메뉴 건너뛰기




Volumn 19, Issue 11, 2014, Pages 17154-17172

Enhancing the delivery of resveratrol in humans: If low bioavailability is the problem, what is the solution?

Author keywords

Nutraceutical; Pharmacodynamics; Pharmacokinetics; Phytochemical; Red wine; SIRT1; Sirtuins; Stilbene

Indexed keywords

RESVERATROL; STILBENE DERIVATIVE;

EID: 84913556203     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules191117154     Document Type: Review
Times cited : (162)

References (112)
  • 1
    • 33745962138 scopus 로고    scopus 로고
    • Therapeutic potential of resveratrol: The in vivo evidence
    • Baur, J.A.; Sinclair, D.A. Therapeutic potential of resveratrol: The in vivo evidence. Nat. Rev. Drug Discov. 2006, 5, 493-506.
    • (2006) Nat. Rev. Drug Discov. , vol.5 , pp. 493-506
    • Baur, J.A.1    Sinclair, D.A.2
  • 2
    • 84891887779 scopus 로고    scopus 로고
    • Aging is not programmed: Genetic pseudo-program is a shadow of developmental growth
    • Blagosklonny, M.V. Aging is not programmed: Genetic pseudo-program is a shadow of developmental growth. Cell Cycle 2013, 12, 3736-3742.
    • (2013) Cell Cycle , vol.12 , pp. 3736-3742
    • Blagosklonny, M.V.1
  • 3
    • 84886731838 scopus 로고    scopus 로고
    • Epigenetic aging: Insights from network biology
    • Teschendorff, A.E. Epigenetic aging: Insights from network biology. Aging 2013, 5, 719-720.
    • (2013) Aging , vol.5 , pp. 719-720
    • Teschendorff, A.E.1
  • 5
    • 84900481225 scopus 로고    scopus 로고
    • Aging synaptic mitochondria exhibit dynamic proteomic changes while maintaining bioenergetic function
    • Stauch, K.L.; Purnell, P.R.; Fox, H.S. Aging synaptic mitochondria exhibit dynamic proteomic changes while maintaining bioenergetic function. Aging 2014, 6, 320-334.
    • (2014) Aging , vol.6 , pp. 320-334
    • Stauch, K.L.1    Purnell, P.R.2    Fox, H.S.3
  • 8
    • 84875431034 scopus 로고    scopus 로고
    • High-dose resveratrol supplementation in obese men: An investigator-initiated, randomized, placebo-controlled clinical trial of substrate metabolism, insulin sensitivity, and body composition
    • Poulsen, M.M.; Vestergaard, P.F.; Clasen, B.F.; Radko, Y.; Christensen, L.P.; Stodkilde-Jorgensen, H.; Moller, N.; Jessen, N.; Pedersen, S.B.; Jorgensen, J.O. High-Dose Resveratrol Supplementation in Obese Men: An Investigator-Initiated, Randomized, Placebo-Controlled Clinical Trial of Substrate Metabolism, Insulin Sensitivity, and Body Composition. Diabetes 2012, 62, 1186-1195.
    • (2012) Diabetes , vol.62 , pp. 1186-1195
    • Poulsen, M.M.1    Vestergaard, P.F.2    Clasen, B.F.3    Radko, Y.4    Christensen, L.P.5    Stodkilde-Jorgensen, H.6    Moller, N.7    Jessen, N.8    Pedersen, S.B.9    Jorgensen, J.O.10
  • 9
    • 9444296057 scopus 로고    scopus 로고
    • High absorption but very low bioavailability of oral resveratrol in humans
    • Walle, T.; Hsieh, F.; DeLegge, M.H.; Oatis, J.E., Jr.; Walle, U.K. High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab. Dispos. 2004, 32, 1377-1382.
    • (2004) Drug Metab. Dispos. , vol.32 , pp. 1377-1382
    • Walle, T.1    Hsieh, F.2    Delegge, M.H.3    Oatis, J.E.4    Walle, U.K.5
  • 10
    • 84898543412 scopus 로고    scopus 로고
    • Exercise training, but not resveratrol, improves metabolic and inflammatory status in skeletal muscle of aged men
    • Olesen, J.; Gliemann, L.; Bienso, R.; Schmidt, J.; Hellsten, Y.; Pilegaard, H. Exercise training, but not resveratrol, improves metabolic and inflammatory status in skeletal muscle of aged men. J. Physiol. 2014, 592, 1873-1886.
    • (2014) J. Physiol. , vol.592 , pp. 1873-1886
    • Olesen, J.1    Gliemann, L.2    Bienso, R.3    Schmidt, J.4    Hellsten, Y.5    Pilegaard, H.6
  • 11
    • 84881104932 scopus 로고    scopus 로고
    • A healthier approach to clinical trials evaluating resveratrol for primary prevention of age-related diseases in healthy populations
    • Smoliga, J.M.; Colombo, E.S.; Campen, M.J. A healthier approach to clinical trials evaluating resveratrol for primary prevention of age-related diseases in healthy populations. Aging 2013, 5, 495-506.
    • (2013) Aging , vol.5 , pp. 495-506
    • Smoliga, J.M.1    Colombo, E.S.2    Campen, M.J.3
  • 12
    • 84863011114 scopus 로고    scopus 로고
    • Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases
    • Park, S.J.; Ahmad, F.; Philp, A.; Baar, K.; Williams, T.; Luo, H.; Ke, H.; Rehmann, H.; Taussig, R.; Brown, A.L.; et al. Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell 2012, 148, 421-433.
    • (2012) Cell , vol.148 , pp. 421-433
    • Park, S.J.1    Ahmad, F.2    Philp, A.3    Baar, K.4    Williams, T.5    Luo, H.6    Ke, H.7    Rehmann, H.8    Taussig, R.9    Brown, A.L.10
  • 19
    • 20344364428 scopus 로고    scopus 로고
    • And bioavailability of trans-resveratrol
    • Wenzel, E.; Somoza, V. Metabolism and bioavailability of trans-resveratrol. Mol. Nutr. Food Res. 2005, 49, 472-481.
