메뉴 건너뛰기




Volumn 20, Issue 43, 2014, Pages 15992-16013

Hepatitis C virus molecular evolution: Transmission, disease progression and antiviral therapy

Author keywords

Clinical outcome; Drug resistance; Evolution; Hepatitis C virus; Phylogenetics

Indexed keywords

ANTIVIRUS AGENT; INTERFERON; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; NS3 PROTEASE INHIBITOR; NS5A INHIBITOR; PROTEINASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 84912523339     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v20.i43.15992     Document Type: Review
Times cited : (54)

References (256)
  • 1
    • 84876149257 scopus 로고    scopus 로고
    • Global epidemiology of hepatitis c virus infection: New estimates of age-specific antibody to hcv seroprevalence
    • PMID: 23172780
    • Mohd Hanafiah K, Groeger J, Flaxman AD, Wiersma ST. Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence. Hepatology 2013; 57: 1333-1342 [PMID: 23172780 DOI: 10.1002/hep.26141].
    • (2013) Hepatology , vol.57 , pp. 1333-1342
    • Mohd Hanafiah, K.1    Groeger, J.2    Flaxman, A.D.3    Wiersma, S.T.4
  • 2
    • 34250679750 scopus 로고    scopus 로고
    • Epidemiology of hepatitis c virus infection
    • PMID: 17552026
    • Alter MJ. Epidemiology of hepatitis C virus infection. World J Gastroenterol 2007; 13: 2436-2441 [PMID: 17552026].
    • (2007) World J Gastroenterol , vol.13 , pp. 2436-2441
    • Alter, M.J.1
  • 3
    • 59149085501 scopus 로고    scopus 로고
    • The global burden of hepatitis c
    • PMID: 19207969
    • Lavanchy D. The global burden of hepatitis C. Liver Int 2009; 29 Suppl 1: 74-81 [PMID: 19207969 DOI: 10.1111/j.1478-3231.2008.01934.x].
    • (2009) Liver Int , vol.29 , pp. 74-81
    • Lavanchy, D.1
  • 4
    • 0035811625 scopus 로고    scopus 로고
    • Hepatitis C virus infection
    • PMID: 11439948
    • Lauer GM, Walker BD. Hepatitis C virus infection. N Engl J Med 2001; 345: 41-52 [PMID: 11439948 DOI: 10.1056/NEJM200107053450107].
    • (2001) N Engl J Med , vol.345 , pp. 41-52
    • Lauer, G.M.1    Walker, B.D.2
  • 5
    • 27644542713 scopus 로고    scopus 로고
    • Chronic hepatitis c: An age wave of disease burden
    • quiz S307-S311 [PMID: 16232012]
    • McHutchison JG, Bacon BR. Chronic hepatitis C: An age wave of disease burden. Am J Manag Care 2005; 11: S286-S295; quiz S307-S311 [PMID: 16232012].
    • (2005) Am J Manag Care , vol.11 , pp. S286-S295
    • McHutchison, J.G.1    Bacon, B.R.2
  • 6
    • 34547094367 scopus 로고    scopus 로고
    • Hepatitis C virus
    • Knipe DM, Howley PM, editors. Philadelphia: Lippincott Williams & Wilkins
    • Stanley ML, Walker C, Alter MJ, Yi M. Hepatitis C Virus In: Knipe DM, Howley PM, editors. Fields Virology. Philadelphia: Lippincott Williams & Wilkins, 2007: 1280.
    • (2007) Fields Virology , pp. 1280
    • Stanley, M.L.1    Walker, C.2    Alter, M.J.3    Yi, M.4
  • 8
    • 79953105820 scopus 로고    scopus 로고
    • Sequence variability of HCV core region: Important predictors of HCV induced pathogenesis and viral production
    • PMID: 21292033
    • Khaliq S, Jahan S, Pervaiz A. Sequence variability of HCV Core region: important predictors of HCV induced pathogenesis and viral production. Infect Genet Evol 2011; 11: 543-556 [PMID: 21292033 DOI: 10.1016/j.meegid.2011.01.017].
    • (2011) Infect Genet Evol , vol.11 , pp. 543-556
    • Khaliq, S.1    Jahan, S.2    Pervaiz, A.3
  • 9
    • 0038508803 scopus 로고    scopus 로고
    • Cell surface expression of functional hepatitis C virus E1 and E2 glycoproteins
    • PMID: 12832074
    • Drummer HE, Maerz A, Poumbourios P. Cell surface expression of functional hepatitis C virus E1 and E2 glycoproteins. FEBS Lett 2003; 546: 385-390 [PMID: 12832074].
    • (2003) FEBS Lett , vol.546 , pp. 385-390
    • Drummer, H.E.1    Maerz, A.2    Poumbourios, P.3
  • 10
    • 33747051965 scopus 로고    scopus 로고
    • Study of a novel hypervariable region in hepatitis C virus (HCV) E2 envelope glycoprotein
    • PMID: 16781757
    • Troesch M, Meunier I, Lapierre P, Lapointe N, Alvarez F, Boucher M, Soudeyns H. Study of a novel hypervariable region in hepatitis C virus (HCV) E2 envelope glycoprotein. Virology 2006; 352: 357-367 [PMID: 16781757 DOI: 10.1016/j.virol.2006.05.015].
    • (2006) Virology , vol.352 , pp. 357-367
    • Troesch, M.1    Meunier, I.2    Lapierre, P.3    Lapointe, N.4    Alvarez, F.5    Boucher, M.6    Soudeyns, H.7
  • 11
    • 34547616693 scopus 로고    scopus 로고
    • Hepatitis C virus p7 protein is crucial for assembly and release of infectious virions
    • PMID: 17658949
    • Steinmann E, Penin F, Kallis S, Patel AH, Bartenschlager R, Pietschmann T. Hepatitis C virus p7 protein is crucial for assembly and release of infectious virions. PLoS Pathog 2007; 3: e103 [PMID: 17658949 DOI: 10.1371/journal.ppat.0030103].
    • (2007) PLoS Pathog , vol.3 , pp. e103
    • Steinmann, E.1    Penin, F.2    Kallis, S.3    Patel, A.H.4    Bartenschlager, R.5    Pietschmann, T.6
  • 12
    • 79952131523 scopus 로고    scopus 로고
    • Hepatitis C virus p7- A viroporin crucial for virus assembly and an emerging target for antiviral therapy
    • PMID: 21994720
    • Steinmann E, Pietschmann T. Hepatitis C virus p7- A viroporin crucial for virus assembly and an emerging target for antiviral therapy. Viruses 2010; 2: 2078-2095 [PMID: 21994720 DOI: 10.3390/v2092078].
    • Viruses 2010 , vol.2 , pp. 2078-2095
    • Steinmann, E.1    Pietschmann, T.2
  • 13
    • 0031902992 scopus 로고    scopus 로고
    • Multiple enzymatic activities associated with recombinant NS3 protein of hepatitis C virus
    • PMID: 9658124
    • Gallinari P, Brennan D, Nardi C, Brunetti M, Tomei L, Steinkühler C, De Francesco R. Multiple enzymatic activities associated with recombinant NS3 protein of hepatitis C virus. J Virol 1998; 72: 6758-6769 [PMID: 9658124].
    • (1998) J Virol , vol.72 , pp. 6758-6769
    • Gallinari, P.1    Brennan, D.2    Nardi, C.3    Brunetti, M.4    Tomei, L.5    Steinkühler, C.6    De Francesco, R.7
  • 14
    • 78951472458 scopus 로고    scopus 로고
    • Hepatitis C virus NS2 coordinates virus particle assembly through physical interactions with the E1-E2 glycoprotein and NS3-NS4A enzyme complexes
    • PMID: 21147927
    • Stapleford KA, Lindenbach BD. Hepatitis C virus NS2 coordinates virus particle assembly through physical interactions with the E1-E2 glycoprotein and NS3-NS4A enzyme complexes. J Virol 2011; 85: 1706-1717 [PMID: 21147927 DOI: 10.1128/JVI.02268-10].
    • (2011) J Virol , vol.85 , pp. 1706-1717
    • Stapleford, K.A.1    Lindenbach, B.D.2
  • 15
    • 29144462494 scopus 로고    scopus 로고
    • Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity
    • PMID: 16301520
    • Li XD, Sun L, Seth RB, Pineda G, Chen ZJ. Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity. Proc Natl Acad Sci USA 2005; 102: 17717-17722 [PMID: 16301520 DOI: 10.1073/pnas.0508531102].
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 17717-17722
    • Li, X.D.1    Sun, L.2    Seth, R.B.3    Pineda, G.4    Chen, Z.J.5
  • 16
    • 27144440476 scopus 로고    scopus 로고
    • Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis c virus
    • PMID: 16177806
    • Meylan E, Curran J, Hofmann K, Moradpour D, Binder M, Bartenschlager R, Tschopp J. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 2005; 437: 1167-1172 [PMID: 16177806 DOI: 10.1038/nature04193].
    • (2005) Nature , vol.437 , pp. 1167-1172
    • Meylan, E.1    Curran, J.2    Hofmann, K.3    Moradpour, D.4    Binder, M.5    Bartenschlager, R.6    Tschopp, J.7
  • 17
    • 14544280209 scopus 로고    scopus 로고
    • Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the toll-like receptor 3 adaptor protein TRIF
    • PMID: 15710891
    • Li K, Foy E, Ferreon JC, Nakamura M, Ferreon AC, Ikeda M, Ray SC, Gale M, Lemon SM. Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF. Proc Natl Acad Sci USA 2005; 102: 2992-2997 [PMID: 15710891 DOI: 10.1073/pnas.0408824102].
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 2992-2997
    • Li, K.1    Foy, E.2    Ferreon, J.C.3    Nakamura, M.4    Ferreon, A.C.5    Ikeda, M.6    Ray, S.C.7    Gale, M.8    Lemon, S.M.9
  • 18
    • 79953905045 scopus 로고    scopus 로고
    • Nonstructural protein 3-4A: The swiss army knife of hepatitis c virus
    • PMID: 21470343
    • Morikawa K, Lange CM, Gouttenoire J, Meylan E, Brass V, Penin F, Moradpour D. Nonstructural protein 3-4A: The Swiss army knife of hepatitis C virus. J Viral Hepat 2011; 18: 305-315 [PMID: 21470343 DOI: 10.1111/j.1365-2893.2011.01451.x].
    • (2011) J Viral Hepat , vol.18 , pp. 305-315
    • Morikawa, K.1    Lange, C.M.2    Gouttenoire, J.3    Meylan, E.4    Brass, V.5    Penin, F.6    Moradpour, D.7
  • 19
    • 77649175920 scopus 로고    scopus 로고
    • Hepatitis C virus nonstructural protein 4B: A journey into unexplored territory
    • PMID: 20069613
    • Gouttenoire J, Penin F, Moradpour D. Hepatitis C virus nonstructural protein 4B: A journey into unexplored territory. Rev Med Virol 2010; 20: 117-129 [PMID: 20069613 DOI: 10.1002/rmv.640].
    • (2010) Rev Med Virol , vol.20 , pp. 117-129
    • Gouttenoire, J.1    Penin, F.2    Moradpour, D.3
  • 20
    • 1642375622 scopus 로고    scopus 로고
    • The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity
    • PMID: 14993658
    • Macdonald A, Crowder K, Street A, McCormick C, Harris M. The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity. J Gen Virol 2004; 85: 721-729 [PMID: 14993658].
    • (2004) J Gen Virol , vol.85 , pp. 721-729
    • MacDonald, A.1    Crowder, K.2    Street, A.3    McCormick, C.4    Harris, M.5
  • 21
    • 0030828466 scopus 로고    scopus 로고
    • Phosphorylation of the hepatitis C virus NS5A protein in vitro and in vivo: Properties of the ns5a- Associated kinase
    • PMID: 9311791
    • Reed KE, Xu J, Rice CM. Phosphorylation of the hepatitis C virus NS5A protein in vitro and in vivo: properties of the NS5A- Associated kinase. J Virol 1997; 71: 7187-7197 [PMID: 9311791].
    • (1997) J Virol , vol.71 , pp. 7187-7197
    • Reed, K.E.1    Xu, J.2    Rice, C.M.3
  • 22
    • 0030051777 scopus 로고    scopus 로고
    • Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus
    • PMID: 8598194
    • Behrens SE, Tomei L, De Francesco R. Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus. EMBO J 1996; 15: 12-22 [PMID: 8598194].
    • (1996) EMBO J , vol.15 , pp. 12-22
    • Behrens, S.E.1    Tomei, L.2    De Francesco, R.3
  • 23
    • 34249024924 scopus 로고    scopus 로고
    • Replication of hepatitis c virus
    • PMID: 17487147
    • Moradpour D, Penin F, Rice CM. Replication of hepatitis C virus. Nat Rev Microbiol 2007; 5: 453-463 [PMID: 17487147 DOI: 10.1038/nrmicro1645].
    • (2007) Nat Rev Microbiol , vol.5 , pp. 453-463
    • Moradpour, D.1    Penin, F.2    Rice, C.M.3
  • 26
    • 0033761870 scopus 로고    scopus 로고
    • Human monoclonal antibodies that inhibit binding of hepatitis C virus E2 protein to CD81 and recognize conserved conformational epitopes
    • PMID: 11044085
    • Hadlock KG, Lanford RE, Perkins S, Rowe J, Yang Q, Levy S, Pileri P, Abrignani S, Foung SK. Human monoclonal antibodies that inhibit binding of hepatitis C virus E2 protein to CD81 and recognize conserved conformational epitopes. J Virol 2000; 74: 10407-10416 [PMID: 11044085].
    • (2000) J Virol , vol.74 , pp. 10407-10416
    • Hadlock, K.G.1    Lanford, R.E.2    Perkins, S.3    Rowe, J.4    Yang, Q.5    Levy, S.6    Pileri, P.7    Abrignani, S.8    Foung, S.K.9
  • 29
    • 60149090028 scopus 로고    scopus 로고
    • Human occludin is a hepatitis c virus entry factor required for infection of mouse cells
    • PMID: 19182773
    • Ploss A, Evans MJ, Gaysinskaya VA, Panis M, You H, de Jong YP, Rice CM. Human occludin is a hepatitis C virus entry factor required for infection of mouse cells. Nature 2009; 457: 882-886 [PMID: 19182773 DOI: 10.1038/nature07684].
