-
1
-
-
0036829652
-
Fibrosis and disease progression in hepatitis C
-
Marcellin P, Asselah T, Boyer N. Fibrosis and disease progression in hepatitis C. Hepatology 2002; 36: S47-56.
-
(2002)
Hepatology
, vol.36
-
-
Marcellin, P.1
Asselah, T.2
Boyer, N.3
-
2
-
-
0024509701
-
Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
-
Choo QL, Kuo G, Weiner AJ, et al. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 1989; 244: 359-62.
-
(1989)
Science
, vol.244
, pp. 359-362
-
-
Choo, Q.L.1
Kuo, G.2
Weiner, A.J.3
-
3
-
-
84855209804
-
Direct acting antivirals for the treatment of chronic hepatitis C: one pill a day for tomorrow
-
Asselah T, Marcellin P. Direct acting antivirals for the treatment of chronic hepatitis C: one pill a day for tomorrow. Liver Int 2012; 32: 88-102.
-
(2012)
Liver Int
, vol.32
, pp. 88-102
-
-
Asselah, T.1
Marcellin, P.2
-
4
-
-
16044364658
-
Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide
-
Kim JL, Morgenstern KA, Lin C, et al. Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide. Cell 1996; 87: 343-55.
-
(1996)
Cell
, vol.87
, pp. 343-355
-
-
Kim, J.L.1
Morgenstern, K.A.2
Lin, C.3
-
5
-
-
0030979410
-
Structure of the hepatitis C virus RNA helicase domain
-
Yao N, Hesson T, Cable M, et al. Structure of the hepatitis C virus RNA helicase domain. Nat Struct Biol 1997; 4: 463-7.
-
(1997)
Nat Struct Biol
, vol.4
, pp. 463-467
-
-
Yao, N.1
Hesson, T.2
Cable, M.3
-
6
-
-
84867571865
-
Genomics and HCV infection: progression of fibrosis and treatment response
-
Estrabaud E, Vidaud M, Marcellin P, Asselah T. Genomics and HCV infection: progression of fibrosis and treatment response. J Hepatol 2012; 57: 1110-25.
-
(2012)
J Hepatol
, vol.57
, pp. 1110-1125
-
-
Estrabaud, E.1
Vidaud, M.2
Marcellin, P.3
Asselah, T.4
-
7
-
-
41149156316
-
Liver gene expression signature to predict response to pegylated interferon plus ribavirin combination therapy in subjects with chronic hepatitis C
-
Asselah T, Bieche I, Narguet S, et al. Liver gene expression signature to predict response to pegylated interferon plus ribavirin combination therapy in subjects with chronic hepatitis C. Gut 2008; 57: 516-24.
-
(2008)
Gut
, vol.57
, pp. 516-524
-
-
Asselah, T.1
Bieche, I.2
Narguet, S.3
-
8
-
-
0344201903
-
An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus
-
Lamarre D, Anderson PC, Bailey M, et al. An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus. Nature 2003; 426: 186-9.
-
(2003)
Nature
, vol.426
, pp. 186-189
-
-
Lamarre, D.1
Anderson, P.C.2
Bailey, M.3
-
9
-
-
7644232426
-
Shortterm antiviral efficacy of BILN 2061, a hepatitis C virus serine protease inhibitor, in hepatitis C genotype 1 patients
-
Hinrichsen H, Benhamou Y, Wedemeyer H, et al. Shortterm antiviral efficacy of BILN 2061, a hepatitis C virus serine protease inhibitor, in hepatitis C genotype 1 patients. Gastroenterology 2004; 127: 1347-55.
-
(2004)
Gastroenterology
, vol.127
, pp. 1347-1355
-
-
Hinrichsen, H.1
Benhamou, Y.2
Wedemeyer, H.3
-
10
-
-
15944389629
-
BILN 2061: a major step toward new therapeutic strategies in hepatitis C
-
Asselah T, Marcellin P. BILN 2061: a major step toward new therapeutic strategies in hepatitis C. J Hepatol 2004; 41: 178-81.
-
(2004)
J Hepatol
, vol.41
, pp. 178-181
-
-
Asselah, T.1
Marcellin, P.2
-
11
-
-
66149128046
-
GT-1a or GT-1b subtype-specific resistance profiles for hepatitis C virus inhibitors telaprevir and HCV-796
-
McCown MF, Rajyaguru S, Kular S, et al. GT-1a or GT-1b subtype-specific resistance profiles for hepatitis C virus inhibitors telaprevir and HCV-796. Antimicrob Agents Chemother 2009; 53: 2129-32.