    • (2005) Mol. Nutr. Food Res. , vol.49 , pp. 472-481
    • Wenzel, E.1    Metabolism, S.V.2
  • 21
    • 0142243190 scopus 로고    scopus 로고
    • Relationship between mechanisms, bioavailibility, and preclinical chemopreventive efficacy of resveratrol: A conundrum
    • Gescher, A.J.; Steward, W.P. Relationship between mechanisms, bioavailibility, and preclinical chemopreventive efficacy of resveratrol: A conundrum. Cancer Epidemiol. Biomark. Prev. 2003, 12, 953-957.
    • (2003) Cancer Epidemiol. Biomark. Prev. , vol.12 , pp. 953-957
    • Gescher, A.J.1    Steward, W.P.2
  • 22
    • 79961047423 scopus 로고    scopus 로고
    • Resveratrol and health-A comprehensive review of human clinical trials
    • Smoliga, J.M.; Baur, J.A.; Hausenblas, H.A. Resveratrol and health-a comprehensive review of human clinical trials. Mol. Nutr. Food Res. 2011, 55, 1129-1141.
    • (2011) Mol. Nutr. Food Res. , vol.55 , pp. 1129-1141
    • Smoliga, J.M.1    Baur, J.A.2    Hausenblas, H.A.3
  • 23
    • 78549288940 scopus 로고    scopus 로고
    • Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: Safety, pharmacokinetics, and effect on the insulin-like growth factor axis
    • Brown, V.A.; Patel, K.R.; Viskaduraki, M.; Crowell, J.A.; Perloff, M.; Booth, T.D.; Vasilinin, G.; Sen, A.; Schinas, A.M.; Piccirilli, G.; et al. Repeat Dose Study of the Cancer Chemopreventive Agent Resveratrol in Healthy Volunteers: Safety, Pharmacokinetics, and Effect on the Insulin-like Growth Factor Axis. Cancer Res. 2010, 70, 9003-9011.
    • (2010) Cancer Res. , vol.70 , pp. 9003-9011
    • Brown, V.A.1    Patel, K.R.2    Viskaduraki, M.3    Crowell, J.A.4    Perloff, M.5    Booth, T.D.6    Vasilinin, G.7    Sen, A.8    Schinas, A.M.9    Piccirilli, G.10
  • 25
    • 84877786892 scopus 로고    scopus 로고
    • Resveratrol for primary prevention of atherosclerosis: Clinical trial evidence for improved gene expression in vascular endothelium
    • Agarwal, B.; Campen, M.J.; Channell, M.M.; Wherry, S.J.; Varamini, B.; Davis, J.G.; Baur, J.A.; Smoliga, J.M. Resveratrol for primary prevention of atherosclerosis: Clinical trial evidence for improved gene expression in vascular endothelium. Int. J. Cardiol. 2013, 166, 246-248.
    • (2013) Int. J. Cardiol. , vol.166 , pp. 246-248
    • Agarwal, B.1    Campen, M.J.2    Channell, M.M.3    Wherry, S.J.4    Varamini, B.5    Davis, J.G.6    Baur, J.A.7    Smoliga, J.M.8
  • 26
    • 84921033588 scopus 로고    scopus 로고
    • Resveratrol treatment as an adjunct to pharmacological management in Type 2 diabetes mellitus-systematic review and meta-analysis
    • Hausenblas, H.A.; Schoulda, J.A.; Smoliga, J.M. Resveratrol treatment as an adjunct to pharmacological management in Type 2 diabetes mellitus-systematic review and meta-analysis. Mol. Nutr. Food Res. 2014, doi:10.1002/mnfr.201400173.
    • (2014) Mol. Nutr. Food Res.
    • Hausenblas, H.A.1    Schoulda, J.A.2    Smoliga, J.M.3
  • 28
    • 77953032816 scopus 로고    scopus 로고
    • Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: A double-blind, placebo-controlled, crossover investigation
    • Kennedy, D.O.; Wightman, E.L.; Reay, J.L.; Lietz, G.; Okello, E.J.; Wilde, A.; Haskell, C.F. Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: A double-blind, placebo-controlled, crossover investigation. Am. J. Clin. Nutr. 2010, 91, 1590-1597.
    • (2010) Am. J. Clin. Nutr. , vol.91 , pp. 1590-1597
    • Kennedy, D.O.1    Wightman, E.L.2    Reay, J.L.3    Lietz, G.4    Okello, E.J.5    Wilde, A.6    Haskell, C.F.7
  • 29
    • 84950170739 scopus 로고    scopus 로고
    • Chronic resveratrol consumption improves brachial flow-mediated dilatation in healthy obese adults
    • Wong, R.H.; Berry, N.M.; Coates, A.M.; Buckley, J.D.; Bryan, J.; Kunz, I.; Howe, P.R. Chronic resveratrol consumption improves brachial flow-mediated dilatation in healthy obese adults. J. Hypertens. 2013, 31, 1819-1827.
    • (2013) J. Hypertens. , vol.31 , pp. 1819-1827
    • Wong, R.H.1    Berry, N.M.2    Coates, A.M.3    Buckley, J.D.4    Bryan, J.5    Kunz, I.6    Howe, P.R.7
  • 30
    • 84950170835 scopus 로고    scopus 로고
    • Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure
    • Wong, R.H.; Howe, P.R.; Buckley, J.D.; Coates, A.M.; Kunz, I.; Berry, N.M. Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure. Nutr. Metab. Cardiovasc. Dis. 2011, 21, 851-856.
