Kaposi's sarcoma-associated herpesvirus-induced upregulation of the c-kit proto-oncogene, as identified by gene expression profiling, is essential for the transformation of endothelial cells

Journal of Virology

Volumn 76, Issue 16, 2002, Pages 8383-8399

  Moses, Ashlee V ^a   Jarvis, Michael A ^a   Raggo, Camilo ^a   Bell, Yolanda C ^a   Ruhl, Rebecca ^a   Luukkonen, B G Mattias ^a   Griffith, Diana J ^a   Wait, Cecily L ^a   Druker, Brian J ^a   Heinrich, Michael C ^a   Nelson, Jay A ^a   Früh, Klaus ^a  

^a NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

STEM CELL FACTOR; STEM CELL FACTOR RECEPTOR;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; CELL STRUCTURE; CELL TRANSFORMATION; CONTROLLED STUDY; ENDOTHELIUM CELL; GENE EXPRESSION PROFILING; HUMAN HERPESVIRUS 8; KAPOSI SARCOMA; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTO ONCOGENE; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; SPINDLE CELL; UNINDEXED SEQUENCE; VASCULARIZATION;

BASE SEQUENCE; CELL ADHESION; CELL DIVISION; CELL LINE; CELL SIZE; CELL TRANSFORMATION, NEOPLASTIC; CELL TRANSFORMATION, VIRAL; DNA; ENDOTHELIUM, VASCULAR; GENE EXPRESSION PROFILING; HERPESVIRUS 8, HUMAN; HUMANS; NEOVASCULARIZATION, PATHOLOGIC; PIPERAZINES; PROTO-ONCOGENE PROTEINS C-KIT; PROTO-ONCOGENES; PYRIMIDINES; SARCOMA, KAPOSI; SIGNAL TRANSDUCTION; STEM CELL FACTOR; UP-REGULATION;

EID: 0036318827     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.16.8383-8399.2002     Document Type: Article

References (116)

