Anti-apoptotic effect of HCV core gene of genotype 3a in Huh-7 cell line

Virology Journal

Volumn 8, Issue , 2011, Pages

  Jahan, Shah ^a,b   Khaliq, Saba ^a,b   Siddiqi, Muhammad ^a   Ijaz, Bushra ^a   Ahmad, Waqar ^a   Ashfaq, Usman A ^a   Hassan, Sajida ^a  

^a UNIVERSITY OF THE PUNJAB   (Pakistan)

^b UNIVERSITY OF HEALTH SCIENCES   (Pakistan)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CASPASE 10; CASPASE 3; CASPASE 8; CASPASE 9; CORE PROTEIN; HEPATITIS C VIRUS CORE PROTEIN 1A; HEPATITIS C VIRUS CORE PROTEIN 3A; PROTEIN KINASE B; PROTEIN P53; UNCLASSIFIED DRUG; NUCLEOCAPSID PROTEIN, HEPATITIS C VIRUS; ONCOPROTEIN; TETRAZOLIUM; THIAZOLE DERIVATIVE; THIAZOLYL BLUE;

APOPTOSIS; ARTICLE; CELL ASSAY; CELL PROLIFERATION; CELL STRAIN; CELL STRAIN HUH 7; CONTROLLED STUDY; DOWN REGULATION; ENZYME PHOSPHORYLATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL CARCINOMA; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION; VIRUS CARCINOGENESIS; WESTERN BLOTTING; CELL LINE; CELL SURVIVAL; CLASSIFICATION; GENE EXPRESSION PROFILING; GENETICS; GENOTYPE; HEPATITIS C VIRUS; ISOLATION AND PURIFICATION; LIVER CELL; METABOLISM; METHODOLOGY; PAKISTAN; PATHOGENICITY; PHOSPHORYLATION; PROTEIN PROCESSING; STAINING; VIROLOGY;

HEPATITIS C VIRUS;

APOPTOSIS; BLOTTING, WESTERN; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; GENE EXPRESSION PROFILING; GENOTYPE; HEPACIVIRUS; HEPATOCYTES; HUMANS; ONCOGENE PROTEIN V-AKT; PAKISTAN; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; REAL-TIME POLYMERASE CHAIN REACTION; STAINING AND LABELING; TETRAZOLIUM SALTS; THIAZOLES; VIRAL CORE PROTEINS;

EID: 81555237181     PISSN: None     EISSN: 1743422X     Source Type: Journal    
DOI: 10.1186/1743-422X-8-522     Document Type: Article

References (40)

