γ-Interferon production in peripheral blood mononuclear cells and tumor infiltrating lymphocytes from Kaposi's sarcoma patients: Correlation with the presence of human herpesvirus-8 in peripheral blood mononuclear cells and lesional macrophages

Blood

Volumn 91, Issue 3, 1998, Pages 968-976

  Sirianni, Maria Caterina ^b   Vincenzi, Laura ^b   Fiorelli, Valeria ^b   Topino, Simone ^b   Scala, Enrico ^b   Uccini, Stefania ^b   Angeloni, Antonio ^b   Faggioni, Alberto ^b   Cerimele, Decio ^b   Cottoni, Francesca ^b   Aiuti, Fernando ^b   Ensoli, Barbara ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON;

ADULT; ARTICLE; CLINICAL ARTICLE; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN HERPESVIRUS 8; IMMUNOPHENOTYPING; KAPOSI SARCOMA; LYMPHOCYTIC INFILTRATION; MACROPHAGE ACTIVATION; MALE; MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SPINDLE CELL; T LYMPHOCYTE ACTIVATION; TUMOR ASSOCIATED LEUKOCYTE; VIRUS INFECTION;

EID: 19244368329     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v91.3.968.968_968_976     Document Type: Article

References (77)

1. Kaposi M: Idiopatisches multiples Pigmensarkom der Haut. Arch Dermatol Syph 4:265, 1872
2. Safai B, Good RA: Kaposi's sarcoma: A review and recent developments. Clin Bull 10:62, 1980
3. Loethe F: Kaposi's sarcoma in Ugandan Africans. Acta Pathol Mic Sc Suppl 161:1, 1963
4. Beral V: Epidemiology of Kaposi's sarcoma. Cancer Surv 10:5, 1991
5. Penn I: Kaposi's sarcoma in organ transplant recipients: Report of 20 cases. Transplantation 27:8, 1979
6. Gottlieb GJ, Ackerman AB: Kaposi's sarcoma: An extensively disseminated form in young homosexual men. Hum Pathol 13:882, 1982
7. Havercos HW, Drotman DP, Morgan M: Prevalence of Kaposi's sarcoma among patients with AIDS. N Engl J Med 312:1518, 1985
8. Rutgers JL, Wieczorek R, Bonetti F, Kaplan KL, Posnett DN, Friedman-Kien AE, Knowles DM: The expression of endothelial cell surface antigens by AIDS-associated Kaposi's sarcoma. Evidence for a vascular endothelial cell origin. Am J Pathol 122:493, 1986
9. Regezi JA, MacPhail LA, Daniels TE, De Souza YG, Greenspan JS, Greenspan D: Human immunodeficiency virus-associated oral Kaposi's sarcoma. Am J Pathol 43:240, 1993
10. Chang Y, Ceserman E, Pessin MS, Lee F, Culpepper J, Knowles DM, Moore PS: Identification of Herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 266:1865, 1994
11. Moore PS, Chang Y: Detection of herpesvirus-like DNA sequences in Kaposi's sarcoma in patients with and those without HIV infection. N Engl J Med 332:1181, 1996
12. Huang YQ, Li JJ, Kaplan MH, Poiesz B, Katabira E, Zhang WC, Feiner D, Friedman-Kien AE: Human herpesvirus-like nucleic acid in various forms of Kaposi's sarcoma. Lancet 345:759, 1995
13. Dupin N, Grandadam M, Calvez V, Gorin I, Aubin JT, Havard S, Lamy F, Leibowitch M, Huraux JM, Escande JP, Agut H: Herpesvirus-like DNA sequences in patients with Mediterranean Kaposi's sarcoma. Lancet 345:761, 1995
14. Boshoff C, Whitby D, Hatzioannou T, Fisher C, van der Walt J, Hatzakis J, Weiss R, Schulz T: Kaposi's sarcoma-associated herpesvirus in HIV-negative Kaposi's sarcoma. Lancet 345:1043, 1995
15. Miller G, Rigsby MO, Heston L, Grogan E, Sun R, Metroka C, Levy JA, Gao S-J, Chang Y, Moore P: Antibodies to butyrate-inducible antigens of Kaposi's sarcoma associated herpesvirus in patients with HIV-1 infection. N Engl J Med 334:1292, 1996
16. Lennette E, Blackbourn DJ, Levy JA: Antibodies to human herpesvirus type 8 in the general population and in Kaposi's sarcoma patients. Lancet 348:858, 1996
17. Uccini S, Pilozzi E, Stoppaccaiaro A, Angeloni A, Santarelli R, Faggioni A, Baroni CD, Ruco LP, Sirianni MC, Vincenzi L, Cerimele D, Masala MV, Cottoni F: Kaposi's sarcoma-associated herpesvirus/ human herpesvirus 8 is not detectable in peripheral blood mononuclear cells of the relatives of sporadic KS patients. J Invest Dermatol 108:119, 1997