-
(2009)
Antimicrob Agents Chemother
, vol.53
, pp. 2129-2132
-
-
McCown, M.F.1
Rajyaguru, S.2
Kular, S.3
-
12
-
-
34547927078
-
Phenotypic and structural analyses of hepatitis C virus NS3 protease Arg155 variants: sensitivity to telaprevir (VX-950) and interferon alpha
-
Zhou Y, Muh U, Hanzelka BL, et al. Phenotypic and structural analyses of hepatitis C virus NS3 protease Arg155 variants: sensitivity to telaprevir (VX-950) and interferon alpha. J Biol Chem 2007; 282: 22619-28.
-
(2007)
J Biol Chem
, vol.282
, pp. 22619-22628
-
-
Zhou, Y.1
Muh, U.2
Hanzelka, B.L.3
-
13
-
-
84890877226
-
Simeprevir (TMC435) with peginterferon/ribavirin for treatment of chronic HCV genotype 1 infection in treatment-naive patients: efficacy in difficult-to-treat patient sub-populations in the QUEST 1 and 2 phase III trials
-
Abstract 1122.
-
Jacobson IM, Dore GJ, Foster GR, et al. Simeprevir (TMC435) with peginterferon/ribavirin for treatment of chronic HCV genotype 1 infection in treatment-naive patients: efficacy in difficult-to-treat patient sub-populations in the QUEST 1 and 2 phase III trials. AASLD 2013. Abstract 1122.
-
(2013)
AASLD
-
-
Jacobson, I.M.1
Dore, G.J.2
Foster, G.R.3
-
14
-
-
84890870532
-
Simeprevir (TMC435) with peg-interferon α-2a/ribavirin for treatment of chronic HCV genotype 1 infection in patients who relapsed after previous interferon-based therapy: efficacy and safety in patient sub-populations in the PROMISE phase III trial
-
Abstract 1092.
-
Forns X, Lawitz E, Zeuzem S, et al. Simeprevir (TMC435) with peg-interferon α-2a/ribavirin for treatment of chronic HCV genotype 1 infection in patients who relapsed after previous interferon-based therapy: efficacy and safety in patient sub-populations in the PROMISE phase III trial. AASLD 2013. Abstract 1092.
-
(2013)
AASLD
-
-
Forns, X.1
Lawitz, E.2
Zeuzem, S.3
-
15
-
-
84878992253
-
Faldaprevir combined with peginterferon alfa-2a and ribivirin in treatment-naïve patients with chronic genotype 1 HCV: SILEN-C1 trial
-
Sulkowski MS, Asselah T, Lalezari J, et al. Faldaprevir combined with peginterferon alfa-2a and ribivirin in treatment-naïve patients with chronic genotype 1 HCV: SILEN-C1 trial. Hepatology 2013; 57: 2143-54.
-
(2013)
Hepatology
, vol.57
, pp. 2143-2154
-
-
Sulkowski, M.S.1
Asselah, T.2
Lalezari, J.3
-
16
-
-
84878980518
-
Faldaprevir combined with peginterferon alfa-2a and ribivirin in chronic hepatitis C virus genotype-1 patients with prior nonresponse: SILEN-C2 trial
-
Sulkowski MS, Bourlière M, Bronowicki JP, et al. Faldaprevir combined with peginterferon alfa-2a and ribivirin in chronic hepatitis C virus genotype-1 patients with prior nonresponse: SILEN-C2 trial. Hepatology 2013; 57: 2155-63.
-
(2013)
Hepatology
, vol.57
, pp. 2155-2163
-
-
Sulkowski, M.S.1
Bourlière, M.2
Bronowicki, J.P.3
-
17
-
-
84890887844
-
A pooled analysis of two randomized, double-blind placebo-controlled Phase III trials (STARTVerso1&2) of faldaprevir plus pegylated interferon alfa-2a and ribavirin in treatment- naïve patients with chronic hepatitis C genotype-1 infection
-
Jensen D, Asselah T, Dieterich D, et al. A pooled analysis of two randomized, double-blind placebo-controlled Phase III trials (STARTVerso1&2) of faldaprevir plus pegylated interferon alfa-2a and ribavirin in treatment- naïve patients with chronic hepatitis C genotype-1 infection. AASLD 2013.
