Hepatitis C virus NS5A protein modulates cell cycle regulatory genes and promotes cell growth

Journal of General Virology

Volumn 80, Issue 5, 1999, Pages 1179-1183

  Ghosh, Asish K ^a   Steele, Robert ^a   Meyer, Keith ^a   Ranjit, Ray ^a   Ray, Ratna B ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLINE; PHOSPHOPROTEIN; PROTEIN P21; VIRUS PROTEIN;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL CELL; ARTICLE; CELL CYCLE; CELL GROWTH; FIBROBLAST; GROWTH REGULATION; HEPATITIS C VIRUS; HEPATOMA CELL; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATOR GENE; TRANSCRIPTION REGULATION;

EID: 0032938224     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-80-5-1179     Document Type: Article

References (36)

1. Bravo, R., Frank, R., Blundell, P. A. & Macdonald-Bravo, H. (1987). Cyclin/PCNA is the auxiliary protein of DNA polymerase-δ. Nature 326, 515-517.
2. Chamberlain, R. W., Adams, N., Saeed, A. A., Simmonds, P. & Elliott, R. M. (1997). Complete nucleotide sequence of a type 4 hepatitis C virus variant, the predominant genotype in the Middle East. Journal of General Virology 78, 1341-1347.
3. Chang, J., Yang, S.-H., Cho, Y. G., Hwang, S. B., Hahn, Y. S. & Sung, Y. C. (1998). Hepatitis C virus core from two different genotypes has an oncogenic potential but is not sufficient for transforming primary rat embryo fibroblasts in cooperation with H-ras oncogene. Journal of Virology 72, 3060-3065.
4. Chomczynski, P. & Sacchi, N. (1987). Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Analytical Biochemistry 162, 156-159.
5. Choo, Q. L., Kuo, G., Weiner, A. J., Overby, L. R., Bradley, D. W. & Houghton, M. (1989). Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 244, 359-362.
6. Clarke, B. (1997). Molecular virology of hepatitis C virus. Journal of General Virology 78, 2397-2410.
7. el-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W. & Vogelstein, B. (1993). WAF1, a potential mediator of p53 tumor suppression. Cell 75, 817-825.
8. Enomoto, N., Sakuma, I., Asahina, Y., Kurosaki, M., Murakami, T., Yamamoto, C., Izumi, N., Marumo, F. & Sato, C. (1995). Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region. Journal of Clinical Investigation 96, 224-230.
9. Gale, M. J., Jr, Korth, M. J., Tang, N. M., Tan, S.-L., Hopkins, D. A., Dever, T. E., Polyak, S. J., Gretch, D. R. & Katze, M. G. (1997). Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein. Virology 230, 217-227.
10. Gale, M., Jr, Blakely, C. M., Kwieciszewski, B., Tan, S.-L., Dossett, M., Tang, N. M., Korth, M. J., Polyak, S. J., Gretch, D. R. & Katze, M. G. (1998). Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation. Molecular and Cellular Biology 18, 5208-5218.
11. Harper, J. W., Adami, G. R., Wei, N., Keyomarsi, K. & Elledge, S. J. (1993). The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75, 805-816.
12. Hsu, I. C., Metcalf, R. A., Sun, T., Welsh, J. A., Wang, N. J. & Harris, C. C. (1991). Mutational hotspot in the p53 gene in human hepatocellular carcinomas. Nature 350, 427-428.
13. Kaneko, T., Tanji, Y., Satoh, S., Hijikata, M., Asabe, S., Kimura, K. & Shimotohno, K. (1994). Production of two phosphoproteins from the NS5 A region of the hepatitis C viral genome. Biochemical and Biophysical Research Communications 205, 320-326.
14. Kato, N., Lan, K. H., Ono-Nita, S. K., Shiratori, Y. & Omata, M. (1997). Hepatitis C virus nonstructural region 5A protein is a potent transcriptional activator. Journal of Virology 71, 8856-8859.