1. Course and outcome of hepatitis C. Hoofnagle JH, Hepatology 2002 36 21 29
2. Epidemiology of hepatitis C. Alter MJ, Hepatology 1997 26 62S 65S (Pubitemid 27388074)
3. Hepatitis C virus biology. Giannini C, Brechot C, Cell Death Differ 2003 10 Suppl 1 27 38
4. Epidemiology of hepatitis C virus infection in Pakistan. Raja NS, Janjua KA, J Microbiol Immunol Infect 2008 41 4 8 (Pubitemid 351792115)
5. Hepatitis C virus genotype 3a infection and hepatocellular carcinoma: Pakistan experience. Idrees M, Rafique S, Rehman I, Akbar H, Yousaf MZ, Butt S, Awan Z, Manzoor S, Akram M, Aftab M, et al. World J Gastroenterol 2009 15 5080 5085
6. Genetic organization and diversity of the hepatitis C virus. Choo QL, Richman KH, Han JH, Berger K, Lee C, Dong C, Gallegos C, Coit D, Medina-Selby R, Barr PJ, et al. Proc Natl Acad Sci USA 1991 88 2451 2455 (Pubitemid 21916435)
7. Processing in the hepatitis C virus E2-NS2 region: identification of p7 and two distinct E2-specific products with different C termini. Lin C, Lindenbach BD, Pragai BM, McCourt DW, Rice CM, J Virol 1994 68 5063 5073 (Pubitemid 24226574)
8. Overview of hepatitis C virus genome structure, polyprotein processing, and protein properties. Reed KE, Rice CM, Curr Top Microbiol Immunol 2000 242 55 84 (Pubitemid 29467521)
9. Oxidative stress in the absence of inflammation in a mouse model for hepatitis C virus-associated hepatocarcinogenesis. Moriya K, Nakagawa K, Santa T, Shintani Y, Fujie H, Miyoshi H, Tsutsumi T, Miyazawa T, Ishibashi K, Horie T, et al. Cancer Res 2001 61 4365 4370 (Pubitemid 32685760)
10. The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice. Moriya K, Fujie H, Shintani Y, Yotsuyanagi H, Tsutsumi T, Ishibashi K, Matsuura Y, Kimura S, Miyamura T, Koike K, Nat Med 1998 4 1065 1067 (Pubitemid 28417341)
11. Caspase activation correlates with the degree of inflammatory liver injury in chronic hepatitis C virus infection. Bantel H, Lugering A, Poremba C, Lugering N, Held J, Domschke W, Schulze-Osthoff K, Hepatology 2001 34 758 767 (Pubitemid 32928001)
12. Detection of elevated caspase activation and early apoptosis in liver diseases. Bantel H, Ruck P, Gregor M, Schulze-Osthoff K, Eur J Cell Biol 2001 80 230 239 (Pubitemid 32241930)
13. Apoptosis in hepatitis C virus infection. Bantel H, Schulze-Osthoff K, Cell Death Differ 2003 10 Suppl 1 48 58
14. Inhibition of tumor necrosis factor (TNF-alpha)-mediated apoptosis by hepatitis C virus core protein. Ray RB, Meyer K, Steele R, Shrivastava A, Aggarwal BB, Ray R, J Biol Chem 1998 273 2256 2259 (Pubitemid 28069278)
15. Sensitization to Fas-mediated apoptosis by hepatitis C virus core protein. Ruggieri A, Harada T, Matsuura Y, Miyamura T, Virology 1997 229 68 76 (Pubitemid 27243489)
16. Inhibition of cytochrome c release in Fas-mediated signaling pathway in transgenic mice induced to express hepatitis C viral proteins. Machida K, Tsukiyama-Kohara K, Seike E, Tone S, Shibasaki F, Shimizu M, Takahashi H, Hayashi Y, Funata N, Taya C, et al. J Biol Chem 2001 276 12140 12146
17. Modulation of p53 transcription regulatory activity and post-translational modification by hepatitis C virus core protein. Kao CF, Chen SY, Chen JY, Wu Lee YH, Oncogene 2004 23 2472 2483
18. Hepatitis C virus core protein enhances p53 function through augmentation of DNA binding affinity and transcriptional ability. Otsuka M, Kato N, Lan K, Yoshida H, Kato J, Goto T, Shiratori Y, Omata M, J Biol Chem 2000 275 34122 34130
19. p53 induction of heparin-binding EGF-like growth factor counteracts p53 growth suppression through activation of MAPK and PI3K/Akt signaling cascades. Fang L, Li G, Liu G, Lee SW, Aaronson SA, Embo J 2001 20 1931 1939 (Pubitemid 32397395)
20. Hepatitis C virus core protein inhibits apoptosis via enhanced Bcl-xL expression. Otsuka M, Kato N, Taniguchi H, Yoshida H, Goto T, Shiratori Y, Omata M, Virology 2002 296 84 93
21. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death - inducing signaling complex. Muzio M, Chinnaiyan AM, Kischkel FC, O'Rourke K, Shevchenko A, Ni J, Scaffidi C, Bretz JD, Zhang M, Gentz R, et al. Cell 1996 85 817 827 (Pubitemid 26193033)
22. Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally. Varfolomeev EE, Schuchmann M, Luria V, Chiannilkulchai N, Beckmann JS, Mett IL, Rebrikov D, Brodianski VM, Kemper OC, Kollet O, et al. Immunity 1998 9 267 276 (Pubitemid 28400040)
23. The protein structures that shape caspase activity, specificity, activation and inhibition. Fuentes-Prior P, Salvesen GS, Biochem J 2004 384 201 232 (Pubitemid 39656233)
24. Hepatitis C virus core protein modulates TRAIL-mediated apoptosis by enhancing Bid cleavage and activation of mitochondria apoptosis signaling pathway. Chou AH, Tsai HF, Wu YY, Hu CY, Hwang LH, Hsu PI, Hsu PN, J Immunol 2005 174 2160 2166
25. Liver cell apoptosis in chronic hepatitis C correlates with histological but not biochemical activity or serum HCV-RNA levels. Calabrese F, Pontisso P, Pettenazzo E, Benvegnu L, Vario A, Chemello L, Alberti A, Valente M, Hepatology 2000 31 1153 1159 (Pubitemid 30233241)
26. Hepatitis C virus infection and apoptosis. Fischer R, Baumert T, Blum HE, World J Gastroenterol 2007 13 4865 4872 (Pubitemid 47496752)
27. Role of HCV Core gene of genotype 1a and 3a and host gene Cox-2 in HCV-induced pathogenesis. Jahan S, Khaliq S, Ijaz B, Ahmad W, Hassan S, Virol J 8 155
28. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Niwa H, Yamamura K, Miyazaki J, Gene 1991 108 193 199
29. Correlation of serum antibody titers against hepatitis C virus core protein with clinical features by western blot (immunoblot) analysis using a recombinant vaccinia virus expression system. Nishizono A, Hiraga M, Mifune K, Terao H, Fujioka T, Nasu M, Goto T, Misumi J, Moriyama M, Arakawa Y, et al. J Clin Microbiol 1993 31 1173 1178 (Pubitemid 23129439)
30. PI 3-kinase, Akt and cell survival. Downward J, Semin Cell Dev Biol 2004 15 177 182 (Pubitemid 38251646)
31. Hepatitis C virus molecular clones: from cDNA to infectious virus particles in cell culture. Bartenschlager R, Curr Opin Microbiol 2006 9 416 422 (Pubitemid 44108723)
32. Flying under the radar: the immunobiology of hepatitis C. Dustin LB, Rice CM, Annu Rev Immunol 2007 25 71 99 (Pubitemid 46697903)
33. The hepatitis C virus persistence: how to evade the immune system? Pavio N, Lai MM, J Biosci 2003 28 287 304 (Pubitemid 36512804)
34. Signaling mechanisms of heparin-binding epidermal growth factor-like growth factor in vascular smooth muscle cells. Reynolds CM, Eguchi S, Frank GD, Motley ED, Hypertension 2002 39 525 529 (Pubitemid 34165177)
35. pRB plays an essential role in cell cycle arrest induced by DNA damage. Harrington EA, Bruce JL, Harlow E, Dyson N, Proc Natl Acad Sci USA 1998 95 11945 11950 (Pubitemid 28460519)
36. Apoptosis and the cell cycle. Evan GI, Brown L, Whyte M, Harrington E, Curr Opin Cell Biol 1995 7 825 834
37. Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity. Wang GL, Iakova P, Wilde M, Awad S, Timchenko NA, Genes Dev 2004 18 912 925 (Pubitemid 38529660)
38. High prevalence of hepatitis C virus infection in the largest province of Pakistan. Idrees M, Lal A, Naseem M, Khalid M, J Dig Dis 2008 9 95 103 (Pubitemid 351566631)
39. Subcellular localization of hepatitis C virus structural proteins in the liver of transgenic mice. Moriya K, Fujie H, Yotsuyanagi H, Shintani Y, Tsutsumi T, Matsuura Y, Miyamura T, Kimura S, Koike K, Jpn J Med Sci Biol 1997 50 169 177 (Pubitemid 28140247)
40. Inhibition of core gene of HCV 3a genotype using synthetic and vector derived siRNAs. Khaliq S, Jahan S, Ijaz B, Ahmad W, Asad S, Pervaiz A, Samreen B, Khan M, Hassan S, Virol J 7 318