    • (2011) Nutr. Metab. Cardiovasc. Dis. , vol.21 , pp. 851-856
    • Wong, R.H.1    Howe, P.R.2    Buckley, J.D.3    Coates, A.M.4    Kunz, I.5    Berry, N.M.6
  • 31
    • 84885403641 scopus 로고    scopus 로고
    • Recent data do not provide evidence that resveratrol causes "mainly negative" or "adverse" effects on exercise training in humans
    • Smoliga, J.M.; Blanchard, O.L. Recent data do not provide evidence that resveratrol causes "mainly negative" or "adverse" effects on exercise training in humans. J. Physiol. 2013, 591, 5251-5252.
    • (2013) J. Physiol. , vol.591 , pp. 5251-5252
    • Smoliga, J.M.1    Blanchard, O.L.2
  • 32
    • 80052226783 scopus 로고    scopus 로고
    • Erroneous analyses of interactions in neuroscience: A problem of significance
    • Nieuwenhuis, S.; Forstmann, B.U.; Wagenmakers, E.J. Erroneous analyses of interactions in neuroscience: A problem of significance. Nat. Neurosci. 2011, 14, 1105-1107.
    • (2011) Nat. Neurosci. , vol.14 , pp. 1105-1107
    • Nieuwenhuis, S.1    Forstmann, B.U.2    Wagenmakers, E.J.3
  • 33
    • 84865849458 scopus 로고    scopus 로고
    • On the proper use of the crossover design in clinical trials: Part 18 of a series on evaluation of scientific publications
    • Wellek, S.; Blettner, M. On the proper use of the crossover design in clinical trials: Part 18 of a series on evaluation of scientific publications. Deutsch. Arztebl. Int. 2012, 109, 276-281.
    • (2012) Deutsch. Arztebl. Int. , vol.109 , pp. 276-281
    • Wellek, S.1    Blettner, M.2
  • 34
    • 84856171338 scopus 로고    scopus 로고
    • Challenges of Translating Basic Research into Therapeutics: Resveratrol as an Example
    • Smoliga, J.M.; Vang, O.; Baur, J.A. Challenges of Translating Basic Research into Therapeutics: Resveratrol as an Example. J. Gerontol. Ser. 2011, 67,158-167.
    • (2011) J. Gerontol. Ser. , vol.67 , pp. 158-167
    • Smoliga, J.M.1    Vang, O.2    Baur, J.A.3
  • 35
    • 84896914528 scopus 로고    scopus 로고
    • Resveratrol induces vascular smooth muscle cell differentiation through stimulation of SirT1 and AMPK
    • Thompson, A.M.; Martin, K.A.; Rzucidlo, E.M. Resveratrol induces vascular smooth muscle cell differentiation through stimulation of SirT1 and AMPK. PLoS One 2014, 9, e85495.
    • (2014) PLoS One , vol.9 , pp. e85495
    • Thompson, A.M.1    Martin, K.A.2    Rzucidlo, E.M.3
  • 36
    • 0034733585 scopus 로고    scopus 로고
    • Dose-dependent effect of resveratrol on proliferation and apoptosis in endothelial and tumor cell cultures
    • Szende, B.; Tyihak, E.; Kiraly-Veghely, Z. Dose-dependent effect of resveratrol on proliferation and apoptosis in endothelial and tumor cell cultures. Exp. Mol. Med. 2000, 32, 88-92.
    • (2000) Exp. Mol. Med. , vol.32 , pp. 88-92
    • Szende, B.1    Tyihak, E.2    Kiraly-Veghely, Z.3
  • 37
    • 79955006810 scopus 로고    scopus 로고
    • Dose-dependent antioxidant function of resveratrol demonstrated via modulation of reactive oxygen species in normal human skin fibroblasts in vitro
    • Jagdeo, J.; Adams, L.; Lev-Tov, H.; Sieminska, J.; Michl, J.; Brody, N. Dose-dependent antioxidant function of resveratrol demonstrated via modulation of reactive oxygen species in normal human skin fibroblasts in vitro. J. Drugs Dermatol. 2010, 9, 1523-1526.
    • (2010) J. Drugs Dermatol. , vol.9 , pp. 1523-1526
    • Jagdeo, J.1    Adams, L.2    Lev-Tov, H.3    Sieminska, J.4    Michl, J.5    Brody, N.6
  • 38
    • 84859551307 scopus 로고    scopus 로고
    • Dose-dependent effect of resveratrol on bladder cancer cells: Chemoprevention and oxidative stress
    • Stocco, B.; Toledo, K.; Salvador, M.; Paulo, M.; Koyama, N.; Torqueti Toloi, M.R. Dose-dependent effect of resveratrol on bladder cancer cells: Chemoprevention and oxidative stress. Maturitas 2012, 72, 72-78.
    • (2012) Maturitas , vol.72 , pp. 72-78
    • Stocco, B.1    Toledo, K.2    Salvador, M.3    Paulo, M.4    Koyama, N.5    Torqueti Toloi, M.R.6
  • 39
    • 84861210529 scopus 로고    scopus 로고
    • Resveratrol exerts dosage and duration dependent effect on human mesenchymal stem cell development
    • Peltz, L.; Gomez, J.; Marquez, M.; Alencastro, F.; Atashpanjeh, N.; Quang, T.; Bach, T.; Zhao, Y. Resveratrol exerts dosage and duration dependent effect on human mesenchymal stem cell development. PLoS One 2012, 7, e37162.
    • (2012) PLoS One , vol.7 , pp. e37162
    • Peltz, L.1    Gomez, J.2    Marquez, M.3    Alencastro, F.4    Atashpanjeh, N.5    Quang, T.6    Bach, T.7    Zhao, Y.8
  • 40
    • 0037167677 scopus 로고    scopus 로고
    • Resveratrol a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase
    • Wallerath, T.; Deckert, G.; Ternes, T.; Anderson, H.; Li, H.; Witte, K.; Forstermann, U. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 2002, 106, 1652-1658.
