Pharmacokinetics and tissue distribution of resveratrol, emodin and their metabolites after intake of Polygonum cuspidatum in rats

Journal of Ethnopharmacology

Volumn 144, Issue 3, 2012, Pages 671-676

  Lin, Shiuan Pey ^a   Chu, Pei Ming ^b   Tsai, Shang Yuan ^a   Wu, Meng Hao ^a   Hou, Yu Chi ^a,c  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Emodin; Metabolites; Pharmacokinetics; Polygonum cuspidatum; Resveratrol; Tissue distribution

Indexed keywords

BETA GLUCURONIDASE; DRUG METABOLITE; EMODIN; POLYGONUM CUSPIDATUM EXTRACT; RESVERATROL; SULFATASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CONJUGATION; DRUG DISTRIBUTION; DRUG LIVER LEVEL; DRUG TISSUE LEVEL; HEART; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; KIDNEY; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NONHUMAN; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION; TISSUE DISTRIBUTION;

ANIMALS; BRAIN; EMODIN; GLUCURONIDES; KIDNEY; LIVER; LUNG; MALE; MYOCARDIUM; PLANT EXTRACTS; POLYGONUM CUSPIDATUM; RATS; RATS, SPRAGUE-DAWLEY; RHIZOME; STILBENES; TISSUE DISTRIBUTION;

POLYGONACEAE; POLYGONUM CUSPIDATUM; RATTUS;

EID: 84870301607     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2012.10.009     Document Type: Article

References (40)

