Prostaglandin endoperoxide synthase: Why two isoforms?

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 270, Issue 3 33-3, 1996, Pages

  Williams, Christopher S ^a   DuBois, Raymond N ^a,b  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

colorectal cancer; cyclooxygenase; eicosanoid; intestinal epithelial cells

Indexed keywords

ACETYLSALICYLIC ACID; ARACHIDONIC ACID; COMPLEMENTARY DNA; ICOSANOID; INDOMETACIN; MESSENGER RNA; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN; PROSTAGLANDIN ENDOPEROXIDE; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR;

ANIMAL CELL; ARACHIDONIC ACID METABOLISM; BIOSYNTHESIS; COLON CARCINOGENESIS; COLORECTAL CANCER; ENZYME ACTIVITY; GENE DISRUPTION; HEART MUSCLE FIBROSIS; HUMAN; HUMAN CELL; INFLAMMATION; INTESTINE EPITHELIUM CELL; KIDNEY DYSPLASIA; MOUSE; NONHUMAN; OVARY DISEASE; PHENOTYPE; PRIORITY JOURNAL; RAT; REVIEW; STOMACH ULCER; TRANSGENIC ANIMAL;

EID: 0029924110     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1996.270.3.g393     Document Type: Review

References (75)

1. Aghib, D. F., and P. D. McCrea. The E-cadherin complex contains the src substrate p120. Exp. Cell Res. 218: 359-369, 1995
2. Allison, M. C., A. G. Howatson, C. J. Torrance, F. D. Lee, and R. I. Russell. Gastrointestinal damage associated with the use of nonsteroidal antiinflammatory drugs. N. Engl. J. Med. 327: 749-754, 1992.
3. Bazan, N. G., B. S. Fletcher, H. R. Herschman, and P. K. Mukherjee. Platelet-activating factor and retinoic acid synergistically activate the inducible prostaglandin synthase gene. Proc. Natl. Acad. Sci. USA 91: 5252-5256, 1994.
4. Capdevila, J. H., J. D. Marrow, Y. Y. Belosludtsev, D. R. Beauchamp, R. N. DuBois, and J. R. Falck. The catalytic outcomes of the constitutive and the mitogen inducible isoforms of prostaglandin H2 synthase are markedly affected by glutathione and glutathione peroxidase(s). Biochemistry 34: 3325-3337, 1995
5. Caput, D., B. Beutler, K. Hartog, R. Thayer, S. Brown-Shimer, and A. Cerami. Identification of a common nucleotide sequence in the 3′-untranslated region of mRNA molecules specifying inflammatory mediators. Proc. Natl. Acad. Sci. USA 83: 1670-1674, 1986.
6. Carroll, K. M., T. T. Wong, D. L. Drabik, and E. B. Chang. Differentiation of rat small intestinal epithelial cells by extracellular matrix. Am. J. Physiol. 254 (Gastrointest. Liver Physiol. 17): G355-G360, 1988.
7. Coyne, D. W., M. Nickols, W. Bertrand, and A. R. Morrison. Regulation of mesangial cell cyclooxygenase synthesis by cytokines and glucocorticoids. Am. J. Physiol. 263 (Renal Fluid Electrolyte Physiol. 32): F97-F102, 1992.
8. DeWitt, D. L., and E. A. Meade. Serum and glucocorticoid regulation of gene transcription and expression of prostaglandin H synthase-1 and prostaglandin H synthase-2 isozymes. Arch. Biochem. Biophys. 306: 94-102, 1993.
9. Diaz, A., A. M. Reginato, and S. A. Jimenez. Alternative splicing of human prostaglandin G/H synthase mRNA and evidence of differential regulation of the resulting transcripts by TGF1, IL-1β, and TNFα. J. Biol. Chem. 267: 10816-10822, 1992.
10. Dinchuk, J. E., B. D. Car, R. J. Focht, J. J. Johnston, B. D. Jaffee, M. B. Covington, N. R. Contel, V. M. Eng, R. J. Collins, P. M. Czerniak, S. A. Gorry, and J. M. Trzaskos. Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II. Nature Lond. 378: 406-409, 1995.
