KSHV activation of VEGF secretion and invasion for endothelial cells is mediated through viral upregulation of emmprin-induced signal transduction

International Journal of Cancer

Volumn 131, Issue 4, 2012, Pages 834-843

  Dai, Lu ^a,b   Bratoeva, Momka ^a   Toole, Bryan P ^a   Qin, Zhiqiang ^a,b,c   Parsons, Chris ^a,c  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

CD147; Kaposi's sarcoma; KSHV; signal transduction; VEGF

Indexed keywords

CD147 ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; VASCULOTROPIN;

ARTICLE; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 8; KAPOSI SARCOMA; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; TUMOR CELL; VIRUS ACTIVATION;

ANTIGENS, CD147; CELL LINE; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; HERPESVIRUS 8, HUMAN; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; REAL-TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84862531262     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.26428     Document Type: Article

References (45)

1. Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles DM, Moore PS,. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 1994; 266: 1865-9.
2. Seaberg EC, Wiley D, Martinez-Maza O, Chmiel JS, Kingsley L, Tang Y, Margolick JB, Jacobson LP,. Cancer incidence in the multicenter AIDS Cohort Study before and during the HAART era: 1984 to 2007. Cancer 2010, 116: 5507-16.
3. Qian LW, Xie J, Ye F, Gao SJ,. Kaposi's sarcoma-associated herpesvirus infection promotes invasion of primary human umbilical vein endothelial cells by inducing matrix metalloproteinases. J Virol 2007; 81: 7001-10. (Pubitemid 46986636)
4. Sun Q, Matta H, Lu G, Chaudhary PM,. Induction of IL-8 expression by human herpesvirus 8 encoded vFLIP K13 via NF-kappaB activation. Oncogene 2006; 25: 2717-26.
5. Montaner S, Sodhi A, Servitja JM, Ramsdell AK, Barac A, Sawai ET, Gutkind JS,. The small GTPase Rac1 links the Kaposi sarcoma-associated herpesvirus vGPCR to cytokine secretion and paracrine neoplasia. Blood 2004; 104: 2903-11. (Pubitemid 39434978)
6. Pati S, Cavrois M, Guo HG, Foulke JS Jr, Kim J, Feldman RA, Reitz M,. Activation of NF-kappaB by the human herpesvirus 8 chemokine receptor ORF74: evidence for a paracrine model of Kaposi's sarcoma pathogenesis. J Virol 2001; 75: 8660-73. (Pubitemid 32768970)
7. Ferrario A, Gomer CJ,. Avastin enhances photodynamic therapy treatment of Kaposi's sarcoma in a mouse tumor model. J Environ Pathol Toxicol Oncol 2006; 25: 251-9. (Pubitemid 43341245)
8. Dezube BJ, Krown SE, Lee JY, Bauer KS, Aboulafia DM,. Randomized phase II trial of matrix metalloproteinase inhibitor COL-3 in AIDS-related Kaposi's sarcoma: an AIDS Malignancy Consortium Study. J Clin Oncol 2006; 24: 1389-94. (Pubitemid 46622003)
9. Fife K, Howard MR, Gracie F, Phillips RH, Bower M,. Activity of thalidomide in AIDS-related Kaposi's sarcoma and correlation with HHV8 titre. Int J STD AIDS 1998; 9: 751-5. (Pubitemid 28563172)
10. Little RF, Wyvill KM, Pluda JM, Welles L, Marshall V, Figg WD, Newcomb FM, Tosato G, Feigal E, Steinberg SM, Whitby D, Goedert JJ, et al. Activity of thalidomide in AIDS-related Kaposi's sarcoma. J Clin Oncol 2000; 18: 2593-602. (Pubitemid 30432526)
11. Yan L, Zucker S, Toole BP,. Roles of the multifunctional glycoprotein, emmprin (basigin; CD147), in tumour progression. Thromb Haemost 2005; 93: 199-204. (Pubitemid 40253722)
12. Tang Y, Nakada MT, Rafferty P, Laraio J, McCabe FL, Millar H, Cunningham M, Snyder LA, Bugelski P, Yan L,. Regulation of vascular endothelial growth factor expression by EMMPRIN via the PI3K-Akt signaling pathway. Mol Cancer Res 2006; 4: 371-7. (Pubitemid 44035156)