18. Foreman KE, Friborg J, Kong W-R, Woffendin C, Polverini PJ, Nickoloff BJ, Nabel GJ: Propagation of a human herpesvirus from AIDS-associated Kaposi's sarcoma. N Engl J Med 336:163, 1997
19. Whitby D, Howard MR, Tenant-Flowers M, Brink NS, Copas A, Boshoff C, Hatzioannou T, Suggett FEA, Aldam DM, Denton AS, Miller RF, Weller IVD, Weiss RA, Tedder RS, Schulz TF: Detection of Kaposi's sarcoma associated herpesvirus in peripheral blood of HIV-infected individuals and progression to Kaposi's sarcoma. Lancet 346:799, 1995
20. Cesarman E, Chang Y, Moore PS, Said JW, Knowles DM: Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N Engl J Med 332:1186, 1995
21. Soulier J, Grollet L, Oksenhendler E, Cacoub P, Cazals-Hatem D, Babinet P, d'Agay MF, Clauvel JP, Raphael M, Degos L, Sigaux F: Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castelman's disease. Blood 86:1276, 1995
22. Ambroziak JA, Blackbourn DJ, Herndier BG, Glogau RG, Gullett JH, McDonald AR, Lennette ET, Levy JA: Herpes-like sequences in HIV-infected and uninfected Kaposi's sarcoma patients. Science 268:582, 1995
23. Browning PJ, Sechler JMG, Kaplan M, Washington RH, Gendelman R, Yarchoan R, Ensoli B, Gallo RC: Identification and culture of Kaposi's sarcoma-like spindle cells from pheripheral blood of HIV-1 infected individuals and normal controls. Blood 84:2711, 1994
24. Sirianni MC, Uccini S, Angeloni A, Faggioni A, Cottoni F, Ensoli B: Circulating spindle cells: Correlation with human herpesvirus-8 (HHV-8) infection and Kaposi's sarcoma. Lancet 349:255, 1997
25. Blasig C, Zietz C, Haar B, Neipel F, Esser S, Brockmeyer NH, Tschachler E, Colombini S, Ensoli B, Stürzl M: Monocytes in Kaposi's sarcoma lesions are productively infected by human herpesvirus-8. J Virol 10:7663, 1997
26. Orenstein JM, Alkan S, Blauvelt A, Jeang K-T, Weinstein MD, Ganem D, Herndier B: Visualization of human herpesvirus type 8 in Kaposi's sarcoma by light and transmission electron microscopy. AIDS 11:35, 1997
27. Zhong W, Wang H, Herndier B, Ganem D: Restricted expression of Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genes in Kaposi sarcoma. Proc Natl Acad Sci USA 93:6641, 1996
28. Boshoff C, Acholz T, Kennedy MM, Graham AK, Fisher C, Thomas A, Mcgee JO'D, Weiss RA, O'Leary J: Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells. Nat Med 1:1274, 1995
29. Li JJ, Huang YQ, Cockerell CJ, Friedman-Kien AE: Localization of human herpes-like virus type 8 in vascular endothelial cells and perivascular spindle-shaped cells of Kaposi's sarcoma lesions by in situ hybridization. Am J Pathol 148:1741, 1996
30. Honda M, Kitamura K, Mizutani Y, Oishi M, Arai M, Okura T, Igarahi S, Yasukawa K, Hirano T, Kishimoto Y, Mitsuyasu R, Chermann JC, Tokugana T: Quantitative analysis of serum IL-6 and its correlation with increased levels of serum IL-2R in HIV-1-induced disease. J Immunol 145:4059, 1990
31. Lahdevirta J, Mauri CPJ, Teppo AM, Repo H: Elevated levels of circulating cachectin/tumor necrosis factor in patients with acquired immunodeficiency syndrome. Am J Med 85:289, 1988
32. Lepe-Zanuga JL, Mansell TWA, Hersh EM: Idiopathic production of Interleukin-1 in acquired immunodeficiency syndrome. J Clin Microbiol 5:1695, 1987
33. Emilie D, Peuchmaur M, Maillot MC, Crevon MC, Brousse N, Delfraissy JF, Dormont J, Galanaud P: Production of interleukins in human immunodeficiency virus-1 replicating lymph nodes. J Clin Invest 86:148, 1990
34. + cells in HIV-1-infected and high risk individuals. Clin Immunol Immunopathol 73:252, 1994
35. DePauli P, Caffau C, D'Andrea M, Tavio M, Tirelli U, Santini G: Serum levels of intercellular adhesion molecule 1 in patients with HIV-related Kaposi's sarcoma. J AIDS 7:695, 1994
36. Nakamura S, Salahuddin S, Biberfeld SZ, Ensoli B, Markhan PD, Wong-Stall F, Gallo RC: Kaposi's sarcoma cells: Long-term sarcoma-derived cells express cytokines with autocrine and paracrine growth effects. Science 243:223, 1988