11. DuBois, R. N., J. Awad, J. Morrow, L. J. Roberts, and P. R. Bishop. Regulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor-α and phorbol ester. J. Clin. Invest. 93: 493-498, 1994.
12. Eberhart, C. E., R. J. Coffey, A. Radhika, F. M. Giardiello, S. Ferrenbach, and R. N. DuBois. Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology 107: 1183-1188, 1994.
13. Eberhart, C. E., and R. N. DuBois. Eicosanoids and the gastrointestinal tract. Gastroenterology 109: 285-301, 1995.
14. Fearon, E. R., and B. Vogelstein. A genetic model for colorectal tumorigenesis. Cell 61: 759-767, 1990.
15. Fu, J. Y., J. L. Masferrer, K. Seibert, A. Raz, and P. Needleman. The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes. J. Biol. Chem. 265: 16737-16740, 1990.
16. Geng, Y., F. Blanco, M. Cornelisson, and M. Lotz. Regulation of cyclooxygenase-2 expression in normal human articular chondrocytes. J. Immunol. 155: 796-801, 1995.
17. Giardiello, F. M., S. R. Hamilton, A. J. Krush, S. Piantadosi, L. M. Hylind, P. Celano, S. V. Booker, C. R. Robinson, and G. J. Offerhaus. Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis. N. Engl. J. Med. 328: 1313-1316, 1993.
18. Giovannucci, E., K. M. Egan, D. J. Hunter, M. J. Stampfer, G. A. Colditz, W. C. Willett, and F. E. Speizer. Aspirin and the risk of colorectal cancer in women. N. Engl. J. Med. 333: 609-614, 1995.
19. Giovannucci, E., E. B. Rimm, M. J. Stampfer, G. A. Colditz, A. Ascherio, and W. C. Willett. Aspirin use and the risk for colorectal cancer and adenoma in male health professionals. Ann. Int. Med. 121: 241-246, 1994.
20. Greenberg, E. R., J. A. Baron, D. H. J. Freeman, J. S. Mandel, and R. Haile. Reduced risk of large-bowel adenomas among aspirin users. The polyp prevention study group. J. Natl. Cancer Inst. 85: 912-916, 1993.
21. Hague, A., A. M. Manning, K. A. Hanlon, L. I. Huschtscha, D. Hart, and C. Paraskeva. Sodium butyrate induces apoptosis in human colonic tumour cell lines in a p53-independent pathway: implications for the possible role of dietary fibre in the prevention of large-bowel cancer. Int. J. Cancer 55: 498-505, 1993.
22. Hamasaki, Y., J. Kitzler, R. Hardman, P. Nettesheim, and T. E. Eling. Phorbol ester and epidermal growth factor enhance the expression of two inducible prostaglandin H synthase genes in rat tracheal epithelial cells. Arch. Biochem. Biophys. 304: 226-234, 1993.
23. Hendrickse, C. W., R. W. Kelly, S. Radley, I. A. Donovan, M. R. Keighley, and J. P. Neoptolemos. Lipid peroxidation and prostaglandins in colorectal cancer. Br. J. Surg. 81: 1219-1223, 1994.
24. Herz, F., A. Schermer, M. Halwer, and L. H. Bogart. Alkaline phosphatase in HT-29, a human colon cancer cell line: influence of sodium butyrate and hyperosmolality. Arch. Biochem. Biophys. 210: 581-591, 1981.
25. Hinck, L., I. S. Nathke, J. Papkoff, and W. J. Nelson. Beta-catenin: a common target for the regulation of cell adhesion by Wnt-1 and Src signaling pathways. Trends Biochem. Sci. 19: 538-542, 1994.
26. Hulsken, J., W. Birchmeier, and J. Behrens. E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton. J. Cell Biol. 127: 2061-2069, 1994.
