Caspase activation correlates with the degree of inflammatory liver injury in chronic Hepatitis C virus infection

Hepatology

Volumn 34, Issue 4 I, 2001, Pages 758-767

  Bantel, Heike ^a   Lügering, Andreas ^a   Poremba, Christopher ^a   Lügering, Norbert ^a   Held, Jürgen ^a   Domschke, Wolfram ^a   Schulze Osthoff, Klaus ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOTRANSFERASE; CASPASE; CASPASE 3; CASPASE 7; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE;

ADULT; AGED; AMINOTRANSFERASE BLOOD LEVEL; APOPTOSIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE MARKER; ENZYME ACTIVATION; ENZYME DEGRADATION; FEMALE; HEPATITIS C; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; LIVER BIOPSY; LIVER FIBROSIS; LIVER INJURY; MALE; PRIORITY JOURNAL; VIRUS LOAD; WESTERN BLOTTING;

EID: 0034808023     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.2001.28229     Document Type: Article

References (50)

1. Cell death by apoptosis: Basic concepts and disease relevance for the gastroenterologist
2. Fas system and apoptosis in viral hepatitis
3. Apoptosis and viral hepatitis
4. Dysregulation of apoptosis as a mechanism of liver disease: An overview
5. Apoptosis signaling by death receptors
6. Lethal effect of anti-fas antibody in mice
7. Immunohistochemical detection of Fas antigen in liver tissue of patients with chronic hepatitis C
8. Hepatic Fas antigen expression before and after interferon therapy in patients with chronic hepatitis C
9. Suppression of apoptotic cell death by hepatitis C virus core protein
10. Sensitisation to Fas-mediated apoptosis by hepatitis C virus core protein
11. Hepatitis C virus core protein inhibits Fas- and tumor necrosis factor alpha-mediated apoptosis via NF-κB activation
12. Hepatitis C virus core protein induces apoptosis and impairs cell-cycle regulation in stably transformed Chinese hamster ovary cells
13. Inhibition of cytochrome c release in Fas-mediated signaling pathway in transgenic mice induced to express hepatitis C viral proteins
14. Caspases: The executioners of apoptosis
15. Caspases: Killer proteases
16. Proteases to die for
17. The role of caspases in development, immunity, and apoptotic signal transduction: Lessons from knockout mice
18. Death by a thousand cuts: An ever increasing list of caspase substrates
19. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
20. Detection of elevated caspase activation and early apoptosis in liver diseases
21. Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region
22. Chronic hepatitis. An update on terminology and reporting
23. Different subcellular distribution of caspase-3 and caspase-7 following Fas-induced apoptosis in mouse liver
24. Caspases: Their intracellular localization and translocation during apoptosis
25. The nature of piecemeal necrosis in chronic active hepatitis
26. Activation of caspases in lethal experimental hepatitis and prevention by acute phase proteins
27. ICE inhibitor YVADcmk is a potent therapeutic agent against in vivo liver apoptosis
28. ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or TNF-alpha
29. In vivo evidence that caspase-3 is required for Fas-mediated apoptosis of hepatocytes
30. Liver cell apoptosis in chronic hepatitis C correlates with histological but not biochemical activity or serum HCV-RNA levels
31. Hepatocellular proliferation in patients with chronic hepatitis C and persistently normal or abnormal aminotransferase levels
32. Cell death: Current difficulties in discriminating apoptosis from necrosis in the context of pathological processes in vivo
33. False positive staining in the TUNEL assay to detect apoptosis in liver and intestine is caused by endogenous nucleases and inhibited by diethyl pyrocarbonate
34. The tunel assay in the diagnosis of graft-versus-host disease: Caveats for interpretation
35. In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note
36. TUNEL apoptotic cell detection in tissue sections: Critical evaluation and improvement
37. Apoptosis is induced by transforming growth factor-β1 within 5 hours in regressing liver without significant fragmentation of the DNA
38. Cell nucleus and DNA fragmentation are not required for apoptosis
39. Histological damage in chronic hepatitis C is not related to the extent of infection in the liver
40. Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy
41. Hepatitis C virus dynamics in vivo: Effect of ribavirin and interferon alpha on viral turnover
42. Caspase activation is required for T cell proliferation
43. Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells
44. Caspase activation is required for terminal erythroid differentiation
45. Immunohistochemical evaluation of Bcl-2 gene family expression in liver of hepatitis C and cirrhotic patients: A novel mechanism to explain the high incidence of hepatocarcinoma in cirrhotics
46. Activation of intracellular signalling by hepatitis B and C viruses: C-viral core is the most potent signal inducer
47. The role of hepatitis C virus-specific cytotoxic T-lymphocytes in chronic hepatitis C
48. Role of Fas ligand in apoptosis induced by hepatitis C virus infection
49. CD95-induced apoptosis in human liver disease
50. Caspase 1-independent IL-1β release and inflammation induced by the apoptosis inducer Fas ligand