Immunological activation markers in the serum of African and European HIV-seropositive and seronegative individuals

AIDS

Volumn 10, Issue 13, 1996, Pages 1535-1542

  Rizzardini, Giuliano ^a   Piconi, Stefania ^a   Ruzzante, Stefania ^a   Fusi, Maria Luisa ^a   Lukwiya, Matthew ^b   Declich, Silvia ^c,d   Tamburini, Mario ^c,d   Villa, Maria Luisa ^a   Fabiani, Massimo ^c,d   Milazzo, Francesco ^a   Clerici, Mario ^a,e  

^a UNIVERSITY OF MILAN   (Italy)

^b St Mary's Hospital Lacor Uganda   (Uganda)

^c ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^d NATIONAL CANCER INSTITUTE   (Italy)

^e UNIVERSITY OF MILAN   (Italy)

Author keywords

Africa; AIDS; Apoptosis; Cytokines; HIV; Immune activation

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4;

ADULT; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; ITALY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; UGANDA;

EID: 10344244491     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199611000-00012     Document Type: Article

References (45)

1. Mann J, Tarantola D, Netter TW: AIDS in the World. A Global Report. Boston: Harvard Press; 1992.
2. Plot P, Kapita B, Ngugl E, et al.: AIDS in Africa: Handbook for the General Practitioner. Geneva: Organization Mondiale de la Sante/WHO Reports; 1993.
3. Piot P, Kapita BM, Were JBO, Laga M, Colebunders RL: AIDS in Africa: the first decade and challenges for the 199Os. AIDS 1991 5 (suppl 1):S1-S5.
4. De Cock KM, Barrere B, Diabey L, et al.: AIDS, the leading cause of adult death in the West African city of Abidjan, Ivory Coast. Science 1990, 249:793-796.
5. Nkowane B: Prevalence and incidence of HIV infection in Africa: a review of data published in 1990. AIDS 1991, 5 (suppl 1):S7-S14.
6. Colebunders RL, Latif AS: Natural history and clinical presentation of HIV-1 infection in adults. AIDS 1991, 5 (suppl 1):S103-S112.
7. Colebunders RL, Ryder R, Francis H, et al.: Seroconversion rate, mortality and clinical manifestations associated with the receipt of an HIV contaminated blood transfusion. J Infect Dis 1991, 164:450-456.
8. N'gali B, Ryder RW, Kapita B, et al.: HIV infection amongst employees in an African hospital. N Engl J Med 1988, 319:1123-1127.
9. Ward JW, Deppe DA, Samson S, et al.: Risk of HIV infection from blood donors who later developed AIDS [letter]. Ann Intern Med 1987, 106:61-62.
10. Mbaga JM, Pallangyo KJ, Banari M, Aris ES: Survival time of patients with AIDS: experience with 274 patients in Dar es Salaam. East Afr Med J 1990, 67:95-99.
11. Gilks CF: The clinical challenge of the HIV epidemic in the developing world. Lancet 1993, 342:1037-1038.
12. Gilks CF, Otieno L, Brindle RJ, et al.: The presentation and outcome of HIV-related disease in Nairobi. Q j Med 1992, 82:25-32.
13. Nunn PP, Brindle R, Carpenter L, et al.: Cohort study of HIV infection in patients with tuberculosis in Nairobi, Kenya. Analysis of early (6 mo) mortality. Am Rev Respir Dis 1992, 146:849-854.
14. De Cock KM, Soro B, Coulibaly IM, Lucas SB: Tuberculosis and HIV infection in Sub-Saharan Africa. JAMA 1992, 268:1581-1587.
15. Quinn TC, Piot P, McCormick JB, et al.: Serologic and immunologie studies in patients with AIDS in North America and Africa. JAMA 1987, 257:2617-2621.
16. Clerici M, Shearer CM: T helper cell immune dysfunction in asymptomatic HIV-1 seropositive individuals: the role of TH1-TH2 cross-regulation. Prog Chem Immunol 1992, 54:21-43.
17. Clerici M, Shearer GM: A TH1→TH2 switch is a critical step in the etiology of HIV infection. Immunol Today 1993, 14:107-111.
18. Karp CL, El-Safi SH, Wynn TA, et al.: In vivo cytokine profiles in patients with kala-azar. Marked elevations of both IL-10 and IFNγ. J Clin Invest 1993, 91:1644-1652.
19. Pearce EJ, Caspar P, Crzych J-M, Lewis FA, Sher A: Downregulation of TH1 cytokine production accompanies induction of TH2 responses by a parasitic helminth, Schistosoma mansonii. J Exp Med 1991, 173:159-166.
20. Yamamura M, Uyemura K, Deans RJ, et al.: Defining protective responses to pathogens: cytokine profiles in leprosy lesions. Science 1991, 254:277-279.
21. Fitzgerald TJ: The TH1/TH2 switch in syphilitic infection: is it detrimental? Infect Immun 1992, 60:3475-3479.
