Loss of immune escape mutations during persistent HCV infection in pregnancy enhances replication of vertically transmitted viruses

Nature Medicine

Volumn 19, Issue 11, 2013, Pages 1529-1533

  Honegger, Jonathan R ^a,b   Kim, Seungtaek ^c,d   Price, Aryn A ^c   Kohout, Jennifer A ^e   McKnight, Kevin L ^a   Prasad, Mona R ^b   Lemon, Stanley M ^c,f   Grakoui, Arash ^e   Walker, Christopher M ^a,b  

^a NATIONWIDE CHILDREN S HOSPITAL   (United States)

^b THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d Yonsei University College of Medicine   (South Korea)

^e EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; HLA ANTIGEN CLASS 1;

ARTICLE; CYTOTOXIC T LYMPHOCYTE; DISEASE ASSOCIATION; ESCAPE MUTATION; FITNESS; GENE MUTATION; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; MOLECULAR RECOGNITION; NONHUMAN; NUCLEOTIDE SEQUENCE; PERSISTENT INFECTION; PREGNANCY; PRIORITY JOURNAL; VERTICAL TRANSMISSION; VIRUS LOAD; VIRUS REPLICATION; VIRUS TRANSMISSION;

HEPATITIS C VIRUS;

ADULT; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; FEMALE; GENES, MHC CLASS I; HEPACIVIRUS; HEPATITIS C, CHRONIC; HLA-B ANTIGENS; HUMANS; INFANT; INFANT, NEWBORN; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; MOLECULAR SEQUENCE DATA; MUTATION; PARTURITION; POSTPARTUM PERIOD; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; T-LYMPHOCYTES, CYTOTOXIC; VIREMIA;

EID: 84887497646     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3351     Document Type: Article

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