    • (2009) Nature , vol.457 , pp. 882-886
    • Ploss, A.1    Evans, M.J.2    Gaysinskaya, V.A.3    Panis, M.4    You, H.5    De Jong, Y.P.6    Rice, C.M.7
  • 33
    • 0038471344 scopus 로고    scopus 로고
    • Hepatitis C virus glycoproteins mediate ph-dependent cell entry of pseudotyped retroviral particles
    • PMID: 12761383
    • Hsu M, Zhang J, Flint M, Logvinoff C, Cheng-Mayer C, Rice CM, McKeating JA. Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles. Proc Natl Acad Sci USA 2003; 100: 7271-7276 [PMID: 12761383 DOI: 10.1073/pnas.0832180100].
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 7271-7276
    • Hsu, M.1    Zhang, J.2    Flint, M.3    Logvinoff, C.4    Cheng-Mayer, C.5    Rice, C.M.6    McKeating, J.A.7
  • 35
    • 84887497646 scopus 로고    scopus 로고
    • Loss of immune escape mutations during persistent HCV infection in pregnancy enhances replication of vertically transmitted viruses
    • PMID: 24162814
    • Honegger JR, Kim S, Price AA, Kohout JA, McKnight KL, Prasad MR, Lemon SM, Grakoui A, Walker CM. Loss of immune escape mutations during persistent HCV infection in pregnancy enhances replication of vertically transmitted viruses. Nat Med 2013; 19: 1529-1533 [PMID: 24162814 DOI: 10.1038/nm.3351].
    • (2013) Nat Med , vol.19 , pp. 1529-1533
    • Honegger, J.R.1    Kim, S.2    Price, A.A.3    Kohout, J.A.4    McKnight, K.L.5    Prasad, M.R.6    Lemon, S.M.7    Grakoui, A.8    Walker, C.M.9
  • 36
    • 33847015308 scopus 로고    scopus 로고
    • Hepatitis C virus continuously escapes from neutralizing antibody and T-cell responses during chronic infection in vivo
    • PMID: 17258731
    • von Hahn T, Yoon JC, Alter H, Rice CM, Rehermann B, Balfe P, McKeating JA. Hepatitis C virus continuously escapes from neutralizing antibody and T-cell responses during chronic infection in vivo. Gastroenterology 2007; 132: 667-678 [PMID: 17258731 DOI: 10.1053/j.gastro.2006.12.008].
    • (2007) Gastroenterology , vol.132 , pp. 667-678
    • Von Hahn, T.1    Yoon, J.C.2    Alter, H.3    Rice, C.M.4    Rehermann, B.5    Balfe, P.6    McKeating, J.A.7
  • 37
    • 84455189490 scopus 로고    scopus 로고
    • The conundrum of relapse in stat-C therapy: Does HCV play the red queen or rip van winkle?
    • PMID: 22189980
    • Ralston R, Jacobson I, Scull M. The conundrum of relapse in STAT-C therapy: does HCV play the Red Queen or Rip Van Winkle? Semin Liver Dis 2011; 31: 410-419 [PMID: 22189980 DOI: 10.1055/s-0031-1297929].
    • (2011) Semin Liver Dis , vol.31 , pp. 410-419
    • Ralston, R.1    Jacobson, I.2    Scull, M.3
  • 38
    • 84894707183 scopus 로고    scopus 로고
    • Expanded classification of hepatitis c virus into 7 genotypes and 67 subtypes: Updated criteria and genotype assignment web resource
    • PMID: 24115039
    • Smith DB, Bukh J, Kuiken C, Muerhoff AS, Rice CM, Stapleton JT, Simmonds P. Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: updated criteria and genotype assignment web resource. Hepatology 2014; 59: 318-327 [PMID: 24115039 DOI: 10.1002/hep.26744].
    • (2014) Hepatology , vol.59 , pp. 318-327
    • Smith, D.B.1    Bukh, J.2    Kuiken, C.3    Muerhoff, A.S.4    Rice, C.M.5    Stapleton, J.T.6    Simmonds, P.7
  • 39
    • 0028945033 scopus 로고
    • Genetic heterogeneity of hepatitis C virus: Quasispecies and genotypes
    • PMID: 7597443
    • Bukh J, Miller RH, Purcell RH. Genetic heterogeneity of hepatitis C virus: quasispecies and genotypes. Semin Liver Dis 1995; 15: 41-63 [PMID: 7597443 DOI: 10.1055/s-2007-1007262].
    • (1995) Semin Liver Dis , vol.15 , pp. 41-63
    • Bukh, J.1    Miller, R.H.2    Purcell, R.H.3
  • 40
    • 0027522145 scopus 로고
    • Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region
    • PMID: 8245854
    • Simmonds P, Holmes EC, Cha TA, Chan SW, McOmish F, Irvine B, Beall E, Yap PL, Kolberg J, Urdea MS. Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region. J Gen Virol 1993; 74 (Pt 11): 2391-2399 [PMID: 8245854].
    • (1993) J Gen Virol , vol.74 , pp. 2391-2399
    • Simmonds, P.1    Holmes, E.C.2    Cha, T.A.3    Chan, S.W.4    McOmish, F.5    Irvine, B.6    Beall, E.7    Yap, P.L.8    Kolberg, J.9    Urdea, M.S.10
  • 41
    • 78751621217 scopus 로고    scopus 로고
    • Evolving epidemiology of hepatitis C virus
    • PMID: 21091831
    • Lavanchy D. Evolving epidemiology of hepatitis C virus. Clin Microbiol Infect 2011; 17: 107-115 [PMID: 21091831 DOI: 10.1111/j.1469-0691.2010.03432.x].
    • (2011) Clin Microbiol Infect , vol.17 , pp. 107-115
    • Lavanchy, D.1
  • 42
    • 11144357184 scopus 로고    scopus 로고
    • Reliability of hepatitis C virus core antigen assay for detection of viremia in HCV genotypes 1, 2, 3, and 4 infected blood donors: A collaborative study between Japan, Egypt, and Uzbekistan
    • PMID: 15122795
    • Agha S, Tanaka Y, Saudy N, Kurbanov F, Abo-Zeid M, El- Malky M, Khalaf M, Ohta N, Yoshizawa H, Mizokami M. Reliability of hepatitis C virus core antigen assay for detection of viremia in HCV genotypes 1, 2, 3, and 4 infected blood donors: A collaborative study between Japan, Egypt, and Uzbekistan. J Med Virol 2004; 73: 216-222 [PMID: 15122795 DOI: 10.1002/jmv.20078].
    • (2004) J Med Virol , vol.73 , pp. 216-222
    • Agha, S.1    Tanaka, Y.2    Saudy, N.3    Kurbanov, F.4    Abo-Zeid, M.5    El-Malky, M.6    Khalaf, M.7    Ohta, N.8    Yoshizawa, H.9    Mizokami, M.10
  • 45
    • 84876572287 scopus 로고    scopus 로고
    • The origin of hepatitis C virus
    • PMID: 23463195
    • Simmonds P. The origin of hepatitis C virus. Curr Top Microbiol Immunol 2013; 369: 1-15 [PMID: 23463195 DOI: 10.1007/9 78-3-642-27340-7-1].
    • (2013) Curr Top Microbiol Immunol , vol.369 , pp. 1-15
    • Simmonds, P.1
  • 46
    • 74049120411 scopus 로고    scopus 로고
    • The global spread of hepatitis C virus 1a and 1b: A phylodynamic and phylogeographic analysis
    • PMID: 20041120
    • Magiorkinis G, Magiorkinis E, Paraskevis D, Ho SY, Shapiro B, Pybus OG, Allain JP, Hatzakis A. The global spread of hepatitis C virus 1a and 1b: A phylodynamic and phylogeographic analysis. PLoS Med 2009; 6: e1000198 [PMID: 20041120 DOI: 10.1371/journal.pmed.1000198].
    • (2009) PLoS Med , vol.6 , pp. e1000198
    • Magiorkinis, G.1    Magiorkinis, E.2    Paraskevis, D.3    Ho, S.Y.4    Shapiro, B.5    Pybus, O.G.6    Allain, J.P.7    Hatzakis, A.8
  • 49
    • 66149098217 scopus 로고    scopus 로고
    • Effect of ribavirin on the mutation rate and spectrum of hepatitis C virus in vivo
    • PMID: 19321623
    • Cuevas JM, González-Candelas F, Moya A, Sanjuán R. Effect of ribavirin on the mutation rate and spectrum of hepatitis C virus in vivo. J Virol 2009; 83: 5760-5764 [PMID: 19321623 DOI: 10.1128/JVI.00201-09].
    • (2009) J Virol , vol.83 , pp. 5760-5764
    • Cuevas, J.M.1    González-Candelas, F.2    Moya, A.3    Sanjuán, R.4
  • 50
    • 0035157218 scopus 로고    scopus 로고
    • Mutations in hepatitis C virus RNAs conferring cell culture adaptation
    • PMID: 11152517
    • Lohmann V, Körner F, Dobierzewska A, Bartenschlager R. Mutations in hepatitis C virus RNAs conferring cell culture adaptation. J Virol 2001; 75: 1437-1449 [PMID: 11152517 DOI: 10.1128/JVI.75.3.1437-1449.2001].
    • (2001) J Virol , vol.75 , pp. 1437-1449
    • Lohmann, V.1    Körner, F.2    Dobierzewska, A.3    Bartenschlager, R.4
  • 52
    • 84455189499 scopus 로고    scopus 로고
    • New insights into the HCV quasispecies and compartmentalization
    • PMID: 22189976
    • Farci P. New insights into the HCV quasispecies and compartmentalization. Semin Liver Dis 2011; 31: 356-374 [PMID: 22189976 DOI: 10.1055/s-0031-1297925].
    • (2011) Semin Liver Dis , vol.31 , pp. 356-374
    • Farci, P.1
  • 53
    • 0035000935 scopus 로고    scopus 로고
    • Conservation of the conformation and positive charges of hepatitis C virus E2 envelope glycoprotein hypervariable region 1 points to a role in cell attachment
    • PMID: 11356980
    • Penin F, Combet C, Germanidis G, Frainais PO, Deléage G, Pawlotsky JM. Conservation of the conformation and positive charges of hepatitis C virus E2 envelope glycoprotein hypervariable region 1 points to a role in cell attachment. J Virol 2001; 75: 5703-5710 [PMID: 11356980 DOI: 10.1128/JVI.75.12.5703-5710.2001].
    • (2001) J Virol , vol.75 , pp. 5703-5710
    • Penin, F.1    Combet, C.2    Germanidis, G.3    Frainais, P.O.4    Deléage, G.5    Pawlotsky, J.M.6
  • 54
    • 29744468807 scopus 로고    scopus 로고
    • Effect of bottlenecking on evolution of the nonstructural protein 3 gene of hepatitis C virus during sexually transmitted acute resolving infection
    • PMID: 16306585
    • Quer J, Esteban JI, Cos J, Sauleda S, Ocaña L, Martell M, Otero T, Cubero M, Palou E, Murillo P, Esteban R, Guàrdia J. Effect of bottlenecking on evolution of the nonstructural protein 3 gene of hepatitis C virus during sexually transmitted acute resolving infection. J Virol 2005; 79: 15131-15141 [PMID: 16306585 DOI: 10.1128/JVI.79.24.15131-15141.2005].
    • (2005) J Virol , vol.79 , pp. 15131-15141
    • Quer, J.1    Esteban, J.I.2    Cos, J.3    Sauleda, S.4    Ocaña, L.5    Martell, M.6    Otero, T.7    Cubero, M.8    Palou, E.9    Murillo, P.10    Esteban, R.11    Guàrdia, J.12
  • 55
    • 34247344418 scopus 로고    scopus 로고
    • Genetic and catalytic efficiency structure of an HCV protease quasispecies
    • PMID: 17393500
    • Franco S, Parera M, Aparicio E, Clotet B, Martinez MA. Genetic and catalytic efficiency structure of an HCV protease quasispecies. Hepatology 2007; 45: 899-910 [PMID: 17393500 DOI: 10.1002/hep.21623].
    • (2007) Hepatology , vol.45 , pp. 899-910
    • Franco, S.1    Parera, M.2    Aparicio, E.3    Clotet, B.4    Martinez, M.A.5
  • 56
    • 77952709675 scopus 로고    scopus 로고
    • Hepatitis c virus transmission bottlenecks analyzed by deep sequencing
    • PMID: 20375170
    • Wang GP, Sherrill-Mix SA, Chang KM, Quince C, Bushman FD. Hepatitis C virus transmission bottlenecks analyzed by deep sequencing. J Virol 2010; 84: 6218-6228 [PMID: 20375170 DOI: 10.1128/JVI.02271-09].
    • (2010) J Virol , vol.84 , pp. 6218-6228
    • Wang, G.P.1    Sherrill-Mix, S.A.2    Chang, K.M.3    Quince, C.4    Bushman, F.D.5
  • 60
    • 0028308318 scopus 로고
    • Genetic drift in hypervariable region 1 of the viral genome in persistent hepatitis C virus infection
    • PMID: 7518526
    • Kato N, Ootsuyama Y, Sekiya H, Ohkoshi S, Nakazawa T, Hijikata M, Shimotohno K. Genetic drift in hypervariable region 1 of the viral genome in persistent hepatitis C virus infection. J Virol 1994; 68: 4776-4784 [PMID: 7518526].
    • (1994) J Virol , vol.68 , pp. 4776-4784
    • Kato, N.1    Ootsuyama, Y.2    Sekiya, H.3    Ohkoshi, S.4    Nakazawa, T.5    Hijikata, M.6    Shimotohno, K.7
  • 63
    • 0034049454 scopus 로고    scopus 로고
    • Evolutionary rate and genetic drift of hepatitis C virus are not correlated with the host immune response: Studies of infected donor-recipient clusters
    • PMID: 10684268
    • Allain JP, Dong Y, Vandamme AM, Moulton V, Salemi M. Evolutionary rate and genetic drift of hepatitis C virus are not correlated with the host immune response: Studies of infected donor-recipient clusters. J Virol 2000; 74: 2541-2549 [PMID: 10684268].
    • (2000) J Virol , vol.74 , pp. 2541-2549
    • Allain, J.P.1    Dong, Y.2    Vandamme, A.M.3    Moulton, V.4    Salemi, M.5
  • 64
    • 0029024922 scopus 로고
    • Quasispecies of hepatitis C virus and genetic drift of the hypervariable region in chronic type C hepatitis
    • PMID: 7797927
    • Kao JH, Chen PJ, Lai MY, Wang TH, Chen DS. Quasispecies of hepatitis C virus and genetic drift of the hypervariable region in chronic type C hepatitis. J Infect Dis 1995; 172: 261-264 [PMID: 7797927].
