Mutations in the hepatitis C virus core gene are associated with advanced liver disease and hepatocellular carcinoma

Clinical Cancer Research

Volumn 15, Issue 9, 2009, Pages 3205-3213

  Fishman, Sarah L ^a   Factor, Stephanie H ^a   Balestrieri, Cinzia ^a   Fan, Xiaofeng ^b   DiBisceglie, Adrian M ^b   Desai, Suresh M ^c   Benson, Gary ^d   Branch, Andrea D ^a,e  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ABBOTT LABORATORIES   (United States)

^d BOSTON UNIVERSITY   (United States)

^e NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CANCER RISK; CONTROLLED STUDY; DNA POLYMORPHISM; GENE SEQUENCE; GENETIC ASSOCIATION; HEPATITIS C VIRUS; HUMAN; LIVER CELL CARCINOMA; LIVER DISEASE; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; START CODON; VIRUS CORE; VIRUS GENE;

CARCINOMA, HEPATOCELLULAR; CASE-CONTROL STUDIES; HEPACIVIRUS; HEPATITIS C; HUMANS; LIVER CIRRHOSIS; LIVER NEOPLASMS; MUTATION; VIRAL CORE PROTEINS;

EID: 65649143507     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-08-2418     Document Type: Article

References (43)

1. Huibregtse JM, Beaudenon SL. Mechanism of HPV E6 proteins in cellular transformation. Semin Cancer Biol 1996;7:317-326 (Pubitemid 27380011)
2. Franco EL, Villa LL, Ruiz A, Costa MC. Transmission of cervical human papillomavirus infection by sexual activity: differences between low and high oncogenic risk types. J Infect Dis 1995;172:756-763
3. Ghosh AK, Steele R, Meyer K, Ray R, Ray RB. Hepatitis C virus NS5A protein modulates cell cycle regulatory genes and promotes cell growth. J Gen Virol 1999;80:1179-1183 (Pubitemid 29213805)
4. Taylor DR, Shi ST, Romano PR, Barber GN, Lai MM. Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein. Science 1999;285:107-110 (Pubitemid 29307576)
5. Sakamuro D, Furukawa T, Takegami T. Hepatitis C virus nonstructural protein NS3 transforms NIH 3T3 cells. J Virol 1995;69:3893-3896
6. Park JS, Yang JM, Min MK. Hepatitis C virus nonstructural protein NS4B transforms NIH3T3 cells in cooperation with the Ha-ras oncogene. Biochem Biophys Res Commun 2000;267:581-587 (Pubitemid 30076841)
7. Sato Y, Kato J, Takimoto R, et al. Hepatitis C virus core protein promotes proliferation of human hepatoma cells through enhancement of transforming growth factor a expression via activation of nuclear factor-κB. Gut 2006;55:1801- 1808.
8. Cho JW, Baek WK, Suh SI, et al. Hepatitis C virus core protein promotes cell proliferation through the upregulation of cyclin E expression levels. Liver 2001;21:137-142
9. Erhardt A, Hassan M, Heintges T, Haussinger D. Hepatitis C virus core protein induces cell proliferation and activates ERK, JNK, and p38 MAP kinases together with the MAP kinase phosphatase MKP-1 in a HepG2 Tet-Off cell line. Virology 2002;292:272-284
10. Marusawa H, Hijikata M, Chiba T, Shimotohno K. Hepatitis C virus core protein inhibits Fas- and tumor necrosis factor α-mediated apoptosis via NF-κB activation. J Virol 1999;73:4713-4720 (Pubitemid 29246730)
11. Ruggieri A, Harada T, Matsuura Y, Miyamura T. Sensitization to Fas-mediated apoptosis by hepatitis C virus core protein. Virology 1997;229:68-76. (Pubitemid 27243489)
12. Ray RB, Meyer K, Steele R, et al. Inhibition of tumor necrosis factor (TNF-α)-mediated apoptosis by hepatitis C virus core protein. J Biol Chem 1998;273:2256-2259
13. Fukutomi T, Zhou Y, Kawai S, et al. Hepatitis C virus core protein stimulates hepatocyte growth: correlation with upregulation of wnt-1 expression. Hepatology 2005;41:1096-1105
14. Honda M, Kaneko S, Shimazaki T, et al. Hepatitis C virus core protein induces apoptosis and impairs cell-cycle regulation in stably transformed Chinese hamster ovary cells. Hepatology 2000;31:1351-1359
15. Ray RB, Lagging LM, Meyer K, Ray R. Hepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype. J Virol 1996;70:4438-4443 (Pubitemid 26187445)
16. Lerat H, Honda M, Beard MR, et al. Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus. Gastroenterology 2002;122:352-365
17. Lemon SM, Lerat H, Weinman SA, Honda M. A transgenic mouse model of steatosis and hepatocellular carcinoma associated with chronic hepatitis C virus infection in humans. Trans Am Clin Climatol Assoc 2000;111:146-156
18. Moriya K, Fujie H, Shintani Y, et al. The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice. Nat Med 1998;4:1065-1067
19. Branch AD, Stump DD, Gutierrez JA, Eng F, Walewski JL. The hepatitis C virus alternate reading frame (ARF) and its family of novel products: the alternate reading frame protein/F-protein, the double-frameshift protein, and others. Semin Liver Dis 2005;25:105-117 (Pubitemid 40322355)
