Current information and asian perspectives on long-chain polyunsaturated fatty acids in pregnancy, lactation, and infancy: Systematic review and practice recommendations from an early nutrition academy workshop

Annals of Nutrition and Metabolism

Volumn 65, Issue 1, 2014, Pages 49-80

  Koletzko, Berthold ^a   Boey, Christopher C M ^b   Campoy, Cristina ^c   Carlson, Susan E ^d   Chang, Namsoo ^e   Guillermo Tuazon, Maria Antonia ^f   Joshi, Sadhana ^g   Prell, Christine ^a   Quak, Seng Hock ^h   Sjarif, Damayanti Rusli ⁱ   Su, Yixiang ⁿ   Supapannachart, Sarayut ^j   Yamashiro, Yuichiro ^k   Osendarp, Saskia J M ^l,m  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF MALAYA   (Malaysia)

^c UNIVERSITY OF GRANADA   (Spain)

^d UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^e Ewha Womans University   (South Korea)

^f UNIVERSITY OF THE PHILIPPINES LOS BAÑOS   (Philippines)

^g Bharati Vidyapeeth Deemed University   (India)

^h NATIONAL UNIVERSITY HOSPITAL   (Singapore)

ⁱ CIPTO MANGUNKUSUMO HOSPITAL   (Indonesia)

^j MAHIDOL UNIVERSITY   (Thailand)

^k JUNTENDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^l Osendarp Nutrition   (Netherlands)

^m MICRONUTRIENT INITIATIVE   (Canada)

ⁿ SUN YAT SEN UNIVERSITY   (China)

more..

Author keywords

Arachidonic acid; Docosahexaenoic acid; Eicosapentaenoic acid; Infant feeding; Nutrition in pregnancy; Perinatal nutrition; Polyunsaturated fatty acids

Indexed keywords

ARACHIDONIC ACID; DOCOSAHEXAENOIC ACID; LONG CHAIN POLYUNSATURATED FATTY ACID; OMEGA 3 FATTY ACID; POLYUNSATURATED FATTY ACID; UNCLASSIFIED DRUG; ICOSAPENTAENOIC ACID; UNSATURATED FATTY ACID;

ALLERGY; ANTHROPOMETRY; ARTICLE; ARTIFICIAL MILK; ASIAN; BREAST FEEDING; CARDIOVASCULAR DISEASE; CHILD GROWTH; COGNITIVE DEVELOPMENT; EYE DEVELOPMENT; HUMAN; IMMUNE RESPONSE; INFANCY; LACTATION; OBESITY; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PREGNANCY; PREMATURE LABOR; PUERPERAL DEPRESSION; RANDOMIZED CONTROLLED TRIAL (TOPIC); SYSTEMATIC REVIEW; WORKSHOP; ASIA; CONSENSUS; DIET; DIETARY SUPPLEMENT; FEMALE; GESTATIONAL AGE; HEALTH CARE POLICY; INFANT; INFANT NUTRITION; MALE; MATERNAL NUTRITION; META ANALYSIS; NEWBORN; NUTRITIONAL REQUIREMENT; PHYSIOLOGY; PREGNANCY OUTCOME; PREMATURE BIRTH;

ARACHIDONIC ACID; ASIA; BREAST FEEDING; CONSENSUS; DIET; DIETARY SUPPLEMENTS; DOCOSAHEXAENOIC ACIDS; EICOSAPENTAENOIC ACID; FATTY ACIDS, UNSATURATED; FEMALE; GESTATIONAL AGE; HUMANS; INFANT; INFANT NUTRITIONAL PHYSIOLOGICAL PHENOMENA; INFANT, NEWBORN; LACTATION; MALE; MATERNAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; NUTRITION POLICY; NUTRITIONAL REQUIREMENTS; PREGNANCY; PREGNANCY OUTCOME; PREMATURE BIRTH;

EID: 84908562442     PISSN: 02506807     EISSN: 14219697     Source Type: Journal    
DOI: 10.1159/000365767     Document Type: Article

References (160)