22. Pirmez C, Yamamura M, Uyemura M, et al.: Cytokine patterns in the pathogenesis of human leishmaniasis. J Clin Invest 1993, 91:1390-1395.
23. Moreno C, Rees AJ: Striking the right balance: the role of cytokines in mycobacterial disease. Clin Exp Immunol 1993, 94:1-3.
24. Kullberg MC, Pearce EJ, Hieny SE, Sher A, Berzofsky JA: Infection with Schistosoma mansonii alters TH1/TH2 c cytokine responses to a non-parasite antigen. J Immunol 1992, 148:3264-3270.
25. Actor JK, Shirai M, Kullberg MC, et al.: Helminth infection results in decreased virus-specific CD8+ cytotoxic T-cell and TH1 cytokine responses as well as delayed virus clearance. Proc Natl Acad Sci USA 1993, 90:948-952.
26. Bentwich Z, Kalinkovich A, Weisman Z: Immune activation is a dominant factor in the pathogenesis of African AIDS. Immunol Today 1995, 16:187-191.
27. Gougeon ML, Olivier S, Garcia D, et al.: Mise en evidence d'un processus d'engagement vers la mort cellulaire par apoptose dans les lympocytes de patients infecte par le VIH. CR Acad Sci Paris Ser III Sc Vie 1991, 312:529-540.
28. Ameisen JC: Programmed cell death (apoptosis) and cell survival regulation: relevance to AIDS and cancer. AIDS 1994, 8:1197-1213.
29. Cheng J, Zhou T, Liu C, et al.: Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule. Science 1994, 263:1759-1762.
30. Knippling E, Debatin KM, Stricker K, et al.: Identification of soluble APO-1 in supernatants of human B and T cell lines and increased serum levels in B and T cell leukemias. Blood 1995, 85:1562-1569.
31. Kuvibidila S, Murthy KK, Suskind RM: Alteration of interleukin-2 production in iron deficiency anemia. J Nutr Immunol 1992, 1:1-9.
32. Chandra RK, Au B: Single nutrient deficiency and cell-mediated immune responses. III. Vitamin A. Nutr Res 1981, 1:181-185.
33. Semba RD, Muhila L, Ward BJ, et al.: Abnormal T-cell subset proportions in vitamin A-deficient children. Lancet 1993, 341:5-8.
34. Bretscher PA, Wei G, Menon JN, Ohmann-Bielefeld H: Establishment of stable cell-mediated immunity that makes 'susceptible' mice resistant to Leishmania major. Science 1992, 257:539-542.
35. Clerici M, Stocks NI, Zajac RA, et al.: Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, HIV seropositive individuals: independence of CD4 cell number and clinical staging. J Clin Invest 1989, 84:1892-1899.
36. Subsung C, Lagacos SW, Schooley RT, Volberding PA: CD4+ lymphocytes are an incomplete surrogate marker for clinical progression in persons with asymptomatic HIV infection taking zidovudine. Ann Intern Med 1993, 118:674-685.
37. Germann T, Gately MK, Shoenhaut DS, et al.: Interleukin-12/T cell stimulatory factor, a cytokine with multiple effects on T helper type 1 (TH1) but not on TH2 cells. Eur J Immunol 1993, 23:1762-1770.
38. Scott P: IL-12: initiation cytokine for cell mediated immunity. Science 1993, 260:496-497.
39. Trinchieri G: Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T helper cells type 1 and cytotoxic lymphocytes. Blood 1994, 84:4008-4013.
40. Clerici M, Sarin A, Coffman RL, et al.: Type 1/type 2 cytokine modulation of T cell programmed cell death as a model for HIV pathogenesis. Proc Natl Acad Sci USA 1994, 91:11811-11815.
41. Radrizzani M, Accornero P, Amidei A, et al.: IL-12 inhibits apoptosis induced in a human TH1 clone by gp120/CD4 crosslinking and CD3/TcR activation or by IL2 deprivation. Cell Immunol 1995, 161:14-21.
42. Estaquier J, IdziorekT, Zou W, et al.: T helper 1/T helper 2 cytokines and T cell death: preventive effect of IL-12 on activation-induced and CD95 (Fas/Apo-1)-mediated apoptosis of CD4+ T cells from HIV-infected persons. J Exp Med 1995, 182:1759-1767.
43. Clerici M, Sarin A, Berzofsky JA, et al.: Antigen-stimulated apoptoT tic-cell death in HIV infection is selective for CD4+T cells, modulated by cytokines and effected by lymphotoxin. AIDS 1996, 10:603-611.
44. Krammer PH, Dhein J, Walczak H, et al.: The role of APO-1-mediated apoptosis in the immune system. Immunol Rev 1994, 142:175-191.
45. Temmerman M, Nagelkerke N, Bwayo J, Chomba EN, Ndinya-Achola J, Piot P: HIV-1 and immunological changes during pregnancy: a comparison between HIV-1-seropositive and HIV-1-seronegative women in Nairobi, Kenya. AIDS 1995, 9:1057-1060.