Determination of quercetin and resveratrol in whole blood-implications for bioavailability studies

Molecules

Volumn 15, Issue 9, 2010, Pages 6570-6579

  Biasutto, Lucia ^a   Marotta, Ester ^a   Garbisa, Spiridione ^a   Zoratti, Mario ^a,b   Paradisi, Cristina ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b CNR   (Italy)

Author keywords

Bioavailability; Blood analysis; HPLC; Plasma; Polyphenols; Quercetin; Resveratrol

Indexed keywords

FLAVONOID; PHENOL DERIVATIVE; POLYPHENOLS; QUERCETIN; RESVERATROL; STILBENE DERIVATIVE;

ARTICLE; BIOAVAILABILITY; BLOOD; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; STANDARD; TECHNIQUE;

BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLAVONOIDS; HUMANS; METHODS; PHENOLS; QUERCETIN; REFERENCE STANDARDS; STILBENES;

EID: 77957315722     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules15096570     Document Type: Article

References (38)

1. Daayf, F., Lattanzio, V., Eds. Recent Advances in Polyphenol Research; Wiley-Blackwell: Oxford, UK, 2008.
2. Bischoff, S. C. Quercetin: potentials in the prevention and therapy of disease. Curr. Opin. Clin. Nutr. Metab. Care 2008, 11, 733-740.
3. Murakami, A.; Ashida, H.; Terao, J. Multitargeted cancer prevention by quercetin. Cancer Lett. 2008, 269, 315-325.
4. Pervaiz, S.; Holme, A. L.; Aggarwal, B. B.; Anekonda, T. S.; Baur, J. A.; Gojkovic-Bukarica, L.; Ragione, F. D.; Kim, A. L.; Pirola, L.; Saiko, P. Resveratrol: its biologic targets and functional activity. Antioxid. Redox Signal. 2009, 11, 2851-2897.
5. Athar, M.; Back, J. H.; Kopelovich, L.; Bickers, D. R.; Kim, A. L. Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms. Arch. Biochem. Biophys. 2009, 486, 95-102.
6. Biasutto, L.; Marotta, E.; De Marchi, U.; Zoratti, M.; Paradisi, C. Ester-based precursors to increase the bioavailability of quercetin. J. Med. Chem. 2007, 50, 241-253.
7. Biasutto, L.; Marotta, E.; Bradaschia, A.; Fallica, M.; Mattarei, A.; Garbisa, S.; Zoratti, M.; Paradisi, C. Soluble polyphenols: synthesis and bioavailability of 3, 4′, 5-tri (alpha-D-glucose-3-O-succinyl) resveratrol. Bioorg. Med. Chem. Lett. 2009, 19, 6721-6724.
8. Das, S.; Lin, H. S.; Ho, P. C.; Ng, K. Y. The impact of aqueous solubility and dose on the pharmacokinetic profiles of resveratrol. Pharm. Res. 2008, 25, 2593-2600.
9. Li, H.; Zhao, X.; Ma, Y.; Zhai, G.; Li, L.; Lou, H. Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles. J. Control. Release 2009, 133, 238-244.
10. Soleas, G. J.; Yan, J.; Goldberg, D. M. Ultrasensitive assay for three polyphenols (catechin, quercetin and resveratrol) and their conjugates in biological fluids utilizing gas chromatography with mass selective detection. J. Chromatogr. B 2001, 757, 161-172.
11. Lai, X.; Zhao, Y.; Liang, H.; Bai, Y.; Wang, B.; Guo, D. SPE-HPLC method for the determination of four flavonols in rat plasma and urine after oral administration of Abelmoschus manihot extract. J. Chromatogr. B 2007, 852, 108-114. (Pubitemid 46830089)
12. Juan, M. E.; Lamuela-Raventòs, R. M.; De La Torre-Boronat, M. C.; Planas, J. M. Determination of trans-resveratrol in plasma by HPLC. Anal. Chem. 1999, 71, 747-750.
13. He, H.; Chen, X.; Wang, G.; Wang, J.; Davey, A. K. High-performance liquid chromatography spectrometric analysis of trans-resveratrol in rat plasma. J. Chromatogr. B 2006, 832, 177-180. (Pubitemid 43339942)
14. Boocock, D. J.; Patel, K. R.; Faust, G. E. S.; Normolle, D. P.; Marczylo, T. H.; Crowell, J. A.; Brenner, D. E.; Booth, T. D.; Gescher, A.; Steward, W. P. Quantitation of trans-resveratrol and detection of its metabolites in human plasma and urine by high performance liquid chromatography. J. Chromatogr. B 2007, 848, 182-187.
15. Jones, D. J. L.; Lim, C. K.; Ferry, D. R.; Gescher, A. Determination of quercetin in human plasma by HPLC with spectrophotometric or electrochemical detection. Biomed. Chromatogr. 1998, 12, 232-235.
16. Ishii, K.; Furuta, T.; Kasuya, Y. High performance liquid chromatographic determination of quercetin in human plasma and urine utilizing solid-phase extraction and ultraviolet detection. J. Chromatogr. B 2003, 794, 49-56.
17. Vitaglione, P.; Sforza, S.; Galaverna, G.; Ghidini, C.; Caporasol, N.; Vescovi, P. P.; Fogliano, V.; Marchelli, R. Bioavailability of trans-resveratrol from red wine in humans. Mol. Nutr. Food Res. 2005, 49, 495-504.