1. Vermunt SH, Mensink RP, Simonis AM, Hornstra G: Effects of age and dietary n-3 fatty acids on the metabolism of [13C]-alphalinolenic acid. Lipids 1999; 34:S127.
2. Pawlosky RJ, Hibbeln JR, Novotny JA, Salem N Jr: Physiological compartmental analysis of alpha-linolenic acid metabolism in adult humans. J Lipid Res 2001; 42: 1257-1265.
3. Brenna JT: Efficiency of conversion of alphalinolenic acid to long chain n-3 fatty acids in man. Curr Opin Clin Nutr Metab Care 2002; 5: 127-132.
4. Lattka E, Klopp N, Demmelmair H, Klingler M, Heinrich J, Koletzko B: Genetic variations in polyunsaturated fatty acid metabolism - implications for child health? Ann Nutr Metab 2012; 60: 8-17.
5. Glaser C, Lattka E, Rzehak P, Steer C, Koletzko B: Genetic variation in polyunsaturated fatty acid metabolism and its potential relevance for human development and health. Matern Child Nutr 2011; 7(suppl 2):27-40.
6. Koletzko B, Lattka E, Zeilinger S, Illig T, Steer C: Genetic variants of the fatty acid desaturase gene cluster predict amounts of red blood cell docosahexaenoic and other polyunsaturated fatty acids in pregnant women: findings from the Avon Longitudinal Study of Parents and Children. Am J Clin Nutr 2011; 93: 211-219.
7. Lattka E, Rzehak P, Szabo E, Jakobik V, Weck M, Weyermann M, Grallert H, Rothenbacher D, Heinrich J, Brenner H, Decsi T, Illig T, Koletzko B: Genetic variants in the fads gene cluster are associated with arachidonic acid concentrations of human breast milk at 1.5 and 6 mo postpartum and influence the course of milk dodecanoic, tetracosenoic, and trans- 9-octadecenoic acid concentrations over the duration of lactation. Am J Clin Nutr 2011; 93: 382-391.
8. Steer CD, Lattka E, Koletzko B, Golding J, Hibbeln JR: Maternal fatty acids in pregnancy, FADS polymorphisms, and child intelligence quotient at 8 y of age. Am J Clin Nutr 2013; 98: 1575-1582.
9. Uauy R, Castillo C: Lipid requirements of infants: implications for nutrient composition of fortified complementary foods. J Nutr 2003; 133: 2962S-2972S.
10. Uauy R, Dangour AD: Fat and fatty acid requirements and recommendations for infants of 0-2 years and children of 2-18 years. Ann Nutr Metab 2009; 55: 76-96.
11. Koletzko B, Cetin I, Brenna JT; Perinatal Lipid Intake Working Group; Child Health Foundation; Diabetic Pregnancy Study Group; European Association of Perinatal Medicine; European Society for Clinical Nutrition and Metabolism; European Society for Paediatric Gastroenterology Hepatology and Nutrition; International Federation of Placenta Associations; International Society for the Study of Fatty Acids and Lipids: Dietary fat intakes for pregnant and lactating women. Br J Nutr 2007; 98: 873-877.
12. Koletzko B, Lien E, Agostoni C, Bohles H, Campoy C, Cetin I, Decsi T, Dudenhausen JW, Dupont C, Forsyth S, Hoesli I, Holzgreve W, Lapillonne A, Putet G, Secher NJ, Symonds M, Szajewska H, Willatts P, Uauy R: The roles of long-chain polyunsaturated fatty acids in pregnancy, lactation and infancy: review of current knowledge and consensus recommendations. J Perinat Med 2008; 36: 5-14.
13. Adu-Afarwuah S, Lartey A, Brown KH, Zlotkin S, Briend A, Dewey KG: Home fortification of complementary foods with micronutrient supplements is well accepted and has positive effects on infant iron status in Ghana. Am J Clin Nutr 2008; 87: 929-938.
14. Chen CM, Wang YY, Chang SY: Effect of inhome fortification of complementary feeding on intellectual development of Chinese children. Biomed Environ Sci 2010; 23: 83-91.
15. Ramakrishnan U, Stein AD, Parra-Cabrera S, Wang M, Imhoff-Kunsch B, Juarez-Marquez S, Rivera J, Martorell R: Effects of docosahexaenoic acid supplementation during pregnancy on gestational age and size at birth: randomized, double-blind, placebo-controlled trial in Mexico. Food Nutr Bull 2010; 31:S108-S116.
16. Su KP, Huang SY, Chiu TH, Huang KC, Huang CL, Chang HC, Pariante CM: Omega- 3 fatty acids for major depressive disorder during pregnancy: results from a randomized, double-blind, placebo-controlled trial. J Clin Psychiatry 2008; 69: 644-651.
17. Imhoff-Kunsch B, Briggs V, Goldenberg T, Ramakrishnan U: Effect of n-3 long-chain polyunsaturated fatty acid intake during pregnancy on maternal, infant, and child health outcomes: a systematic review. Paediatr Perinat Epidemiol 2012; 26(suppl 1):91-107.
18. Szajewska H, Horvath A, Koletzko B: Effect of n-3 long-chain polyunsaturated fatty acid supplementation of women with low-risk pregnancies on pregnancy outcomes and growth measures at birth: a meta-analysis of randomized controlled trials. Am J Clin Nutr 2006; 83: 1337-1344.
19. Makrides M, Duley L, Olsen SF: Marine oil, and other prostaglandin precursor, supplementation for pregnancy uncomplicated by pre-eclampsia or intrauterine growth restriction. Cochrane Database Syst Rev 2006; 3:CD003402.
20. Horvath A, Koletzko B, Szajewska H: Effect of supplementation of women in high-risk pregnancies with long-chain polyunsaturated fatty acids on pregnancy outcomes and growth measures at birth: a meta-analysis of randomized controlled trials. Br J Nutr 2007; 98: 253-259.
21. Much D, Brunner S, Vollhardt C, Schmid D, Sedlmeier EM, Bruderl M, Heimberg E, Bartke N, Boehm G, Bader BL, Amann-Gassner U, Hauner H: Effect of dietary intervention to reduce the n-6/n-3 fatty acid ratio on maternal and fetal fatty acid profile and its relation to offspring growth and body composition at 1 year of age. Eur J Clin Nutr 2013; 67: 282-288.
22. Carlson SE, Colombo J, Gajewski BJ, Gustafson KM, Mundy D, Yeast J, Georgieff MK, Markley LA, Kerling EH, Shaddy DJ: DHA supplementation and pregnancy outcomes. Am J Clin Nutr 2013; 97: 808-815.
23. Courville AB, Harel O, Lammi-Keefe CJ: Consumption of a DHA-containing functional food during pregnancy is associated with lower infant ponderal index and cord plasma insulin concentration. Br J Nutr 2011; 106: 208-212.