13. Huang Z, Wang C, Wei L, Wang J, Fan Y, Wang L, Wang Y, Chen T,. Resveratrol inhibits EMMPRIN expression via P38 and ERK1/2 pathways in PMA-induced THP-1 cells. Biochem Biophys Res Commun 2008; 374: 517-21.
14. Venkatesan B, Valente AJ, Prabhu SD, Shanmugam P, Delafontaine P, Chandrasekar B,. EMMPRIN activates multiple transcription factors in cardiomyocytes, and induces interleukin-18 expression via Rac1-dependent PI3K/Akt/IKK/NF-kappaB andMKK7/JNK/AP-1 signaling. J Mol Cell Cardiol 2010; 49: 655-63.
15. Bougatef F, Quemener C, Kellouche S, Naimi B, Podgorniak MP, Millot G, Gabison EE, Calvo F, Dosquet C, Lebbe C, Menashi S, Mourah S,. EMMPRIN promotes angiogenesis through hypoxia-inducible factor-2alpha-mediated regulation of soluble VEGF isoforms and their receptor VEGFR-2. Blood 2009; 114: 5547-56.
16. Wang L, Damania B,. Kaposi's sarcoma-associated herpesvirus confers a survival advantage to endothelial cells. Cancer Res 2008; 68: 4640-8.
17. Qin Z, DeFee M, Isaacs JS, Parsons C,. Extracellular Hsp90 serves as a co-factor for MAPK activation and latent viral gene expression during de novo infection by KSHV. Virology 2010; 403: 92-102.
18. Bais C, Van Geelen A, Eroles P, Mutlu A, Chiozzini C, Dias S, Silverstein RL, Rafii S, Mesri EA,. Kaposi's sarcoma associated herpesvirus G protein-coupled receptor immortalizes human endothelial cells by activation of the VEGF receptor-2/ KDR. Cancer Cell 2003; 3: 131-43. (Pubitemid 37443386)
19. Montaner S, Sodhi A, Pece S, Mesri EA, Gutkind JS,. The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor promotes endothelial cell survival through the activation of Akt/protein kinase B. Cancer Res 2001; 61: 2641-8. (Pubitemid 32685850)
20. Sadagopan S, Sharma-Walia N, Veettil MV, Raghu H, Sivakumar R, Bottero V, Chandran B,. Kaposi's sarcoma-associated herpesvirus induces sustained NF-kappaB activation during de novo infection of primary human dermal microvascular endothelial cells that is essential for viral gene expression. J Virol 2007; 81: 3949-68. (Pubitemid 46586891)
21. Martin D, Galisteo R, Ji Y, Montaner S, Gutkind JS,. An NF-kappaB gene expression signature contributes to Kaposi's sarcoma virus vGPCR-induced direct and paracrine neoplasia. Oncogene 2008; 27: 1844-52. (Pubitemid 351430813)
22. Jham BC, Ma T, Hu J, Chaisuparat R, Friedman ER, Pandolfi PP, Schneider A, Sodhi A, Montaner S,. Amplification of the Angiogenic Signal through the Activation of the TSC/mTOR/HIF Axis by the KSHV vGPCR in Kaposi's Sarcoma. PLoS One 2011; 6: e19103.
23. Qin Z, Dai L, Slomiany MG, Toole BP, Parsons C,. Direct activation of emmprin and associated pathogenesis by an oncogenic herpesvirus. Cancer Res 2010; 70: 3884-89.
24. Li R, Huang L, Guo H, Toole BP,. Basigin (murine EMMPRIN) stimulates matrix metalloproteinase production by fibroblasts. J Cell Physiol 2001; 186: 371-9. (Pubitemid 32147720)
25. Belton RJ, Jr, Chen L, Mesquita FS, Nowak RA,. Basigin-2 is a cell surface receptor for soluble basigin ligand. J Biol Chem 2008; 283: 17805-14.
26. Oksenhendler E, Carcelain G, Aoki Y, Boulanger E, Maillard A, Clauvel JP, Agbalika F,. High levels of human herpesvirus 8 viral load, human interleukin-6, interleukin-10, and C reactive protein correlate with exacerbation of multicentric castleman disease in HIV-infected patients. Blood 2000; 96: 2069-73.
27. Aoki Y, Yarchoan R, Braun J, Iwamoto A, Tosato G,. Viral and cellular cytokines in AIDS-related malignant lymphomatous effusions. Blood 2000; 96: 1599-601. (Pubitemid 30658500)
28. Drexler HG, Meyer C, Gaidano G, Carbone A,. Constitutive cytokine production by primary effusion (body cavity-based) lymphoma-derived cell lines. Leukemia 1999; 13: 634-40. (Pubitemid 29195295)