    • (1995) J Infect Dis , vol.172 , pp. 261-264
    • Kao, J.H.1    Chen, P.J.2    Lai, M.Y.3    Wang, T.H.4    Chen, D.S.5
  • 65
    • 0032853634 scopus 로고    scopus 로고
    • Evolutionary aspects of recombination in RNA VIRUSES
    • PMID: 10573145
    • Worobey M, Holmes EC. Evolutionary aspects of recombination in RNA viruses. J Gen Virol 1999; 80 (Pt 10): 2535-2543 [PMID: 10573145].
    • (1999) J Gen Virol , vol.80 , pp. 2535-2543
    • Worobey, M.1    Holmes, E.C.2
  • 66
    • 84875984443 scopus 로고    scopus 로고
    • Productive homologous and non-homologous recombination of hepatitis c virus in cell culture
    • PMID: 23555245
    • Scheel TK, Galli A, Li YP, Mikkelsen LS, Gottwein JM, Bukh J. Productive homologous and non-homologous recombination of hepatitis C virus in cell culture. PLoS Pathog 2013; 9: e1003228 [PMID: 23555245 DOI: 10.1371/journal. ppat.1003228].
    • (2013) PLoS Pathog , vol.9 , pp. e1003228
    • Scheel, T.K.1    Galli, A.2    Li, Y.P.3    Mikkelsen, L.S.4    Gottwein, J.M.5    Bukh, J.6
  • 67
    • 80055004056 scopus 로고    scopus 로고
    • Recombination in hepatitis C virus
    • PMID: 22069526
    • González-Candelas F, López-Labrador FX, Bracho MA. Recombination in hepatitis C virus. Viruses 2011; 3: 2006-2024 [PMID: 22069526 DOI: 10.3390/v3102006].
    • (2011) Viruses , vol.3 , pp. 2006-2024
    • González-Candelas, F.1    López-Labrador, F.X.2    Bracho, M.A.3
  • 68
    • 84864249998 scopus 로고    scopus 로고
    • Recombination in hepatitis c virus: Identification of four novel naturally occurring inter-subtype recombinants
    • PMID: 22911872
    • Shi W, Freitas IT, Zhu C, Zheng W, Hall WW, Higgins DG. Recombination in hepatitis C virus: identification of four novel naturally occurring inter-subtype recombinants. PLoS One 2012; 7: e41997 [PMID: 22911872 DOI: 10.1371/journal. pone.0041997].
    • (2012) PLoS One , vol.7 , pp. e41997
    • Shi, W.1    Freitas, I.T.2    Zhu, C.3    Zheng, W.4    Hall, W.W.5    Higgins, D.G.6
  • 70
    • 84888054988 scopus 로고    scopus 로고
    • Evasion of superinfection exclusion and elimination of primary viral RNA by an adapted strain of hepatitis C virus
    • PMID: 24089557
    • Webster B, Ott M, Greene WC. Evasion of superinfection exclusion and elimination of primary viral RNA by an adapted strain of hepatitis C virus. J Virol 2013; 87: 13354-13369 [PMID: 24089557 DOI: 10.1128/JVI.02465-13].
    • (2013) J Virol , vol.87 , pp. 13354-13369
    • Webster, B.1    Ott, M.2    Greene, W.C.3
  • 71
    • 84871993454 scopus 로고    scopus 로고
    • Rapid intracellular competition between hepatitis C viral genomes as a result of mitosis
    • PMID: 23097449
    • Webster B, Wissing S, Herker E, Ott M, Greene WC. Rapid intracellular competition between hepatitis C viral genomes as a result of mitosis. J Virol 2013; 87: 581-596 [PMID: 23097449 DOI: 10.1128/JVI.01047-12].
    • (2013) J Virol , vol.87 , pp. 581-596
    • Webster, B.1    Wissing, S.2    Herker, E.3    Ott, M.4    Greene, W.C.5
  • 72
    • 34247631514 scopus 로고    scopus 로고
    • Analysis of hepatitis C virus superinfection exclusion by using novel fluorochrome gene-tagged viral genomes
    • PMID: 17301154
    • Schaller T, Appel N, Koutsoudakis G, Kallis S, Lohmann V, Pietschmann T, Bartenschlager R. Analysis of hepatitis C virus superinfection exclusion by using novel fluorochrome gene-tagged viral genomes. J Virol 2007; 81: 4591-4603 [PMID: 17301154 DOI: 10.1128/JVI.02144-06].
    • (2007) J Virol , vol.81 , pp. 4591-4603
    • Schaller, T.1    Appel, N.2    Koutsoudakis, G.3    Kallis, S.4    Lohmann, V.5    Pietschmann, T.6    Bartenschlager, R.7
  • 73
    • 0036196640 scopus 로고    scopus 로고
    • A natural intergenotypic recombinant of hepatitis C virus identified in St. Petersburg
    • PMID: 11907242
    • Kalinina O, Norder H, Mukomolov S, Magnius LO. A natural intergenotypic recombinant of hepatitis C virus identified in St. Petersburg. J Virol 2002; 76: 4034-4043 [PMID: 11907242].
    • (2002) J Virol , vol.76 , pp. 4034-4043
    • Kalinina, O.1    Norder, H.2    Mukomolov, S.3    Magnius, L.O.4
  • 76
    • 3342985091 scopus 로고    scopus 로고
    • Full-length open reading frame of a recombinant hepatitis c virus strain from St Petersburg: Proposed mechanism for its formation
    • PMID: 15218169
    • Kalinina O, Norder H, Magnius LO. Full-length open reading frame of a recombinant hepatitis C virus strain from St Petersburg: proposed mechanism for its formation. J Gen Virol 2004; 85: 1853-1857 [PMID: 15218169 DOI: 10.1099/vir.0.79984-0].
    • (2004) J Gen Virol , vol.85 , pp. 1853-1857
    • Kalinina, O.1    Norder, H.2    Magnius, L.O.3
  • 77
    • 24944485118 scopus 로고    scopus 로고
    • Quasispecies theory in the context of population genetics
    • PMID: 16107214
    • Wilke CO. Quasispecies theory in the context of population genetics. BMC Evol Biol 2005; 5: 44 [PMID: 16107214 DOI: 10.1186/1471-2148-5-44].
    • (2005) BMC Evol Biol , vol.5 , pp. 44
    • Wilke, C.O.1
  • 78
    • 77954383399 scopus 로고    scopus 로고
    • The RNA virus quasispecies: Fact or fiction?
    • PMID: 20493194
    • Holmes EC. The RNA virus quasispecies: fact or fiction? J Mol Biol 2010; 400: 271-273 [PMID: 20493194 DOI: 10.1016/j.jmb.2010.05.032].
    • (2010) J Mol Biol , vol.400 , pp. 271-273
    • Holmes, E.C.1
  • 79
    • 77951974356 scopus 로고    scopus 로고
    • Does hepatitis C virus really form quasispecies?
    • PMID: 20304103
    • Holmes EC. Does hepatitis C virus really form quasispecies? Infect Genet Evol 2010; 10: 431-432 [PMID: 20304103 DOI: 10.1016/j.meegid.2010.03.006].
    • (2010) Infect Genet Evol , vol.10 , pp. 431-432
    • Holmes, E.C.1
  • 80
    • 63549135752 scopus 로고    scopus 로고
    • Evolution of hepatitis C virus hypervariable region 1 in immunocompetent children born to HCV-infected mothers
    • PMID: 19228286
    • Gismondi MI, Becker PD, Díaz Carrasco JM, Guzmán CA, Campos RH, Preciado MV. Evolution of hepatitis C virus hypervariable region 1 in immunocompetent children born to HCV-infected mothers. J Viral Hepat 2009; 16: 332-339 [PMID: 19228286].
    • (2009) J Viral Hepat , vol.16 , pp. 332-339
    • Gismondi, M.I.1    Becker, P.D.2    Díaz, C.J.M.3    Guzmán, C.A.4    Campos, R.H.5    Preciado, M.V.6
  • 81
    • 84884954835 scopus 로고    scopus 로고
    • Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children
    • PMID: 24210114
    • Gismondi MI, Díaz Carrasco JM, Valva P, Becker PD, Guzmán CA, Campos RH, Preciado MV. Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children. Virology 2013; 447: 187-196 [PMID: 24210114 DOI: 10.1016/j.virol.2013.09.002].
    • (2013) Virology , vol.447 , pp. 187-196
    • Gismondi, M.I.1    Díaz Carrasco, J.M.2    Valva, P.3    Becker, P.D.4    Guzmán, C.A.5    Campos, R.H.6    Preciado, M.V.7
  • 82
    • 22344447485 scopus 로고    scopus 로고
    • Divergent and convergent evolution after a common-source outbreak of hepatitis C virus
    • PMID: 15939791
    • Ray SC, Fanning L, Wang XH, Netski DM, Kenny-Walsh E, Thomas DL. Divergent and convergent evolution after a common-source outbreak of hepatitis C virus. J Exp Med 2005; 201: 1753-1759 [PMID: 15939791 DOI: 10.1084/jem.20050122].
    • (2005) J Exp Med , vol.201 , pp. 1753-1759
    • Ray, S.C.1    Fanning, L.2    Wang, X.H.3    Netski, D.M.4    Kenny-Walsh, E.5    Thomas, D.L.6
  • 85
    • 79960848222 scopus 로고    scopus 로고
    • Temporal variations in the hepatitis C virus intrahost population during chronic infection
    • PMID: 21525348
    • Ramachandran S, Campo DS, Dimitrova ZE, Xia GL, Purdy MA, Khudyakov YE. Temporal variations in the hepatitis C virus intrahost population during chronic infection. J Virol 2011; 85: 6369-6380 [PMID: 21525348 DOI: 10.1128/JVI.02204-10].
    • (2011) J Virol , vol.85 , pp. 6369-6380
    • Ramachandran, S.1    Campo, D.S.2    Dimitrova, Z.E.3    Xia, G.L.4    Purdy, M.A.5    Khudyakov, Y.E.6
  • 86
    • 84862119350 scopus 로고    scopus 로고
    • A new evolutionary model for hepatitis C virus chronic infection
    • PMID: 22570609
    • Gray RR, Salemi M, Klenerman P, Pybus OG. A new evolutionary model for hepatitis C virus chronic infection. PLoS Pathog 2012; 8: e1002656 [PMID: 22570609 DOI: 10.1371/journal.ppat.1002656].
    • (2012) PLoS Pathog , vol.8 , pp. e1002656
    • Gray, R.R.1    Salemi, M.2    Klenerman, P.3    Pybus, O.G.4
  • 87
    • 84871984813 scopus 로고    scopus 로고
    • Molecular surveillance of hepatitis C
    • PMID: 23321496
    • Khudyakov Y. Molecular surveillance of hepatitis C. Antivir Ther 2012; 17: 1465-1470 [PMID: 23321496 DOI: 10.3851/IMP2476].
    • (2012) Antivir Ther , vol.17 , pp. 1465-1470
    • Khudyakov, Y.1
  • 89
    • 0030837422 scopus 로고    scopus 로고
    • Sequence analysis of the hepatitis C virus genome recovered from serum, liver, and peripheral blood mononuclear cells of infected chimpanzees
    • PMID: 9223464
    • Shimizu YK, Igarashi H, Kanematu T, Fujiwara K, Wong DC, Purcell RH, Yoshikura H. Sequence analysis of the hepatitis C virus genome recovered from serum, liver, and peripheral blood mononuclear cells of infected chimpanzees. J Virol 1997; 71: 5769-5773 [PMID: 9223464].
    • (1997) J Virol , vol.71 , pp. 5769-5773
    • Shimizu, Y.K.1    Igarashi, H.2    Kanematu, T.3    Fujiwara, K.4    Wong, D.C.5    Purcell, R.H.6    Yoshikura, H.7
  • 90
    • 0031034803 scopus 로고    scopus 로고
    • Structure of replicating hepatitis C virus (HCV) quasispecies in the liver may not be reflected by analysis of circulating HCV virions
    • PMID: 8995709
    • Cabot B, Esteban JI, Martell M, Genescà J, Vargas V, Esteban R, Guardia J, Gómez J. Structure of replicating hepatitis C virus (HCV) quasispecies in the liver may not be reflected by analysis of circulating HCV virions. J Virol 1997; 71: 1732-1734 [PMID: 8995709].
    • (1997) J Virol , vol.71 , pp. 1732-1734
    • Cabot, B.1    Esteban, J.I.2    Martell, M.3    Genescà, J.4    Vargas, V.5    Esteban, R.6    Guardia, J.7    Gómez, J.8
  • 91
    • 0031932434 scopus 로고    scopus 로고
    • Genetic diversity and tissue compartmentalization of the hepatitis c virus genome in blood mononuclear cells, liver, and serum from chronic hepatitis C patients
    • PMID: 9445070
    • Navas S, Martín J, Quiroga JA, Castillo I, Carreño V. Genetic diversity and tissue compartmentalization of the hepatitis C virus genome in blood mononuclear cells, liver, and serum from chronic hepatitis C patients. J Virol 1998; 72: 1640-1646 [PMID: 9445070].
    • (1998) J Virol , vol.72 , pp. 1640-1646
    • Navas, S.1    Martín, J.2    Quiroga, J.A.3    Castillo, I.4    Carreño, V.5
  • 92
  • 93
    • 2342655833 scopus 로고    scopus 로고
    • Identification of unique hepatitis C virus quasispecies in the central nervous system and comparative analysis of internal translational efficiency of brain, liver, and serum variants
    • PMID: 15113899
    • Forton DM, Karayiannis P, Mahmud N, Taylor-Robinson SD, Thomas HC. Identification of unique hepatitis C virus quasispecies in the central nervous system and comparative analysis of internal translational efficiency of brain, liver, and serum variants. J Virol 2004; 78: 5170-5183 [PMID: 15113899].
    • (2004) J Virol , vol.78 , pp. 5170-5183
    • Forton, D.M.1    Karayiannis, P.2    Mahmud, N.3    Taylor-Robinson, S.D.4    Thomas, H.C.5
  • 94
    • 34948827431 scopus 로고    scopus 로고
    • Hepatitis C virus lymphotropism: Lessons from a decade of studies
    • PMID: 17936221
    • Zignego AL, Giannini C, Monti M, Gragnani L. Hepatitis C virus lymphotropism: lessons from a decade of studies. Dig Liver Dis 2007; 39 Suppl 1: S38-S45 [PMID: 17936221].