    • (2002) Circulation , vol.106 , pp. 1652-1658
    • Wallerath, T.1    Deckert, G.2    Ternes, T.3    Anderson, H.4    Li, H.5    Witte, K.6    Forstermann, U.7
  • 41
    • 33344471952 scopus 로고    scopus 로고
    • Benzo[A] pyrene-induced oral carcinogenesis and chemoprevention: Studies in bioengineered human tissue
    • Walle, T.; Walle, U.K.; Sedmera, D.; Klausner, M. Benzo[A]pyrene-induced oral carcinogenesis and chemoprevention: Studies in bioengineered human tissue. Drug Metab. Dispos. 2006, 34, 346-50.
    • (2006) Drug Metab. Dispos. , vol.34 , pp. 346-350
    • Walle, T.1    Walle, U.K.2    Sedmera, D.3    Klausner, M.4
  • 42
    • 84867099595 scopus 로고    scopus 로고
    • The bioavailability and distribution of trans-resveratrol are constrained by ABC transporters
    • Planas, J.M.; Alfaras, I.; Colom, H.; Juan, M.E. The bioavailability and distribution of trans-resveratrol are constrained by ABC transporters. Arch. Biochem. Biophys. 2012, 527, 67-73.
    • (2012) Arch. Biochem. Biophys. , vol.527 , pp. 67-73
    • Planas, J.M.1    Alfaras, I.2    Colom, H.3    Juan, M.E.4
  • 51
    • 53849145999 scopus 로고    scopus 로고
    • The impact of aqueous solubility and dose on the pharmacokinetic profiles of resveratrol
    • Das, S.; Lin, H.S.; Ho, P.C.; Ng, K.Y. The impact of aqueous solubility and dose on the pharmacokinetic profiles of resveratrol. Pharmaceut. Res. 2008, 25, 2593-2600.
    • (2008) Pharmaceut. Res. , vol.25 , pp. 2593-2600
    • Das, S.1    Lin, H.S.2    Ho, P.C.3    Ng, K.Y.4
  • 52
    • 84905819966 scopus 로고    scopus 로고
    • In vivo pharmacokinetics and biodistribution of resveratrol-loaded solid lipid nanoparticles for brain delivery
    • Jose, S.; Anju, S.S.; Cinu, T.A.; Aleykutty, N.A.; Thomas, S.; Souto, E.B. In vivo pharmacokinetics and biodistribution of resveratrol-loaded solid lipid nanoparticles for brain delivery. Int. J. Pharmaceut. 2014, 474, 6-13.
    • (2014) Int. J. Pharmaceut. , vol.474 , pp. 6-13
    • Jose, S.1    Anju, S.S.2    Cinu, T.A.3    Aleykutty, N.A.4    Thomas, S.5    Souto, E.B.6
  • 53
    • 84858709095 scopus 로고    scopus 로고
    • Administration of resveratrol: What formulation solutions to bioavailability limitations?
    • Amri, A.; Chaumeil, J.C.; Sfar, S.; Charrueau, C. Administration of resveratrol: What formulation solutions to bioavailability limitations? J. Control. Release 2012, 158, 182-193.
    • (2012) J. Control. Release , vol.158 , pp. 182-193
    • Amri, A.1    Chaumeil, J.C.2    Sfar, S.3    Charrueau, C.4
  • 54
    • 80052572943 scopus 로고    scopus 로고
    • Phase i randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases-safety, pharmacokinetics, and pharmacodynamics
    • Howells, L.M.; Berry, D.P.; Elliott, P.J.; Jacobson, E.W.; Hoffmann, E.; Hegarty, B.; Brown, K.; Steward, W.P.; Gescher, A.J. Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases-safety, pharmacokinetics, and pharmacodynamics. Cancer Prev. Res. 2011, 4, 1419-1425.
    • (2011) Cancer Prev. Res. , vol.4 , pp. 1419-1425
    • Howells, L.M.1    Berry, D.P.2    Elliott, P.J.3    Jacobson, E.W.4    Hoffmann, E.5    Hegarty, B.6    Brown, K.7    Steward, W.P.8    Gescher, A.J.9
  • 56
    • 0037248470 scopus 로고    scopus 로고
    • Absorption of three wine-related polyphenols in three different matrices by healthy subjects
    • Goldberg, D.M.; Yan, J.; Soleas, G.J. Absorption of three wine-related polyphenols in three different matrices by healthy subjects. Clin. Biochem. 2003, 36, 79-87.
    • (2003) Clin. Biochem. , vol.36 , pp. 79-87
    • Goldberg, D.M.1    Yan, J.2    Soleas, G.J.3
  • 57
    • 77953353711 scopus 로고    scopus 로고
    • Steady-State pharmacokinetics and tolerability of trans-resveratrol 2000 mg twice daily with food, quercetin and alcohol (ethanol) in healthy human subjects
    • La Porte, C.; Voduc, N.; Zhang, G.; Seguin, I.; Tardiff, D.; Singhal, N.; Cameron, D.W. Steady-State pharmacokinetics and tolerability of trans-resveratrol 2000 mg twice daily with food, quercetin and alcohol (ethanol) in healthy human subjects. Clin. Pharmacokinet. 2010, 49, 449-454.
    • (2010) Clin. Pharmacokinet. , vol.49 , pp. 449-454
    • La Porte, C.1    Voduc, N.2    Zhang, G.3    Seguin, I.4    Tardiff, D.5    Singhal, N.6    Cameron, D.W.7
  • 60
    • 84861800818 scopus 로고    scopus 로고
    • Resveratrol and piperine enhance radiosensitivity of tumor cells
    • Tak, J.K.; Lee, J.H.; Park, J.W. Resveratrol and piperine enhance radiosensitivity of tumor cells. BMB Rep. 2012, 45, 242-246.