18. Boocock, D. J.; Faust, G. E. S.; Patel, K. R.; Schinas, A. M.; Brown, V. A.; Ducharme, M. P.; Booth, T. D.; Crowell, J. A.; Perloff, M.; Gescher, A. J.; Steward, W. P.; Brenner, D. E. Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent. Cancer Epidem. Biomarker. Prev. 2007, 16, 1246-1252.
19. Moon, Y. J.; Wang, L.; Di Cenzo, R.; Morris, M. E. Quercetin pharmacokinetics in humans. Biopharm. Drug Dispos. 2008, 29, 205-217.
20. Fiorani, M.; Accorsi, A.; Cantoni, O. Human red blood cells as a natural flavonoid reservoir. Free Radical Res. 2003, 37, 1331-1338.
21. Fiorani, M.; Guidarelli, A.; Blasa, M.; Azzolini, C.; Candiracci, M.; Piatti, E.; Cantoni, O. Mitochondria accumulate large amounts of quercetin: prevention of mitochondrial damage and release upon oxidation of the extramitochondrial fraction of the flavonoid. J. Nutr. Biochem. 2010, 21, 397-404.
22. Chandhuri, S.; Banerjee, A.; Basu, K.; Sengupta, B.; Sengupta, P. K. Interaction of flavonoids with red blood cell membrane lipids and proteins: antioxidant and antihemolytic effects. Int. J. Biol. Macromol. 2007, 41, 42-48.
23. Blache, D.; Rustan, I.; Durand, P.; Lesgards, G.; Loreau, N. Gas chromatographic analysis of resveratrol in plasma, lipoproteins and cells after in vitro incubations. J. Chromatogr. B 1997, 702, 103-110.
24. Chen, Y.; Deuster, P. Comparison of quercetin and dihydroquercetin: antioxidant-independent actions on erythrocyte and platelet membrane. Chem.-Biol. Interact. 2009, 182, 7-12.
25. Shank, R. P.; Doose, D. R.; Streeter, A. J.; Bialer, M. Plasma and whole blood pharmacokinetics of topiramate: the role of carbonic anhydrase. Epilepsy Res. 2005, 63, 103-112.
26. Diniz, A.; Escuder-Gilabert, L.; Lopes, N. P.; Villanueva-Camañas, R. M.; Sagrado, S.; Medina-Hernández, M. J. Characterization of interactions between polyphenolic compounds and human serum proteins by capillary electrophoresis. Anal. Bioanal. Chem. 2008, 391, 625-632.
27. Rolinski, O. J.; Martin, A.; Birch, D. J. Human serum albumin-flavonoid interactions monitored by means of tryptophan kinetics. Ann. N. Y. Acad. Sci. 2008, 1130, 314-319.
28. Xiao, J.; Suzuki, M.; Jiang, X.; Chen, X.; Yamamoto, K.; Ren, F.; Xu, M. Influence of B-ring hydroxylation on interactions of flavonols with bovine serum albumin. J. Agric. Food Chem. 2008, 56, 2350-2356.
29. Hui, Y.; Raedschelders, K.; Zhang, H.; Ansley, D. M.; Chen, D. D. Y. Quantitative analysis of propofol in whole blood using capillary electrophoresis. J. Chromatogr. B 2009, 877, 703-709.
30. Li, H.; Luo, W.; Zeng, Q.; Lin, Z.; Luo, H.; Zhang, Y. Method for the determination of blood methotrexate by high performance liquid chromatography with online post-column electrochemical oxidation and fluorescence detection. J. Chromatogr. B 2006, 845, 164-168.
31. Zaghloul, A.-A.; Hussain, A.; Khan, M. A.; Ahsan, F. Development of a HPLC method for the determination of cyclosporine-A in rat blood and plasma using naproxen as an internal standard. J. Pharm. Biomed. Anal. 2003, 31, 1101-1107.
32. Boocock, D. J.; Faust, G. E.; Patel, K. R.; Schinas, A. M.; Brown, V. A.; Ducharme, M. P.; Booth, T. D.; Crowell, J. A.; Perloff, M.; Gescher, A. J.; Steward, W. P.; Brenner, D. E. Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent. Cancer Epidem. Biomarker. Prev. 2007, 16, 1246-1252.
33. Juan, M. E.; Buenafuente, J.; Casals, I.; Planas, J. M. Plasmatic levels of trans-resveratrol in rats. Food Res. Int. 2002, 35, 195-199.
34. Marier, J. F.; Vachon, P.; Gritsas, A.; Zhang, J.; Moreau, J. P.; Ducharme, M. P. Metabolism and disposition of resveratrol in rats: extent of absorption, glucuronidation, and enterohepatic recirculation evidenced by a linked-rat model. J. Pharmacol. Exp. Ther. 2002, 302, 369-373.
35. Hollman, P. C.; van Trijp, J. M.; Buysman, M. N.; van der Gaag, M. S.; Mengelers, M. J.; De Vries, J. H.; Katan, M. B. Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man. FEBS Lett. 1997, 418, 152-156.
36. Egert, S.; Wolffram, S.; Bosy-Westphal, A.; Boesch-Saadatmandi, C.; Wagner, A. E.; Frank, J.; Rimbach, G.; Mueller, M. J. Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans. J. Nutr. 2008, 138, 1615-1621.
37. Scalbert, A.; Williamson, G. Dietary intake and bioavailability of polyphenols. J. Nutr. 2000, 130, 2073S-2085S.
38. Brockman, H.; Hatsis, P.; Paton, M.; Wu, J.-T. Impact of differential recovery in bioanalysis: the example of Bortezomib in whole blood. Anal. Chem. 2007, 79, 1599-1603.