-
(2013)
AASLD
-
-
Jensen, D.1
Asselah, T.2
Dieterich, D.3
-
18
-
-
84896504351
-
STARTVerso3: a randomized, double-blind, placebo-controlled Phase III trial of faldaprevir in combination with pegylated interferon alfa-2a and ribavirin in treatment-experienced patients with chronic hepatitis C genotype-1 infection
-
Jacobson I, Asselah T, Ferenci P, et al. STARTVerso3: a randomized, double-blind, placebo-controlled Phase III trial of faldaprevir in combination with pegylated interferon alfa-2a and ribavirin in treatment-experienced patients with chronic hepatitis C genotype-1 infection. AASLD 2013.
-
(2013)
AASLD
-
-
Jacobson, I.1
Asselah, T.2
Ferenci, P.3
-
19
-
-
34548285424
-
Recent progress in the development of inhibitors of the hepatitis C virus RNA-dependent RNA polymerase
-
Koch U, Narjes F. Recent progress in the development of inhibitors of the hepatitis C virus RNA-dependent RNA polymerase. Curr Top Med Chem 2007; 7: 1302-29.
-
(2007)
Curr Top Med Chem
, vol.7
, pp. 1302-1329
-
-
Koch, U.1
Narjes, F.2
-
20
-
-
80051939098
-
The NS5A replication complex inhibitors: difference makers?
-
Gish RG, Meanwell NA. The NS5A replication complex inhibitors: difference makers? Clin Liver Dis 2011; 15: 627-39.
-
(2011)
Clin Liver Dis
, vol.15
, pp. 627-639
-
-
Gish, R.G.1
Meanwell, N.A.2
-
21
-
-
77952035218
-
Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect
-
Gao M, Nettles RE, Belema M, et al. Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect. Nature 2010; 465: 96-100.
-
(2010)
Nature
, vol.465
, pp. 96-100
-
-
Gao, M.1
Nettles, R.E.2
Belema, M.3
-
22
-
-
79954831999
-
NS5A inhibitors: a new breakthrough for the treatment of chronic hepatitis C
-
Asselah T. NS5A inhibitors: a new breakthrough for the treatment of chronic hepatitis C. J Hepatol 2011; 54: 1069-72.
-
(2011)
J Hepatol
, vol.54
, pp. 1069-1072
-
-
Asselah, T.1
-
23
-
-
79958830099
-
Hepatitis C virus resistance to protease inhibitors
-
Halfon P, Locarnini S. Hepatitis C virus resistance to protease inhibitors. J Hepatol 2011; 55: 192-206.
-
(2011)
J Hepatol
, vol.55
, pp. 192-206
-
-
Halfon, P.1
Locarnini, S.2
-
24
-
-
84857359539
-
IL28B polymorphism is associated with treatment response in patients with genotype 4 chronic hepatitis C
-
Asselah T, De Muynck S, Broet P, et al. IL28B polymorphism is associated with treatment response in patients with genotype 4 chronic hepatitis C. J Hepatol 2011; 3: 527-32.
-
(2011)
J Hepatol
, vol.3
, pp. 527-532
-
-
Asselah, T.1
De Muynck, S.2
Broet, P.3
-
25
-
-
77950597305
-
Twelve weeks posttreatment follow-up is as relevant as 24 weeks to determine the sustained virologic response in patients with hepatitis C virus receiving pegylated interferon and ribavirin
-
Martinot-Peignoux M, Stern C, Maylin S, et al. Twelve weeks posttreatment follow-up is as relevant as 24 weeks to determine the sustained virologic response in patients with hepatitis C virus receiving pegylated interferon and ribavirin. Hepatology 2010; 51: 1122-6.
-
(2010)
Hepatology
, vol.51
, pp. 1122-1126
-
-
Martinot-Peignoux, M.1
Stern, C.2
Maylin, S.3
-
26
-
-
81855228070
-
Efficacy of the protease inhibitor BI201335, polymerase inhibitor BI 207127, and ribavirin in patients with chronic HCV infection
-
Zeuzem S, Asselah T, Angus P, et al. Efficacy of the protease inhibitor BI201335, polymerase inhibitor BI 207127, and ribavirin in patients with chronic HCV infection. Gastroenterology 2011; 141: 2047-55.
-
(2011)
Gastroenterology
, vol.141
, pp. 2047-2055
-
-
Zeuzem, S.1
Asselah, T.2
Angus, P.3
-
27
-
-
84881405876
-
Faldaprevir and deleobuvir for HCV genotype 1 infection
-
Zeuzem S, Soriano V, Asselah T, et al. Faldaprevir and deleobuvir for HCV genotype 1 infection. N Engl J Med 2013; 369: 630-9.