24. Makrides M, Gibson RA, McPhee AJ, Yelland L, Quinlivan J, Ryan P; DOMInO Investigative Team: Effect of DHA supplementation during pregnancy on maternal depression and neurodevelopment of young children: a randomized controlled trial. JAMA 2010; 304: 1675-1683.
25. Harper M, Thom E, Klebanoff MA, Thorp J, Sorokin Y, Varner MW, Wapner RJ, Caritis SN, Iams JD, Carpenter MW, Peaceman AM, Mercer BM, Sciscione A, Rouse DJ, Ramin SM, Anderson GD; Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentMaternal-Fetal Medicine Units Network: Omega-3 fatty acid supplementation to prevent recurrent preterm birth a randomized controlled trial. Obstet Gynecol 2010; 115: 234-242.
26. Zhou SJ, Yelland L, McPhee AJ, Quinlivan J, Gibson RA, Makrides M: Fish-oil supplementation in pregnancy does not reduce the risk of gestational diabetes or preeclampsia. Am J Clin Nutr 2012; 95: 1378-1384.
27. Muthayya S, Dwarkanath P, Thomas T, Ramprakash S, Mehra R, Mhaskar A, Mhaskar R, Thomas A, Bhat S, Vaz M, Kurpad AV: The effect of fish and omega-3 LCPUFA intake on low birth weight in Indian pregnant women. Eur J Clin Nutr 2009; 63: 340-346.
28. Lederman SA, Jones RL, Caldwell KL, Rauh V, Sheets SE, Tang D, Viswanathan S, Becker M, Stein JL, Wang RY, Perera FP: Relation between cord blood mercury levels and early child development in a world trade center cohort. Environ Health Perspect 2008; 116: 1085-1091.
29. Oken E, Radesky JS, Wright RO, Bellinger DC, Amarasiriwardena CJ, Kleinman KP, Hu H, Gillman MW: Maternal fish intake during pregnancy, blood mercury levels, and child cognition at age 3 years in a US cohort. Am J Epidemiol 2008; 167: 1171-1181.
30. Gale CR, Marriott LD, Martyn CN, Limond J, Inskip HM, Godfrey KM, Law CM, Cooper C, West C, Robinson SM: Breastfeeding, the use of docosahexaenoic acid-fortified formulas in infancy and neuropsychological function in childhood. Arch Dis Child 2010; 95: 174-179.
31. Gould JF, Smithers LG, Makrides M: The effect of maternal omega-3 (n-3) LCPUFA supplementation during pregnancy on early childhood cognitive and visual development: a systematic review and meta-analysis of randomized controlled trials. Am J Clin Nutr 2013; 97: 531-544.
32. Campoy C, Escolano-Margarit MV, Ramos R, Parrilla-Roure M, Csabi G, Beyer J, Ramirez-Tortosa MC, Molloy AM, Decsi T, Koletzko BV: Effects of prenatal fish-oil and 5-methyltetrahydrofolate supplementation on cognitive development of children at 6.5 y of age. Am J Clin Nutr 2011; 94: 1880S-1888S.
33. Campoy C, Escolano-Margarit MV, Anjos T, Szajewska H, Uauy R: Omega 3 fatty acids on child growth, visual acuity and neurodevelopment. Br J Nutr 2012; 107(suppl 2):S85-S106.
34. Stein AD, Wang M, Rivera JA, Martorell R, Ramakrishnan U: Auditory- and visualevoked potentials in Mexican infants are not affected by maternal supplementation with 400 mg/d docosahexaenoic acid in the second half of pregnancy. J Nutr 2012; 142: 1577-1581.
35. Smithers LG, Gibson RA, Makrides M: Maternal supplementation with docosahexaenoic acid during pregnancy does not affect early visual development in the infant: a randomized controlled trial. Am J Clin Nutr 2011; 93: 1293-1299.
36. Gustafson KM, Carlson SE, Colombo J, Yeh HW, Shaddy DJ, Li S, Kerling EH: Effects of docosahexaenoic acid supplementation during pregnancy on fetal heart rate and variability: a randomized clinical trial. Prostaglandins Leukot Essent Fatty Acids 2013; 88: 331-338.
37. Judge MP, Cong X, Harel O, Courville AB, Lammi-Keefe CJ: Maternal consumption of a DHA-containing functional food benefits infant sleep patterning: an early neurodevelopmental measure. Early Hum Dev 2012; 88: 531-537.
38. Kohlboeck G, Glaser C, Tiesler C, Demmelmair H, Standl M, Romanos M, Koletzko B, Lehmann I, Heinrich J, LISAplus Study Group: Effect of fatty acid status in cord blood serum on children's behavioral difficulties at 10 y of age: results from the LISAplus Study. Am J Clin Nutr 2011; 94: 1592-1599.
39. van Goor SA, Dijck-Brouwer DA, Erwich JJ, Schaafsma A, Hadders-Algra M: The influence of supplemental docosahexaenoic and arachidonic acids during pregnancy and lactation on neurodevelopment at eighteen months. Prostaglandins Leukot Essent Fatty Acids 2011; 84: 139-146.
40. Helland IB, Smith L, Blomen B, Saarem K, Saugstad OD, Drevon CA: Effect of supplementing pregnant and lactating mothers with n-3 very-long-chain fatty acids on children's IQ and body mass index at 7 years of age. Pediatrics 2008; 122:e472-e479.
41. Delgado-Noguera MF, Calvache JA, Bonfill Cosp X: Supplementation with long chain polyunsaturated fatty acids (LCPUFA) to breastfeeding mothers for improving child growth and development. Cochrane Database Syst Rev 2010, p CD007901.
42. Jensen CL, Voigt RG, Llorente AM, Peters SU, Prager TC, Zou YL, Rozelle JC, Turcich MR, Fraley JK, Anderson RE, Heird WC: Effects of early maternal docosahexaenoic acid intake on neuropsychological status and visual acuity at five years of age of breast-fed term infants. J Pediatr 2010; 157: 900-905.
43. Jensen CL, Voigt RG, Prager TC, Zou YL, Fraley JK, Rozelle JC, Turcich MR, Llorente AM, Anderson RE, Heird WC: Effects of maternal docosahexaenoic acid intake on visual function and neurodevelopment in breastfed term infants. Am J Clin Nutr 2005; 82: 125-132.
44. Cheatham CL, Nerhammer AS, Asserhoj M, Michaelsen KF, Lauritzen L: Fish oil supplementation during lactation: effects on cognition and behavior at 7 years of age. Lipids 2011; 46: 637-645.
45. Steer CD, Davey Smith G, Emmett PM, Hibbeln JR, Golding J: FADS2 polymorphisms modify the effect of breastfeeding on child IQ. PLoS One 2010; 5:e11570.
46. Morales E, Bustamante M, Gonzalez JR, Guxens M, Torrent M, Mendez M, Garcia-Esteban R, Julvez J, Forns J, Vrijheid M, Molto-Puigmarti C, Lopez-Sabater C, Estivill X, Sunyer J: Genetic variants of the FADS gene cluster and ELOVL gene family, colostrums LC-PUFA levels, breastfeeding, and child cognition. PLoS One 2011; 6:e17181.
