Ultrastructure of Kaposi sarcoma

Ultrastructural Pathology

Volumn 32, Issue 5, 2008, Pages 211-220

  Orenstein, Jan Marc ^a  

^a GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

Kaposi sarcoma; TEM

Indexed keywords

FERRITIN; HEMOSIDERIN; HYALIN;

ARTICLE; CELL ULTRASTRUCTURE; ENDOTHELIUM CELL; ERYTHROCYTE; GAP JUNCTION; KAPOSI SARCOMA; LYMPHOCYTE; PHAGOCYTE; PRIORITY JOURNAL; SPINDLE CELL; TRANSMISSION ELECTRON MICROSCOPY; WEIBEL PALADE BODY;

ENDOTHELIAL CELLS; ENDOTHELIUM, LYMPHATIC; ENDOTHELIUM, VASCULAR; ERYTHROCYTES; GAP JUNCTIONS; HUMANS; IMMUNOHISTOCHEMISTRY; MICROSCOPY, ELECTRON, TRANSMISSION; PHAGOCYTES; SARCOMA, KAPOSI; WEIBEL-PALADE BODIES;

HUMAN HERPESVIRUS 8; HUMAN IMMUNODEFICIENCY VIRUS;

EID: 55049139641     PISSN: 01913123     EISSN: 15210758     Source Type: Journal    
DOI: 10.1080/01913120802343871     Document Type: Article

References (30)