27. Jones, D. A., D. P. Carlton, T. M. McIntyre, G. A. Zimmerman, and S. M. Prescott. Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines. J. Biol. Chem. 268: 9049-9054, 1993.
28. Kargman, S., G. O'Neill, P. Vickers, J. Evans, J. Mancini, and S. Jothy. Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer. Cancer Res. 55: 2556-2559, 1995.
29. Kester, M., E. Coroneos, P. J. Thomas, and M. J. Dunn. Endothelin stimulates prostaglandin endoperoxide synthase-2 mRNA expression and protein synthesis through a tyrosine kinase-signaling pathway in rat mesangial cells. J. Biol. Chem. 269: 22574-22580, 1994.
30. Kinzler, K. W., M. C. Nilbert, L. K. Su, B. Vogelstein, T. M. Bryan, D. B. Levy, K. J. Smith, A. C. Preisinger, P. Hedge, D. McKechnie. Identification of FAP locus genes from chromosome 5q21. Science Wash. DC 253: 661-665, 1991.
31. Kosaka, T., A. Miyata, H. Ihara, S. Hara, T. Sugimoto, O. Takeda, E. Takahashi, and T. Tanabe. Characterization of the human gene (PTOS2) encoding prostaglandin-endoperoxide synthase 2. Eur. J Biochem. 221: 889-897, 1994.
32. Kraemer, S., E. Meade, and D. DeWitt. Prostaglandin endoperoxide synthase gene structure: identification of the transcriptional start site and 5′ flanking regulatory sequence. Arch. Biochem. Biophys. 293: 391-400, 1992.
33. Kujubu, D. A., B. S. Fletcher, B. C. Varnum, R. W. Lim, and H. R. Herschman. TIS10, a phorbol ester tumor promoter-inducible mRNAfrom Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. J. Biol. Chem. 266: 12866-12872, 1991.
34. Kujubu, D. A., and H. R. Herschman. Dexamethasone inhibits mitogen induction of the TIS10 prostaglandin synthase/cyclooxygenase gene. J. Biol. Chem. 267: 7991-7994, 1992.
35. Langenbach, R., S. G. Morham, H. F. Tiano, C. D. Loftin, B. I. Ghanayem, P. C. Chulada, J. F. Mahler, C. A. Lee, E. H. Goulding, K. D. Kluckman, H. S. Kim, and O. Smithies. Prostaglandin synthase-1 gene disruption in mice reduces arachidonic acid induced inflammation and indomethacin induced gastric ulceration. Cell 83: 483-492, 1995.
36. Lecomte, M., O. Laneuville, C. Ji, D. L. DeWitt, and W. L. Smith. Acetylation of human prostaglandin endoperoxide synthase-2 (cyclooxygenase-2) by aspirin. J. Biol. Chem. 269: 13207-13215, 1994.
37. Lee, S. H., E. Soyoola, P. Chanmugam, S. Hart, W. Sun, H. Zhong, S. Liou, D. Simmons, and D. Hwang. Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide. J. Biol. Chem. 267: 25934-25938, 1992.
38. Logan, R. F., J. Little, P. G. Hawkin, and J. D. Hardcastle. Effect of aspirin and non-steroidal anti-inflammatory drugs on colorectal adenomas: case-control study of subjects participating in the Nottingham faecal occult blood screening programme. Br. Med. J. 307: 285-289, 1993.
39. 2 gene is a candidate for the Mom1 locus, a major modifier of Apamin-induced intestinal neoplasia. Cell 81: 957-966, 1995.
40. Masferrer, J. L., B. S. Zweifel, P. T. Manning, S. D. Hauser, K. M. Leahy, W. G. Smith, P. C. Isakson, and K. Seibert. Selective inhibition of inducible cyclooxygenase-2 in vivo is antiinflammatory and nonulcerogenic. Proc. Natl. Acad. Sci. USA 91: 3228-3232, 1994.
41. Miettinen, P. J., J. E. Berger, J. Meneses, Y. Phung, R. A. Pedersen, Z. Werb, and R. Derynck. Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature Lond. 376: 337-341, 1995.