47. Fidler N, Sauerwald T, Pohl A, Demmelmair H, Koletzko B: Docosahexaenoic acid transfer into human milk after dietary supplementation: a randomized clinical trial. J Lipid Res 2000; 41: 1376-1383.
48. Del Prado M, Villalpando S, Elizondo A, Rodriguez M, Demmelmair H, Koletzko B: Contribution of dietary and newly formed arachidonic acid to human milk lipids in women eating a low-fat diet. Am J Clin Nutr 2001; 74: 242-247.
49. Klemens CM, Berman DR, Mozurkewich EL: The effect of perinatal omega-3 fatty acid supplementation on inflammatory markers and allergic diseases: a systematic review. BJOG 2011; 118: 916-925.
50. Urwin HJ, Miles EA, Noakes PS, Kremmyda LS, Vlachava M, Diaper ND, Perez-Cano FJ, Godfrey KM, Calder PC, Yaqoob P: Salmon consumption during pregnancy alters fatty acid composition and secretory IgA concentration in human breast milk. J Nutr 2012; 142: 1603-1610.
51. Noakes PS, Vlachava M, Kremmyda LS, Diaper ND, Miles EA, Erlewyn-Lajeunesse M, Williams AP, Godfrey KM, Calder PC: Increased intake of oily fish in pregnancy: effects on neonatal immune responses and on clinical outcomes in infants at 6 mo. Am J Clin Nutr 2012; 95: 395-404.
52. Furuhjelm C, Jenmalm MC, Falth-Magnusson K, Duchen K: Th1 and Th2 chemokines, vaccine-induced immunity, and allergic disease in infants after maternal omega-3 fatty acid supplementation during pregnancy and lactation. Pediatr Res 2011; 69: 259-264.
53. Krauss-Etschmann S, Hartl D, Rzehak P, Heinrich J, Shadid R, Del Carmen Ramirez- Tortosa M, Campoy C, Pardillo S, Schendel DJ, Decsi T, Demmelmair H, Koletzko BV; Nutraceuticals for Healthier Life Study Group: Decreased cord blood IL-4, IL-13, and CCR4 and increased TGF-beta levels after fish oil supplementation of pregnant women. J Allergy Clin Immunol 2008; 121: 464-470.e466.
54. Warstedt K, Furuhjelm C, Duchen K, Falth-Magnusson K, Fageras M: The effects of omega- 3 fatty acid supplementation in pregnancy on maternal eicosanoid, cytokine, and chemokine secretion. Pediatr Res 2009; 66: 212-217.
55. Palmer DJ, Sullivan T, Gold MS, Prescott SL, Heddle R, Gibson RA, Makrides M: Effect of n-3 long chain polyunsaturated fatty acid supplementation in pregnancy on infants' allergies in first year of life: randomised controlled trial. BMJ 2012; 344:e184.
56. Furuhjelm C, Warstedt K, Larsson J, Fredriksson M, Bottcher MF, Falth-Magnusson K, Duchen K: Fish oil supplementation in pregnancy and lactation may decrease the risk of infant allergy. Acta Paediatr 2009; 98: 1461-1467.
57. Olsen SF, Osterdal ML, Salvig JD, Mortensen LM, Rytter D, Secher NJ, Henriksen TB: Fish oil intake compared with olive oil intake in late pregnancy and asthma in the offspring: 16 y of registry-based follow-up from a randomized controlled trial. Am J Clin Nutr 2008; 88: 167-175.
58. Imhoff-Kunsch B, Stein AD, Martorell R, Parra-Cabrera S, Romieu I, Ramakrishnan U: Prenatal docosahexaenoic acid supplementation and infant morbidity: randomized controlled trial. Pediatrics 2011; 128:e505-e512.
59. Furuhjelm C, Warstedt K, Fageras M, Falth- Magnusson K, Larsson J, Fredriksson M, Duchen K: Allergic disease in infants up to 2 years of age in relation to plasma omega-3 fatty acids and maternal fish oil supplementation in pregnancy and lactation. Pediatr Allergy Immunol 2011; 22: 505-514.
60. Granot E, Jakobovich E, Rabinowitz R, Levy P, Schlesinger M: DHA supplementation during pregnancy and lactation affects infants' cellular but not humoral immune response. Mediators Inflamm 2011; 2011: 493925.
61. Linnamaa P, Savolainen J, Koulu L, Tuomasjukka S, Kallio H, Yang B, Vahlberg T, Tahvonen R: Blackcurrant seed oil for prevention of atopic dermatitis in newborns: a randomized, double-blind, placebo-controlled trial. Clin Exp Allergy 2010; 40: 1247-1255.
62. Sausenthaler S, Koletzko S, Schaaf B, Lehmann I, Borte M, Herbarth O, von Berg A, Wichmann HE, Heinrich J, Group LS: Maternal diet during pregnancy in relation to eczema and allergic sensitization in the offspring at 2 y of age. Am J Clin Nutr 2007; 85: 530-537.
63. Calvani M, Alessandri C, Sopo SM, Panetta V, Pingitore G, Tripodi S, Zappala D, Zicari AM: Consumption of fish, butter and margarine during pregnancy and development of allergic sensitizations in the offspring: role of maternal atopy. Pediatr Allergy Immunol 2006; 17: 94-102.
64. Willers SM, Devereux G, Craig LC, McNeill G, Wijga AH, Abou El-Magd W, Turner SW, Helms PJ, Seaton A: Maternal food consumption during pregnancy and asthma, respiratory and atopic symptoms in 5-year-old children. Thorax 2007; 62: 773-779.
65. Romieu I, Torrent M, Garcia-Esteban R, Ferrer C, Ribas-Fito N, Anto JM, Sunyer J: Maternal fish intake during pregnancy and atopy and asthma in infancy. Clin Exp Allergy 2007; 37: 518-525.
66. Standl M, Sausenthaler S, Lattka E, Koletzko S, Bauer CP, Wichmann HE, von Berg A, Berdel D, Kramer U, Schaaf B, Lehmann I, Herbarth O, Klopp N, Koletzko B, Heinrich J; GINIplus and LISAplus Study Group: FADS gene cluster modulates the effect of breastfeeding on asthma. Results from the GINIplus and LISAplus studies. Allergy 2012;67:83-90.
67. Lee HS, Barraza-Villarreal A, Hernandez-Vargas H, Sly PD, Biessy C, Ramakrishnan U, Romieu I, Herceg Z: Modulation of DNA methylation states and infant immune system by dietary supplementation with omega- 3 PUFA during pregnancy in an intervention study. Am J Clin Nutr 2013; 98: 480-487.
68. Wojcicki JM, Heyman MB: Maternal omega- 3 fatty acid supplementation and risk for perinatal maternal depression. J Matern Fetal Neonatal Med 2011; 24: 680-686.
69. Mozurkewich EL, Clinton CM, Chilimigras JL, Hamilton SE, Allbaugh LJ, Berman DR, Marcus SM, Romero VC, Treadwell MC, Keeton KL, Vahratian AM, Schrader RM, Ren J, Djuric Z: The Mothers, Omega-3, and Mental Health Study: a double-blind, randomized controlled trial. Am J Obstet Gynecol 2013; 208: 313.e311-313.e319.