    • (2007) Dig Liver Dis , vol.39 , pp. S38-S45
    • Zignego, A.L.1    Giannini, C.2    Monti, M.3    Gragnani, L.4
  • 95
    • 80053351186 scopus 로고    scopus 로고
    • Hepatitis C virus and peripheral blood mononuclear cell reservoirs patricia bar
    • PMID: 21160967
    • Baré P. Hepatitis C virus and peripheral blood mononuclear cell reservoirs Patricia Baré. World J Hepatol 2009; 1: 67-71 [PMID: 21160967 DOI: 10.4254/wjh.v1.i1.67].
    • (2009) World J Hepatol , vol.1 , pp. 67-71
    • Baré, P.1
  • 98
    • 33745880701 scopus 로고    scopus 로고
    • Extrahepatic replication of HCV: Insights into clinical manifestations and biological consequences
    • PMID: 16799966
    • Blackard JT, Kemmer N, Sherman KE. Extrahepatic replication of HCV: insights into clinical manifestations and biological consequences. Hepatology 2006; 44: 15-22 [PMID: 16799966 DOI: 10.1002/hep.21283].
    • (2006) Hepatology , vol.44 , pp. 15-22
    • Blackard, J.T.1    Kemmer, N.2    Sherman, K.E.3
  • 99
    • 37749010468 scopus 로고    scopus 로고
    • Distinct hepatitis C virus core and f protein quasispecies in tumoral and nontumoral hepatocytes isolated via microdissection
    • PMID: 17935229
    • Sobesky R, Feray C, Rimlinger F, Derian N, Dos Santos A, Roque-Afonso AM, Samuel D, Bréchot C, Thiers V. Distinct hepatitis C virus core and F protein quasispecies in tumoral and nontumoral hepatocytes isolated via microdissection. Hepatology 2007; 46: 1704-1712 [PMID: 17935229 DOI: 10.1002/hep.21898].
    • (2007) Hepatology , vol.46 , pp. 1704-1712
    • Sobesky, R.1    Feray, C.2    Rimlinger, F.3    Derian, N.4    Dos Santos, A.5    Roque-Afonso, A.M.6    Samuel, D.7    Bréchot, C.8    Thiers, V.9
  • 101
    • 68949197614 scopus 로고    scopus 로고
    • Hepatitis C virus quasispecies in plasma and peripheral blood mononuclear cells of treatment naïve chronically infected patients
    • PMID: 19254350
    • Vera-Otarola J, Barría MI, León U, Marsac D, Carvallo P, Soza A, López-Lastra M. Hepatitis C virus quasispecies in plasma and peripheral blood mononuclear cells of treatment naïve chronically infected patients. J Viral Hepat 2009; 16: 633-643 [PMID: 19254350 DOI: 10.1111/j.1365-2893.2009.01112.x].
    • (2009) J Viral Hepat , vol.16 , pp. 633-643
    • Vera-Otarola, J.1    Barría, M.I.2    León, U.3    Marsac, D.4    Carvallo, P.5    Soza, A.6    López-Lastra, M.7
  • 102
    • 18144379843 scopus 로고    scopus 로고
    • Compartmentalization of hepatitis C virus genotypes between plasma and peripheral blood mononuclear cells
    • PMID: 15858018
    • Roque-Afonso AM, Ducoulombier D, Di Liberto G, Kara R, Gigou M, Dussaix E, Samuel D, Féray C. Compartmentalization of hepatitis C virus genotypes between plasma and peripheral blood mononuclear cells. J Virol 2005; 79: 6349-6357 [PMID: 15858018 DOI: 10.1128/JVI.79.10.6349-6357.2005].
    • (2005) J Virol , vol.79 , pp. 6349-6357
    • Roque-Afonso, A.M.1    Ducoulombier, D.2    Di Liberto, G.3    Kara, R.4    Gigou, M.5    Dussaix, E.6    Samuel, D.7    Féray, C.8
  • 104
    • 0037221403 scopus 로고    scopus 로고
    • Differential distribution and internal translation efficiency of hepatitis C virus quasispecies present in dendritic and liver cells
    • PMID: 12393733
    • Laporte J, Bain C, Maurel P, Inchauspe G, Agut H, Cahour A. Differential distribution and internal translation efficiency of hepatitis C virus quasispecies present in dendritic and liver cells. Blood 2003; 101: 52-57 [PMID: 12393733 DOI: 10.1182/blood-2002-03-0818].
    • (2003) Blood , vol.101 , pp. 52-57
    • Laporte, J.1    Bain, C.2    Maurel, P.3    Inchauspe, G.4    Agut, H.5    Cahour, A.6
  • 105
    • 16544372861 scopus 로고    scopus 로고
    • Hepatitis C virus quasispecies variability modulates nonstructural protein 5A transcriptional activation, pointing to cellular compartmentalization of virus-host interactions
    • PMID: 15078944
    • Pellerin M, Lopez-Aguirre Y, Penin F, Dhumeaux D, Pawlotsky JM. Hepatitis C virus quasispecies variability modulates nonstructural protein 5A transcriptional activation, pointing to cellular compartmentalization of virus-host interactions. J Virol 2004; 78: 4617-4627 [PMID: 15078944].
    • (2004) J Virol , vol.78 , pp. 4617-4627
    • Pellerin, M.1    Lopez-Aguirre, Y.2    Penin, F.3    Dhumeaux, D.4    Pawlotsky, J.M.5
  • 106
    • 83655203637 scopus 로고    scopus 로고
    • Analysis of a non-structural gene reveals evidence of possible hepatitis C virus (HCV) compartmentalization
    • PMID: 22170544
    • Blackard JT, Ma G, Welge JA, Martin CM, Sherman KE, Taylor LE, Mayer KH, Jamieson DJ. Analysis of a non-structural gene reveals evidence of possible hepatitis C virus (HCV) compartmentalization. J Med Virol 2012; 84: 242-252 [PMID: 22170544 DOI: 10.1002/jmv.22269].
    • (2012) J Med Virol , vol.84 , pp. 242-252
    • Blackard, J.T.1    Ma, G.2    Welge, J.A.3    Martin, C.M.4    Sherman, K.E.5    Taylor, L.E.6    Mayer, K.H.7    Jamieson, D.J.8
  • 108
    • 79951504671 scopus 로고    scopus 로고
    • Comparison of envelope 2 CD81 binding regions in PBMC-derived versus serum-derived hepatitis c virus isolates: Higher conservation of CD81 region 2 in PBMC isolates
    • PMID: 20367804
    • Welker MW, Welsch C, Ochs D, Hofmann WP, Herrmann E, Piiper A, Hartmann RW, Zeuzem S, Sarrazin C, Kronenberger B. Comparison of envelope 2 CD81 binding regions in PBMC-derived versus serum-derived hepatitis C virus isolates: higher conservation of CD81 region 2 in PBMC isolates. J Viral Hepat 2011; 18: 181-192 [PMID: 20367804 DOI: 10.1111/j.1365-2893.2010.01296.x].
    • (2011) J Viral Hepat , vol.18 , pp. 181-192
    • Welker, M.W.1    Welsch, C.2    Ochs, D.3    Hofmann, W.P.4    Herrmann, E.5    Piiper, A.6    Hartmann, R.W.7    Zeuzem, S.8    Sarrazin, C.9    Kronenberger, B.10
  • 109
    • 79955374432 scopus 로고    scopus 로고
    • Hepatitis C virus protects human B lymphocytes from FAS-mediated apoptosis via E2-CD81 engagement
    • PMID: 21526201
    • Chen Z, Zhu Y, Ren Y, Tong Y, Hua X, Zhu F, Huang L, Liu Y, Luo Y, Lu W, Zhao P, Qi Z. Hepatitis C virus protects human B lymphocytes from Fas-mediated apoptosis via E2-CD81 engagement. PLoS One 2011; 6: e18933 [PMID: 21526201 DOI: 10.1371/journal.pone.0018933].
    • (2011) PLoS One , vol.6 , pp. e18933
    • Chen, Z.1    Zhu, Y.2    Ren, Y.3    Tong, Y.4    Hua, X.5    Zhu, F.6    Huang, L.7    Liu, Y.8    Luo, Y.9    Lu, W.10    Zhao, P.11    Qi, Z.12
  • 110
    • 84861321809 scopus 로고    scopus 로고
    • Hepatitis C virus infection of human T lymphocytes is mediated by CD5
    • PMID: 22278227
    • Sarhan MA, Pham TN, Chen AY, Michalak TI. Hepatitis C virus infection of human T lymphocytes is mediated by CD5. J Virol 2012; 86: 3723-3735 [PMID: 22278227 DOI: 10.1128/JVI.06956-11].
    • (2012) J Virol , vol.86 , pp. 3723-3735
    • Sarhan, M.A.1    Pham, T.N.2    Chen, A.Y.3    Michalak, T.I.4
  • 112
    • 0028818269 scopus 로고
    • Lack of detection of negative-strand hepatitis c virus RNA in peripheral blood mononuclear cells and other extrahepatic tissues by the highly strand-specific RTTH reverse transcriptase PCR
    • PMID: 7494326
    • Lanford RE, Chavez D, Chisari FV, Sureau C. Lack of detection of negative-strand hepatitis C virus RNA in peripheral blood mononuclear cells and other extrahepatic tissues by the highly strand-specific rTth reverse transcriptase PCR. J Virol 1995; 69: 8079-8083 [PMID: 7494326].
    • (1995) J Virol , vol.69 , pp. 8079-8083
    • Lanford, R.E.1    Chavez, D.2    Chisari, F.V.3    Sureau, C.4
  • 113
    • 0030700022 scopus 로고    scopus 로고
    • Hepatitis C virus negative strand RNA is not detected in peripheral blood mononuclear cells and viral sequences are identical to those in serum: A case against extrahepatic replication
    • PMID: 9367359
    • Laskus T, Radkowski M, Wang LF, Cianciara J, Vargas H, Rakela J. Hepatitis C virus negative strand RNA is not detected in peripheral blood mononuclear cells and viral sequences are identical to those in serum: A case against extrahepatic replication. J Gen Virol 1997; 78 (Pt 11): 2747-2750 [PMID: 9367359].
    • (1997) J Gen Virol , vol.78 , pp. 2747-2750
    • Laskus, T.1    Radkowski, M.2    Wang, L.F.3    Cianciara, J.4    Vargas, H.5    Rakela, J.6
  • 114
    • 0142185450 scopus 로고    scopus 로고
    • Commentary: Modelling the epidemiology of hepatitis C and its complications
    • PMID: 14559739
    • Armstrong GL. Commentary: Modelling the epidemiology of hepatitis C and its complications. Int J Epidemiol 2003; 32: 725-726 [PMID: 14559739].
    • (2003) Int J Epidemiol , vol.32 , pp. 725-726
    • Armstrong, G.L.1
  • 115
    • 0029026169 scopus 로고
    • Relationship between hepatitis c virus genotypes and sources of infection in patients with chronic hepatitis C
    • PMID: 7769300
    • Pawlotsky JM, Tsakiris L, Roudot-Thoraval F, Pellet C, Stuyver L, Duval J, Dhumeaux D. Relationship between hepatitis C virus genotypes and sources of infection in patients with chronic hepatitis C. J Infect Dis 1995; 171: 1607-1610 [PMID: 7769300].
    • (1995) J Infect Dis , vol.171 , pp. 1607-1610
    • Pawlotsky, J.M.1    Tsakiris, L.2    Roudot-Thoraval, F.3    Pellet, C.4    Stuyver, L.5    Duval, J.6    Dhumeaux, D.7
  • 116
    • 11844281595 scopus 로고    scopus 로고
    • The hepatitis C virus epidemic among injecting drug users
    • PMID: 15639745
    • Pybus OG, Cochrane A, Holmes EC, Simmonds P. The hepatitis C virus epidemic among injecting drug users. Infect Genet Evol 2005; 5: 131-139 [PMID: 15639745 DOI: 10.1016/j.meegid.2004.08.001].
    • (2005) Infect Genet Evol , vol.5 , pp. 131-139
    • Pybus, O.G.1    Cochrane, A.2    Holmes, E.C.3    Simmonds, P.4
  • 118
    • 13844267622 scopus 로고    scopus 로고
    • Hepatitis C virus infection
    • PMID: 15679481
    • Thomson BJ, Finch RG. Hepatitis C virus infection. Clin Microbiol Infect 2005; 11: 86-94 [PMID: 15679481 DOI: 10.1111/j.1469-0691.2004.01061.x].
    • (2005) Clin Microbiol Infect , vol.11 , pp. 86-94
    • Thomson, B.J.1    Finch, R.G.2
  • 120
    • 79951522447 scopus 로고    scopus 로고
    • Incidence and transmission patterns of acute hepatitis C in the United States, 1982-2006
    • PMID: 21325115
    • Williams IT, Bell BP, Kuhnert W, Alter MJ. Incidence and transmission patterns of acute hepatitis C in the United States, 1982-2006. Arch Intern Med 2011; 171: 242-248 [PMID: 21325115 DOI: 10.1001/archinternmed.2010.511].
    • (2011) Arch Intern Med , vol.171 , pp. 242-248
    • Williams, I.T.1    Bell, B.P.2    Kuhnert, W.3    Alter, M.J.4
  • 121
    • 0032538246 scopus 로고    scopus 로고
    • Recommendations for prevention and control of hepatitis C virus (HCV) infection and HCV-related chronic disease
    • Centers for Disease Control and Prevention [PMID: 9790221]
    • Recommendations for prevention and control of hepatitis C virus (HCV) infection and HCV-related chronic disease. Centers for Disease Control and Prevention. MMWR Recomm Rep 1998; 47: 1-39 [PMID: 9790221].
    • (1998) MMWR Recomm Rep , vol.47 , pp. 1-39
  • 122
    • 84871984694 scopus 로고    scopus 로고
    • Antibody- And genome-based identification of recent HCV infection
    • PMID: 23322615
    • Araujo AC. Antibody- And genome-based identification of recent HCV infection. Antivir Ther 2012; 17: 1459-1464 [PMID: 23322615 DOI: 10.3851/IMP2464].
    • (2012) Antivir Ther , vol.17 , pp. 1459-1464
    • Araujo, A.C.1
  • 124
    • 84880676029 scopus 로고    scopus 로고
    • Viral phylogeny in court: The unusual case of the valencian anesthetist
    • PMID: 24059471
    • Vandamme AM, Pybus OG. Viral phylogeny in court: The unusual case of the Valencian anesthetist. BMC Biol 2013; 11: 83 [PMID: 24059471 DOI: 10.1186/1741-7007-11-83].
