
    • 0031937076 scopus 로고    scopus 로고
    • G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator
    • Bais C, Santomasso B, Coso O, et al. G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator. Nature 1998; 391: 86-89.
    • (1998) Nature , vol.391 , pp. 86-89
    • Bais, C.1    Santomasso, B.2    Coso, O.3
  • 147
    • 1542313867 scopus 로고    scopus 로고
    • Does dysregulated expression of a deregulated viral GPCR trigger Kaposi's sarcomagenesis?
    • Sodhi A, Montaner S, Gutkind JS. Does dysregulated expression of a deregulated viral GPCR trigger Kaposi's sarcomagenesis? FA S E B J 2004; 18: 422-427.
    • (2004) FA S e B J , vol.18 , pp. 422-427
    • Sodhi, A.1    Montaner, S.2    Gutkind, J.S.3
  • 148
    • 1842687489 scopus 로고    scopus 로고
    • Akt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptor
    • Sodhi A, Montaner S, Patel V, et al. Akt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptor. Proc Natl Acad Sci USA 2004; 101: 4821-4826.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 4821-4826
    • Sodhi, A.1    Montaner, S.2    Patel, V.3
  • 149
    • 0035399819 scopus 로고    scopus 로고
    • Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor constitutively activates NF-κB and induces proinfammatory cytokine and chemokine production via a C-terminal signaling determinant
    • Schwarz M, Murphy PM. Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor constitutively activates NF-κB and induces proinfammatory cytokine and chemokine production via a C-terminal signaling determinant. J Immunol 2001; 167: 505-513.
    • (2001) J Immunol , vol.167 , pp. 505-513
    • Schwarz, M.1    Murphy, P.M.2
  • 150
    • 0037772150 scopus 로고    scopus 로고
    • Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes
    • Montaner S, Sodhi A, Molinolo A, et al. Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes. Cancer Cell 2003; 3: 23-36.
    • (2003) Cancer Cell , vol.3 , pp. 23-36
    • Montaner, S.1    Sodhi, A.2    Molinolo, A.3
  • 151
    • 0035667560 scopus 로고    scopus 로고
    • Tumorigenesis induced by the HHV8-encoded chemokine receptor requires ligand modulation of high constitutive activity
    • Holst PJ, Rosenkilde MM, Manfra D, et al. Tumorigenesis induced by the HHV8-encoded chemokine receptor requires ligand modulation of high constitutive activity. J Clin Invest 2001; 108: 1789-1796.
    • (2001) J Clin Invest , vol.108 , pp. 1789-1796
    • Holst, P.J.1    Rosenkilde, M.M.2    Manfra, D.3
  • 152
    • 0034614888 scopus 로고    scopus 로고
    • Transgenic expression of the chemokine receptor encoded by human herpesvirus 8 induces an angioproliferative disease resembling Kaposi's sarcoma
    • Yang TY, Chen SC, Leach MW, et al. Transgenic expression of the chemokine receptor encoded by human herpesvirus 8 induces an angioproliferative disease resembling Kaposi's sarcoma. J Exp Med 2000; 191: 445-454.
    • (2000) J Exp Med , vol.191 , pp. 445-454
    • Yang, T.Y.1    Chen, S.C.2    Leach, M.W.3
  • 153
    • 0030771974 scopus 로고    scopus 로고
    • Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokines
    • Boshoff C, Endo Y, Collins PD, et al. Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokines. Science 1997; 278: 290-294.
    • (1997) Science , vol.278 , pp. 290-294
    • Boshoff, C.1    Endo, Y.2    Collins, P.D.3
  • 154
    • 34250723250 scopus 로고    scopus 로고
    • Lentiviral gene delivery of vMIP-II to transplanted endothelial cells and endothe-lial progenitors is proangiogenic in vivo
    • Cherqui S, Kingdon KM, Thorpe C, et al. Lentiviral gene delivery of vMIP-II to transplanted endothelial cells and endothe-lial progenitors is proangiogenic in vivo. Mol Ther 2007; 15: 1264-1272.
    • (2007) Mol Ther , vol.15 , pp. 1264-1272
    • Cherqui, S.1    Kingdon, K.M.2    Thorpe, C.3
  • 155
    • 0034758867 scopus 로고    scopus 로고
    • Human herpesvirus 8 (HHV-8)-encoded cytokines induce expression of and autocrine signaling by vascular endothelial growth factor (VEGF) in HHV-8-infected primary-effusion lymphoma cell lines and mediate VEGF-independent antiapoptotic effects
    • Liu C, Okruzhnov Y, Li H, et al. Human herpesvirus 8 (HHV-8)-encoded cytokines induce expression of and autocrine signaling by vascular endothelial growth factor (VEGF) in HHV-8-infected primary-effusion lymphoma cell lines and mediate VEGF-independent antiapoptotic effects. J Virol 2001; 75: 10933-10940.