    • (2012) BMB Rep. , vol.45 , pp. 242-246
    • Tak, J.K.1    Lee, J.H.2    Park, J.W.3
  • 61
    • 84887238400 scopus 로고    scopus 로고
    • Piperine potentiates the antidepressant-like effect of trans-resveratrol: Involvement of monoaminergic system
    • Huang, W.; Chen, Z.; Wang, Q.; Lin, M.; Wu, S.; Yan, Q.; Wu, F.; Yu, X.; Xie, X.; Li, G.; et al. Piperine potentiates the antidepressant-like effect of trans-resveratrol: Involvement of monoaminergic system. Metab. Brain Dis. 2013, 28, 585-595.
    • (2013) Metab. Brain Dis. , vol.28 , pp. 585-595
    • Huang, W.1    Chen, Z.2    Wang, Q.3    Lin, M.4    Wu, S.5    Yan, Q.6    Wu, F.7    Yu, X.8    Xie, X.9    Li, G.10
  • 62
    • 84903218648 scopus 로고    scopus 로고
    • Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: A randomised, double-blind, placebo-controlled, cross-over investigation
    • Wightman, E.L.; Reay, J.L.; Haskell, C.F.; Williamson, G.; Dew, T.P.; Kennedy, D.O. Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: A randomised, double-blind, placebo-controlled, cross-over investigation. Br. J. Nutr. 2014, 112, 203-213.
    • (2014) Br. J. Nutr. , vol.112 , pp. 203-213
    • Wightman, E.L.1    Reay, J.L.2    Haskell, C.F.3    Williamson, G.4    Dew, T.P.5    Kennedy, D.O.6
  • 63
    • 47949101818 scopus 로고    scopus 로고
    • Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor
    • Volak, L.P.; Ghirmai, S.; Cashman, J.R.; Court, M.H. Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor. Drug Metab. Dispos. 2008, 36, 1594-1605.
    • (2008) Drug Metab. Dispos. , vol.36 , pp. 1594-1605
    • Volak, L.P.1    Ghirmai, S.2    Cashman, J.R.3    Court, M.H.4
  • 64
    • 0034491047 scopus 로고    scopus 로고
    • Glucuronidation of resveratrol, a natural compound present in wine, in the human liver
    • DeSanti, C.; Pietrabissa, A.; Mosca, F.; Pacifici, G.M. Glucuronidation of resveratrol, a natural compound present in wine, in the human liver. Xenobiotica 2000, 30, 1047-1054.
    • (2000) Xenobiotica , vol.30 , pp. 1047-1054
    • Desanti, C.1    Pietrabissa, A.2    Mosca, F.3    Pacifici, G.M.4
  • 65
    • 0033777342 scopus 로고    scopus 로고
    • Sulphation of resveratrol, a natural compound present in wine, and its inhibition by natural flavonoids
    • DeSanti, C.; Pietrabissa, A.; Spisni, R.; Mosca, F.; Pacifici, G.M. Sulphation of resveratrol, a natural compound present in wine, and its inhibition by natural flavonoids. Xenobiotica 2000, 30, 857-866.
    • (2000) Xenobiotica , vol.30 , pp. 857-866
    • Desanti, C.1    Pietrabissa, A.2    Spisni, R.3    Mosca, F.4    Pacifici, G.M.5
  • 66
    • 13844281685 scopus 로고    scopus 로고
    • Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
    • Manach, C.; Williamson, G.; Morand, C.; Scalbert, A.; Remesy, C. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am. J. Clin. Nutr. 2005, 81, 230S-242S.
    • (2005) Am. J. Clin. Nutr. , vol.81 , pp. 230S-242S
    • Manach, C.1    Williamson, G.2    Morand, C.3    Scalbert, A.4    Remesy, C.5
  • 67
    • 84896352537 scopus 로고    scopus 로고
    • Prodrugs of quercetin and resveratrol: A strategy under development
    • Biasutto, L.; Zoratti, M. Prodrugs of quercetin and resveratrol: A strategy under development. Curr. Drug Metab. 2014, 15, 77-95.
    • (2014) Curr. Drug Metab. , vol.15 , pp. 77-95
    • Biasutto, L.1    Zoratti, M.2
  • 68
    • 84875948396 scopus 로고    scopus 로고
    • Pharmacokinetics tissue distribution and excretion study of resveratrol and its prodrug 3,5,4'-tri-O-acetylresveratrol in rats
    • Liang, L.; Liu, X.; Wang, Q.; Cheng, S.; Zhang, S.; Zhang, M. Pharmacokinetics, tissue distribution and excretion study of resveratrol and its prodrug 3,5,4'-tri-O-acetylresveratrol in rats. Phytomedicine 2013, 20, 558-563.
    • (2013) Phytomedicine , vol.20 , pp. 558-563
    • Liang, L.1    Liu, X.2    Wang, Q.3    Cheng, S.4    Zhang, S.5    Zhang, M.6
  • 69
    • 79954613672 scopus 로고    scopus 로고
    • The Use of 3,5,4'-Tri-O-acetylresveratrol as a Potential Pro-drug for Resveratrol Protects Mice from gamma-Irradiation-Induced Death
    • Koide, K.; Osman, S.; Garner, A.L.; Song, F.; Dixon, T.; Greenberger, J.S.; Epperly, M.W. The Use of 3,5,4'-Tri-O-acetylresveratrol as a Potential Pro-drug for Resveratrol Protects Mice from gamma-Irradiation-Induced Death. ACS Med. Chem. Lett. 2011, 2, 270-274.
    • (2011) ACS Med. Chem. Lett. , vol.2 , pp. 270-274
    • Koide, K.1    Osman, S.2    Garner, A.L.3    Song, F.4    Dixon, T.5    Greenberger, J.S.6    Epperly, M.W.7
  • 70
    • 84899586416 scopus 로고    scopus 로고
    • Inhibition of CYP17A1 activity by resveratrol, piceatannol, and synthetic resveratrol analogs
    • Oskarsson, A.; Spatafora, C.; Tringali, C.; Andersson, A.O. Inhibition of CYP17A1 activity by resveratrol, piceatannol, and synthetic resveratrol analogs. Prostate 2014, 74, 839-851.