    • (2013) BMC Biol , vol.11 , pp. 83
    • Vandamme, A.M.1    Pybus, O.G.2
  • 125
    • 84880673210 scopus 로고    scopus 로고
    • Molecular evolution in court: Analysis of a large hepatitis C virus outbreak from an evolving source
    • PMID: 23870105
    • González-Candelas F, Bracho MA, Wróbel B, Moya A. Molecular evolution in court: Analysis of a large hepatitis C virus outbreak from an evolving source. BMC Biol 2013; 11: 76 [PMID: 23870105 DOI: 10.1186/1741-7007-11-76].
    • (2013) BMC Biol , vol.11 , pp. 76
    • González-Candelas, F.1    Bracho, M.A.2    Wróbel, B.3    Moya, A.4
  • 126
    • 33646857240 scopus 로고    scopus 로고
    • Analysis of the overdispersed clock in the short-term evolution of hepatitis c virus: Using the E1/E2 gene sequences to infer infection dates in a single source outbreak
    • PMID: 16585120
    • Wróbel B, Torres-Puente M, Jiménez N, Bracho MA, García- Robles I, Moya A, González-Candelas F. Analysis of the overdispersed clock in the short-term evolution of hepatitis C virus: Using the E1/E2 gene sequences to infer infection dates in a single source outbreak. Mol Biol Evol 2006; 23: 1242-1253 [PMID: 16585120 DOI: 10.1093/molbev/msk012].
    • (2006) Mol Biol Evol , vol.23 , pp. 1242-1253
    • Wróbel, B.1    Torres-Puente, M.2    Jiménez, N.3    Bracho, M.A.4    García-, R.I.5    Moya, A.6    González-Candelas, F.7
  • 128
    • 84891748563 scopus 로고    scopus 로고
    • Hepatitis: Immunoregulation in pregnancy and perinatal transmission of HCV
    • PMID: 24296582
    • Indolfi G, Azzari C, Resti M. Hepatitis: Immunoregulation in pregnancy and perinatal transmission of HCV. Nat Rev Gastroenterol Hepatol 2014; 11: 6-7 [PMID: 24296582 DOI: 10.1038/nrgastro.2013.230].
    • (2014) Nat Rev Gastroenterol Hepatol , vol.11 , pp. 6-7
    • Indolfi, G.1    Azzari, C.2    Resti, M.3
  • 129
    • 84888308845 scopus 로고    scopus 로고
    • Perinatal transmission of hepatitis C virus
    • PMID: 23919905
    • Indolfi G, Azzari C, Resti M. Perinatal transmission of hepatitis C virus. J Pediatr 2013; 163: 1549-1552.e1 [PMID: 23919905 DOI: 10.1016/j.jpeds.2013.06.077].
    • (2013) J Pediatr , vol.163 , pp. 1549-1552
    • Indolfi, G.1    Azzari, C.2    Resti, M.3
  • 130
    • 36849028812 scopus 로고    scopus 로고
    • Higher risk of hepatitis C virus perinatal transmission from drug user mothers is mediated by peripheral blood mononuclear cell infection
    • PMID: 18041020
    • Azzari C, Moriondo M, Indolfi G, Betti L, Gambineri E, de Martino M, Resti M. Higher risk of hepatitis C virus perinatal transmission from drug user mothers is mediated by peripheral blood mononuclear cell infection. J Med Virol 2008; 80: 65-71 [PMID: 18041020 DOI: 10.1002/jmv.21023].
    • (2008) J Med Virol , vol.80 , pp. 65-71
    • Azzari, C.1    Moriondo, M.2    Indolfi, G.3    Betti, L.4    Gambineri, E.5    De Martino, M.6    Resti, M.7
  • 131
    • 0034665772 scopus 로고    scopus 로고
    • Vertical transmission of HCV is related to maternal peripheral blood mononuclear cell infection
    • PMID: 10979945
    • Azzari C, Resti M, Moriondo M, Ferrari R, Lionetti P, Vierucci A. Vertical transmission of HCV is related to maternal peripheral blood mononuclear cell infection. Blood 2000; 96: 2045-2048 [PMID: 10979945].
    • (2000) Blood , vol.96 , pp. 2045-2048
    • Azzari, C.1    Resti, M.2    Moriondo, M.3    Ferrari, R.4    Lionetti, P.5    Vierucci, A.6
  • 132
    • 0030916108 scopus 로고    scopus 로고
    • Analysis of mother-to-infant transmission of hepatitis C virus: Quasispecies nature and buoyant densities of maternal virus populations
    • PMID: 9139088
    • Kudo T, Yanase Y, Ohshiro M, Yamamoto M, Morita M, Shibata M, Morishima T. Analysis of mother-to-infant transmission of hepatitis C virus: quasispecies nature and buoyant densities of maternal virus populations. J Med Virol 1997; 51: 225-230 [PMID: 9139088].
    • (1997) J Med Virol , vol.51 , pp. 225-230
    • Kudo, T.1    Yanase, Y.2    Ohshiro, M.3    Yamamoto, M.4    Morita, M.5    Shibata, M.6    Morishima, T.7
  • 134
    • 79959847561 scopus 로고    scopus 로고
    • Interleukin-28B genotyping by melt-mismatch amplification mutation assay PCR analysis using single nucleotide polymorphisms rs12979860 and rs8099917, a useful tool for prediction of therapy response in hepatitis c patients
    • PMID: 21613433
    • Fonseca-Coronado S, Vaughan G, Cruz-Rivera MY, Carpio- Pedroza JC, Ruiz-Tovar K, Ruiz-Pacheco JA, Escobar- Gutiérrez A. Interleukin-28B genotyping by melt-mismatch amplification mutation assay PCR analysis using single nucleotide polymorphisms rs12979860 and rs8099917, a useful tool for prediction of therapy response in hepatitis C patients. J Clin Microbiol 2011; 49: 2706-2710 [PMID: 21613433 DOI: 10.1128/JCM.00877-11].
    • (2011) J Clin Microbiol , vol.49 , pp. 2706-2710
    • Fonseca-Coronado, S.1    Vaughan, G.2    Cruz-Rivera, M.Y.3    Carpio-Pedroza, J.C.4    Ruiz-Tovar, K.5    Ruiz-Pacheco, J.A.6    Escobar-Gutiérrez, A.7
  • 135
    • 46749091188 scopus 로고    scopus 로고
    • End-point limiting-dilution real-time PCR assay for evaluation of hepatitis C virus quasispecies in serum: Performance under optimal and suboptimal conditions
    • PMID: 18571738
    • Ramachandran S, Xia GL, Ganova-Raeva LM, Nainan OV, Khudyakov Y. End-point limiting-dilution real-time PCR assay for evaluation of hepatitis C virus quasispecies in serum: performance under optimal and suboptimal conditions. J Virol Methods 2008; 151: 217-224 [PMID: 18571738 DOI: 10.1016/j.jviromet.2008.05.005].
    • (2008) J Virol Methods , vol.151 , pp. 217-224
    • Ramachandran, S.1    Xia, G.L.2    Ganova-Raeva, L.M.3    Nainan, O.V.4    Khudyakov, Y.5
  • 140
    • 84874964797 scopus 로고    scopus 로고
    • Challenges and opportunities in estimating viral genetic diversity from next-generation sequencing data
    • PMID: 22973268
    • Beerenwinkel N, Günthard HF, Roth V, Metzner KJ. Challenges and opportunities in estimating viral genetic diversity from next-generation sequencing data. Front Microbiol 2012; 3: 329 [PMID: 22973268 DOI: 10.3389/fmicb.2012.00329].
    • (2012) Front Microbiol , vol.3 , pp. 329
    • Beerenwinkel, N.1    Günthard, H.F.2    Roth, V.3    Metzner, K.J.4
  • 145
    • 80052723449 scopus 로고    scopus 로고
    • Impact of HCV genetic differences on pathobiology of disease
    • PMID: 21905784
    • Ripoli M, Pazienza V. Impact of HCV genetic differences on pathobiology of disease. Expert Rev Anti Infect Ther 2011; 9: 747-759 [PMID: 21905784 DOI: 10.1586/eri.11.94].
    • (2011) Expert Rev Anti Infect Ther , vol.9 , pp. 747-759
    • Ripoli, M.1    Pazienza, V.2
  • 147
    • 0034808023 scopus 로고    scopus 로고
    • Caspase activation correlates with the degree of inflammatory liver injury in chronic hepatitis C virus infection
    • PMID: 11584373
    • Bantel H, Lügering A, Poremba C, Lügering N, Held J, Domschke W, Schulze-Osthoff K. Caspase activation correlates with the degree of inflammatory liver injury in chronic hepatitis C virus infection. Hepatology 2001; 34: 758-767 [PMID: 11584373 DOI: 10.1053/jhep.2001.28229].
    • (2001) Hepatology , vol.34 , pp. 758-767
    • Bantel, H.1    Lügering, A.2    Poremba, C.3    Lügering, N.4    Held, J.5    Domschke, W.6    Schulze-Osthoff, K.7
  • 148
    • 79954997858 scopus 로고    scopus 로고
    • Modulation of programmed cell death pathways by the hepatitis C virus
    • PMID: 21196192
    • Aweya JJ, Tan YJ. Modulation of programmed cell death pathways by the hepatitis C virus. Front Biosci (Landmark Ed) 2011; 16: 608-618 [PMID: 21196192].
    • (2011) Front Biosci (Landmark Ed) , vol.16 , pp. 608-618
    • Aweya, J.J.1    Tan, Y.J.2
  • 149
    • 42949086433 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of liver injury
    • PMID: 18471544
    • Malhi H, Gores GJ. Cellular and molecular mechanisms of liver injury. Gastroenterology 2008; 134: 1641-1654 [PMID: 18471544 DOI: 10.1053/j.gastro.2008.03.002].
    • (2008) Gastroenterology , vol.134 , pp. 1641-1654
    • Malhi, H.1    Gores, G.J.2
  • 150
    • 84875991033 scopus 로고    scopus 로고
    • Hepatitis C virus core protein down-regulates p21(Waf1/Cip1) and inhibits curcumin-induced apoptosis through microrna-345 targeting in human hepatoma cells
    • PMID: 23577194
    • Shiu TY, Huang SM, Shih YL, Chu HC, Chang WK, Hsieh TY. Hepatitis C virus core protein down-regulates p21(Waf1/Cip1) and inhibits curcumin-induced apoptosis through microRNA-345 targeting in human hepatoma cells. PLoS One 2013; 8: e61089 [PMID: 23577194 DOI: 10.1371/journal. pone.0061089].
    • (2013) PLoS One , vol.8 , pp. e61089
    • Shiu, T.Y.1    Huang, S.M.2    Shih, Y.L.3    Chu, H.C.4    Chang, W.K.5    Hsieh, T.Y.6
  • 151
    • 81555237181 scopus 로고    scopus 로고
    • Anti- Apoptotic effect of HCV core gene of genotype 3a in huh-7 cell line
    • PMID: 22108100
    • Jahan S, Khaliq S, Siddiqi MH, Ijaz B, Ahmad W, Ashfaq UA, Hassan S. Anti- Apoptotic effect of HCV core gene of genotype 3a in Huh-7 cell line. Virol J 2011; 8: 522 [PMID: 22108100 DOI: 10.1186/1743-422X-8-522].
    • (2011) Virol J , vol.8 , pp. 522
    • Jahan, S.1    Khaliq, S.2    Siddiqi, M.H.3    Ijaz, B.4    Ahmad, W.5    Ashfaq, U.A.6    Hassan, S.7
  • 152
    • 79955164804 scopus 로고    scopus 로고
    • HCV core protein promotes heparin binding EGF-like growth factor expression and activates Akt
    • PMID: 21418450
    • Nakamura H, Aoki H, Hino O, Moriyama M. HCV core protein promotes heparin binding EGF-like growth factor expression and activates Akt. Hepatol Res 2011; 41: 455-462 [PMID: 21418450 DOI: 10.1111/j.1872-034X.2011.00792.x].
    • (2011) Hepatol Res , vol.41 , pp. 455-462
    • Nakamura, H.1    Aoki, H.2    Hino, O.3    Moriyama, M.4
  • 153
  • 154
    • 12944293008 scopus 로고    scopus 로고
    • Hepatitis C virus core, NS3, NS5A, NS5B proteins induce apoptosis in mature dendritic cells
    • PMID: 15648076
    • Siavoshian S, Abraham JD, Thumann C, Kieny MP, Schuster C. Hepatitis C virus core, NS3, NS5A, NS5B proteins induce apoptosis in mature dendritic cells. J Med Virol 2005; 75: 402-411 [PMID: 15648076 DOI: 10.1002/jmv.20283].
    • (2005) J Med Virol , vol.75 , pp. 402-411
    • Siavoshian, S.1    Abraham, J.D.2    Thumann, C.3    Kieny, M.P.4    Schuster, C.5
  • 156
    • 33646166625 scopus 로고    scopus 로고
    • Hepatitis C virus core protein inhibits tumor necrosis factor alphamediated apoptosis by a protective effect involving cellular flice inhibitory protein
    • PMID: 16611896
    • Saito K, Meyer K, Warner R, Basu A, Ray RB, Ray R. Hepatitis C virus core protein inhibits tumor necrosis factor alphamediated apoptosis by a protective effect involving cellular FLICE inhibitory protein. J Virol 2006; 80: 4372-4379 [PMID: 16611896 DOI: 10.1128/JVI.80.9.4372-4379.2006].
    • (2006) J Virol , vol.80 , pp. 4372-4379
    • Saito, K.1    Meyer, K.2    Warner, R.3    Basu, A.4    Ray, R.B.5    Ray, R.6
  • 157
    • 1942436893 scopus 로고    scopus 로고
    • Modulation of p53 transcription regulatory activity and post-translational modification by hepatitis c virus core protein
    • PMID: 14968111
    • Kao CF, Chen SY, Chen JY, Wu Lee YH. Modulation of p53 transcription regulatory activity and post-translational modification by hepatitis C virus core protein. Oncogene 2004; 23: 2472-2483 [PMID: 14968111 DOI: 10.1038/sj.onc.1207368].
