Oral transmucosal etomidate in volunteers

Anesthesiology

Volumn 88, Issue 1, 1998, Pages 89-95

  Streisand, James B ^a,c   Jaarsma, Ruurd L ^b   Gay, Mason A ^b   Badger, Mary Jane ^b   Maland, Lynn ^a   Nordbrock, Earl ^b   Stanley, Theodore H ^b  

^a UNIVERSITY OF UTAH   (United States)

^b Anesta Corporation   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Dose proportionality; Etomidate; Hypnotics; Transmucosal drug delivery

Indexed keywords

ETOMIDATE;

ADULT; ARTICLE; DOSE RESPONSE; DROWSINESS; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG FORMULATION; DRUG UPTAKE; HUMAN; HUMAN EXPERIMENT; MALE; MOUTH MUCOSA; NAUSEA; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SEDATION; TRANQUILIZING ACTIVITY; TREMOR;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; ETOMIDATE; HUMANS; HYPNOTICS AND SEDATIVES; MALE; MOUTH MUCOSA;

EID: 0031962519     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-199801000-00016     Document Type: Article

References (14)

1. Karl H\V, RosenbergerJL, Larach MG, Ruffle JM, Transmucosal administration of midazolam for premedication of pédiatrie patients: A comparison of the nasal sublingual routes. ANESTIIESIOLOGY 1993; 78:885-91
2. Streisand J, Van-el J, Stanski D, LeMaire L, Asburn MA, Hague BI, Tarver SD, Stanley TH, Absorption and bioavailabilitj' of oral transmucosal fentanyl citrate. AXESTHESIOLOGY 1991; 75:223-9
3. Zhang J, Niu S, Maland L, Hague BI, Hamilton C, Coleman DL, Streisand JB, Stanley TH, Buccal absorption kinetics of etomidate from a solid dosage form in dogs: A deconvolution analysis. Pharm Res 1993; 10:5202
4. LeMoing J, Levron J, High-performance liquid Chromatographie determination of etomidate in plasma. J Chrom 1990; 529:217-22
5. Avram M, Fragen R, Linde H, High-performance liquid Chromatographie assay for etomidate in human plasma: Results of preliminary clinical studies using etomidate for hypnosis in total intravenous anesthesia. J Pharm Sei 1983; 72:1424-6
6. Gibaldi M, Perrier D, Absorption kinetics and bioavailability, Pharmacokinetics. Edited by J Swarbrick. New York, Marcel Dekker, 1982, pp 145-98
7. Urquhart M, White P, Comparison of sedative infusions during regional anesthesia-methohexital, etomidate, and midazolam. Anesth Analg 1989; 68:249-54
8. Glass P, Gupta V, Ginsberg B, Gan T: Do sedatives at equipo tency produce equivalent respirator}' depression? ANESTHESIOLOGY 1996; 85(3A):A1120
9. Giese J, Stockham R, Stanley T, Pace N, Nelissen R, Etomidate versus thiopental for induction of anesthesia. Anesth Analg 1985; 64:871-6
10. Longnecker D: Stress free: To be or not to be? ANESTHESIOLOGY 1984; 61:643-4
11. Wagner R, White P, Etomidate inhibits adrenocortical function in surgical patients. ANESTHESIOLOGY 1984; 61:647-51
12. Streisand J, Busch M, Gaylord B, Gay M, East K, Dose proportionality of oral transmucosal fentanyl citrate in human volunteers. ANESTHESIOLOGY 1996; 85(3A):A322
13. Arden J, Holley F, Stanski D, Increased sensitivity to etomidate in the elderly: Initial distribution versus altered brain response. ANESTHESIOLOGY 1986; 65:19-27
14. Schuttler J, Schwilden H, Stoeckel II, Infusion strategies to investigate the pharmacokinetics and pharmacodynamics of hypnotic drugs: Etomidate as an example. Eur J Anaesthesiol 1985; 2:133-42