    • (2001) J Virol , vol.75 , pp. 10933-10940
    • Liu, C.1    Okruzhnov, Y.2    Li, H.3
  • 156
    • 0842285678 scopus 로고    scopus 로고
    • Chemokine receptor-8 (CCR8) mediates human vascular smooth muscle cell chemotaxis and metalloproteinase-2 secretion
    • Haque NS, Fallon JT, Pan JJ, et al. Chemokine receptor-8 (CCR8) mediates human vascular smooth muscle cell chemotaxis and metalloproteinase-2 secretion. Blood 2004; 103: 1296-1304.
    • (2004) Blood , vol.103 , pp. 1296-1304
    • Haque, N.S.1    Fallon, J.T.2    Pan, J.J.3
  • 157
    • 84897570098 scopus 로고    scopus 로고
    • Prospective stage-stratifed approach to AIDS-related Kaposi's sarcoma
    • Bower M, Dalla Pria A, Coyle C, et al. Prospective stage-stratifed approach to AIDS-related Kaposi's sarcoma. J Clin Oncol 2014; 32: 409-414.
    • (2014) J Clin Oncol , vol.32 , pp. 409-414
    • Bower, M.1    Dalla Pria, A.2    Coyle, C.3
  • 158
    • 84897576509 scopus 로고    scopus 로고
    • Broader implications of a stage-guided stratifed therapeutic approach for AIDS-related Kaposi's sarcoma
    • Krell J, Stebbing J. Broader implications of a stage-guided stratifed therapeutic approach for AIDS-related Kaposi's sarcoma. J Clin Oncol 2014; 32: 373-375.
    • (2014) J Clin Oncol , vol.32 , pp. 373-375
    • Krell, J.1    Stebbing, J.2
  • 159
    • 0033576358 scopus 로고    scopus 로고
    • Infuence of foscarnet on HIV-associated Kaposi's sarcoma-derived cell lines
    • Willers CP, Reimann G, Mertins L, et al. Infuence of foscarnet on HIV-associated Kaposi's sarcoma-derived cell lines. Eur J Med Res 1999; 4: 514-516.
    • (1999) Eur J Med Res , vol.4 , pp. 514-516
    • Willers, C.P.1    Reimann, G.2    Mertins, L.3
  • 160
    • 0036318827 scopus 로고    scopus 로고
    • Kaposi's sarcoma-associated herpesvirus-induced upregulation of the c-kit proto-oncogene, as identifed by gene expression profling, is essential for the transformation of endothelial cells
    • Moses AV, Jarvis MA, Raggo C, et al. Kaposi's sarcoma-associated herpesvirus-induced upregulation of the c-kit proto-oncogene, as identifed by gene expression profling, is essential for the transformation of endothelial cells. J Virol 2002; 76: 8383-8399.
    • (2002) J Virol , vol.76 , pp. 8383-8399
    • Moses, A.V.1    Jarvis, M.A.2    Raggo, C.3
  • 161
    • 20044393819 scopus 로고    scopus 로고
    • Imatinib-induced regression of AIDS-related Kaposi's sarcoma
    • Koon HB, Bubley GJ, Pantanowitz L, et al. Imatinib-induced regression of AIDS-related Kaposi's sarcoma. J Clin Oncol 2005; 23: 982-989.
    • (2005) J Clin Oncol , vol.23 , pp. 982-989
    • Koon, H.B.1    Bubley, G.J.2    Pantanowitz, L.3
  • 162
    • 84897574876 scopus 로고    scopus 로고
    • Phase II trial of imatinib in AIDS-associated Kaposi's sarcoma, AIDS Malignancy Consortium Protocol 042
    • Koon HB, Krown SE, Lee JY, et al. Phase II trial of imatinib in AIDS-associated Kaposi's sarcoma, AIDS Malignancy Consortium Protocol 042. J Clin Oncol 2014; 32: 402-408.
    • (2014) J Clin Oncol , vol.32 , pp. 402-408
    • Koon, H.B.1    Krown, S.E.2    Lee, J.Y.3
  • 163
    • 50849126469 scopus 로고    scopus 로고
    • A Kaposi's sarcoma complete clinical response after sorafenib administration
    • Ardavanis A, Doufexis D, Kountourakis P, et al. A Kaposi's sarcoma complete clinical response after sorafenib administration. Ann Oncol 2008; 19: 1658-1659.
    • (2008) Ann Oncol , vol.19 , pp. 1658-1659
    • Ardavanis, A.1    Doufexis, D.2    Kountourakis, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.