    • (2004) Oncogene , vol.23 , pp. 2472-2483
    • Kao, C.F.1    Chen, S.Y.2    Chen, J.Y.3    Wu, L.Y.H.4
  • 158
    • 0034602420 scopus 로고    scopus 로고
    • Hepatitis c virus core protein enhances p53 function through augmentation of DNA binding affinity and transcriptional ability
    • PMID: 10924497
    • Otsuka M, Kato N, Lan K, Yoshida H, Kato J, Goto T, Shiratori Y, Omata M. Hepatitis C virus core protein enhances p53 function through augmentation of DNA binding affinity and transcriptional ability. J Biol Chem 2000; 275: 34122-34130 [PMID: 10924497 DOI: 10.1074/jbc.M000578200].
    • (2000) J Biol Chem , vol.275 , pp. 34122-34130
    • Otsuka, M.1    Kato, N.2    Lan, K.3    Yoshida, H.4    Kato, J.5    Goto, T.6    Shiratori, Y.7    Omata, M.8
  • 159
    • 26444492154 scopus 로고    scopus 로고
    • Molecular basis of hepatitis C virus- Associated hepatocarcinogenesis: Lessons from animal model studies
    • PMID: 16234061
    • Koike K. Molecular basis of hepatitis C virus- Associated hepatocarcinogenesis: lessons from animal model studies. Clin Gastroenterol Hepatol 2005; 3: S132-S135 [PMID: 16234061].
    • (2005) Clin Gastroenterol Hepatol , vol.3 , pp. S132-S135
    • Koike, K.1
  • 162
    • 46049115059 scopus 로고    scopus 로고
    • Substitution of amino acid 70 in the hepatitis c virus core region of genotype 1B is an important predictor of elevated alpha-fetoprotein in patients without hepatocellular carcinoma
    • PMID: 18551609
    • Akuta N, Suzuki F, Kawamura Y, Yatsuji H, Sezaki H, Suzuki Y, Hosaka T, Kobayashi M, Kobayashi M, Arase Y, Ikeda K, Kumada H. Substitution of amino acid 70 in the hepatitis C virus core region of genotype 1b is an important predictor of elevated alpha-fetoprotein in patients without hepatocellular carcinoma. J Med Virol 2008; 80: 1354-1362 [PMID: 18551609 DOI: 10.1002/jmv.21202].
    • (2008) J Med Virol , vol.80 , pp. 1354-1362
    • Akuta, N.1    Suzuki, F.2    Kawamura, Y.3    Yatsuji, H.4    Sezaki, H.5    Suzuki, Y.6    Hosaka, T.7    Kobayashi, M.8    Kobayashi, M.9    Arase, Y.10    Ikeda, K.11    Kumada, H.12
  • 163
    • 65649143507 scopus 로고    scopus 로고
    • Mutations in the hepatitis C virus core gene are associated with advanced liver disease and hepatocellular carcinoma
    • PMID: 19383824
    • Fishman SL, Factor SH, Balestrieri C, Fan X, Dibisceglie AM, Desai SM, Benson G, Branch AD. Mutations in the hepatitis C virus core gene are associated with advanced liver disease and hepatocellular carcinoma. Clin Cancer Res 2009; 15: 3205-3213 [PMID: 19383824 DOI: 10.1158/1078-0432.CCR-08-2418].
    • (2009) Clin Cancer Res , vol.15 , pp. 3205-3213
    • Fishman, S.L.1    Factor, S.H.2    Balestrieri, C.3    Fan, X.4    Dibisceglie, A.M.5    Desai, S.M.6    Benson, G.7    Branch, A.D.8
  • 164
    • 0035129174 scopus 로고    scopus 로고
    • Comparative sequence analysis of the core- And NS5-region of hepatitis C virus from tumor and adjacent non-tumor tissue
    • PMID: 11170049
    • Rüster B, Zeuzem S, Krump-Konvalinkova V, Berg T, Jonas S, Severin K, Roth WK. Comparative sequence analysis of the core- And NS5-region of hepatitis C virus from tumor and adjacent non-tumor tissue. J Med Virol 2001; 63: 128-134 [PMID: 11170049].
    • (2001) J Med Virol , vol.63 , pp. 128-134
    • Rüster, B.1    Zeuzem, S.2    Krump-Konvalinkova, V.3    Berg, T.4    Jonas, S.5    Severin, K.6    Roth, W.K.7
  • 165
    • 0036594910 scopus 로고    scopus 로고
    • Hepatitis C virus quasispecies in cancerous and noncancerous hepatic lesions: The core protein- encoding region
    • PMID: 12108585
    • Alam SS, Nakamura T, Naganuma A, Nozaki A, Nouso K, Shimomura H, Kato N. Hepatitis C virus quasispecies in cancerous and noncancerous hepatic lesions: The core protein- encoding region. Acta Med Okayama 2002; 56: 141-147 [PMID: 12108585].
    • (2002) Acta Med Okayama , vol.56 , pp. 141-147
    • Alam, S.S.1    Nakamura, T.2    Naganuma, A.3    Nozaki, A.4    Nouso, K.5    Shimomura, H.6    Kato, N.7
  • 166
    • 0032403095 scopus 로고    scopus 로고
    • Comparison of serum and liver hepatitis C virus quasispecies in HCV-related hepatocellular carcinoma
    • PMID: 9875634
    • De Mitri MS, Mele L, Chen CH, Piccinini A, Chianese R, D' Errico A, Alberti A, Pisi E. Comparison of serum and liver hepatitis C virus quasispecies in HCV-related hepatocellular carcinoma. J Hepatol 1998; 29: 887-892 [PMID: 9875634].
    • (1998) J Hepatol , vol.29 , pp. 887-892
    • De Mitri, M.S.1    Mele, L.2    Chen, C.H.3    Piccinini, A.4    Chianese, R.5    D'Errico, A.6    Alberti, A.7    Pisi, E.8
  • 168
    • 0036790144 scopus 로고    scopus 로고
    • Comparative sequence analysis of the core protein and its frameshift product, the F protein, of hepatitis C virus subtype 1B strains obtained from patients with and without hepatocellular carcinoma
    • PMID: 12354856
    • Ogata S, Nagano-Fujii M, Ku Y, Yoon S, Hotta H. Comparative sequence analysis of the core protein and its frameshift product, the F protein, of hepatitis C virus subtype 1b strains obtained from patients with and without hepatocellular carcinoma. J Clin Microbiol 2002; 40: 3625-3630 [PMID: 12354856].
    • (2002) J Clin Microbiol , vol.40 , pp. 3625-3630
    • Ogata, S.1    Nagano-Fujii, M.2    Ku, Y.3    Yoon, S.4    Hotta, H.5
  • 169
    • 0028618516 scopus 로고
    • Evidence for a link between hepatitis C virus infection and diabetes mellitus in a cirrhotic population
    • PMID: 7699240
    • Allison ME, Wreghitt T, Palmer CR, Alexander GJ. Evidence for a link between hepatitis C virus infection and diabetes mellitus in a cirrhotic population. J Hepatol 1994; 21: 1135-1139 [PMID: 7699240].
    • (1994) J Hepatol , vol.21 , pp. 1135-1139
    • Allison, M.E.1    Wreghitt, T.2    Palmer, C.R.3    Alexander, G.J.4
  • 171
    • 66449096358 scopus 로고    scopus 로고
    • Amino acid substitutions in the hepatitis C virus core region of genotype 1b are the important predictor of severe insulin resistance in patients without cirrhosis and diabetes mellitus
    • PMID: 19382270
    • Akuta N, Suzuki F, Hirakawa M, Kawamura Y, Yatsuji H, Sezaki H, Suzuki Y, Hosaka T, Kobayashi M, Kobayashi M, Saitoh S, Arase Y, Ikeda K, Kumada H. Amino acid substitutions in the hepatitis C virus core region of genotype 1b are the important predictor of severe insulin resistance in patients without cirrhosis and diabetes mellitus. J Med Virol 2009; 81: 1032-1039 [PMID: 19382270 DOI: 10.1002/jmv.21473].
    • (2009) J Med Virol , vol.81 , pp. 1032-1039
    • Akuta, N.1    Suzuki, F.2    Hirakawa, M.3    Kawamura, Y.4    Yatsuji, H.5    Sezaki, H.6    Suzuki, Y.7    Hosaka, T.8    Kobayashi, M.9    Kobayashi, M.10    Saitoh, S.11    Arase, Y.12    Ikeda, K.13    Kumada, H.14
  • 172
    • 0034987263 scopus 로고    scopus 로고
    • Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity
    • PMID: 11391523
    • Adinolfi LE, Gambardella M, Andreana A, Tripodi MF, Utili R, Ruggiero G. Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity. Hepatology 2001; 33: 1358-1364 [PMID: 11391523 DOI: 10.1053/jhep.2001.24432].
    • (2001) Hepatology , vol.33 , pp. 1358-1364
    • Adinolfi, L.E.1    Gambardella, M.2    Andreana, A.3    Tripodi, M.F.4    Utili, R.5    Ruggiero, G.6
  • 173
    • 0035572430 scopus 로고    scopus 로고
    • Liver steatosis in chronic hepatitis C: A morphological sign suggesting infection with HCV genotype 3
    • PMID: 11493327
    • Rubbia-Brandt L, Leandro G, Spahr L, Giostra E, Quadri R, Malé PJ, Negro F. Liver steatosis in chronic hepatitis C: A morphological sign suggesting infection with HCV genotype 3. Histopathology 2001; 39: 119-124 [PMID: 11493327].
    • (2001) Histopathology , vol.39 , pp. 119-124
    • Rubbia-Brandt, L.1    Leandro, G.2    Spahr, L.3    Giostra, E.4    Quadri, R.5    Malé, P.J.6    Negro, F.7
  • 174
    • 77950605678 scopus 로고    scopus 로고
    • Impact of amino acid substitutions in the hepatitis C virus genotype 1B core region on liver steatosis and hepatic oxidative stress in patients with chronic hepatitis c
    • PMID: 19951380
    • Tachi Y, Katano Y, Honda T, Hayashi K, Ishigami M, Itoh A, Hirooka Y, Nakano I, Samejima Y, Goto H. Impact of amino acid substitutions in the hepatitis C virus genotype 1b core region on liver steatosis and hepatic oxidative stress in patients with chronic hepatitis C. Liver Int 2010; 30: 554-559 [PMID: 19951380 DOI: 10.1111/j.1478-3231.2009.02164.x].
    • (2010) Liver Int , vol.30 , pp. 554-559
    • Tachi, Y.1    Katano, Y.2    Honda, T.3    Hayashi, K.4    Ishigami, M.5    Itoh, A.6    Hirooka, Y.7    Nakano, I.8    Samejima, Y.9    Goto, H.10
  • 176
    • 34548639595 scopus 로고    scopus 로고
    • Evolution of hepatitis c virus nonstructural 5A gene in the progression of liver disease to hepatocellular carcinoma
    • PMID: 17845542
    • De Mitri MS, Cassini R, Bagaglio S, Morsica G, Andreone P, Marino N, Bernardi M. Evolution of hepatitis C virus nonstructural 5A gene in the progression of liver disease to hepatocellular carcinoma. Liver Int 2007; 27: 1126-1133 [PMID: 17845542 DOI: 10.1111/j.1478-3231.2007.01537.x].
    • (2007) Liver Int , vol.27 , pp. 1126-1133
    • De Mitri, M.S.1    Cassini, R.2    Bagaglio, S.3    Morsica, G.4    Andreone, P.5    Marino, N.6    Bernardi, M.7
  • 177
    • 0034084529 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A protein protects against TNF- Alpha mediated apoptotic cell death
    • PMID: 10867196
    • Ghosh AK, Majumder M, Steele R, Meyer K, Ray R, Ray RB. Hepatitis C virus NS5A protein protects against TNF- Alpha mediated apoptotic cell death. Virus Res 2000; 67: 173-178 [PMID: 10867196].
    • (2000) Virus Res , vol.67 , pp. 173-178
    • Ghosh, A.K.1    Majumder, M.2    Steele, R.3    Meyer, K.4    Ray, R.5    Ray, R.B.6
  • 178
    • 0032938224 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A protein modulates cell cycle regulatory genes and promotes cell growth
    • PMID: 10355764
    • Ghosh AK, Steele R, Meyer K, Ray R, Ray RB. Hepatitis C virus NS5A protein modulates cell cycle regulatory genes and promotes cell growth. J Gen Virol 1999; 80 (Pt 5): 1179-1183 [PMID: 10355764].
    • (1999) J Gen Virol , vol.80 , pp. 1179-1183
    • Ghosh, A.K.1    Steele, R.2    Meyer, K.3    Ray, R.4    Ray, R.B.5
  • 180
    • 0031592827 scopus 로고    scopus 로고
    • Hepatitis C virus nonstructural protein 5A contains potential transcriptional activator domains
    • PMID: 9387155
    • Chung KM, Song OK, Jang SK. Hepatitis C virus nonstructural protein 5A contains potential transcriptional activator domains. Mol Cells 1997; 7: 661-667 [PMID: 9387155].
    • (1997) Mol Cells , vol.7 , pp. 661-667
    • Chung, K.M.1    Song, O.K.2    Jang, S.K.3
  • 181
    • 9144257569 scopus 로고    scopus 로고
    • Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis c virus 1b infection
    • PMID: 8531962
    • Enomoto N, Sakuma I, Asahina Y, Kurosaki M, Murakami T, Yamamoto C, Ogura Y, Izumi N, Marumo F, Sato C. Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection. N Engl J Med 1996; 334: 77-81 [PMID: 8531962 DOI: 10.1056/NEJM199601113340203].
    • (1996) N Engl J Med , vol.334 , pp. 77-81
    • Enomoto, N.1    Sakuma, I.2    Asahina, Y.3    Kurosaki, M.4    Murakami, T.5    Yamamoto, C.6    Ogura, Y.7    Izumi, N.8    Marumo, F.9    Sato, C.10
  • 182
    • 11244345995 scopus 로고    scopus 로고
    • HCV quasispecies evolution: Association with progression to end-stage liver disease in hemophiliacs infected with HCV or HCV/HIV
    • PMID: 15374882
    • Qin H, Shire NJ, Keenan ED, Rouster SD, Eyster ME, Goedert JJ, Koziel MJ, Sherman KE. HCV quasispecies evolution: Association with progression to end-stage liver disease in hemophiliacs infected with HCV or HCV/HIV. Blood 2005; 105: 533-541 [PMID: 15374882 DOI: 10.1182/blood-2004-04-1452].