1. Kostianovsky M, Lamy Y, Greco MA. Immunohistochemical and electron microscopic profiles of cutaneous Kaposi's sarcoma and bacillary angiomatosis. Ultrastruct Pathol. 1992;16:629-640.
2. Waldo ED, Vuletin JC, Kaye GI. The ultrastructure of vascular tumors: additional observations and a review of the literature. Pathol Ann. 1977;12:279-309.
3. McNutt NS, Fletcher V, Conant MA. Early lesions of Kaposi's sarcoma in homosexual men: an ultrastructural comparison with other vascular proliferations in skin. Am J Pathol. 1983;111:62-77.
4. Gallo RC. The enigmas of Kaposi's sarcoma. Science. 1998;282:1837-1839.
5. Dupin N, Fisher C, Kellman P, et al. Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma. Proc Natl Acad Sci USA. 1999;96:4546-4551.
6. Ablashi DV, Chatlynne LG, Whitman JE Jr, Cesarman E. Spectrum of Kaposi's sarcoma-associated herpesvirus, or human herpesvirus 8, diseases. Clin Microbiol Rev. 2002;15:439-464.
7. Rutgers JL, Wieczorek R, Bonetti F, et al. The expression of endothelial cell surface antigens by AIDS-associated Kaposi's sarcoma: evidence for a vascular endotheial cell origin. Am J Pathol. 1986;122:493-499.
8. Regezi JA, MacPhail LA, Daniels TE, DeSouza YG, Greenspan JS, Greenspan D. Human immunodeficiency virus-associated oral Kaposi's sarcoma: a heterogeneous cell population dominated by spindle-shaped endothelial cells. Am J Pathol. 1993;143:240-249.
9. Nickoloff BJ, Griffiths CEM. The spindle-shaped cells in cutaneous Kaposi's sarcoma: histologic simulators include factor XIIIa dermal dendrocytes. Am J Pathol. 1989;135:793-800.
10. Wang H-W, Trotter MWB, Lagos D, et al. Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma. Nat Genet. 2004;36:687-693.
11. Weninger W, Partanen TA, Breiteneder-Geleff S, et al. Expression of vascular endotheial growth factor receptor-3 and podoplanin suggests a lymphatic endotheial cell origin of Kaposi's sarcoma tumor cells. Lab Invest. 1999;79:243-251.
12. Kahn HJ, Bailey D, Marks A. Monoclonal antibody D2-40, a new marker of lymphatic endothelium, reacts with Kaposi's sarcoma and a subset of angiosarcomas. Mod Pathol. 2002;15:434-440.
13. Beckstead JH, Wood GS, Fletcher V. Evidence for the origin of Kaposi's sarcoma from lymphatic endothelium. Am J Pathol. 1985;119:294-300.
14. Blackbourne DJ, Lennette E, Klencke B, et al. The restricted cellular host range of human herpesvirus 8. AIDS. 2000;14:1123-1133.
15. Carroll PA, Brazeau E, Lagunoff M. Kaposi's sarcoma-associated herpesvirus infection of blood endothelial cells induces lymphatic differentiation. Virology. 2004;328:7-18.
16. Sturzl M, Ascherl G, Blasig C, Opalenik SR, Ensoli B, Browning PJ. Expression of the human herpesvirus 8-encoded viral macrophage inflammatory protein-1 gene in Kaposi's sarcoma lesions. AIDS. 1998;12:1105-1106.
17. Staskus KA, Zhong W, Gebhard K, et al. Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells. J Virol. 1997;71:715-719.
18. Boshoff C, Schulz TF, Kennedy MM, et al. Kaposi's sarcoma-associated herpesvirus infects endotheial and spindle cells. Nat Med. 1995;1:1274-1278.
19. Li JJ, Huang YQ, Cockerell CJ, Friedman-Kien AE. Localization of human herpes-like virus type 8 in vascular endothelial cells and perivascular spindle-shaped cells of Kaposi's sarcoma lesions by in situ hybridization. Am J Pathol. 1996;148:1741-1748.
20. Sturzl M, Blasig C, Schreier A, et al. Expression of HHV-8 latency-associated T0.7 RNA in spindle cells and endothelial cells of AIDS-associated, classical and African Kaposi's sarcoma. Int J Cancer. 1997;72:68-71.
21. Hisaoka M, Hashimoto H, Iwamasa T. Diagnostic implication of Kaposi's sarcoma-associated herpesvirus with reference to the distinction between spindle cell hemangioendothelioma and Kaposi's sarcoma. Arch Pathol Lam Med. 1998;122:72-76.
22. Dictor M, Rambech E, Way D, Witte M, Bendsoe N. Human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) DNA in Kaposi's sarcoma lesions, AIDS Kaposi's sarcoma cell lines, endothelial Kaposi's sarcoma simulators, and the skin of immunosuppressed patients. Am J Pathol. 1996;148:2009-2016.
23. Jin Y-T, Tsai S-T, Yan J-J, Hsiao J-H, Lee Y-Y, Su I-J. Detection of Kaposi's sarcoma-associated herpesvirus-like DNA sequence in vascular lesions: a reliable diagnostic marker for Kaposi's sarcoma. Am J Clin Pathol. 1996;105:360-363.
24. Robin Y-M, Guillou L, Michels J-J, Coindre J-M. Human herpesvirus 8 immunostaining: a sensitive and specific method for diagnosing Kaposi sarcoma in paraffin-embedded sections. Am J Clin Pathol. 2004;121:330-334.
25. Fife K, Bower M. Recent insights into the pathogenesis of Kaposi's sarcoma. Br J Can. 1996;73:1317-1322.
26. Cockerell CJ. Histopathological features of Kaposi's sarcoma in HIV infected individuals. Can Surv. 1991;10:73-89.
27. Orenstein JM, Alkan S, Blauvelt A, et al. Visualization of human herpesvirus type 8 in Kaposi's sarcoma by light and transmission electron microscopy. AIDS. 1997;11:F35-F45.
28. Brousset P, Cesarman E, Meggetto F, Lamant L, Delsol G. Colocalization of the viral interleukin-6 with latent nuclear antigen-1 of human herpesvirus-8 in endothelial spindle cells of Kaposi's sarcoma and lymphoid cells of multicentric Castleman's disease. Hum Pathol. 2001;32:95-100.
29. Cannon JS, Nicholas J, Orenstein JM, et al. Heterogeneity of viral IL-6 expression in HHV-8-associated diseases. J Infect Dis. 1999;180:824-828.
30. Graham L, Orenstein JM. Processing tissue and cells for transmission electron microscopy in diagnostic pathology and research. Nature Protocols. 2007;2:2439-2450.