    • (2014) Prostate , vol.74 , pp. 839-851
    • Oskarsson, A.1    Spatafora, C.2    Tringali, C.3    Andersson, A.O.4
  • 72
    • 79959910572 scopus 로고    scopus 로고
    • Population pharmacokinetic modeling of trans-resveratrol and its glucuronide and sulfate conjugates after oral and intravenous administration in rats
    • Colom, H.; Alfaras, I.; Maijo, M.; Juan, M.E.; Planas, J.M. Population pharmacokinetic modeling of trans-resveratrol and its glucuronide and sulfate conjugates after oral and intravenous administration in rats. Pharm. Res. 2011, 28, 1606-1621.
    • (2011) Pharm. Res. , vol.28 , pp. 1606-1621
    • Colom, H.1    Alfaras, I.2    Maijo, M.3    Juan, M.E.4    Planas, J.M.5
  • 73
    • 70349843880 scopus 로고    scopus 로고
    • Quantification of trans-resveratrol and its metabolites in rat plasma and tissues by HPLC
    • Juan, M.E.; Maijo, M.; Planas, J.M. Quantification of trans-resveratrol and its metabolites in rat plasma and tissues by HPLC. J. Pharm. Biomed. Anal. 2010, 51, 391-398.
    • (2010) J. Pharm. Biomed. Anal. , vol.51 , pp. 391-398
    • Juan, M.E.1    Maijo, M.2    Planas, J.M.3
  • 74
    • 84899138870 scopus 로고    scopus 로고
    • Resveratrol induces acute endothelium-dependent renal vasodilation mediated through nitric oxide and reactive oxygen species scavenging
    • Gordish, K.L.; Beierwaltes, W.H. Resveratrol induces acute endothelium-dependent renal vasodilation mediated through nitric oxide and reactive oxygen species scavenging. Am. J. Physiol.-Ren. Physiol. 2014, 306, F542-F550.
    • (2014) Am. J. Physiol.-Ren. Physiol. , vol.306 , pp. F542-F550
    • Gordish, K.L.1    Beierwaltes, W.H.2
  • 75
    • 51349111445 scopus 로고    scopus 로고
    • The effects of resveratrol on vasospasm after experimental subarachnoidal hemorrhage in rats
    • Karaoglan, A.; Akdemir, O.; Barut, S.; Kokturk, S.; Uzun, H.; Tasyurekli, M.; Colak, A. The effects of resveratrol on vasospasm after experimental subarachnoidal hemorrhage in rats. Surg. Neurol. 2008, 70, 337-343.
    • (2008) Surg. Neurol. , vol.70 , pp. 337-343
    • Karaoglan, A.1    Akdemir, O.2    Barut, S.3    Kokturk, S.4    Uzun, H.5    Tasyurekli, M.6    Colak, A.7
  • 76
    • 77956647573 scopus 로고    scopus 로고
    • Therapeutic effects of resveratrol during acute periods following experimental ischemic stroke
    • Shin, J.A.; Lee, H.; Lim, Y.K.; Koh, Y.; Choi, J.H.; Park, E.M. Therapeutic effects of resveratrol during acute periods following experimental ischemic stroke. J. Neuroimmunol. 2010, 227, 93-100.
    • (2010) J. Neuroimmunol. , vol.227 , pp. 93-100
    • Shin, J.A.1    Lee, H.2    Lim, Y.K.3    Koh, Y.4    Choi, J.H.5    Park, E.M.6
  • 77
    • 79954424091 scopus 로고    scopus 로고
    • Cyclodextrin-based nanosponges for delivery of resveratrol: In vitro characterisation, stability, cytotoxicity and permeation study
    • Ansari, K.A.; Vavia, P.R.; Trotta, F.; Cavalli, R. Cyclodextrin-Based Nanosponges for Delivery of Resveratrol: In Vitro Characterisation, Stability, Cytotoxicity and Permeation Study. AAPS PharmSciTech 2011, 12, 279-286.
    • (2011) AAPS PharmSciTech , vol.12 , pp. 279-286
    • Ansari, K.A.1    Vavia, P.R.2    Trotta, F.3    Cavalli, R.4
  • 78
    • 84896373168 scopus 로고    scopus 로고
    • Development of a lozenge for oral transmucosal delivery of trans-resveratrol in humans: Proof of concept
    • Blanchard, O.L.; Friesenhahn, G.; Javors, M.A.; Smoliga, J.M. Development of a lozenge for oral transmucosal delivery of trans-resveratrol in humans: Proof of concept. PLoS One 2014, 9, e90131.
    • (2014) PLoS One , vol.9 , pp. e90131
    • Blanchard, O.L.1    Friesenhahn, G.2    Javors, M.A.3    Smoliga, J.M.4
  • 80
    • 0036058720 scopus 로고    scopus 로고
    • Oral mucosal drug delivery: Clinical pharmacokinetics and therapeutic applications
    • Zhang, H.; Zhang, J.; Streisand, J.B. Oral mucosal drug delivery: Clinical pharmacokinetics and therapeutic applications. Clin. Pharmacokinet. 2002, 41, 661-680.
    • (2002) Clin. Pharmacokinet. , vol.41 , pp. 661-680
    • Zhang, H.1    Zhang, J.2    Streisand, J.B.3
  • 82
    • 84878923206 scopus 로고    scopus 로고
    • Pharmacokinetics of pterostilbene in Sprague-Dawley rats: The impacts of aqueous solubility, fasting, dose escalation, and dosing route on bioavailability
    • Yeo, S.C.; Ho, P.C.; Lin, H.S. Pharmacokinetics of pterostilbene in Sprague-Dawley rats: The impacts of aqueous solubility, fasting, dose escalation, and dosing route on bioavailability. Mol. Nutr. Food Res. 2013, 57, 1015-1025.