    • (2005) Blood , vol.105 , pp. 533-541
    • Qin, H.1    Shire, N.J.2    Keenan, E.D.3    Rouster, S.D.4    Eyster, M.E.5    Goedert, J.J.6    Koziel, M.J.7    Sherman, K.E.8
  • 183
    • 4644319350 scopus 로고    scopus 로고
    • Differing patterns of liver disease progression and hepatitis C virus (HCV) quasispecies evolution in children vertically coinfected with HCV and human immunodeficiency virus type 1
    • PMID: 15365046
    • Canobio S, Guilbert CM, Troesch M, Samson J, Lemay M, Pelletier VA, Bernard-Bonnin AC, Kozielski R, Lapointe N, Martin SR, Soudeyns H. Differing patterns of liver disease progression and hepatitis C virus (HCV) quasispecies evolution in children vertically coinfected with HCV and human immunodeficiency virus type 1. J Clin Microbiol 2004; 42: 4365-4369 [PMID: 15365046 DOI: 10.1128/JCM.42.9.4365-4369.2004].
    • (2004) J Clin Microbiol , vol.42 , pp. 4365-4369
    • Canobio, S.1    Guilbert, C.M.2    Troesch, M.3    Samson, J.4    Lemay, M.5    Pelletier, V.A.6    Bernard-Bonnin, A.C.7    Kozielski, R.8    Lapointe, N.9    Martin, S.R.10    Soudeyns, H.11
  • 185
    • 0028271727 scopus 로고
    • Dynamic behavior of hepatitis C virus quasispecies in patients undergoing orthotopic liver transplantation
    • PMID: 8151804
    • Martell M, Esteban JI, Quer J, Vargas V, Esteban R, Guardia J, Gómez J. Dynamic behavior of hepatitis C virus quasispecies in patients undergoing orthotopic liver transplantation. J Virol 1994; 68: 3425-3436 [PMID: 8151804].
    • (1994) J Virol , vol.68 , pp. 3425-3436
    • Martell, M.1    Esteban, J.I.2    Quer, J.3    Vargas, V.4    Esteban, R.5    Guardia, J.6    Gómez, J.7
  • 186
    • 0029842879 scopus 로고    scopus 로고
    • Tracking hepatitis c virus quasispecies major and minor variants in symptomatic and asymptomatic liver transplant recipients
    • PMID: 8892882
    • Gretch DR, Polyak SJ, Wilson JJ, Carithers RL, Perkins JD, Corey L. Tracking hepatitis C virus quasispecies major and minor variants in symptomatic and asymptomatic liver transplant recipients. J Virol 1996; 70: 7622-7631 [PMID: 8892882].
    • (1996) J Virol , vol.70 , pp. 7622-7631
    • Gretch, D.R.1    Polyak, S.J.2    Wilson, J.J.3    Carithers, R.L.4    Perkins, J.D.5    Corey, L.6
  • 187
    • 0032694939 scopus 로고    scopus 로고
    • Evolution of hepatitis C virus quasispecies in patients with severe cholestatic hepatitis after liver transplantation
    • PMID: 10573532
    • Pessoa MG, Bzowej N, Berenguer M, Phung Y, Kim M, Ferrell L, Hassoba H, Wright TL. Evolution of hepatitis C virus quasispecies in patients with severe cholestatic hepatitis after liver transplantation. Hepatology 1999; 30: 1513-1520 [PMID: 10573532 DOI: 10.1002/hep.510300610].
    • (1999) Hepatology , vol.30 , pp. 1513-1520
    • Pessoa, M.G.1    Bzowej, N.2    Berenguer, M.3    Phung, Y.4    Kim, M.5    Ferrell, L.6    Hassoba, H.7    Wright, T.L.8
  • 189
    • 0031042110 scopus 로고    scopus 로고
    • Hepatitis C after orthotopic liver transplantation
    • PMID: 9024312
    • Araya V, Rakela J, Wright T. Hepatitis C after orthotopic liver transplantation. Gastroenterology 1997; 112: 575-582 [PMID: 9024312].
    • (1997) Gastroenterology , vol.112 , pp. 575-582
    • Araya, V.1    Rakela, J.2    Wright, T.3
  • 192
    • 0031783001 scopus 로고    scopus 로고
    • Predictors of patient and graft survival following liver transplantation for hepatitis C
    • PMID: 9731579
    • Charlton M, Seaberg E, Wiesner R, Everhart J, Zetterman R, Lake J, Detre K, Hoofnagle J. Predictors of patient and graft survival following liver transplantation for hepatitis C. Hepatology 1998; 28: 823-830 [PMID: 9731579 DOI: 10.1002/hep.510280333].
    • (1998) Hepatology , vol.28 , pp. 823-830
    • Charlton, M.1    Seaberg, E.2    Wiesner, R.3    Everhart, J.4    Zetterman, R.5    Lake, J.6    Detre, K.7    Hoofnagle, J.8
  • 193
    • 0036250743 scopus 로고    scopus 로고
    • Impact of cytomegalovirus infection, year of transplantation, and donor age on outcomes after liver transplantation for hepatitis C
    • PMID: 11965581
    • Burak KW, Kremers WK, Batts KP, Wiesner RH, Rosen CB, Razonable RR, Paya CV, Charlton MR. Impact of cytomegalovirus infection, year of transplantation, and donor age on outcomes after liver transplantation for hepatitis C. Liver Transpl 2002; 8: 362-369 [PMID: 11965581 DOI: 10.1053/jlts.2002.32282].
    • (2002) Liver Transpl , vol.8 , pp. 362-369
    • Burak, K.W.1    Kremers, W.K.2    Batts, K.P.3    Wiesner, R.H.4    Rosen, C.B.5    Razonable, R.R.6    Paya, C.V.7    Charlton, M.R.8
  • 195
    • 0035112776 scopus 로고    scopus 로고
    • Increasing mortality due to end-stage liver disease in patients with human immunodeficiency virus infection
    • PMID: 11170959
    • Bica I, McGovern B, Dhar R, Stone D, McGowan K, Scheib R, Snydman DR. Increasing mortality due to end-stage liver disease in patients with human immunodeficiency virus infection. Clin Infect Dis 2001; 32: 492-497 [PMID: 11170959 DOI: 10.1086/318501].
    • (2001) Clin Infect Dis , vol.32 , pp. 492-497
    • Bica, I.1    McGovern, B.2    Dhar, R.3    Stone, D.4    McGowan, K.5    Scheib, R.6    Snydman, D.R.7
  • 196
    • 2442683905 scopus 로고    scopus 로고
    • Peginterferon alfa-2b plus ribavirin for treatment of chronic hepatitis c in previously untreated patients infected with hcv genotypes 2 or 3
    • PMID: 15158341
    • Zeuzem S, Hultcrantz R, Bourliere M, Goeser T, Marcellin P, Sanchez-Tapias J, Sarrazin C, Harvey J, Brass C, Albrecht J. Peginterferon alfa-2b plus ribavirin for treatment of chronic hepatitis C in previously untreated patients infected with HCV genotypes 2 or 3. J Hepatol 2004; 40: 993-999 [PMID: 15158341 DOI: 10.1016/j.jhep.2004.02.007].
    • (2004) J Hepatol , vol.40 , pp. 993-999
    • Zeuzem, S.1    Hultcrantz, R.2    Bourliere, M.3    Goeser, T.4    Marcellin, P.5    Sanchez-Tapias, J.6    Sarrazin, C.7    Harvey, J.8    Brass, C.9    Albrecht, J.10
  • 198
    • 37749051824 scopus 로고    scopus 로고
    • Treatment extension to 72 weeks of peginterferon and ribavirin in hepatitis c genotype 1-infected slow responders
    • PMID: 18046717
    • Pearlman BL, Ehleben C, Saifee S. Treatment extension to 72 weeks of peginterferon and ribavirin in hepatitis c genotype 1-infected slow responders. Hepatology 2007; 46: 1688-1694 [PMID: 18046717 DOI: 10.1002/hep.21919].
    • (2007) Hepatology , vol.46 , pp. 1688-1694
    • Pearlman, B.L.1    Ehleben, C.2    Saifee, S.3
  • 200
    • 34948902233 scopus 로고    scopus 로고
    • Mutations in ISDR of NS5A gene influence interferon efficacy in Chinese patients with chronic hepatitis c virus genotype 1b infection
    • PMID: 17914967
    • Shen C, Hu T, Shen L, Gao L, Xie W, Zhang J. Mutations in ISDR of NS5A gene influence interferon efficacy in Chinese patients with chronic hepatitis C virus genotype 1b infection. J Gastroenterol Hepatol 2007; 22: 1898-1903 [PMID: 17914967 DOI: 10.1111/j.1440-1746.2006.04566.x].
    • (2007) J Gastroenterol Hepatol , vol.22 , pp. 1898-1903
    • Shen, C.1    Hu, T.2    Shen, L.3    Gao, L.4    Xie, W.5    Zhang, J.6
  • 201
    • 0032861258 scopus 로고    scopus 로고
    • Mutations in nonstructural protein 5A gene and response to interferon in hepatitis C virus genotype 2 infection
    • PMID: 10498658
    • Murakami T, Enomoto N, Kurosaki M, Izumi N, Marumo F, Sato C. Mutations in nonstructural protein 5A gene and response to interferon in hepatitis C virus genotype 2 infection. Hepatology 1999; 30: 1045-1053 [PMID: 10498658 DOI: 10.1002/hep.510300405].
    • (1999) Hepatology , vol.30 , pp. 1045-1053
    • Murakami, T.1    Enomoto, N.2    Kurosaki, M.3    Izumi, N.4    Marumo, F.5    Sato, C.6
  • 202
    • 0031056446 scopus 로고    scopus 로고
    • Mutations in the nonstructural 5A gene of European hepatitis C virus isolates and response to interferon alfa
    • PMID: 9049228
    • Zeuzem S, Lee JH, Roth WK. Mutations in the nonstructural 5A gene of European hepatitis C virus isolates and response to interferon alfa. Hepatology 1997; 25: 740-744 [PMID: 9049228 DOI: 10.1002/hep.510250341].
    • (1997) Hepatology , vol.25 , pp. 740-744
    • Zeuzem, S.1    Lee, J.H.2    Roth, W.K.3
  • 203
    • 0036277038 scopus 로고    scopus 로고
    • Analysis of sequence configurations of the ISDR, PKR-binding domain, and V3 region as predictors of response to induction interferon- Alpha and ribavirin therapy in chronic hepatitis C infection
    • PMID: 12064791
    • Murphy MD, Rosen HR, Marousek GI, Chou S. Analysis of sequence configurations of the ISDR, PKR-binding domain, and V3 region as predictors of response to induction interferon- Alpha and ribavirin therapy in chronic hepatitis C infection. Dig Dis Sci 2002; 47: 1195-1205 [PMID: 12064791].
    • (2002) Dig Dis Sci , vol.47 , pp. 1195-1205
    • Murphy, M.D.1    Rosen, H.R.2    Marousek, G.I.3    Chou, S.4
  • 204
    • 84888020792 scopus 로고    scopus 로고
    • An overview of emerging therapies for the treatment of chronic hepatitis c
    • PMID: 24266912
    • Ilyas JA, Vierling JM. An overview of emerging therapies for the treatment of chronic hepatitis C. Med Clin North Am 2014; 98: 17-38 [PMID: 24266912 DOI: 10.1016/j.mcna.2013.10.011].
    • (2014) Med Clin North Am , vol.98 , pp. 17-38
    • Ilyas, J.A.1    Vierling, J.M.2
  • 205
    • 84860324912 scopus 로고    scopus 로고
    • New advances in the molecular biology of hepatitis C virus infection: Towards the identification of new treatment targets
    • PMID: 22504917
    • Ploss A, Dubuisson J. New advances in the molecular biology of hepatitis C virus infection: Towards the identification of new treatment targets. Gut 2012; 61 Suppl 1: i25-i35 [PMID: 22504917 DOI: 10.1136/gutjnl-2012-302048].
    • (2012) Gut , vol.61 , pp. i25-i35
    • Ploss, A.1    Dubuisson, J.2
  • 211
    • 84860322902 scopus 로고    scopus 로고
    • New directacting antiviral agents for the treatment of hepatitis C virus infection and perspectives
    • PMID: 22504918
    • Welsch C, Jesudian A, Zeuzem S, Jacobson I. New directacting antiviral agents for the treatment of hepatitis C virus infection and perspectives. Gut 2012; 61 Suppl 1: i36-i46 [PMID: 22504918 DOI: 10.1136/gutjnl-2012-302144].
    • (2012) Gut , vol.61 , pp. i36-i46
    • Welsch, C.1    Jesudian, A.2    Zeuzem, S.3    Jacobson, I.4
  • 213
    • 0029075130 scopus 로고
    • Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptase
    • PMID: 7541846
    • Mansky LM, Temin HM. Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptase. J Virol 1995; 69: 5087-5094 [PMID: 7541846].
    • (1995) J Virol , vol.69 , pp. 5087-5094
    • Mansky, L.M.1    Temin, H.M.2
  • 215
    • 36549028822 scopus 로고    scopus 로고
    • Naturally occurring NS3-proteaseinhibitor resistant mutant A156t in the liver of an untreated chronic hepatitis c patient
    • PMID: 18006035
    • Cubero M, Esteban JI, Otero T, Sauleda S, Bes M, Esteban R, Guardia J, Quer J. Naturally occurring NS3-proteaseinhibitor resistant mutant A156T in the liver of an untreated chronic hepatitis C patient. Virology 2008; 370: 237-245 [PMID: 18006035 DOI: 10.1016/j.virol.2007.10.006].
    • (2008) Virology , vol.370 , pp. 237-245
    • Cubero, M.1    Esteban, J.I.2    Otero, T.3    Sauleda, S.4    Bes, M.5    Esteban, R.6    Guardia, J.7    Quer, J.8
  • 217
    • 34548758435 scopus 로고    scopus 로고
    • Telaprevir and pegylated interferon- Alpha-2a inhibit wild-type and resistant genotype 1 hepatitis C virus replication in patients
    • PMID: 17680654
    • Kieffer TL, Sarrazin C, Miller JS, Welker MW, Forestier N, Reesink HW, Kwong AD, Zeuzem S. Telaprevir and pegylated interferon- Alpha-2a inhibit wild-type and resistant genotype 1 hepatitis C virus replication in patients. Hepatology 2007; 46: 631-639 [PMID: 17680654 DOI: 10.1002/hep.21781].
