Cyclooxygenase-2 is overexpressed in human cervical cancer

Clinical Cancer Research

Volumn 7, Issue 2, 2001, Pages 429-434

  Kulkarni, Swati ^a   Rader, Janet S ^c   Zhang, Fan ^b,c   Liapis, Helen ^c   Koki, Alane T ^d   Masferrer, Jaime L ^d   Subbaramaiah, Kotha ^a,b   Dannenberg, Andrew J ^a,b  

^a NEW YORK PRESBYTERIAN HOSPITAL   (United States)

^b STRANG CANCER PREVENTION CENTER   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN TYROSINE KINASE; RNA; STRESS ACTIVATED PROTEIN KINASE;

ADENOCARCINOMA; ARTICLE; CONTROLLED STUDY; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; UTERINE CERVIX CANCER; UTERINE CERVIX CARCINOMA IN SITU;

ADENOCARCINOMA; BLOTTING, NORTHERN; BLOTTING, WESTERN; CARCINOMA, ADENOSQUAMOUS; CARCINOMA, SQUAMOUS CELL; CYCLOOXYGENASE 2; FEMALE; GENES, ERBB-1; HUMANS; IMMUNOENZYME TECHNIQUES; ISOENZYMES; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; PLASMIDS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RNA, MESSENGER; SARCOMA; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; UTERINE CERVICAL NEOPLASMS;

EID: 0035126879     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Cancer statistics, 2000
2. Epidemiology and biology of cervical cancer
3. Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2
4. Transcription of cyclooxygenase-2 is enhanced in transformed mammary epithelial cells
5. T1S10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue
6. Regulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor-α and phorbol ester
7. Retinoids suppress epidermal growth factor-induced transcription of cyclooxygenase-2 in human oral squamous carcinoma cells
8. Prostaglandin H synthase 2 is expressed abnormally in human colon cancer: Evidence for a transcriptional effects
9. Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas
10. Expression of cyclooxygenase-2 in human gastric carcinoma
11. High cyclooxygenase-2 expression in stage 1B cervical cancer with lymph node metastasis or parametrial invasion
12. Cyclooxygenase-2 gene expression in human breast cancer
13. Cyclooxygenase-2 expression is up-regulated in squamous cell carcinoma of the head and neck
14. Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer
15. Δ716knockout mice by inhibition of cyclooxygenase 2 (COX-2)
16. Effects of cyclooxygenase deficiency on inflammation and papilloma development in mouse skin
17. Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis
18. Prevention of NNK-induced lung tumorigenesis in A/J mice by acetylsalicylic acid and NS-398
19. Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, and indomethacin against ultraviolet-light induced skin carcinogenesis
20. The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis
21. Protein measurement with the Folin phenol reagent
22. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
23. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
24. Retinoids suppress phorbol ester-mediated induction of cyclooxygenase-2
25. Clinical implications of the epidermal growth factor receptor in the squamous cell carcinoma of the uterine cervix
26. Epidermal growth factor receptor expression in cervical intraepithelial neoplasia and its modulation during an α-difluoromethylornithine chemoprevention trial
27. PI-3 kinase in signal transduction, cell transformation, and as a target for chemoprevention of cancer
28. Differential expression of cyclooxygenase-1 and -2 proteins in rat uterus and cervix during the estrous cycle, pregnancy, labor and in myometrial cells
29. Expression of cyclooxygenase-1 and -2 in ovine endometrium during the estrous cycle and early pregnancy
30. Ceramide regulates the transcription of cyclooxygenase-2. Evidence for involvement of extracellular signal-regulated kinase/c-Jun N-terminal kinase and p38 mitogen-activated protein kinase pathways
31. Transcriptional regulation of prostaglandin synthase 2 gene expression by platelet-derived growth factor and serum
32. 2-terminal kinase and p38 MAPK signal pathways in rat renal mesangial cells
33. Transcriptional regulation of the cyclooxygenase-2 gene in activated mast cells
34. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways
35. v-src induces prostaglandin synthase 2 gene expression by activation of the c-Jun N-terminal kinase and the c-Jun transcription factor
36. Microtubule-interfering agents stimulate the transcription of cyclooxygenase-2
37. Effect of human papillomavirus type 16 oncogenes on MAP kinase activity
38. The human papillomavirus type 16 E7 gene product interacts with and trans-activates the API family of transcription factors
39. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
40. Inhibition of cyclooxygenase-2 gene expression by p53
41. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2
42. Specific inhibition of cyclooxygenase 2 restores antitumor reactivity by altering the balance of IL-10 and IL-12 synthesis
43. Cyclooxygenase regulates angiogenesis induced by colon cancer cells
44. Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential
45. Modulation of methylcholanthrene-induced carcinogenesis in the uterine cervix of mouse by indomethacin
46. Adverse upper gastrointestinal effects of rofecoxib compared with NSAIDs
47. Chemopreventive effects of nimesulide, a selective cyclooxygenase-2 inhibitor, on the development of rat urinary bladder carcinomas initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine
48. Chemoprevention of breast cancer in rats by celecoxib, a cyclooxygenase 2 inhibitor
49. Inhibition of cyclooxygenase-2 suppresses angiogenesis and the growth of prostate cancer in vivo