Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection

New England Journal of Medicine

Volumn 334, Issue 2, 1996, Pages 77-81

  Enomoto, Nobuyuki ^a   Sakuma, Ikuo ^a   Asahina, Yasuhiro ^a   Kurosaki, Masayuki ^a   Murakami, Takeshi ^a   Yamamoto, Chikara ^a   Ogura, Yuki ^a   Izumi, Namiki ^b   Marumo, Fumiaki ^a   Sato, Chifumi ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b MUSASHINO RED CROSS HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA INTERFERON; LYMPHOBLAST INTERFERON; RECOMBINANT ALPHA2A INTERFERON; RECOMBINANT ALPHA2B INTERFERON; VIRUS RNA;

ADULT; AMINO ACID SUBSTITUTION; ARTICLE; BLOOD TRANSFUSION; CLINICAL PROTOCOL; CONTROLLED STUDY; DRUG RESPONSE; FEMALE; GENE MUTATION; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN TISSUE; INTRAMUSCULAR DRUG ADMINISTRATION; LIVER BIOPSY; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRACTICE GUIDELINE; PRIORITY JOURNAL; TREATMENT OUTCOME; VIRUS GENOME;

AMINO ACID SEQUENCE; BASE SEQUENCE; CHRONIC DISEASE; FEMALE; HEPACIVIRUS; HEPATITIS C; HUMANS; INTERFERON-ALPHA; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MULTIVARIATE ANALYSIS; MUTATION; RETROSPECTIVE STUDIES; RNA, VIRAL; TREATMENT OUTCOME; VIRAL NONSTRUCTURAL PROTEINS;

EID: 9144257569     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199601113340203     Document Type: Article

References (32)