    • (2013) Mol. Nutr. Food Res. , vol.57 , pp. 1015-1025
    • Yeo, S.C.1    Ho, P.C.2    Lin, H.S.3
  • 83
    • 0036082463 scopus 로고    scopus 로고
    • Metabolism and disposition of resveratrol in rats: Extent of absorption, glucuronidation, and enterohepatic recirculation evidenced by a linked-rat model
    • Marier, J.F.; Vachon, P.; Gritsas, A.; Zhang, J.; Moreau, J.P.; Ducharme, M.P. Metabolism and disposition of resveratrol in rats: Extent of absorption, glucuronidation, and enterohepatic recirculation evidenced by a linked-rat model. J. Pharmacol. Exp. Ther. 2002, 302, 369-373.
    • (2002) J. Pharmacol. Exp. Ther. , vol.302 , pp. 369-373
    • Marier, J.F.1    Vachon, P.2    Gritsas, A.3    Zhang, J.4    Moreau, J.P.5    Ducharme, M.P.6
  • 84
    • 41149108165 scopus 로고    scopus 로고
    • Miracle stents"-A future without restenosis
    • Hamid, H.; Coltart, J. "Miracle stents"-A future without restenosis. McGill J. Med. 2007, 10, 105-111.
    • (2007) McGill J. Med. , vol.10 , pp. 105-111
    • Hamid, H.1    Coltart, J.2
  • 85
    • 84859486576 scopus 로고    scopus 로고
    • Novel nanocomposite stent coating releasing resveratrol and quercetin reduces neointimal hyperplasia and promotes re-endothelialization
    • Kleinedler, J.J.; Foley, J.D.; Orchard, E.A.; Dugas, T.R. Novel nanocomposite stent coating releasing resveratrol and quercetin reduces neointimal hyperplasia and promotes re-endothelialization. J. Control. Release 2012, 159, 27-33.
    • (2012) J. Control. Release , vol.159 , pp. 27-33
    • Kleinedler, J.J.1    Foley, J.D.2    Orchard, E.A.3    Dugas, T.R.4
  • 86
    • 84900539922 scopus 로고    scopus 로고
    • Resveratrol promotes endothelial cell wound healing under laminar shear stress through an estrogen receptor-alpha-dependent pathway
    • Yurdagul, A., Jr.; Kleinedler, J.J.; McInnis, M.C.; Khandelwal, A.R.; Spence, A.L.; Orr, A.W.; Dugas, T.R. Resveratrol promotes endothelial cell wound healing under laminar shear stress through an estrogen receptor-alpha-dependent pathway. Am. J. Physiol. 2014, 306, H797-H806.
    • (2014) Am. J. Physiol. , vol.306 , pp. H797-H806
    • Yurdagul, A.1    Kleinedler, J.J.2    McInnis, M.C.3    Khandelwal, A.R.4    Spence, A.L.5    Orr, A.W.6    Dugas, T.R.7
  • 87
    • 78249238536 scopus 로고    scopus 로고
    • Essential role of ER-alpha-dependent NO production in resveratrol-mediated inhibition of restenosis
    • Khandelwal, A.R.; Hebert, V.Y.; Dugas, T.R. Essential role of ER-alpha-dependent NO production in resveratrol-mediated inhibition of restenosis. Am. J. Physiol. 2010, 299, H1451-H1458.
    • (2010) Am. J. Physiol. , vol.299 , pp. H1451-H1458
    • Khandelwal, A.R.1    Hebert, V.Y.2    Dugas, T.R.3
  • 88
    • 83055165711 scopus 로고    scopus 로고
    • Evaluation of the stability and antioxidant activity of nanoencapsulated resveratrol during in vitro digestion
    • Sessa, M.; Tsao, R.; Liu, R.; Ferrari, G.; Donsi, F. Evaluation of the stability and antioxidant activity of nanoencapsulated resveratrol during in vitro digestion. J. Agric. Food Chem. 2011, 59, 12352-12360.
    • (2011) J. Agric. Food Chem. , vol.59 , pp. 12352-12360
    • Sessa, M.1    Tsao, R.2    Liu, R.3    Ferrari, G.4    Donsi, F.5
  • 90
    • 77956156498 scopus 로고    scopus 로고
    • Anticancer activity and molecular mechanism of resveratrol-bovine serum albumin nanoparticles on subcutaneously implanted human primary ovarian carcinoma cells in nude mice
    • Guo, L.; Peng, Y.; Yao, J.; Sui, L.; Gu, A.; Wang, J. Anticancer activity and molecular mechanism of resveratrol-bovine serum albumin nanoparticles on subcutaneously implanted human primary ovarian carcinoma cells in nude mice. Cancer Biother. Radiopharm. 2010, 25, 471-477.
    • (2010) Cancer Biother. Radiopharm. , vol.25 , pp. 471-477
    • Guo, L.1    Peng, Y.2    Yao, J.3    Sui, L.4    Gu, A.5    Wang, J.6
  • 91
    • 84870301607 scopus 로고    scopus 로고
    • Pharmacokinetics and tissue distribution of resveratrol, emodin and their metabolites after intake of Polygonum cuspidatum in rats
    • Lin, S.P.; Chu, P.M.; Tsai, S.Y.; Wu, M.H.; Hou, Y.C. Pharmacokinetics and tissue distribution of resveratrol, emodin and their metabolites after intake of Polygonum cuspidatum in rats. J. Ethnopharmacol. 2012, 144, 671-676.
    • (2012) J. Ethnopharmacol. , vol.144 , pp. 671-676
    • Lin, S.P.1    Chu, P.M.2    Tsai, S.Y.3    Wu, M.H.4    Hou, Y.C.5
  • 92
    • 84894232455 scopus 로고    scopus 로고
    • Simultaneous quantification of trans-resveratrol and its sulfate and glucuronide metabolites in rat tissues by stable isotope-dilution UPLC-MS/MS analysis
    • Lou, B.S.; Wu, P.S.; Hou, C.W.; Cheng, F.Y.; Chen, J.K. Simultaneous quantification of trans-resveratrol and its sulfate and glucuronide metabolites in rat tissues by stable isotope-dilution UPLC-MS/MS analysis. J. Pharmaceut. Biomed. Anal. 2014, 94, 99-105.
