Hepatitis C virus NS5A protein protects against TNF-α mediated apoptotic cell death

Virus Research

Volumn 67, Issue 2, 2000, Pages 173-178

  Ghosh, Asish K ^a   Majumder, Mainak ^a   Steele, Robert ^a   Meyer, Keith ^b   Ray, Ranjit ^b   Ray, Ratna B ^a,b  

^a School of Medicine   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Hepatitis C virus; TNF

Indexed keywords

POLYDEOXYRIBONUCLEOTIDE SYNTHASE; TUMOR NECROSIS FACTOR ALPHA; VIRUS PROTEIN;

APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL STRAIN HEPG2; CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; HEPATITIS C VIRUS; LIVER CELL CARCINOMA; NONHUMAN; PATHOGENESIS; PERSISTENT INFECTION; PRIORITY JOURNAL;

BLOTTING, WESTERN; CASPASE 3; CASPASES; CELL DEATH; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPACIVIRUS; HUMANS; MICROSCOPY, CONFOCAL; POLY(ADP-RIBOSE) POLYMERASES; PROTEINS; RECOMBINANT PROTEINS; TIME FACTORS; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 0034084529     PISSN: 01681702     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-1702(00)00141-6     Document Type: Article

References (23)

1. Abraham N., Stojdl D.F., Duncan P.I. et al. Characterization of transgenic mice with target disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR. J. Biol. Chem. 274:1999;5953-5962.
2. Beg A.A., Baltimore D. An essential role for NK-κB in preventing TNF-α-induced cell death. Science. 274:1996;782-784.
3. Enomoto N., Sakuma I., Asahina Y., Kurosaki M., Murakami T., Yamamoto C., Izumi N., Marumo F., Sato C. Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b: sensitivity to interferon is conferred by amino acid substitutions in the NS5A region. J. Clin. Invest. 96:1995;224-230.
4. Gale Jr M., Kwieciszewski B., Dossett M., Nakao H., Katze M.G. Antiapoptotic and oncogenic potentials of hepatitis C virus are linked to interferon resistance by viral repression of the PKR protein kinase. J. Virol. 73:1999;6506-6516.
5. Ghosh A.K., Steele R., Meyer K., Ray R., Ray R.B. Hepatitis C virus NS5A protein modulates cell cycle regulatory genes and promotes cell growth. J. Gen. Virol. 80:1999;1179-1183.
6. Grakoui A., Wychowski C., Lin C., Feinstone S.M., Rice C.M. Expression and identification of hepatitis C virus polyprotein cleavage products. J. Virol. 67:1993;1385-1395.
7. Hirota M., Satoh S., Asabe S.-I. et al. Phosphorylation of nonstructural 5A protein of hepatitis C virus: HCV group-specific hyperphosphorylation. Virology. 257:1999;130-137.
8. Ide Y., Tanimoto A., Sasaguri Y., Padmanabhan R. Hepatitis C virus NS5A protein is phosphorylated in vitro by a study bound protein kinase from HeLa cells and by cAMP-dependent protein kinase A-alpha catalytic subunit. Gene. 201:1997;151-158.
9. Jansen-Durr P. Viral oncogenesis and cell cycle control. Virus Res. 42:1996;187-191.
10. Kaneko T., Tanji Y., Satoh S., Hijikata M., Asabe S., Kimura K., Shimotohno K. Production of two phosphoproteins from the NS5A region of the hepatitis C viral genome. Biochem. Biophys. Res. Commun. 205:1994;320-326.
11. Marusawa H., Hijikata M., Chiba T., Shimotohno K. Hepatitis C virus core protein inhibits fas- and tumor necrosis factor alpha-mediated apoptosis via NF-κB activation. J. Virol. 73:1999;4713-4720.
12. Nagata S. Apoptosis by death factor. Cell. 88:1997;355-365.
13. O'Brien V. Viruses and apoptosis. J. Gen. Virol. 79:1998;1833-1845.
14. Ray R.B., Meyer K., Steele R., Shrivastava A., Aggarwal B.B., Ray R. Inhibition of tumor necrosis factor (TNF-α) mediated apoptosis by hepatitis C virus core protein. J. Biol. Chem. 273:1998;2256-2259.
15. Reed K.E., Xu J., Rice C.M. Phosphorylation of the hepatitis C virus NS5A protein in vitro and in vivo: properties of the NS5A-associated kinase. J. Virol. 71:1997;7187-7197.
16. Shisler J.L., Gooding L.R. Adenoviral inhibitors of the apoptotic cascade. Trends Microbiol. 6:1998;337-339.
17. Tanji Y., Kaneko T., Satoh S., Shimotohno K. Phosphorylation of hepatitis C virus- encoded nonstructural protein NS5A. J. Virol. 69:1995;3980-3986.
18. Taylor D.R., Shi S.T., Romano P.R., Barber G.N., Lai M.M.C. Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein. Science. 285:1999;107-110.
19. Thanos D., Maniatis T. NF-κB: a lesson in family values. Cell. 80:1995;529-532.
20. Thompson C.B. Apoptosis in the pathogenesis and treatment of disease. Science. 267:1995;1456-1462.
21. Wang X.W., Gibson M.K., Vermculen W. et al. Abrogation of p53-induced apoptosis by the hepatitis B virus X gene. Cancer Res. 55:1995;6012-6016.
22. White E. Life, death, and the pursuit of apoptosis. Genes Devel. 10:1996;1-15.
23. Zhu N., Khoshnan A., Schneider R. et al. Hepatitis C virus core protein binds to the cytoplasmic domain of tumor necrosis factor (TNF) receptor 1 and enhances TNF-induced apoptosis. J. Virol. 72:1998;3691-3697.