70. Doornbos B, van Goor SA, Dijck-Brouwer DAJ, Schaafsma A, Korf J, Muskiet FAJ: Supplementation of a low dose of DHA or DHA plus AA does not prevent peripartum depressive symptoms in a small population based sample. Prog Neuropsychopharmacol Biol Psychiatry 2009; 33: 49-52.
71. Hauner H, Much D, Vollhardt C, Brunner S, Schmid D, Sedlmeier EM, Heimberg E, Schuster T, Zimmermann A, Schneider KT, Bader BL, Amann-Gassner U: Effect of reducing the n-6:n-3 long-chain PUFA ratio during pregnancy and lactation on infant adipose tissue growth within the first year of life: an open-label randomized controlled trial. Am J Clin Nutr 2012; 95: 383-394.
72. Rodriguez G, Iglesia I, Bel-Serrat S, Moreno LA: Effect of n-3 long chain polyunsaturated fatty acids during the perinatal period on later body composition. Br J Nutr 2012; 107(suppl 2):S117-S128.
73. Martinez-Victoria E, Yago MD: Omega 3 polyunsaturated fatty acids and body weight. Br J Nutr 2012; 107(suppl 2):S107-S116.
74. Muhlhausler BS, Gibson RA, Makrides M: Effect of long-chain polyunsaturated fatty acid supplementation during pregnancy or lactation on infant and child body composition: a systematic review. Am J Clin Nutr 2010; 92: 857-863.
75. Hauner H, Brunner S, Amann-Gassner U: The role of dietary fatty acids for early human adipose tissue growth. Am J Clin Nutr 2013; 98: 549S-555S.
76. Asserhoj M, Nehammer S, Matthiessen J, Michaelsen KF, Lauritzen L: Maternal fish oil supplementation during lactation may adversely affect long-term blood pressure, energy intake, and physical activity of 7-year-old boys. J Nutr 2009; 139: 298-304.
77. Rytter D, Bech BH, Christensen JH, Schmidt EB, Henriksen TB, Olsen SF: Intake of fish oil during pregnancy and adiposity in 19-y-old offspring: follow-up on a randomized controlled trial. Am J Clin Nutr 2011; 94: 701-708.
78. Rytter D, Christensen JH, Bech BH, Schmidt EB, Henriksen TB, Olsen SF: The effect of maternal fish oil supplementation during the last trimester of pregnancy on blood pressure, heart rate and heart rate variability in the 19-year-old offspring. Br J Nutr 2012; 108: 1475-1483.
79. Rytter D, Schmidt EB, Bech BH, Christensen JH, Henriksen TB, Olsen SF: Fish oil supplementation during late pregnancy does not influence plasma lipids or lipoprotein levels in young adult offspring. Lipids 2011; 46: 1091-1099.
80. Franke C, Demmelmair H, Decsi T, Campoy C, Cruz M, Molina-Font JA, Mueller K, Koletzko B: Influence of fish oil or folate supplementation on the time course of plasma redox markers during pregnancy. Br J Nutr 2010; 103: 1648-1656.
81. Garcia-Rodriguez CE, Helmersson-Karlqvist J, Mesa MD, Miles EA, Noakes PS, Vlachava M, Kremmyda LS, Diaper ND, Godfrey KM, Calder PC, Gil A, Basu S: Does increased intake of salmon increase markers of oxidative stress in pregnant women? The Salmon in Pregnancy Study. Antiox Redox Signal 2011; 15: 2819-2823.
82. Simmer K, Patole SK, Rao SC: Long-chain polyunsaturated fatty acid supplementation in infants born at term. Cochrane Database Syst Rev 2011;12:CD000376.
83. Qawasmi A, Landeros-Weisenberger A, Bloch MH: Meta-analysis of LCPUFA supplementation of infant formula and visual acuity. Pediatrics 2013; 131:e262-e272.
84. Qawasmi A, Landeros-Weisenberger A, Leckman JF, Bloch MH: Meta-analysis of long-chain polyunsaturated fatty acid supplementation of formula and infant cognition. Pediatrics 2012; 129: 1141-1149.
85. Drover JR, Hoffman DR, Castaneda YS, Morale SE, Garfield S, Wheaton DH, Birch EE: Cognitive function in 18-month-old term infants of the DIAMOND study: a randomized, controlled clinical trial with multiple dietary levels of docosahexaenoic acid. Early Hum Dev 2011; 87: 223-230.
86. Birch EE, Carlson SE, Hoffman DR, Fitzgerald-Gustafson KM, Fu VL, Drover JR, Castaneda YS, Minns L, Wheaton DK, Mundy D, Marunycz J, Diersen-Schade DA: The DIAMOND (DHA Intake And Measurement Of Neural Development) study: a double- masked, randomized controlled clinical trial of the maturation of infant visual acuity as a function of the dietary level of docosahexaenoic acid. Am J Clin Nutr 2010; 91: 848-859.
87. Meldrum SJ, D'Vaz N, Simmer K, Dunstan JA, Hird K, Prescott SL: Effects of high-dose fish oil supplementation during early infancy on neurodevelopment and language: a randomised controlled trial. Br J Nutr 2012; 108: 1443-1454.
88. Agostoni C, Zuccotti GV, Radaelli G, Besana R, Podesta A, Sterpa A, Rottoli A, Riva E, Giovannini M: Docosahexaenoic acid supplementation and time at achievement of gross motor milestones in healthy infants: a randomized, prospective, double-blind, placebocontrolled trial. Am J Clin Nutr 2009; 89: 64-70.
89. Colombo J, Carlson SE, Cheatham CL, Shaddy DJ, Kerling EH, Thodosoff JM, Gustafson KM, Brez C: Long-term effects of LCPUFA supplementation on childhood cognitive outcomes. Am J Clin Nutr 2013; 98: 403-412.
90. Willatts P, Forsyth S, Agostoni C, Casaer P, Riva E, Boehm G: Effects of long-chain PUFA supplementation in infant formula on cognitive function in later childhood. Am J Clin Nutr 2013; 98: 536S-542S.
91. de Jong C, Kikkert HK, Fidler V, Hadders-Algra M: Effects of long-chain polyunsaturated fatty acid supplementation of infant formula on cognition and behaviour at 9 years of age. Dev Med Child Neurol 2012; 54: 1102-1108.
92. Drover JR, Felius J, Hoffman DR, Castaneda YS, Garfield S, Wheaton DH, Birch EE: A randomized trial of DHA intake during infancy: school readiness and receptive vocabulary at 2-3.5 years of age. Early Hum Dev 2012; 88: 885-891.
93. Rosenfeld E, Beyerlein A, Hadders-Algra M, Kennedy K, Singhal A, Fewtrell M, Lucas A, Koletzko B, von Kries R: IPD meta-analysis shows no effect of LC-PUFA supplementation on infant growth at 18 months. Acta Paediatr 2009; 98: 91-97.