-
(2013)
N Engl J Med
, vol.369
, pp. 630-639
-
-
Zeuzem, S.1
Soriano, V.2
Asselah, T.3
-
28
-
-
84890868170
-
Rapid and Consistent Virologic Responses in a Phase 2 Trial of a New All-Oral Combination of Faldaprevir, Deleobuvir, and PPI-668, with and without Ribavirin, in Patients with HCV Genotype-1a Infection
-
Abstract LB-20.
-
Lalezari J, Holland L, Glutzer E, et al. Rapid and Consistent Virologic Responses in a Phase 2 Trial of a New All-Oral Combination of Faldaprevir, Deleobuvir, and PPI-668, with and without Ribavirin, in Patients with HCV Genotype-1a Infection. AASLD 2013. 2013. Abstract LB-20.
-
(2013)
AASLD 2013
-
-
Lalezari, J.1
Holland, L.2
Glutzer, E.3
-
29
-
-
84879602765
-
A 12-week interferon-free treatment regimen with ABT-450/r, ABT-267,ABT-333 and ribavirin achieves SVR rates (observed data) of 99% in treatment-naive patients and 93% in prior null responders with HCV genotype 1 infection
-
Kowdley KV, Lawitz E, Poordad F, et al. A 12-week interferon-free treatment regimen with ABT-450/r, ABT-267, ABT-333 and ribavirin achieves SVR rates (observed data) of 99% in treatment-naive patients and 93% in prior null responders with HCV genotype 1 infection. Hepatology 2012; 56(Suppl): LB1.
-
(2012)
Hepatology
, vol.56
, Issue.SUPPL
-
-
Kowdley, K.V.1
Lawitz, E.2
Poordad, F.3
-
30
-
-
84871765489
-
Exploratory study of oral combination antiviral therapy for hepatitis C
-
Poordad F, Lawitz E, Kowdley KV, et al. Exploratory study of oral combination antiviral therapy for hepatitis C. N Engl J Med 2013; 368: 45-53.
-
(2013)
N Engl J Med
, vol.368
, pp. 45-53
-
-
Poordad, F.1
Lawitz, E.2
Kowdley, K.V.3
-
31
-
-
84890871185
-
Interferon- and Ribavirin-free regimen of ABT-450/r + ABT-267 in HCV genotype 1b-infected treatment-naïve patients and prior null responders
-
Abstract 75.
-
Lawitz E, Hezode C, Varunok P, et al. Interferon- and Ribavirin-free regimen of ABT-450/r + ABT-267 in HCV genotype 1b-infected treatment-naïve patients and prior null responders. AASLD 2013; 2013. Abstract 75.
-
(2013)
AASLD 2013
-
-
Lawitz, E.1
Hezode, C.2
Varunok, P.3
-
32
-
-
84890878971
-
-
All-oral sofosbuvir-based 12-week regimes for the treatment of chronic HCV infection: the ELECTRON study. 48th Annual Meeting of the European Association for the Study of the Liver, April 24-28, Amsterdam, Netherlands; abstract 14.
-
Gane ED, Stedman CA, Hyland RH, et al. All-oral sofosbuvir-based 12-week regimes for the treatment of chronic HCV infection: the ELECTRON study. 48th Annual Meeting of the European Association for the Study of the Liver, April 24-28, 2013, Amsterdam, Netherlands; abstract 14.
-
(2013)
-
-
Gane, E.D.1
Stedman, C.A.2
Hyland, R.H.3
-
33
-
-
84890880086
-
-
Sustained virological response with daclatasvir plus sofosbuvir ± ribavirin (RBV) in chronic HCV genotype (GT) 1-infected patients who previously failed telaprevir (TVR) or boceprevir (BOC). 48th Annual Meeting of the EASL, April 24-28, Amsterdam, Netherlands; abstract 1417.
-
Sulkowski MS, Gardiner DF, Rodriguez-Torres M, et al. Sustained virological response with daclatasvir plus sofosbuvir ± ribavirin (RBV) in chronic HCV genotype (GT) 1-infected patients who previously failed telaprevir (TVR) or boceprevir (BOC). 48th Annual Meeting of the EASL, April 24-28, 2013, Amsterdam, Netherlands; abstract 1417.
-
(2013)
-
-
Sulkowski, M.S.1
Gardiner, D.F.2
Rodriguez-Torres, M.3
-
34
-
-
84890880553
-
Phase 2b study of the interferon-free and Ribavirin-free combination of Daclatasvir, Asunaprevir, and BMS-791325 for 12 weeks in treatment-naive patients with chronic HCV genotype 1 infection
-
Abstract 211.