1. Expression of functional c-kit receptors rescues the genetic defect of W mutant mast cells
2. Gastrointestinal stromal tumors with KIT mutations exhibit a remarkably homogeneous gene expression profile
3. KSHV sequences in biopsies and cultured spindle cells of epidemic, iatrogenic and Mediterranean forms of Kaposi's sarcoma
4. Herpes-like sequences in HIV-infected and uninfected Kaposi's sarcoma patients
5. Angiogenesis and hematopoiesis induced by Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6
6. Insulin and cancer
7. Establishment and characterization of a primary effusion (body cavity-based) lymphoma cell line (BC-3) harboring Kaposi's sarcoma-associated herpesvirus (KSHV/IIHV-8) in the absence of Epstein-Barr virus
8. Expression of stem cell factor and c-kit mRNA in cultured endothelial cells, monocytes and cloned human bone marrow stromal cells (CFU-RF)
9. G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator
10. The insulin-like growth factor axis: A review of atherosclerosis and restenosis
11. Evidence for the origin of Kaposi's sarcoma from lymphatic endothelium
12. c-Kit and c-kit mutations in mastocytosis and other hematological diseases
13. Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokines
14. Establishing a KSHV+ cell line (BCP-1) from peripheral blood and characterizing its growth in nod/SCID mice
15. Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells
16. Human umbilical vein endothelial cells display high-affinity c-kit receptors and produce a soluble form of the c-kit receptor
17. Inhibition of the Ab1 protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative
18. Selective inhibition of the plalelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenylaminopyrimidine class
19. Coordinate regulation of Steel factor, its receptor (Kit), and cytoadhesion molecule (1CAM 1 and ELAM-1) mRNA expression in human vascular endothelial cells of differing origins
20. Human herpesvirus 8-encoded thymidine kinase and phosphotransferase homologues confer sensitivity to ganciclovir
21. Transformation of N1H3T3 fibroblasts by the c-Kit receptor tyrosine kinase: Effect of receptor density and ligand-requirement
22. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body cavity-based lymphomas
23. Kaposi's sarcoma-associated herpes-virus contains G protein-coupled receptor and cyclin D homologs which are expressed in Kaposi's sarcoma and malignant lymphoma
24. Identification and characterization of human herpesvirus-8 lytic cycle-associated ORF 59 protein and the encoding cDNA hy monoclonal antibody
25. Gene expression analysis in aggressive NHL
26. Human herpesvirus-8 ORF K8.1 gene encodes immunogenic glycoproteins generated by spliced transcripts
27. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma
28. Cyclin encoded by KS herpesvirus
29. Microarray analysis identifies interferon-inducible genes and Stat-1 as major transcriptional targets of human pappilomavirus type 31
30. A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak
31. Spindle cell conversion by Kaposi's sarcoma-associated herpesvirus: Formation of colonies and plaques with mixed lyric and latent gene expression in infected primary dermal microvascular endothelial cell cultures
32. Gene expression microarray analysis in cancer biology, pharmacology, and drug development; progress and potential
33. Comparative analysis of the transforming mechanisms of Epstein-Barr virus, Kaposi's sarcoma-associated herpesvirus, and Herpesvirus saimiri
34. Expression of human herpesvirus 8-encoded cyclin D in Kaposi's sarcoma spindle cells
35. Effects of a selective inhibitor of the Ab1 tyrosine kinase on the growth of Bcr-Ab1 positive cells
36. Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma
37. Kaposi's sarcoma pathogenesis: A link between immunology and tumor biology
38. Multiple role for Cdc42 in cell regulation
39. Peroxisome proliferator-activated receptor-gamma: From adipogenesis to carcinogenesis
40. CD36: A class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism
41. Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutant
42. Transformation of primary human endothelial cells by Kaposi's sarcoma-associated herpesvirus
43. Virogenomics: A novel approach to antiviral drug discovery
44. KSHV ORF K9 (v1RF) is an oncogene which inhibits the interferon signaling pathway
45. Cloning and developmental expression analysis of the murine c-mer tyrosine kinase
46. Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis
47. Characterization of a chemokine receptor-related gene in human herpesvirus 8 and its expression in Kaposi's sarcoma
48. Identification of tumor markers in models of human colorectal cancer using a 19,200-element complementary DNA microarray
49. Constitutive expression of steel factor gene by human stromal cells
50. Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor
51. Coexpression of the c-kit and stem cell factor genes in breast carcinomas
52. Global gene expression analysis of gastric cancer by oligonucleotide microarrays
53. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors
54. Insulin-like growth factor-binding protein 2 in tumorigenesis: Protector or promoter?
55. Induction of plasminogen activator inhibitor 1 gene expression in adipocytes by thiazolidinediones
56. Coexpression of the c-kit receptor and the stem cell factor in gynecological tumors
57. Kaposi's sarcoma-associated herpesvirus latent and lytic gene expression as revealed by DNA arrays
58. Autocrine growth of small cell lung cancer mediated by coexpression of c-kit and stem cell factor
59. The selective tyrosine kinase inhibitor STI571 inhibits small cell lung cancer growth
60. De novo infection and serial transmission of Kaposi's sarcoma-associated herpesvirus in cultured endothelial cells
61. Receptor functions and ligand-dependent transforming potential of a chimeric kit proto-oncogene