1. Houghton M, Weiner A, Han J, Kuo G, Choo QL. Molecular biology of the hepatitis C viruses implications for diagnosis, development and control of viral disease. Hepatology 1991,14.381-8.
2. Choo QL, Kuo G, Weiner AJ, Overby LR, Bradley DW, Houghton M. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 1989;244 359-62
3. Kiyosawa K, Sodeyama T, Tanaka E, et al. Interrelationship of blood transfusion, non-A, non-B hepatitis and hepatocellular carcinoma analysis by detection of antibody to hepatitis C virus. Hepatology 1990;12:671-5
4. Hoofnagle JH. Therapy of acute and chronic viral hepatitis Adv Intern Med 1994;39:241-75.
5. Simmonds P. Variability of hepatitis C virus Hepatology 1995,21 570-83.
6. Takada N, Takase S, Enomoto N, Takada A, Date T. Clinical backgrounds of the patients having different types of hepatitis C virus genomes J Hepatol 1992,14:35-40. [Erratum, J Hepatol 1992;14:435]
7. Yoshioka K, Kakumu S, Wakita T, et al Detection of hepatitis C virus by polymerase chain reaction and response to interferon-alpha therapy: relationship to genotypes of hepatitis C virus. Hepatology 1992;16 293-9.
8. Mita E, Hayashi N, Hagiwara H, et al. Predicting interferon therapy efficacy from hepatitis C virus genotype and RNA titer Dig Dis Sci 1994;39:977-82.
9. Hino K, Samokami S, Shimoda K, et al. Genotypes and titers of hepatitis C virus for predicting response to interferon in patients with chronic hepatitis C. J Med Virol 1994;42:299-305.
10. Tsubota A, Chayama K, Ikeda K, et al. Factors predictive of response to interferon-alpha therapy in hepatitis C virus infection Hepatology 1994;19: 1088-94.
11. Enomoto N, Takada A, Nakao T, Date T. There are two major types of hepatitis C virus in Japan. Biochem Biophys Res Commun 1990;170:1021-5
12. Nakao T, Enomoto N, Takada N, Takada A, Date T. Typing of hepatitis C virus genomes by restriction fragment length polymorphism J Gen Virol 1991;72:2105-12.
13. van Doorn LJ. Review molecular biology of the hepatitis C virus. J Med Virol 1994;43:345-56
14. Mahaney K, Tedeschi V, Maertens G, et al. Genotypic analysis of hepatitis C virus in American patients. Hepatology 1994;20:1405-11.
15. van der Poel CL, Cuypers HT, Reesink HW. Hepatitis C virus six years on. Lancet 1994;344:1475-9.
16. Nousbaum J-P, Pol S, Nalpas B, Landais P, Berthelot P, Brechot C. Hepatitis C virus type 1b (II) infection in France and Italy Ann Intern Med 1995;122: 161-8.
17. Sihni E, Bono F, Cividini A, et al. Differential distribution of hepatitis C virus genotypes in patients with and without liver function abnormalities. Hepatology 1995;21:285-90.
18. Takada N, Takase S, Takada A, Date T. Differences in the hepatitis C virus genotypes in different countries. J Hepatol 1993;17:277-83.
19. Davis GL Recombinant alpha-interferon treatment of non-A, non-B (type C) hepatitis: review of studies and recommendations for treatment. J Hepatol 1990,11.Suppl 1.S72-S77.
20. Enomoto N, Sakuma I, Asahina Y, et al. Comparison of full-length sequences of interferon-sensnive and resistant hepatitis C virus 1b: sensitivity to interferon is conferred by amino acid substitutions in the NS5A region J Clin Invest 1995;96 224-30
21. Kato N, Hijikata M, Ootsuyama Y, et al Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis Proc Natl Acad Sci U S A 1990;87:9524-8
22. Okamoto H, Kojima M, Okada S, et al. Genetic drift of hepatitis C virus during an 8.2-year infection in a chimpanzee- variability and stability. Virology 1992;190:894-9.
23. Tanaka T, Kato N, Nakagawa M, et al Molecular cloning of hepatitis C virus genome from a single Japanese carrier, sequence variation within the same individual and among infected individuals. Virus Res 1992;23:39-53.
24. Okamoto H, Okada S, Sugiyama Y, et al. Detection of hepatitis C virus RNA by a two-stage polymerase chain reaction with two pairs of primers deduced from the 5′-noncoding region Jpn J Exp Med 1990;60:215-22
25. Okamoto H, Sugiyama Y, Okada S, et al. Typing hepatitis C virus by polymerase chain reaction with type-specific primers: application to clinical surveys and tracing infectious sources. J Gen Virol 1992;73 673-9.
26. Desmet VJ, Gerber M, Hoofnagle JH, Manns M, Scheuer PJ. Classification of chronic hepatitis: diagnosis, grading and staging Hepatology 1994,19: 1513-20
27. Lau JY, Davis GL, Kniffen J, et al. Significance of serum hepatitis C virus RNA levels in chronic hepatitis C. Lancet 1993;341:1501-4 [Erratum, Lancet 1993;342:504]
28. Sakamoto N, Enomoto N, Kurosaki M, Marumo F, Sato C. Detection and quantification of hepatitis C virus RNA replication in the liver. J Hepatol 1994;20:593-7.
29. Davis GL, Lau JY, Urdea MS, et al. Quantitative detection of hepatitis C virus RNA with a solid-phase amplification method definition of optimal conditions for specimen collection and clinical application in interferon-treated patients. Hepatology 1994;19:1337-41.
30. Enomoto N, Kurosaki M, Tanaka Y, Marumo F, Sato C. Fluctuation of hepatitis C virus quasispecies in persistent infection and interferon treatment revealed by single-strand conformation polymorphism analysis. J Gen Virol 1994;75:1361-9.
31. Hagiwara H, Hayashi N, Mita E, et al. Quantitative analysis of hepatitis C virus RNA in serum during interferon alfa therapy Gastroenterology 1993; 104:877-83.
32. Tauji Y, Kaneko T, Satoh S, Shimotohno K. Phosphorylation of hepatitis C virus-encoded nonstructural protein NS5A J Virol 1995;69:3980-6