29. Nilsson MB, Langley RR, Fidler IJ,. Interleukin-6, secreted by human ovarian carcinoma cells, is a potent proangiogenic cytokine. Cancer Res 2005; 65: 10794-800. (Pubitemid 41713347)
30. Jee SH, Chu CY, Chiu HC, Huang YL, Tsai WL, Liao YH, Kuo ML,. Interleukin-6 induced basic fibroblast growth factor-dependent angiogenesis in basal cell carcinoma cell line via JAK/STAT3 and PI3-kinase/Akt pathways. J Invest Dermatol 2004; 123: 1169-75.
31. Jego G.R., Bataille, and, C. Pellat-Deceunynck,. Interleukin-6 is a growth factor for nonmalignant human plasmablasts. Blood 2001; 97: 1817-22. (Pubitemid 32217251)
32. Cirone M, Lucania G, Aleandri S, Borgia G, Trivedi P, Cuomo L, Frati L, Faggioni A,. Suppression of dendritic cell differentiation through cytokines released by Primary Effusion Lymphoma cells. Immunol Lett 2008; 120: 37-41.
33. Sun Q, Matta H, Lu G, Chaudhary PM,. Induction of IL-8 expression by human herpesvirus 8 encoded vFLIP K13 via NF-kappaB activation. Oncogene 2006; 25: 2717-26.
34. Qin Z, Dai L, Bratoeva M, Slomiany MG, Toole BP, Parsons C,. Cooperative roles for emmprin and LYVE-1 in the regulation of chemoresistance for primary effusion lymphoma. Leukemia 2011; doi: 10.1038/leu.2011.144.
35. Ghayad SE, Vendrell JA, Larbi SB, Dumontet C, Bieche I, Cohen PA,. Endocrine resistance associated with activated ErbB system in breast cancer cells is reversed by inhibiting MAPK or PI3K/Akt signaling pathways. Int J Cancer 2010; 126: 545-62.
36. Martelli AM, Evangelisti C, Chiarini F, Grimaldi C, Manzoli L, McCubrey JA,. Targeting the PI3K/AKT/mTOR signaling network in acute myelogenous leukemia. Expert Opin Investig Drugs 2009; 18: 1333-49.
37. Zhang HY, Zhang PN, Sun H,. Aberration of the PI3K/AKT/mTOR signaling in epithelial ovarian cancer and its implication in cisplatin-based chemotherapy. Eur J Obstet Gynecol Reprod Biol 2009; 146: 81-6.
38. Misra S, Ghatak S, Zoltan-Jones A, Toole BP,. Regulation of multidrug resistance in cancer cells by hyaluronan. J Biol Chem 2003; 278: 25285-8. (Pubitemid 36835275)
39. Guo X, Ma N, Wang J, Song J, Bu X, Cheng Y, Sun K, Xiong H, Jiang G, Zhang B, Wu M, Wei L,. Increased p38-MAPK is responsible for chemotherapy resistance in human gastric cancer cells. BMC Cancer 2008; 8: 375.
40. Daouti S, Wang H, Li WH, Higgins B, Kolinsky K, Packman K, Specian A, Jr, Kong N, Huby N, Wen Y, Xiang Q, Podlaski FJ, et al. Characterization of a novel mitogen-activated protein kinase kinase 1/2 inhibitor with a unique mechanism of action for cancer therapy. Cancer Res 2009; 69: 1924-32.
41. Nguyen HQ, Magaret AS, Kitahata MM, Van Rompaey SE, Wald A, Casper C,. Persistent Kaposi sarcoma in the era of highly active antiretroviral therapy: characterizing the predictors of clinical response. AIDS 2008; 22: 937-45. (Pubitemid 351652244)
42. Flaitz CM, Jin YT, Hicks MJ, Nichols CM, Wang YW, Su IJ,. Kaposi's sarcoma-associated herpesvirus-like DNA sequences (KSHV/HHV-8) in oral AIDS-Kaposi's sarcoma: a PCR and clinicopathologic study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997; 83: 259-64. (Pubitemid 127670960)
43. Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM, Donner DB,. NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 1999; 401: 82-5.
44. Defee M, Qin Z, Dai L, Toole BP, Isaacs JS, Parsons C,. Extracellular Hsp90 serves as a co-factor for NF-ηB activation and cellular pathogenesis induced by an oncogenic herpesvirus. Am J Cancer Res 2011; 1: 686-99.
45. Rucci N, Millimaggi D, Mari M, Del Fattore A, Bologna M, Teti A, Angelucci A, Dolo V,. Receptor activator of NF-kappaB ligand enhances breast cancer-induced osteolytic lesions through upregulation of extracellular matrix metalloproteinase inducer/CD147. Cancer Res 2010; 70: 6150-60.