37. Barillari G, Buonaguro L, Fiorelli V, Hoffman J, Michaels F, Gallo RC, Ensoli B: Effects of cytokines from activated immune cells on vascular cell growth and HIV-1 gene expression. Implications for AIDS-Kaposi's sarcoma pathogenesis. J Immunol 149:3727, 1992
38. Nair BC, DeVico AL, Nakamura S, Copeland TD, Chen Y, Patel A, O'Neil T, Orozlan S, Gallo RC, Sarngadharan MG: Identification of a major growth factor for AIDS-Kaposi's sarcoma cells as Oncostatin M. Science 255:1430, 1992
39. Miles SA, Martinez-Maza O, Rezai A, Maypantay L, Kishimoto T, Nakamura S, Radka SF, Linsey PS: Oncostatin M as a potent mitogen for AIDS-Kaposi's sarcoma-derived cells. Science 255:1432, 1992
40. Ensoli B, Nakamura S, Salahuddin SZ, Biberfeld P, Larsson L, Beaver B, Wong-Staal F, Gallo RC: AIDS Kaposi's sarcoma derived cells express cytokines with autocrine and paracrine growth effects. Science 243:223, 1989
41. Salahuddin SZ, Nakamura S, Biberfeld P, Kaplan MH, Markham PD, Larsson L, Gallo RC: Angiogenic properties of Kaposi's sarcoma-derived cells after long-term culture in vitro. Science 242:430, 1988
42. Ensoli B, Gallo RC: AIDS associated Kaposi's sarcoma: A new perspective of its pathogenesis and treatment. Proc Assoc Am Phys 107:9, 1995
43. Ensoli B, Gendelman R, Markham P, Fiorelli V, Colombini S, Farreld M, Cafaro A, Chang HK, Brady JN, Gallo RC: Synergy between basic fibroblast growth factor and human immunodeficiency virus type 1 Tat protein in induction of Kaposi's sarcoma. Nature 371:674, 1994
44. Cornali E, Zietz C, Benelli L, Wninger W, Masiello L, Breier G, Tschachler E, Albini A, Stürzl M: Vascular endothelial growth factor regulates angiogenesis and vascular permeability in Kaposi's sarcoma. Am J Pathol 149:1851, 1996
45. Uccini S, Sirianni MC, Vincenzi L, Topino S, Stoppacciaro A, Lesnoni La Parola I, Capuano M, Masini C, Cerimele D, Cella M, Lanzavecchia A, Allavena P, Mantovani A, Baroni CD, Ruco LP: Kaposi's sarcoma (KS) cells express the macrophage associated antigen mannose receptor and develop in peripheral blood cultures of KS patients. Am J Pathol 150:929, 1997
46. Miles SA, Rezai AR, Salazar-Gonzalez JF, VanderMeyden M, Stevens RH, Logan DM, Mitsuyasu RT, TagaT, Hirano T, Kishimoto T, Martinez-Maza O: AIDS Kaposi sarcoma-derived cells produce and respond to interleukin 6. Proc Natl Acad Sci USA 87:4068, 1990
47. Oxholm A, Oxholm P, Permin H, Bendtzen K: Epidermal tumour necrosis factor (alpha) and interleukin 6-like activities in AIDS-related Kaposi's sarcoma. Acta Pathol Mic Sc 97:533, 1989
48. Cai J, Gill PS, Masood R, Chandrasoma P, Jung E, Law RF, Radka SF: Oncostatin-M is an autocrine growth factor in Kaposi's sarcoma. Am J Pathol 145:74, 1994
49. Fiorelli V, Gendelman R, Samaniego F, Markham PD, Ensoli B: Cytokines from activated T cells induce normal endothelial cells to acquire the phenotypic and functional features of AIDS-Kaposi's sarcoma spindle cells. J Clin Invest 95:1723, 1995
50. + T cells infiltrating Kaposi's sarcoma induces spindle cells with angiogenic phenotype and synergy with human immunodeficiency virus-1 Tat protein: An immune response to human herpes virus-8 infection? Blood 91:956, 1998
51. Ensoli B, Barillari G, Salahuddin SZ, Gallo RC, Wong-Staal F: Tat protein of HIV-1 stimulates growth of AIDS-Kaposi's sarcoma-derived cells. Nature 345:84, 1990
52. Ensoli B, Buonaguro L, Barillari G, Fiorelli V, Gendelman R, Morgan RA, Wingfield P, Gallo RC: Release, uptake and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation. J Virol 67:277, 1993
53. Clerici M, Shearer GM: The Th1-Th2 hypothesis of HIV infection: New insights. Immunol Today 15:575, 1994
54. Tabata MA, Langford A, Becker J, Reichart PA: Distribution of immunocompetent cells in oral Kaposi's sarcoma. Eur J Cancer B Oral Oncol 29B:209, 1993