42. Miyaki, M., M. Konishi, R. Kikuchi-Yanoshita, M. Enomoto, T. Igari, K. Tanaka, M. Muraoka, H. Takahashi, Y. Amada, M. Fukayama, Y. Maeda, T. Iwama, Y. Mishima, T. Mori, and M. Koike. Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors. Cancer Res. 54: 3011-3020, 1994.
43. Miyamoto, T., N. Ogino, S. Yamamoto, and O. Hayaishi. Purification of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes. J. Biol. Chem. 251: 2629-2636, 1976.
44. Morham, S. G., R. Langenbach, C. D. Loftin, H. F. Tiano, N. Vouloumanos, J. C. Jennette, J. F. Mahler, K. D. Kluckman, A. Ledford, C. A. Lee, and O. Smithies. Prostaglandin synthase-2 gene disruption causes severe renal pathology in the mouse. Cell 83: 473-482, 1995.
45. Morita, I., M. Schindler, M. K. Regier, J. C. Otto, T. Hori, D. L. DeWitt, and W. L. Smith. Different intracellular locations for prostaglandin endoperoxide H synthase-1 and -2. J. Biol. Chem. 270. 10902-8, 1995.
46. Nathans, D., L. F. Lau, B. Christy, S. Hartzell, Y. Nakabeppu, and K. Ryder. Genomic response to growth factors. Cold Spring Harbor Symp. Quant. Biol. 53: 893-900, 1988.
47. Neoptolemos, J. P., D. Husband, C. Imray, S. Rowley, and N. Lawson. Arachidonic acid and docosahexaenoic acid are increased in human colorectal cancer. Gut 32: 278-281, 1991.
48. Nishisho, I., Y. Nakamura, Y. Miyoshi, Y. Miki, H. Ando, A. Horii, K. Koyama, J. Utsunomiya, S. Baba, and P. Hedge. Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science Wash. DC 253: 665-669, 1991.
49. Nugent, K. P., K. C. Farmer, A. D. Spigelman, C. B. Williams, and R. K. Phillips. Randomized controlled trial of the effect of sulindac on duodenal and rectal polyposis and cell proliferation in patients with familial adenomatous polyposis. Br. J. Surg. 80: 1618-1619, 1993.
50. O'Banion, M. K., V. D. Winn, and D. A. Young. cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase. Proc. Natl. Acad. Sci. USA 89: 4888-4892, 1992.
51. O'Sullivan, M. G., F. H. Chilton, E. M. Huggins, and C. E. McCall. Lipopolysaccharide priming of alveolar macrophages for enhanced synthesis of prostanoids involves induction of a novel prostaglandin H synthase. J. Biol. Chem. 267: 14547-14550, 1992.
52. 2 levels and lymphocyte subsets in portal venous drainage of colorectal cancers. Am. J. Surg. 167: 264-267, 1994.
53. 2. Gut 35: 675-8, 1994.
54. Regier, M. K., D. L. DeWitt, M. S. Schindler, and W. L. Smith. Subcelmlar localization of prostaglandin endoperoxide synthase-2 in munne 3T3 cells. Arch. Biochem. Biophys. 301: 439-444, 1993.
55. Regier, M. K., J. C. Otto, D. L. DeWitt, and W. L. Smith. Localization of prostaglandin endoperoxide synthase-1 to the endoplasmic reticulum and nuclear envelope is independent of its C-terminal tetrapeptide-PTEL. Arch. Biochem. Biophys. 317: 457-463, 1995.
56. Riese, J., T. Hoff, A. Nordhoff, D. L. DeWitt, K. Resch, and V. Kaever. Transient expression of prostaglandin endoperoxide synthase-2 during mouse macrophage activation. J. Leukocyte Biol. 55: 476-482, 1994.
57. Rubinfeld, B., B. Souza, I. Albert, S. Munemitsu, and P. Polakis. The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin. J. Biol. Chem. 270: 5549-5555, 1995.
58. Ryseck, R. P., C. Raynoschek, H. MacDonald-Bravo, K. Dorfman, M. G. Mattei, and R. Bravo. Identification of an immediate early gene, PGHS-β, whose protein product has prostaglandin synthase/cyclooxygenase activity. Cell Growth Differ. 3: 443-450, 1992.