94. Makrides M, Gibson RA, Udell T, Ried K; International LCPUFA Investigators: Supplementation of infant formula with long-chain polyunsaturated fatty acids does not influence the growth of term infants. Am J Clin Nutr 2005; 81: 1094-1101.
95. Vivatvakin B, Mahayosnond A, Theamboonlers A, Steenhout PG, Conus NJ: Effect of a whey-predominant starter formula containing LCPUFAs and oligosaccharides (FOS/ GOS) on gastrointestinal comfort in infants. Asia Pac J Clin Nutr 2010; 19: 473-480.
96. Rzehak P, Koletzko S, Koletzko B, Sausenthaler S, Reinhardt D, Grubl A, Bauer CP, Kramer U, Bollrath C, von Berg A, Berdel D, Wichmann HE, Heinrich J; GINI Study Group: Growth of infants fed formula rich in canola oil (low erucic acid rapeseed oil). Clin Nutr 2011; 30: 339-345.
97. Gibson RA, Barclay D, Marshall H, Moulin J, Maire JC, Makrides M: Safety of supplementing infant formula with long-chain polyunsaturated fatty acids and Bifidobacterium lactis in term infants: a randomised controlled trial. Br J Nutr 2009; 101: 1706-1713.
98. Larnkjaer A, Hoppe C, Molgaard C, Michaelsen KF: The effects of whole milk and infant formula on growth and IGF-I in late infancy. Eur J Clin Nutr 2009; 63: 956-963.
99. de Jong C, Boehm G, Kikkert HK, Hadders-Algra M: The Groningen LCPUFA Study: no effect of short-term postnatal long-chain polyunsaturated fatty acids in healthy term infants on cardiovascular and anthropometric development at 9 years. Pediatr Res 2011; 70: 411-416.
100. Foolad N, Brezinski EA, Chase EP, Armstrong AW: Effect of nutrient supplementation on atopic dermatitis in children: a systematic review of probiotics, prebiotics, formula, and fatty acids. JAMA Dermatol 2013; 149: 350-355.
101. Field CJ, Van Aerde JE, Goruk S, Clandinin MT: Effect of feeding a formula supplemented with long-chain polyunsaturated fatty acids for 14 weeks improves the ex vivo response to a mitogen and reduces the response to a soy protein in infants at low risk for allergy. J Pediatr Gastroenterol Nutr 2010; 50: 661-669.
102. D'Vaz N, Meldrum SJ, Dunstan JA, Lee-Pullen TF, Metcalfe J, Holt BJ, Serralha M, Tulic MK, Mori TA, Prescott SL: Fish oil supplementation in early infancy modulates developing infant immune responses. Clin Exp Allergy 2012; 42: 1206-1216.
103. Birch EE, Khoury JC, Berseth CL, Castaneda YS, Couch JM, Bean J, Tamer R, Harris CL, Mitmesser SH, Scalabrin DM: The impact of early nutrition on incidence of allergic manifestations and common respiratory illnesses in children. J Pediatr 2010; 156: 902-906, 906.e901.
104. D'Vaz N, Meldrum SJ, Dunstan JA, Martino D, McCarthy S, Metcalfe J, Tulic MK, Mori TA, Prescott SL: Postnatal fish oil supplementation in high-risk infants to prevent allergy: randomized controlled trial. Pediatrics 2012; 130: 674-682.
105. Alm B, Aberg N, Erdes L, Mollborg P, Pettersson R, Norvenius SG, Goksor E, Wennergren G: Early introduction of fish decreases the risk of eczema in infants. Arch Dis Child 2009; 94: 11-15.
106. Kull I, Bergstrom A, Melen E, Lilja G, van Hage M, Pershagen G, Wickman M: Earlylife supplementation of vitamins A and D, in water-soluble form or in peanut oil, and allergic diseases during childhood. J Allergy Clin Immunol 2006; 118: 1299-1304.
107. Colombo J, Carlson SE, Cheatham CL, Fitzgerald-Gustafson KM, Kepler A, Doty T: Long-chain polyunsaturated fatty acid supplementation in infancy reduces heart rate and positively affects distribution of attention. Pediatr Res 2011; 70: 406-410.
108. Pivik RT, Dykman RA, Jing H, Gilchrist JM, Badger TM: Early infant diet and the omega 3 fatty acid DHA: effects on resting cardiovascular activity and behavioral development during the first half-year of life. Dev Neuropsychol 2009; 34: 139-158.
109. van der Merwe LF, Moore SE, Fulford AJ, Halliday KE, Drammeh S, Young S, Prentice AM: Long-chain PUFA supplementation in rural African infants: a randomized controlled trial of effects on gut integrity, growth, and cognitive development. Am J Clin Nutr 2013; 97: 45-57.
110. Andersen AD, Michaelsen KF, Hellgren LI, Trolle E, Lauritzen L: A randomized controlled intervention with fish oil versus sunflower oil from 9 to 18 months of age: exploring changes in growth and skinfold thicknesses. Pediatr Res 2011; 70: 368-374.
111. Andersen AD, Molbak L, Michaelsen KF, Lauritzen L: Molecular fingerprints of the human fecal microbiota from 9 to 18 months old and the effect of fish oil supplementation. J Pediatr Gastroenterol Nutr 2011; 53: 303-309.
112. Ayer JG, Harmer JA, Xuan W, Toelle B, Webb K, Almqvist C, Marks GB, Celermajer DS: Dietary supplementation with n-3 polyunsaturated fatty acids in early childhood: effects on blood pressure and arterial structure and function at age 8 y. Am J Clin Nutr 2009; 90: 438-446.
113. Lauritzen L, Christensen JH, Damsgaard CT, Michaelsen KF: The effect of fish oil supplementation on heart rate in healthy Danish infants. Pediatr Res 2008; 64: 610-614.
114. Harbild HL, Harslof LB, Christensen JH, Kannass KN, Lauritzen L: Fish oil-supplementation from 9 to 12 months of age affects infant attention in a free-play test and is related to change in blood pressure. Prostaglandins Leukot Essent Fatty Acids 2013; 89: 327-333.
115. Makrides M, Gibson RA, McPhee AJ, Collins CT, Davis PG, Doyle LW, Simmer K, Colditz PB, Morris S, Smithers LG, Willson K, Ryan P: Neurodevelopmental outcomes of preterm infants fed high-dose docosahexaenoic acid a randomized controlled trial. JAMA 2009; 301: 175-182.
116. Atwell K, Collins CT, Sullivan TR, Ryan P, Gibson RA, Makrides M, McPhee AJ: Respiratory hospitalisation of infants supplemented with docosahexaenoic acid as preterm neonates. J Paediatr Child Health 2013; 49:E17-E22.
117. Manley BJ, Makrides M, Collins CT, McPhee AJ, Gibson RA, Ryan P, Sullivan TR, Davis PG: High-dose docosahexaenoic acid supplementation of preterm infants: respiratory and allergy outcomes. Pediatrics 2011; 128:e71-e77.