62. Localization of human herpes-like virus type 8 in vascular endothelial cells and perivascular spindle-shaped cells of Kaposi's sarcoma lesions by in situ hybridization
63. Early signaling pathways activated by c-Kit in hematopoietic cells
64. Human herpesvirus 8 (HHV-8)-encoded cytokines induce expression of and autocrine signaling by vascular endothelial growth factor (VEGF) in HHV-8-infected primary-effusion lymphoma cell lines and mediate VEGF-independent antiapoptotic effects
65. Retroviral-mediated gene transduction of c-kit into single hematopoietic progenitor cells from cord blood enhances erythroid colony formation and decreases sensitivity to inhibition by tumor necrosis factor-alpha and transforming growth factor-β1
66. KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors
67. Primary structure and functional expression of rat and human stem cell factor DNAs
68. Expression of the c-kit protein in human solid tumors and in corresponding fetal and adult normal tissues
69. KIT expression in angiosarcomas and fetal endothelial cells: Lack of mutations of exon 11 and exon 17 of C-kit
70. Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV
71. Long-term infection and transformation of dermal microvascular endothelial cells by human herpesvirus 8
72. New mechanisms and pathways for monocyte recruitment
73. Identification of kaposin (open reading frame K12) as a human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) transforming gene
74. Neuritin: A gene induced by neural activity and neurotrophins that promotes neuritogenesis
75. Novel organizational features, captured cellular genes, and strain variability within the genome of KSHV/HHV8
76. Familial gastrointestinal stromal tumours with germline mutation of the KIT gene
77. Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, HCC-1, LEC, and RANTES
78. Transcription program of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus)
79. Extracellular proteolysis and angiogenesis
80. Altered patterns of cellular gene expression in dermal microvascular endothelial cells infected with Kaposi's sarcoma-associated herpesvirus
81. Chromosomal translocations and leukaemia: A role for LMO2 in T cell acute leukaemia, in transcription and in erythropoiesis
82. The 222- to 234-kilodalton latent nuclear protein (LNA) of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) is encoded by orf73 and is a component of the latency-associated nuclear antigen
83. Multiclass cancer diagnosis using tumor gene expression signatures
84. Modulation of cellular and viral gene expression by the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus
85. Limited transmission of Kaposi's sarcoma-associated herpesvirus in cultured cells
86. The size and conformation of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) DNA in infected cells and virions
87. Insulin and insulin-like growth factor 1 antagonize the stimulation of ob gene expression by dexamethasone in cultured rat adipose tissue
88. An improved colorimetric assay for cell proliferation and viability utilizing the tetrazolium salt XTT
89. Cellular and molecular features of HIV-associated Kaposi's sarcoma
90. Cultured, AIDS-related Kaposi's sarcoma cells express endothelial cell markers and are weakly malignant in vitro
91. The expression of endothelial cell surface antigens by AIDS-associated Kaposi's sarcoma. Evidence for a vascular endothelial cell origin
92. Gene expression analysis via cDNA microarrays of laser capture microdissected cells from fixed tissue
93. Transcription mapping of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) genome in a body cavity-based lymphoma cell line (BC-1)
94. Expression of adhesion molecules, platelet-activating factor, and chemokines by Kaposi's sarcoma cells
95. Phagocytosis and clearance of apoptotic cells is mediated by MER
96. AIDS-related Kaposi's sarcoma displays differential expression of endothelial surface antigens
97. Global modulation of cellular transcription by human cytomegalovirus is initiated by viral glycoprotein B
98. The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1α
99. Cellular tropism and viral interleukin-6 expression distinguish human herpesvirus 8 involvement in Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease
100. Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells
101. The human cytomegalovirus chemokine receptor US28 mediates vascular smooth muscle cell migration
102. Expression of HHV-8 latency-associated TO.7 RNA in spindle cells and endothelial cells of AIDS-associated, classical and African Kaposi's sarcoma
103. Kinetics of Kaposi's sarcoma-associated herpesvirus gene expression
104. Herpes viral cyclin/Cdk6 complexes evade inhibition by CDK inhibitor proteins
105. Thrombospondin-1 inhibits Kaposi's sarcoma (KS) cell and HIV-1 Tat-induced angiogenesis and is poorly expressed in KS lesions
106. Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors
107. Activating c-kit gene mutations in human germ cell tumors
108. PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL
109. Nonhematopoietic tumor cell lines express stem cell factor and display c-kit receptors
110. Activation of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) lytic replication by human cytomegalovirus
111. Growth inhibition and modulation of kinase pathways of small cell lung cancer cell lines by the novel tyrosine kinase inhibitor STI 571
112. The oncogenic LIM-only transcription factor Lmo2 regulates angiogenesis but not vasculogenesis in mice
113. Umbilical vein endothelial cells are an important source of c-kit and stem cell factor which regulate the proliferation of haemopoietic progenitor cells
114. Human proto-oncogene c-kit: A new cell surface receptor tyrosine kinase for an unidentified ligand
115. Human endothelial cell response to gram-negative lipopolysaccharide assessed with cDNA microarrays
116. Restricted expression of Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genes in Kaposi sarcoma