59. Sano, H., Y. Kawahito, R. L. Wilder, A. Hashiramoto, S. Mukai, K. Asai, S. Kimura, H. Kato, M. Kondo, and T. Hla. Expression of cyclooxygenase-1 and -2 in human colorectal cancer. Cancer Res. 55: 3785-3789, 1995
60. Shaw, G., and R. Kamen. A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell 46: 659-667, 1986.
61. Shimokawa, T., and W. L. Smith. Prostaglandin endoperoxide synthase. The aspirin acetylation region. J. Biol. Chem. 267: 12387-12392, 1992.
62. Simmons, D. L., D. B. Levy, Y. Yannoni, and R. L. Erikson. Identification of a phorbol ester-repressible v-src-inducible gene. Proc. Natl. Acad. Sci. USA 86: 1178-1182, 1989.
63. Sirois, J. Induction of prostaglandin endoperoxide synthase-2 by human chorionic gonadotropin in bovine preovulatory follicles in vivo. Endocrinology 135: 841-848, 1994
64. Sirois, J., and J. S. Richards. Transcriptional regulation of the rat prostaglandin endoperoxide synthase 2 gene in granulosa cells. Evidence for the role of a cis-acting C/EBP-β promoter element. J. Biol Chem. 268: 21931-21938, 1993.
65. Soll, A. H., W. M. Weinstein, J. Kurata, and D. McCarthy. Nonsteroidal anti-inflammatory drugs and peptic ulcer disease. Ann. Intern. Med. 114: 307-319, 1991.
66. Spagnesi, M. T., F. Tonelli, P. Dolara, G. Caderni, R. Valanzano, A. Anastasi, and F. Bianchini. Rectal proliferation and polyp occurrence in patients with familial adenomatous polyposis after sulindac treatment. Gastroenterology 106: 362-366, 1994.
67. Su, L. K., K. W. Kinzler, B. Vogelstein, A. C. Preisinger, A. R. Moser, C. Luongo, K. A. Gould, and W. F. Dove. Multiple intestinal neoplasia caused by a mutation in the murine homologue of the APC gene. Science Wash. DC 256: 668-670, 1992.
68. Sun, O., C. Mettlin, and N. J. Petrelli. Aspirin use, cancer, and polyps of the large bowel. Cancer 72: 1171-1177, 1993.
69. Threadgill, D. W., A. A. Dlugosz, L. Hansen, T. Tennenbaum, U. Lichti, D. Yee, C. LeMantia, T. Mourton, K. Herrup, R. C. Harris, J. A. Barnard, S. H. Yuspa, R. J. Coffey, and T. Magnuson. Targeted disruption of mouse EGF-receptor: evidence that genetic background affects mutant phenotype. Science Wash. DC 269: 230-234, 1995.
70. Thun, M. J., M. M. Namboodiri, E. E. Calle, W. D. Flanders, and C. W. J. Heath. Aspirin use and risk of fatal cancer. Cancer Res. 53: 1322-1327, 1993.
71. Tsujii, M., and R. N. DuBois. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressmg prostaglandin endoperoxide synthase-2. Cell 83: 495-501, 1995.
72. Winde, G., H. G. Gumbinger, H. Osswald, F. Kemper, and H. Bunte. The NSAID sulindac reverses rectal adenomas in colectomized patients with familial adenomatous polyposis: clinical results of a dose-finding study on rectal sulindac administration. Int. J. Colorectal Dis. 8: 13-17, 1993.
73. Xie, W., J. Chipman, D. Robertson, R. Erikson, and D. Simmons. Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Proc. Natl. Acad. Sci. USA 88: 2692-2696, 1991.
74. Yamagata, K., K. I. Andreasson, W. E. Kaufmann, C. A. Barnes, and P. F. Worley. Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids. Neuron 11: 371-386, 1993.
75. Yokoyama, C., and T. Tanabe. Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme. Biochem. Biophys. Res. Commun. 165: 888-894, 1989.