118. Collins CT, Makrides M, Gibson RA, McPhee AJ, Davis PG, Doyle LW, Simmer K, Colditz PB, Morris S, Sullivan TR, Ryan P: Pre- and post-term growth in pre-term infants supplemented with higher-dose DHA: a randomised controlled trial. Br J Nutr 2011; 105: 1635-1643.
119. Smithers LG, Gibson RA, McPhee A, Makrides M: Effect of two doses of docosahexaenoic acid (DHA) in the diet of preterm infants on infant fatty acid status: results from the DINO trial. Prostaglandins Leukot Essent Fatty Acids 2008; 79: 141-146.
120. Schulzke SM, Patole SK, Simmer K: Longchain polyunsaturated fatty acid supplementation in preterm infants. Cochrane Database Syst Rev 2011;2:CD000375.
121. Smithers LG, Collins CT, Simmonds LA, Gibson RA, McPhee A, Makrides M: Feeding preterm infants milk with a higher dose of docosahexaenoic acid than that used in current practice does not influence language or behavior in early childhood: a follow-up study of a randomized controlled trial. Am J Clin Nutr 2010; 91: 628-634.
122. Isaacs EB, Ross S, Kennedy K, Weaver LT, Lucas A, Fewtrell MS: 10-year cognition in preterms after random assignment to fatty acid supplementation in infancy. Pediatrics 2011; 128:e890-e898.
123. Henriksen C, Haugholt K, Lindgren M, Aurvag AK, Ronnestad A, Gronn M, Solberg R, Moen A, Nakstad B, Berge RK, Smith L, Iversen PO, Drevon CA: Improved cognitive development among preterm infants attributable to early supplementation of human milk with docosahexaenoic acid and arachidonic acid. Pediatrics 2008; 121: 1137-1145.
124. Smithers LG, Gibson RA, McPhee A, Makrides M: Higher dose of docosahexaenoic acid in the neonatal period improves visual acuity of preterm infants: results of a randomized controlled trial. Am J Clin Nutr 2008; 88: 1049-1056.
125. Field CJ, Thomson CA, Van Aerde JE, Parrott A, Euler A, Lien E, Clandinin MT: Lower proportion of CD45R0+ cells and deficient interleukin-10 production by formulafed infants, compared with human-fed, is corrected with supplementation of longchain polyunsaturated fatty acids. J Pediatr Gastroenterol Nutr 2000; 31: 291-299.
126. Kennedy K, Ross S, Isaacs EB, Weaver LT, Singhal A, Lucas A, Fewtrell MS: The 10- year follow-up of a randomised trial of longchain polyunsaturated fatty acid supplementation in preterm infants: effects on growth and blood pressure. Arch Dis Child 2010; 95: 588-595.
127. Koletzko B, Lien E, Agostoni C, Bohles H, Campoy C, Cetin I, Decsi T, Dudenhausen JW, Dupont C, Forsyth S, Hoesli I, Holzgreve W, Lapillonne A, Putet G, Secher NJ, Symonds M, Szajewska H, Willatts P, Uauy R; World Association of Perinatal Medicine Dietary Guidelines Working Group: The roles of long-chain polyunsaturated fatty acids in pregnancy, lactation and infancy: review of current knowledge and consensus recommendations. J Perinat Med 2008; 36: 5-14.
128. Koletzko B, Cetin I, Brenna JT; Perinatal Lipid Intake Working Group; Child Health Foundation, Diabetic Pregnancy Study Group, European Association of Perinatal Medicine; European Society for Clinical Nutrition and Metabolis; European Society for Paediatric Gastroenterology, Hepatology and Nutrition, Committee on Nutrition; International Federation of Placenta Associations; International Society for the Study of Fatty Acids and Lipids. Dietary fat intakes for pregnant and lactating women. Br J Nutr 2007; 98: 873-877.
129. ESPGHAN Committee on Nutrition; Agostoni C, Braegger C, Decsi T, Kolacek S, Koletzko B, Michaelsen KF, Mihatsch W, Moreno LA, Puntis J, Shamir R, Szajewska H, Turck D, van Goudoever J: Breast-feeding: a commentary by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr 2009; 49: 112-125.
130. EFSA Panel on Dietetic Products, Nutrition, and Allergies: Scientific opinion on dietary reference values for fats, including saturated fatty acids, polyunsaturated fatty acids, monounsaturated fatty acids, trans fatty acids, and cholesterol. EFSA J 2010; 8: 1461-1468.
131. EFSA Panel on Dietetic Products, Nutrition, and Allergies: Scientific opinion on nutrient requirements and dietary intakes of infants and young children in the European Union. EFSA J 2013; 11: 3408.
132. EFSA Panel on Dietetic Products, Nutrition, and Allergies: Draft scientific Opinion on the Essential Composition of Infant and Follow- on Formulae. Parma, EFSA, 2014.
133. Food and Agriculture Organization of the United Nations: Fats and Fatty Acids in Human Nutrition: Report of a Joint FAO/ WHO Expert Consultation. Rome, FAO, 2010.
134. Koletzko B, Bhutta ZA, Cai W, Cruchet S, Guindi ME, Fuchs GJ, Goddard EA, van Goudoever JB, Quak SH, Kulkarni B, Makrides M, Ribeiro H, Walker A: Compositional requirements of follow-up formula for use in infancy: recommendations of an international expert group coordinated by the Early Nutrition Academy. Ann Nutr Metab 2013; 62: 44-54.
135. Koletzko B, Sauerwald T, Demmelmair H, Herzog M, von Schenck U, Bohles H, Wendel U, Seidel J: Dietary long-chain polyunsaturated fatty acid supplementation in infants with phenylketonuria: a randomized controlled trial. J Inherit Metab Dis 2007; 30: 326-332.
136. ESPGHAN Committee on Nutrition; Agostoni C, Buonocore G, Carnielli VP, De Curtis M, Darmaun D, Decsi T, Domellof M, Embleton ND, Fusch C, Genzel-Boroviczeny O, Goulet O, Kalhan SC, Kolacek S, Koletzko B, Lapillonne A, Mihatsch W, Moreno L, Neu J, Poindexter B, Puntis J, Putet G, Rigo J, Riskin A, Salle B, Sauer P, Shamir R, Szajewska H, Thureen P, Turck D, van Goudoever JB, Ziegler EE: Enteral nutrient supply for preterm infants: commentary from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition. J Pediatr Gastroenterol Nutr 2010; 50: 85-91.
137. Makrides M, Gibson RA, McPhee AJ, Collins CT, Davis PG, Doyle LW, Simmer K, Colditz PB, Morris S, Smithers LG, Willson K, Ryan P: Neurodevelopmental outcomes of preterm infants fed high-dose docosahexaenoic acid: a randomized controlled trial. JAMA 2009; 301: 175-182.