15. Kitabayashi, I., Kawakami, Z., Chiu, R., Ozawa, K., Matsuoka, T., Toyoshima, S., Umesono, K., Evans, R. M., Gachelin, G. & Yokoyama, K. (1992). Transcriptional regulation of the c-jun gene by retinoic acid and E1A during differentiation of F9 cells. EMBO Journal 11, 167-175.
16. Koromilas, A. E., Roy, S., Barber, G. N., Katze, M. G. & Sonenberg, N. (1992). Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase. Science 257, 1685-1689.
17. Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R., Bigner, S. H., Giovanella, B. C., Ittmann, M., Tycko, B., Hibshoosh, H., Wigler, M. H. & Parsons, R. (1997). PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275, 1943-1947.
18. WAF1/CIP1 expression through mitogen-activated protein kinase signaling pathway. Cancer Research 56, 31-35.
19. Michieli, P., Chedid, M., Lin, D., Pierce, J. H., Mercer, W. E. & Givol, D. (1994). Induction of WAF1/CIP1 by a p53-independent pathway. Cancer Research 54, 3391-3395.
20. Morgan, D. O. (1995). Principles of CDK regulation. Nature 374, 131-134.
21. Morris, G. F. & Mathews, M. B. (1990). Analysis of the proliferating cell nuclear antigen promoter and its response to adenovirus early region 1. Journal of Biological Chemistry 265, 16116-16125.
22. Ray, R. B. (1995). Induction of cell death in murine fibroblasts by a c-myc promoter binding protein. Cell Growth & Differentiation 6, 1089-1096.
23. Ray, R. & Miller, D. M. (1991). Cloning and characterization of a human c-myc promoter-binding protein. Molecular and Cellular Biology 11, 2154-2161.
24. Ray, R. B., Lagging, L. M., Meyer, K. & Ray, R. (1996). Hepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype. Journal of Virology 70, 4438-4443.
25. Ray, R. B., Steele, R., Meyer, K. & Ray, R. (1997). Transcriptional repression of p53 promoter by hepatitis C virus core protein. Journal of Biological Chemistry 272, 10983-10986.
26. WAF1/CiP1/Sid1 promoter activity. Gene 208, 331-336.
27. Reed, K. E., Xu, J. & Rice, C. M. (1997). Phosphorylation of the hepatitis C virus NS5A protein in vitro and in vivo: properties of the NS5A-associated kinase. Journal of Virology 71, 7187-7197.
28. Sakamuro, D., Furukawa, T. & Takegami, T. (1995). Hepatitis C virus nonstructural protein NS3 transforms NIH 3T3 cells. Journal of Virology 69, 3893-3896.
29. WAF1/CIP1 induces growth arrest, giant cell formation and apoptosis in human breast carcinoma cell lines. Oncogene 11, 1899-1905.
30. Simmonds, P. (1998). Variability of the hepatitis C virus genome. Current Studies in Hematology and Blood Transfusion 62, 38-63.
31. Stillman, B. (1989). Initiation of eukaryotic DNA replication in vitro. Annual Review of Cell Biology 5, 197-245.
32. Tanimoto, A., Ide, Y., Arima, N., Sasaguri, Y. & Padmanabhan, R. (1997). The amino terminal deletion mutants of hepatitis C virus nonstructural protein NS5A function as transcriptional activators in yeast. Biochemical and Biophysical Research Communications 236, 360-364.
33. Tanji, Y., Kaneko, T., Satoh, S. & Shimotohno, K. (1995). Phosphorylation of hepatitis C virus-encoded nonstructural protein NS5A. Journal of Virology 69, 3980-3986.
34. Xiong, Y., Hannon, G. J., Zhang, H., Casso, D., Kobayashi, R. & Beach, D. (1993). p21 is a universal inhibitor of cyclin kinases. Nature 366, 701-704.
35. Yang, Z-Y., Perkins, N. D., Ohno, T., Nabel, E. G. & Nabel, G. J. (1995). The p21 cyclin-dependent kinase inhibitor suppresses tumorigenicity in vivo. Nature Medicine 1, 1052-1056.
36. Zanotto, P. M. de A., Gibbs, M. J., Gould, E. A. & Holmes, E. C. (1996). A reevaluation of the higher taxonomy of viruses based on RNA polymerases. Journal of Virology 70, 6083-6096.