55. + T cells showing B cell helper function and reduced cytolytic activity in human immunodeficiency virus type 1 infection. J Exp Med 180:489, 1994
56. - T cells bearing T-cell receptor α and β chains in two normal men. Blood 79:2965, 1992
57. - T lymphocytes to a microbial agent. Nature 360:593, 1992
58. + T helper cells in humans augment the production of pathogenic anti-DNA autoantibodies associated with lupus nephritis. J Immunol 143:103, 1989
59. Crispe JN, Mehal WZ: Strange brew: T cells in the liver. Immunol Today 17:522, 1996
60. Wirt DP, Brooks EG, Vaidya S, Klimpel GR, Waldmann TA, Goldblum RM: Novel T-lymphocyte population in combined immunodeficiency with features of graft-versus-host disease. N Engl J Med 321:370, 1989
61. Carne WP, Iacoviello V, Hirsh HS: Functional properties of T lymphocytes and their subsets in cytomegalovirus mononucleosis. J Immunol 130:390, 1983
62. + T cells in acute infectious mononucleosis. Nature Med 2:906, 1996
63. Lenardo MJ: Interleukin-2 programs mouse αβ T lymphocytes for apoptosis. Nature 353:858, 1991
64. Razvi ES, Welsh RM: Programmed cell death of T lymphocytes during acute viral infection: A mechanism for virus-induced immune deficiency. J Virol 67:5754, 1993
65. Moore PS, Boshoff C, Weiss RA, Chang Y: Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV. Science 274:1739, 1996
66. Mesri EA, Ceserman E, Arvanitakis L, Rafii S, Moore MAS, Posnett DN, Knowles DM, Asch A: Human herpesvirus 8/Kaposi's sarcoma-associated herpesvirus is a new transmissible virus that infects B cells. J Exp Med 183:2385, 1996
67. Harrington WJ, Bagasra O, Sosa CE, Bobroski LE, Baum M, Wen XL, Cabrai L, Byrne GE, Pomerantz RJ, Wood C: Human herpesvirus type 8 DNA sequences in cell-free plasma and mononuclear cells of Kaposi's sarcoma patients. J Infect Dis 174:1101, 1996
68. Uccini S, Ruco LP, Monardo F, Stoppacciaro A, Dejana E, Lesnoni La Parola I, Cerimele D, Baroni CD: Co-expression of endothelial cell and macrophage antigens in Kaposi's sarcoma cells. J Pathol 173:23, 1994
69. Pulford KAF, Rigney EM, Micklem KJ, Jones M, Stross WP, Gatter KC, Mason DY: KP1: A new monoclonal antibody that detects a monocyte/macrophage associated antigen in routinely processed tissue section. J Clin Pathol 42:414, 1989
70. Parslow TG: The phagocytes: Neutrophils and macrophages, in Stites DP, Terr AI, Parslow TG (eds): Basic and Clinical Immunology. Norwalk, CT, Appleton & Lange, 1994
71. + T lymphocytes. Blood 85:3213, 1995
72. Samaniego F, Markham PD, Gallo RC, Ensoli B: Inflammatory cytokines induce AIDS-Kaposi's sarcoma-derived spindle cells to produce and release basic fibroblast growth factor and enhance Kaposi's sarcoma-like lesion formation in nude mice. J Immunol 154:3582, 1995
73. Samaniego F, Markham PD, Gendelman R, Gallo RC, Ensoli B: Inflammatory cytokines induce endothelial cells to produce and release basic fibroblast growth factor and to promote Kaposi's sarcoma-like lesions in nude mice. J Immunol 158:1887, 1997
74. Pammer J, Plettensberg A, Weninger W, Diller B, Mildner M, Uthman A, Issing W, Stürzl M, Tshachler E: CD40 antigen is expressed by endothelial cells and tumour cells in Kaposi's sarcoma. Am J Pathol 148:1387, 1996
75. Epperson DE, Pober JS: Antigen-presenting function of human endothelial cells. Direct activation of resting CD8 T cells. J Immunol 153:5402, 1994
76. Albrecht H, Stellbrink H-J, Gross G, Berg B, Helmchen U, Mensing H: Treatment of atypical leishmaniasis with ginterferon resulting in progression of Kaposi's sarcoma in an AIDS patient. Clin Invest 72:1041, 1994
77. Krigel RL, Padavic-Shaller KA, Rudolph AR, Poiesz BJ, Comis RL: Exacerbation of epidemic Kaposi's sarcoma with a combination of interleukin-2 and gamma interferon: Results of a phase 2 study. J Biol Response Mod 8:359, 1989