138. Koletzko B, Poindexter B, Uauy R: Recommended nutrient intake levels for stable, fully enterally fed very low birthweight infants; in Koletzko B, Poindexter B, Uauy R (eds): Nutritional Care of Preterm Infants. Basel, Karger, 2014, pp 300-305.
139. Ministry of Health, Labour, and Welfare, Japanese Government: The National Health and Nutrition Survey Japan 2011. Tokyo, Ministry of Health, Labour and Welfare, Japanese Government, 2012.
140. Kim CS, Ko SH, Kwon HS, Kim NH, Kim JH, Lim S, Choi SH, Song KH, Won JC, Kim DJ, Cha BY; Taskforce Team of Diabetes Fact Sheet of the Korean Diabetes Association: Prevalence, awareness, and management of obesity in Korea: data from the Korea National Health and Nutrition Examination Survey (1998-2011). Diabetes Metab J 2014; 38: 35-43.
141. Bae SG, Kim JY, Kim KY, Park SW, Bae J, Lee WK: Changes in dietary behavior among adolescents and their association with government nutrition policies in Korea, 2005- 2009. J Prev Med Public Health 2012; 45: 47-59.
142. Nguyen VQ, Goto A, Nguyen TV, Vo KT, Ta TM, Nguyen TN, Nguyen TM, Ho MB, Phan NA, Vu HH, Truong TM, Nguyen HT: Prevalence and correlates of zinc deficiency in pregnant Vietnamese women in Ho Chi Minh City. Asia Pac J Clin Nutr 2013; 22: 614-619.
143. Chiang JK, Lin YL, Chen CL, Ouyang CM, Wu YT, Chi YC, Huang KC, Yang WS: Reduced risk for metabolic syndrome and insulin resistance associated with ovo-lactovegetarian behavior in female Buddhists: a case-control study. PLoS One 2013; 8:e71799.
144. Cui X, Dai Q, Tseng M, Shu XO, Gao YT, Zheng W: Dietary patterns and breast cancer risk in the Shanghai Breast Cancer Study. Cancer Epidemiol Biomarkers Prev 2007; 16: 1443-1448.
145. Setiarini A, Utari DM, Mardatilah M, Putra WKY, Sudiarti T: Development of food pyramid for vegetarian in Indonesia. Vegetarian Nutr J 2013; 1: 8-13.
146. Huffman SL, Harika RK, Eilander A, Osendarp SJ: Essential fats: how do they affect growth and development of infants and young children in developing countries? A literature review. Matern Child Nutr 2011; 7(suppl 3):44-65.
147. Yakes EA, Arsenault JE, Islam MM, Ahmed T, German JB, Drake C, Hossain MB, Lewis BL, Rahman AS, Jamil KM, Brown KH: Dietary intake of polyunsaturated fatty acids among breast-feeding and non-breastfeeding 24- to 48-month-old children in Bangladesh. J Pediatr Gastroenterol Nutr 2011; 52: 351-359.
148. Glew RH, Huang YS, Vander Jagt TA, Chuang LT, Bhatt SK, Magnussen MA, Vander Jagt DJ: Fatty acid composition of the milk lipids of Nepalese women: correlation between fatty acid composition of serum phospholipids and melting point. Prostaglandins Leukot Essent Fatty Acids 2001; 65: 147-156.
149. Brenna JT, Varamini B, Jensen RG, Diersen-Schade DA, Boettcher JA, Arterburn LM: Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. Am J Clin Nutr 2007; 85: 1457-1464.
150. Peng Y, Zhou T, Wang Q, Liu P, Zhang T, Zetterstrom R, Strandvik B: Fatty acid composition of diet, cord blood and breast milk in Chinese mothers with different dietary habits. Prostaglandins Leukot Essent Fatty Acids 2009; 81: 325-330.
151. Yuhas R, Pramuk K, Lien EL: Human milk fatty acid composition from nine countries varies most in DHA. Lipids 2006; 41: 851-858.
152. Barbarich BN, Willows ND, Wang L, Clandinin MT: Polyunsaturated fatty acids and anthropometric indices of children in rural China. Eur J Clin Nutr 2006; 60: 1100-1107.
153. Smit EN, Oelen EA, Seerat E, Muskiet FA, Boersma ER: Breast milk docosahexaenoic acid (DHA) correlates with DHA status of malnourished infants. Arch Dis Child 2000; 82: 493-494.
154. Agostoni C, Giovannini M, Sala D, Usuelli M, Livio L, Francescato G, Braga M, Riva E, Martiello A, Colombo C, Marangoni F, Galli C: Double-blind, placebo-controlled trial comparing effects of supplementation of two micronutrient sprinkles on fatty acid status in Cambodian infants. J Pediatr Gastroenterol Nutr 2007; 44: 136-142.
155. Stein AD, Wang M, Martorell R, Neufeld LM, Flores-Ayala R, Rivera JA, Ramakrishnan U: Growth to age 18 months following prenatal supplementation with docosahexaenoic acid differs by maternal gravidity in Mexico. J Nutr 2011;141:316-320. Doi: 10.3945/jn.110.128215. Epub 2010 Dec 22.
156. Miles EA, Noakes PS, Kremmyda LS, Vlachava M, Diaper ND, Rosenlund G, Urwin H, Yaqoob P, Rossary A, Farges MC, Vasson MP, Liaset B, Froyland L, Helmersson J, Basu S, Garcia E, Olza J, Mesa MD, Aguilera CM, Gil A, Robinson SM, Inskip HM, Godfrey KM, Calder PC: The Salmon in Pregnancy Study: study design, subject characteristics, maternal fish and marine n-3 fatty acid intake, and marine n-3 fatty acid status in maternal and umbilical cord blood. Am J Clin Nutr 2011;94(6 suppl):1986S-1992S. Doi: 10.3945/ajcn.110.001636. Epub 2011 Aug 17.
157. de Jong C, Kikkert HK, Fidler V, Hadders- Algra M: The Groningen LCPUFA study: no effect of postnatal long-chain polyunsaturated fatty acids in healthy term infants on neurological condition at 9 years. Br J Nutr 2010;104:566-572. Doi: 10.1017/S0007114510000863. Epub 2010 Apr 7. PubMed PMID: 20370943.
158. Westerberg AC, Schei R, Henriksen C, Smith L, Veierod MB, Drevon CA, et al: Attention among very low birth weight infants following early supplementation with docosahexaenoic and arachidonic acid. Acta Paediatr 2011;100:47-52. PubMed PMID: WOS:000285101100014. English.
159. Drover J, Hoffman DR, Castaneda YS, Morale SE, Birch EE: Three randomized controlled trials of early long-chain polyunsaturated Fatty Acid supplementation on meansend problem solving in 9-month-olds. Child Dev 2009;80:1376-1384. Doi: 10.1111/j.1467-8624.2009.01339.x.
160. Schwartz J, Dube K, Sichert-Hellert W, Kannenberg F, Kunz C, Kalhoff H, Kersting M: Modification of dietary polyunsaturated fatty acids via complementary food enhances n-3 long-chain polyunsaturated fatty acid synthesis in healthy infants: a double blinded randomised controlled trial. Arch Dis Child 2009;94:876-882. Doi: 10.1136/adc.2008.146027. Epub 2009 Feb 4.