1. M. Azorin-Ortuno, M.J. Yanez-Gascon, F.J. Pallares, F. Vallejo, M. Larrosa, M.T. Garcia-Conesa, F. Tomas-Barberan, and J.C. Espin Pharmacokinetic study of trans-resveratrol in adult pigs Journal of Agricultural Food Chemistry 58 2010 11165 11171
2. M. Azorin-Ortuno, M.J. Yanez-Gascon, F. Vallejo, F.J. Pallares, M. Larrosa, R. Lucas, J.C. Morales, F.A. Tomas-Barberan, M.T. Garcia-Conesa, and J.C. Espin Metabolites and tissue distribution of resveratrol in the pig Molecular Nutrition & Food Research 55 2011 1154 1168
3. L. Baolin, Y. Inami, H. Tanaka, N. Inagaki, M. Iinuma, and H. Nagai Resveratrol inhibits the release of mediators from bone marrow-derived mouse mast cells in vitro Planta Medica 70 2004 305 309
4. S. Bastianetto, W.H. Zheng, and R. Quirion Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide-related toxicity in cultured hippocampal neurons British Journal of Pharmacology 131 2000 711 720
5. J.A. Baur, and D.A. Sinclair Therapeutic potential of resveratrol: the in vivo evidence Nature Reviews Drug Discovery 5 2006 493 506
6. M. Bhadauria Dose-dependent hepatoprotective effect of emodin against acetaminophen-induced acute damage in rats Experimental and Toxicologic Pathology 62 2010 627 635
7. Chinese Pharmacopoeia Committee 2000 Chemical Industry Press Beijing
8. C. De Santi, A. Pietrabissa, F. Mosca, and G.M. Pacifici Glucuronidation of resveratrol, a natural product present in grape and wine, in the human liver Xenobiotica 30 2000 1047 1054
9. C. De Santi, A. Pietrabissa, R. Spisni, F. Mosca, and G.M. Pacifici Sulphation of resveratrol, a natural product present in grapes and wine, in the human liver and duodenum Xenobiotica 30 2000 609 617
10. S. Fabris, F. Momo, G. Ravagnan, and R. Stevanato Antioxidant properties of resveratrol and piceid on lipid peroxidation in micelles and monolamellar liposomes Biophysical Chemistry 135 2008 76 83
11. S.H. Fang, Y.C. Hou, W.C. Chang, S.L. Hsiu, P.D. Chao, and B.L. Chiang Morin sulfates/glucuronides exert anti-inflammatory activity on activated macrophages and decreased the incidence of septic shock Life Sciences 74 2003 743 756
12. J.W. Gu, H. Hasuo, M. Takeya, and T. Akasu Effects of emodin on synaptic transmission in rat hippocampal CA1 pyramidal neurons in vitro Neuropharmacology 49 2005 103 111
13. Y.S. Han, W.H. Zheng, S. Bastianetto, J.G. Chabot, and R. Quirion Neuroprotective effects of resveratrol against beta-amyloid-induced neurotoxicity in rat hippocampal neurons: involvement of protein kinase C British Journal of Pharmacology 141 2004 997 1005
14. C.M. Hsu, Y.A. Hsu, Y. Tsai, F.K. Shieh, S.H. Huang, L. Wan, and F.J. Tsai Emodin inhibits the growth of hepatoma cells: finding the common anti-cancer pathway using Huh7, Hep3B, and HepG2 cells Biochemical and Biophysical Research Communications 392 2010 473 478
15. W.Y. Huang, Y.Z. Cai, J. Xing, H. Corke, and M. Sun Comparative analysis of bioactivities of four Polygonum species Planta Medica 74 2008 43 49
16. J.H. Jang, and Y.J. Surh Protective effect of resveratrol on beta-amyloid-induced oxidative PC12 cell death Free Radical Biology & Medicine 34 2003 1100 1110
17. M. Jang, L. Cai, G.O. Udeani, K.V. Slowing, C.F. Thomas, C.W. Beecher, H.H. Fong, N.R. Farnsworth, A.D. Kinghorn, R.G. Mehta, R.C. Moon, and J.M. Pezzuto Cancer chemopreventive activity of resveratrol, a natural product derived from grapes Science 275 1997 218 220
18. Y. Kimura, H. Ohminami, H. Okuda, K. Baba, M. Kozawa, and S. Arichi Effects of stilbene components of roots of Polygonum ssp. on liver injury in peroxidized oil-fed rats Planta Medica 49 1983 51 54
19. A. Kitano, S. Saika, O. Yamanaka, K. Ikeda, Y. Okada, K. Shirai, and P.S. Reinach Emodin suppression of ocular surface inflammatory reaction Investigative Ophthalmology & Visual Science 48 2007 5013 5022
20. M. Kumerz, E.H. Heiss, D. Schachner, A.G. Atanasov, and V.M. Dirsch Resveratrol inhibits migration and Rac1 activation in EGF-but not PDGF-activated vascular smooth muscle cells Molecular Nutrition & Food Research 55 2011 1230 1236