    • (2014) J. Pharmaceut. Biomed. Anal. , vol.94 , pp. 99-105
    • Lou, B.S.1    Wu, P.S.2    Hou, C.W.3    Cheng, F.Y.4    Chen, J.K.5
  • 93
    • 51549099603 scopus 로고    scopus 로고
    • Tissue distribution and excretion of resveratrol in rat after oral administration of Polygonum cuspidatum extract (PCE)
    • Wang, D.; Xu, Y.; Liu, W. Tissue distribution and excretion of resveratrol in rat after oral administration of Polygonum cuspidatum extract (PCE). Phytomedicine 2008, 15, 859-866.
    • (2008) Phytomedicine , vol.15 , pp. 859-866
    • Wang, D.1    Xu, Y.2    Liu, W.3
  • 94
    • 84907197092 scopus 로고    scopus 로고
    • Recent advances of resveratrol in nanostructured based delivery systems and in the management of HIV/AIDS
    • Singh, G.; Pai, R.S. Recent advances of resveratrol in nanostructured based delivery systems and in the management of HIV/AIDS. J. Control. Release 2014, 194, 178-188.
    • (2014) J. Control. Release , vol.194 , pp. 178-188
    • Singh, G.1    Pai, R.S.2
  • 95
    • 84895928174 scopus 로고    scopus 로고
    • Application of nanotechnology in improving bioavailability and bioactivity of diet-derived phytochemicals
    • Wang, S.; Su, R.; Nie, S.; Sun, M.; Zhang, J.; Wu, D.; Moustaid-Moussa, N. Application of nanotechnology in improving bioavailability and bioactivity of diet-derived phytochemicals. J. Nutr. Biochem. 2014, 25, 363-376.
    • (2014) J. Nutr. Biochem. , vol.25 , pp. 363-376
    • Wang, S.1    Su, R.2    Nie, S.3    Sun, M.4    Zhang, J.5    Wu, D.6    Moustaid-Moussa, N.7
  • 101
    • 84878061243 scopus 로고    scopus 로고
    • Resveratrol Metabolites Modify Adipokine Expression and Secretion in 3T3-L1 Pre-Adipocytes and Mature Adipocytes
    • Eseberri, I.; Lasa, A.; Churruca, I.; Portillo, M.P. Resveratrol Metabolites Modify Adipokine Expression and Secretion in 3T3-L1 Pre-Adipocytes and Mature Adipocytes. PLoS One 2013, 8, e63918.
    • (2013) PLoS One , vol.8 , pp. e63918
    • Eseberri, I.1    Lasa, A.2    Churruca, I.3    Portillo, M.P.4
  • 102
    • 84879080696 scopus 로고    scopus 로고
    • Influence of glucuronidation and reduction modifications of resveratrol on its biological activities
    • Lu, D.L.; Ding, D.J.; Yan, W.J.; Li, R.R.; Dai, F.; Wang, Q.; Yu, S.S.; Li, Y.; Jin, X.L.; Zhou, B. Influence of glucuronidation and reduction modifications of resveratrol on its biological activities. ChemBioChem 2013, 14, 1094-1104.
    • (2013) ChemBioChem , vol.14 , pp. 1094-1104
    • Lu, D.L.1    Ding, D.J.2    Yan, W.J.3    Li, R.R.4    Dai, F.5    Wang, Q.6    Yu, S.S.7    Li, Y.8    Jin, X.L.9    Zhou, B.10
  • 105
    • 84864296345 scopus 로고    scopus 로고
    • Arterial pharmacokinetics of red wine polyphenols: Implications for novel endovascular therapies targeting restenosis
    • Kleinedler, J.J.; Pjescic, I.; Bullock, K.K.; Khaliq, A.; Foley, J.D.; Dugas, T.R. Arterial pharmacokinetics of red wine polyphenols: Implications for novel endovascular therapies targeting restenosis. J. Pharm. Sci. 2012, 101, 1917-1931.
    • (2012) J. Pharm. Sci. , vol.101 , pp. 1917-1931
    • Kleinedler, J.J.1    Pjescic, I.2    Bullock, K.K.3    Khaliq, A.4    Foley, J.D.5    Dugas, T.R.6
  • 106
    • 33645780634 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase in vascular disease: From marvel to menace
    • Forstermann, U.; Munzel, T. Endothelial nitric oxide synthase in vascular disease: From marvel to menace. Circulation 2006, 113, 1708-1714.
    • (2006) Circulation , vol.113 , pp. 1708-1714
    • Forstermann, U.1    Munzel, T.2
  • 107
    • 0031582881 scopus 로고    scopus 로고
    • Gas chromatographic analysis of resveratrol in plasma, lipoproteins and cells after in vitro incubations
    • Blache, D.; Rustan, I.; Durand, P.; Lesgards, G.; Loreau, N. Gas chromatographic analysis of resveratrol in plasma, lipoproteins and cells after in vitro incubations. J. Chromatogr. B 1997, 702, 103-110.
    • (1997) J. Chromatogr. B , vol.702 , pp. 103-110
    • Blache, D.1    Rustan, I.2    Durand, P.3    Lesgards, G.4    Loreau, N.5
  • 108
    • 77957315722 scopus 로고    scopus 로고
    • Determination of quercetin and resveratrol in whole blood-implications for bioavailability studies
    • Biasutto, L.; Marotta, E.; Garbisa, S.; Zoratti, M.; Paradisi, C. Determination of quercetin and resveratrol in whole blood-implications for bioavailability studies. Molecules 2010, 15, 6570-6579.
    • (2010) Molecules , vol.15 , pp. 6570-6579
    • Biasutto, L.1    Marotta, E.2    Garbisa, S.3    Zoratti, M.4    Paradisi, C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.