    • (2007) Hepatology , vol.46 , pp. 631-639
    • Kieffer, T.L.1    Sarrazin, C.2    Miller, J.S.3    Welker, M.W.4    Forestier, N.5    Reesink, H.W.6    Kwong, A.D.7    Zeuzem, S.8
  • 218
    • 75149151884 scopus 로고    scopus 로고
    • Resistance, to direct antiviral agents in patients with hepatitis C virus infection
    • PMID: 20006612
    • Sarrazin C, Zeuzem S. Resistance to direct antiviral agents in patients with hepatitis C virus infection. Gastroenterology 2010; 138: 447-462 [PMID: 20006612 DOI: 10.1053/j.gastro.2009.11.055].
    • (2010) Gastroenterology , vol.138 , pp. 447-462
    • Sarrazin, C.1    Zeuzem, S.2
  • 219
    • 84875454492 scopus 로고    scopus 로고
    • Variability and resistance mutations in the hepatitis C virus NS3 protease in patients not treated with protease inhibitors
    • PMID: 23440108
    • Zeminian LB, Padovani JL, Corvino SM, Silva GF, Pardini MI, Grotto RM. Variability and resistance mutations in the hepatitis C virus NS3 protease in patients not treated with protease inhibitors. Mem Inst Oswaldo Cruz 2013; 108: 13-17 [PMID: 23440108].
    • (2013) Mem Inst Oswaldo Cruz , vol.108 , pp. 13-17
    • Zeminian, L.B.1    Padovani, J.L.2    Corvino, S.M.3    Silva, G.F.4    Pardini, M.I.5    Grotto, R.M.6
  • 220
    • 84873604286 scopus 로고    scopus 로고
    • Antiviral resistance and the future landscape of hepatitis C virus infection therapy
    • PMID: 23390303
    • Wyles DL. Antiviral resistance and the future landscape of hepatitis C virus infection therapy. J Infect Dis 2013; 207 Suppl 1: S33-S39 [PMID: 23390303 DOI: 10.1093/infdis/jis761].
    • (2013) J Infect Dis , vol.207 , pp. S33-S39
    • Wyles, D.L.1
  • 221
    • 82755182674 scopus 로고    scopus 로고
    • Analysis of long-term persistence of resistance mutations within the hepatitis C virus NS3 protease after treatment with telaprevir or boceprevir
    • PMID: 21924672
    • Susser S, Vermehren J, Forestier N, Welker MW, Grigorian N, Füller C, Perner D, Zeuzem S, Sarrazin C. Analysis of long-term persistence of resistance mutations within the hepatitis C virus NS3 protease after treatment with telaprevir or boceprevir. J Clin Virol 2011; 52: 321-327 [PMID: 21924672 DOI: 10.1016/j.jcv.2011.08.015].
    • (2011) J Clin Virol , vol.52 , pp. 321-327
    • Susser, S.1    Vermehren, J.2    Forestier, N.3    Welker, M.W.4    Grigorian, N.5    Füller, C.6    Perner, D.7    Zeuzem, S.8    Sarrazin, C.9
  • 222
    • 79958830099 scopus 로고    scopus 로고
    • Hepatitis C virus resistance to protease inhibitors
    • PMID: 21284949
    • Halfon P, Locarnini S. Hepatitis C virus resistance to protease inhibitors. J Hepatol 2011; 55: 192-206 [PMID: 21284949 DOI: 10.1016/j.jhep.2011.01.011].
    • (2011) J Hepatol , vol.55 , pp. 192-206
    • Halfon, P.1    Locarnini, S.2
  • 223
    • 84881314351 scopus 로고    scopus 로고
    • Novel therapies for hepatitis C - One pill fits all?
    • PMID: 23807378
    • Manns MP, von Hahn T. Novel therapies for hepatitis C - one pill fits all? Nat Rev Drug Discov 2013; 12: 595-610 [PMID: 23807378 DOI: 10.1038/nrd4050].
    • (2013) Nat Rev Drug Discov , vol.12 , pp. 595-610
    • Manns, M.P.1    Von Hahn, T.2
  • 224
    • 84882242612 scopus 로고    scopus 로고
    • Review of direct- Acting antiviral agents for the treatment of chronic hepatitis C
    • PMID: 23735127
    • Shah N, Pierce T, Kowdley KV. Review of direct- Acting antiviral agents for the treatment of chronic hepatitis C. Expert Opin Investig Drugs 2013; 22: 1107-1121 [PMID: 23735127 DOI: 10.1517/13543784.2013.806482].
    • (2013) Expert Opin Investig Drugs , vol.22 , pp. 1107-1121
    • Shah, N.1    Pierce, T.2    Kowdley, K.V.3
  • 225
    • 66149128046 scopus 로고    scopus 로고
    • GT-1a or Gt-1b subtype-specific resistance profiles for hepatitis C virus inhibitors telaprevir and hcv-796
    • PMID: 19273674
    • McCown MF, Rajyaguru S, Kular S, Cammack N, Nájera I. GT-1a or GT-1b subtype-specific resistance profiles for hepatitis C virus inhibitors telaprevir and HCV-796. Antimicrob Agents Chemother 2009; 53: 2129-2132 [PMID: 19273674 DOI: 10.1128/AAC.01598-08].
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 2129-2132
    • McCown, M.F.1    Rajyaguru, S.2    Kular, S.3    Cammack, N.4    Nájera, I.5
  • 226
    • 80051920720 scopus 로고    scopus 로고
    • Second-wave protease inhibitors: Choosing an heir
    • PMID: 21867939
    • Ciesek S, von Hahn T, Manns MP. Second-wave protease inhibitors: choosing an heir. Clin Liver Dis 2011; 15: 597-609 [PMID: 21867939 DOI: 10.1016/j.cld.2011.05.014].
    • (2011) Clin Liver Dis , vol.15 , pp. 597-609
    • Ciesek, S.1    Von Hahn, T.2    Manns, M.P.3
  • 232
    • 84871859044 scopus 로고    scopus 로고
    • Rapid and sharp decline in HCV upon monotherapy with NS3 protease inhibitor, ACH-1625
    • PMID: 22976492
    • Agarwal A, Zhang B, Olek E, Robison H, Robarge L, Deshpande M. Rapid and sharp decline in HCV upon monotherapy with NS3 protease inhibitor, ACH-1625. Antivir Ther 2012; 17: 1533-1539 [PMID: 22976492 DOI: 10.3851/IMP2359].
    • (2012) Antivir Ther , vol.17 , pp. 1533-1539
    • Agarwal, A.1    Zhang, B.2    Olek, E.3    Robison, H.4    Robarge, L.5    Deshpande, M.6
  • 236
    • 84861188748 scopus 로고    scopus 로고
    • Antiviral activity of TMC435 monotherapy in patients infected with HCV genotypes 2-6: TMC435-C202, a phase IIA, open-label study
    • PMID: 22326470
    • Moreno C, Berg T, Tanwandee T, Thongsawat S, Van Vlierberghe H, Zeuzem S, Lenz O, Peeters M, Sekar V, De Smedt G. Antiviral activity of TMC435 monotherapy in patients infected with HCV genotypes 2-6: TMC435-C202, a phase IIa, open-label study. J Hepatol 2012; 56: 1247-1253 [PMID: 22326470 DOI: 10.1016/j.jhep.2011.12.033].
    • (2012) J Hepatol , vol.56 , pp. 1247-1253
    • Moreno, C.1    Berg, T.2    Tanwandee, T.3    Thongsawat, S.4    Van Vlierberghe, H.5    Zeuzem, S.6    Lenz, O.7    Peeters, M.8    Sekar, V.9    De Smedt, G.10
  • 241
    • 34548285424 scopus 로고    scopus 로고
    • Recent progress in the development of inhibitors of the hepatitis C virus RNA-dependent RNA polymerase
    • PMID: 17627559
    • Koch U, Narjes F. Recent progress in the development of inhibitors of the hepatitis C virus RNA-dependent RNA polymerase. Curr Top Med Chem 2007; 7: 1302-1329 [PMID: 17627559].
    • (2007) Curr Top Med Chem , vol.7 , pp. 1302-1329
    • Koch, U.1    Narjes, F.2
  • 242
    • 67649225512 scopus 로고    scopus 로고
    • Targeting the non-structural proteins of hepatitis C virus: Beyond hepatitis c virus protease and polymerase
    • PMID: 23489127
    • Holler TP, Parkinson T, Pryde DC. Targeting the non-structural proteins of hepatitis C virus: beyond hepatitis C virus protease and polymerase. Expert Opin Drug Discov 2009; 4: 293-314 [PMID: 23489127 DOI: 10.1517/17460440902762802].
    • (2009) Expert Opin Drug Discov , vol.4 , pp. 293-314
    • Holler, T.P.1    Parkinson, T.2    Pryde, D.C.3
  • 243
    • 84861655785 scopus 로고    scopus 로고
    • Resistance to mericitabine, a nucleoside analogue inhibitor of HCV RNA-dependent RNA polymerase
    • PMID: 22402762
    • Pawlotsky JM, Najera I, Jacobson I. Resistance to mericitabine, a nucleoside analogue inhibitor of HCV RNA-dependent RNA polymerase. Antivir Ther 2012; 17: 411-423 [PMID: 22402762 DOI: 10.3851/IMP2088].
    • (2012) Antivir Ther , vol.17 , pp. 411-423
    • Pawlotsky, J.M.1    Najera, I.2    Jacobson, I.3
  • 247
    • 84894271490 scopus 로고    scopus 로고
    • Civo emergence of a novel mutant L159F/L320F in the NS5B polymerase confers lowlevel resistance to the HCV polymerase inhibitors mericitabine and sofosbuvir
    • PMID: 24154738
    • Tong X, Le Pogam S, Li L, Haines K, Piso K, Baronas V, Yan JM, So SS, Klumpp K, Nájera I. In vivo emergence of a novel mutant L159F/L320F in the NS5B polymerase confers lowlevel resistance to the HCV polymerase inhibitors mericitabine and sofosbuvir. J Infect Dis 2014; 209: 668-675 [PMID: 24154738 DOI: 10.1093/infdis/jit562].
    • (2014) J Infect Dis , vol.209 , pp. 668-675
    • Tong, X.1    Le, P.S.2    Li, L.3    Haines, K.4    Piso, K.5    Baronas, V.6    Yan, J.M.7    So, S.S.8    Klumpp, K.9    Nájera, I.10
  • 248
    • 84874644131 scopus 로고    scopus 로고
    • Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus halflife
    • PMID: 23431163
    • Guedj J, Dahari H, Rong L, Sansone ND, Nettles RE, Cotler SJ, Layden TJ, Uprichard SL, Perelson AS. Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus halflife. Proc Natl Acad Sci USA 2013; 110: 3991-3996 [PMID: 23431163 DOI: 10.1073/pnas.1203110110].
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 3991-3996
    • Guedj, J.1    Dahari, H.2    Rong, L.3    Sansone, N.D.4    Nettles, R.E.5    Cotler, S.J.6    Layden, T.J.7    Uprichard, S.L.8    Perelson, A.S.9
  • 250
    • 84857824116 scopus 로고    scopus 로고
    • New antiviral agents for hepatitis C
    • PMID: 22403588
    • Pawlotsky JM. New antiviral agents for hepatitis C. F1000 Biol Rep 2012; 4: 5 [PMID: 22403588 DOI: 10.3410/B4-5].
    • (2012) F1000 Biol Rep , vol.4 , pp. 5
    • Pawlotsky, J.M.1
  • 251
    • 79954831999 scopus 로고    scopus 로고
    • NS5A inhibitors: A new breakthrough for the treatment of chronic hepatitis C
    • PMID: 21167889
    • Asselah T. NS5A inhibitors: A new breakthrough for the treatment of chronic hepatitis C. J Hepatol 2011; 54: 1069-1072 [PMID: 21167889 DOI: 10.1016/j.jhep.2010.11.033].
    • (2011) J Hepatol , vol.54 , pp. 1069-1072
    • Asselah, T.1
  • 253
    • 84855209804 scopus 로고    scopus 로고
    • Direct acting antivirals for the treatment of chronic hepatitis C: One pill a day for tomorrow
    • PMID: 22212578
    • Asselah T, Marcellin P. Direct acting antivirals for the treatment of chronic hepatitis C: one pill a day for tomorrow. Liver Int 2012; 32 Suppl 1: 88-102 [PMID: 22212578 DOI: 10.1111/j.1478-3231.2011.02699.x].
    • (2012) Liver Int , vol.32 , pp. 88-102
    • Asselah, T.1    Marcellin, P.2
  • 254
    • 82455192239 scopus 로고    scopus 로고
    • Genotypic and phenotypic analysis of variants resistant to hepatitis C virus nonstructural protein 5a replication complex inhibitor BMS-790052 in humans: In vitro and in vivo correlations
    • PMID: 21809362
    • Fridell RA, Wang C, Sun JH, O'Boyle DR, Nower P, Valera L, Qiu D, Roberts S, Huang X, Kienzle B, Bifano M, Nettles RE, Gao M. Genotypic and phenotypic analysis of variants resistant to hepatitis C virus nonstructural protein 5A replication complex inhibitor BMS-790052 in humans: in vitro and in vivo correlations. Hepatology 2011; 54: 1924-1935 [PMID: 21809362 DOI: 10.1002/hep.24594].
    • (2011) Hepatology , vol.54 , pp. 1924-1935
    • Fridell, R.A.1    Wang, C.2    Sun, J.H.3    O'Boyle, D.R.4    Nower, P.5    Valera, L.6    Qiu, D.7    Roberts, S.8    Huang, X.9    Kienzle, B.10    Bifano, M.11    Nettles, R.E.12    Gao, M.13
  • 255
    • 84890869379 scopus 로고    scopus 로고
    • HCV directacting antiviral agents: The best interferon-free combinations
    • PMID: 2437308
    • Schinazi R, Halfon P, Marcellin P, Asselah T. HCV directacting antiviral agents: The best interferon-free combinations. Liver Int 2014; 34 Suppl 1: 69-78 [PMID: 24373081 DOI: 10.1111/liv.12423].
    • (2014) Liver Int , vol.34 , pp. 69-78
    • Schinazi, R.1    Halfon, P.2    Marcellin, P.3    Asselah, T.4
  • 256
    • 84855211921 scopus 로고    scopus 로고
    • Treatment of chronic hepatitis C- Are interferons really necessary?
    • PMID: 22212580
    • Ferenci P. Treatment of chronic hepatitis C- Are interferons really necessary? Liver Int 2012; 32 Suppl 1: 108-112 [PMID: 22212580 DOI: 10.1111/j.1478-3231.2011.02705.x].
    • (2012) Liver Int , vol.32 , pp. 108-112
    • Ferenci, P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.