21. B.H. Lee, Y.Y. Huang, P.D. Duh, and S.C. Wu Hepatoprotection of emodin and Polygonum multiflorum against CCl(4)-induced liver injury Pharmaceutical Biology 50 2012 351 359
22. C.C. Lin, C.H. Chang, J.J. Yang, T. Namba, and M. Hattori Hepatoprotective effects of emodin from Ventilago leiocarpa Journal of Ethnopharmacology 52 1996 107 111
23. J.F. Marier, P. Vachon, A. Gritsas, J. Zhang, J.P. Moreau, and M.P. Ducharme Metabolism and disposition of resveratrol in rats: extent of absorption, glucuronidation, and enterohepatic recirculation evidenced by a linked-rat model The Journal of Pharmacology Experimental Therapeutics 302 2002 369 373
24. K.D. McMurtrey Resveratrol in wine T.R. Watkins, Wine: Nutritional and Therapeutic Benefits 1996 American Chemical Society Washington, DC
25. X. Shang, and Z. Yuan Determination of active components in rhubarb and study of their hydrophobicity by micellar electrokinetic chromatography Bioorganic & Medicinal Chemistry Letters 13 2003 617 622
26. C.S. Shia, Y.C. Hou, S.H. Juang, S.Y. Tsai, P.H. Hsieh, L.C. Ho, and P.D. Chao Metabolism and pharmacokinetics of San-Huang-Xie-Xin-Tang, a polyphenol-rich Chinese medicine formula, in rats and ex-vivo antioxidant activity Evidence Based Complementary and Alternative Medicine 2011 2009 721293
27. C.S. Shia, Y.C. Hou, S.Y. Tsai, P.H. Huieh, Y.L. Leu, and P.D. Chao Differences in pharmacokinetics and ex vivo antioxidant activity following intravenous and oral administrations of emodin to rats Journal of Pharmaceutical Sciences 99 2010 2185 2195
28. C.S. Shia, S.H. Juang, S.Y. Tsai, P.H. Chang, S.C. Kuo, Y.C. Hou, and P.D. Chao Metabolism and pharmacokinetics of anthraquinones in Rheum palmatum in rats and ex vivo antioxidant activity Planta Medica 75 2009 1386 1392
29. C.S. Shia, S.Y. Tsai, J.C. Lin, M.L. Li, M.H. Ko, P.D. Chao, Y.C. Huang, and Y.C. Hou Steady-state pharmacokinetics and tissue distribution of anthraquinones of Rhei Rhizoma in rats Journal of Ethnopharmacology 137 2011 1388 1394
30. M. Shirai, Y. Kawai, R. Yamanishi, T. Kinoshita, H. Chuman, and J. Terao Effect of a conjugated quercetin metabolite, quercetin 3-glucuronide, on lipid hydroperoxide-dependent formation of reactive oxygen species in differentiated PC-12 cells Free Radical Research 40 2006 1047 1053
31. J.M. Smoliga, J.A. Baur, and H.A. Hausenblas Resveratrol and health-a comprehensive review of human clinical trials Molecular Nutrition & Food Research 55 2011 1129 1141
32. P. Vitaglione, S. Sforza, G. Galaverna, C. Ghidini, N. Caporaso, P.P. Vescovi, V. Fogliano, and R. Marchelli Bioavailability of trans-resveratrol from red wine in humans Molecular Nutrition & Food Research 49 2005 495 504
33. D. Wang, Y. Xu, and W. Liu Tissue distribution and excretion of resveratrol in rat after oral administration of Polygonum cuspidatum extract (PCE) Phytomedicine 15 2008 859 866
34. E. Wenzel, and V. Somoza Metabolism and bioavailability of trans-resveratrol Molecular Nutrition & Food Research 49 2005 472 481
35. X.B. Wu, X.Q. Luo, S.Y. Gu, and J.H. Xu The effects of Polygonum cuspidatum extract on wound healing in rats Journal of Ethnopharmacology 141 2012 934 937
36. H.R. Xiong, J. Luo, W. Hou, H. Xiao, and Z.Q. Yang The effect of emodin, an anthraquinone derivative extracted from the roots of Rheum tanguticum, against herpes simplex virus in vitro and in vivo Journal of Ethnopharmacology 133 2011 718 723
37. J.H. Yang, T.C. Hsia, H.M. Kuo, P.D. Chao, C.C. Chou, Y.H. Wei, and J.G. Chung Inhibition of lung cancer cell growth by quercetin glucuronides via G2/M arrest and induction of apoptosis Drug Metabolism and Disposition 34 2006 296 304
38. S.F. Yeh, T.C. Chou, and T.S. Liu Effects of anthraquinones of Polygonum cuspidatum on HL-60 cells Planta Medica 54 1988 413 414
39. S. Yoshino, A. Hara, H. Sakakibara, K. Kawabata, A. Tokumura, A. Ishisaka, Y. Kawai, and J. Terao Effect of quercetin and glucuronide metabolites on the monoamine oxidase-A reaction in mouse brain mitochondria Nutrition 27 2011 847 852
40. Y. Zhan, D. Li, H. Wei, Z. Wang, X. Huang, Q. Xu, and H. Lu Emodin on hepatic fibrosis in rats Chinese Medical Journal 113 2000 599 601