20. Smith DB, Simmonds P. Characteristics of nucleotide substitution in the hepatitis C virus genome: constraints on sequence change in coding regions at both ends of the genome. J Mol Evol 1997;45:238-246 (Pubitemid 27418350)
21. Tuplin A, Evans DJ, Simmonds P. Detailed mapping of RNA secondary structures in core and NS5B-encoding region sequences of hepatitis C virus by RNase cleavage and novel bioinformatic prediction methods. J Gen Virol 2004;85:3037-3047 (Pubitemid 39360048)
22. Qin H, Shire NJ, Keenan ED, et al. HCV quasispecies evolution: association with progression to end-stage liver disease in hemophiliacs infected with HCV or HCV/HIV. Blood 2005;105:533-541
23. Gimenez-Barcons M, Franco S, Suarez Y, et al. High amino acid variability within the NS5A of hepatitis C virus (HCV) is associated with hepatocellular carcinoma in patients with HCV-1b-related cirrhosis. Hepatology 2001;34:158-167
24. Takahashi K, Iwata K, Matsumoto M, et al. Hepatitis C virus (HCV) genotype 1b sequences from fifteen patients with hepatocellular carcinoma: the 'progression score' revisited. Hepatol Res 2001;20:161-171
25. Nagayama K, Kurosaki M, Enomoto N, et al. Time-related changes in full-length hepatitis C virus sequences and hepatitis activity. Virology 1999;263:244-253
26. Nagayama K, Kurosaki M, Enomoto N, et al. Characteristics of hepatitis C viral genome associated with disease progression. Hepatology 2000;31:745-750
27. Ogata S, Nagano-Fujii M, Ku Y, Yoon S, Hotta H. Comparative sequence analysis of the core protein and its frameshift product, the F protein, of hepatitis C virus subtype 1b strains obtained from patients with and without hepatocellular carcinoma. J Clin Microbiol 2002;40:3625-3630
28. Ruster B, Zeuzem S, Krump-Konvalinkova V, et al. Comparative sequence analysis of the core- and NS5-region of hepatitis C virus from tumor and adjacent non-tumor tissue. J Med Virol 2001;63:128-134
29. DeMitri MS, Mele L, Chen CH, et al. Comparison of serum and liver hepatitis C virus quasispecies in HCV-related hepatocellular carcinoma. J Hepatol 1998;29:887-892
30. Delhem N, Sabile A, Gajardo R, et al. Activation of the interferon-inducible protein kinase PKR by hepatocellular carcinoma derived-hepatitis C virus core protein. Oncogene 2001;20:5836-5845
31. Horie C, Iwahana H, Horie T, et al. Detection of different quasispecies of hepatitis C virus core region in cancerous and noncancerous lesions. Biochem Biophys Res Commun 1996;218:674-681
32. Alam SS, Nakamura T, Naganuma A, et al. Hepatitis C virus quasispecies in cancerous and noncancerous hepatic lesions: the core protein-encoding region. Acta Med Okayama 2002;56:141-147
33. Zuker M. Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res 2003;31:3406-3415 (Pubitemid 37442169)
34. Mathews DH, Sabina J, Zuker M, Turner DH. Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure. J Mol Biol 1999;288:911-940 (Pubitemid 29248642)
35. Eng F, McMullan LK, Klepper A, et al. A novel IRES in the core-encoding region stimulates production of mini-core, a small protein comprised of the C-terminal portion of the core protein. 8th International Conference on HCV and Related Viruses; Glasgow, Scotland; 2007.
36. Walewski JL, Gutierrez JA, Branch-Elliman W, et al. Mutation Master: profiles of substitutions in hepatitis C virus RNA of the core, alternate reading frame, and NS2 coding regions. RNA 2002;8:557-571
37. Reynolds JE, Kaminski A, Kettinen HJ, et al. Unique features of internal initiation of hepatitis C virus RNA translation. EMBO J 1995;14:6010-6020
38. Honda M, Ping LH, Rijnbrand RC, et al. Structural requirements for initiation of translation by internal ribosome entry within genome-length hepatitis C virus RNA. Virology 1996;222:31-42.
39. Honda M, Kaneko S, Unoura M, Kobayashi K, Murakami S. Sequence analysis of putative structural regions of hepatitis C virus isolated from 5 Japanese patients with hepatocellular carcinoma. Arch Virol 1993;128:163-169
40. Akuta N, Suzuki F, Kawamura Y, et al. Amino acid substitutions in the hepatitis C virus core region are the important predictor of hepatocarcinogenesis. Hepatology 2007;46:1357-1364
41. Donlin MJ, Cannon NA, Yao E, et al. Pretreatment sequence diversity differences in the full-length hepatitis C virus open reading frame correlate with early response to therapy. J Virol 2007;81:8211-8224
42. Eng F, Klepper A, Walewski JL, et al. Infectious HCV produces a family of mini-core proteins. Hepatology 2008;48:754-754A.
43. Boulant S, Montserret R, Hope RG, et al. Structural determinants that target the hepatitis C virus core protein to lipid droplets. J Biol Chem 2006;281:22236-22247