-
Everson GT, Sims KD, Thuluvath PJ, et al. Phase 2b study of the interferon-free and Ribavirin-free combination of Daclatasvir, Asunaprevir, and BMS-791325 for 12 weeks in treatment-naive patients with chronic HCV genotype 1 infection. AASLD 2013; Abstract 211.
-
AASLD 2013
-
-
Everson, G.T.1
Sims, K.D.2
Thuluvath, P.J.3
-
35
-
-
84856159009
-
Preliminary study of two antiviral agents for hepatitis C genotype 1
-
Lok AS, Gardiner DF, Lawitz E, et al. Preliminary study of two antiviral agents for hepatitis C genotype 1. N Engl J Med 2012; 366: 216-24.
-
(2012)
N Engl J Med
, vol.366
, pp. 216-224
-
-
Lok, A.S.1
Gardiner, D.F.2
Lawitz, E.3
-
36
-
-
84890888239
-
AASLD 2013; Phase III study, with all-oral regimen of daclatasvir and asunaprevir achieved an overall SVR 84.7 percent in Japanese patients with chronic hepaptitis C (HCV) genotype 1b who were either interferon-ineligible/intolerant or non-responders to interferon-based ttherapies
-
Abstract 211.
-
Chayama K, Takahashi S, Toyota J, et al. AASLD 2013; Phase III study, with all-oral regimen of daclatasvir and asunaprevir achieved an overall SVR 84.7 percent in Japanese patients with chronic hepaptitis C (HCV) genotype 1b who were either interferon-ineligible/intolerant or non-responders to interferon-based ttherapies. AASLD 2013; Abstract 211.
-
AASLD 2013
-
-
Chayama, K.1
Takahashi, S.2
Toyota, J.3
-
37
-
-
84890868284
-
Efficacy and safety of an interferon-free regimen of MK-5172 + ribavirin for 12 weeks or 24 weeks in treatment naive, noncirrhotic subjects with HCV GT1 infection: the C-SPIRIT Study
-
Abstract 1110.
-
Gane EJ, Ari ZB, Mollison L, et al. Efficacy and safety of an interferon-free regimen of MK-5172 + ribavirin for 12 weeks or 24 weeks in treatment naive, noncirrhotic subjects with HCV GT1 infection: the C-SPIRIT Study. AASLD 2013; Abstract 1110.
-
(2013)
AASLD
-
-
Gane, E.J.1
Ari, Z.B.2
Mollison, L.3
-
38
-
-
84890878380
-
SVR results of a once-daily regimen of simeprevir (TMC435) plus sofosbuvir (GS-7977) with or without ribavirin in cirrhotic and non-cirrhotic HCV genotype 1 traetment-naive and prior null responder patients: the COSMOS study
-
Abstract LB-3.
-
Jacobson JM, Ghalib RM, Rodriguez-Torres M, et al. SVR results of a once-daily regimen of simeprevir (TMC435) plus sofosbuvir (GS-7977) with or without ribavirin in cirrhotic and non-cirrhotic HCV genotype 1 traetment-naive and prior null responder patients: the COSMOS study. AASLD 2013. Abstract LB-3.
-
AASLD 2013
-
-
Jacobson, J.M.1
Ghalib, R.M.2
Rodriguez-Torres, M.3
-
39
-
-
84877730954
-
Sofosbuvir for previously untreated chronic hepatitis C infection
-
Lawitz E, Mangia A, Wyles D, et al. Sofosbuvir for previously untreated chronic hepatitis C infection. N Engl J Med 2013; 368: 1878-87.
-
(2013)
N Engl J Med
, vol.368
, pp. 1878-1887
-
-
Lawitz, E.1
Mangia, A.2
Wyles, D.3
-
40
-
-
84877739274
-
Sofosbuvir for hepatitis C genotype 2 or 3 in patients without treatment option
-
Jacobson IM, Gordon SC, Kowdley KV, et al. Sofosbuvir for hepatitis C genotype 2 or 3 in patients without treatment option. N Engl J Med 2013; 368: 1867-77.
-
(2013)
N Engl J Med
, vol.368
, pp. 1867-1877
-
-
Jacobson, I.M.1
Gordon, S.C.2
Kowdley, K.V.3
-
41
-
-
84890757693
-
Sofosbuvir for the treatment of hepatitis C virus
-
Asselah T. Sofosbuvir for the treatment of hepatitis C virus. Expert Opin Pharmacother 2013; 15: 121-30.
-
(2013)
Expert Opin Pharmacother
, vol.15
, pp. 121-130
-
-
Asselah, T.1
|