The effect of maternal fish oil supplementation during the last trimester of pregnancy on blood pressure, heart rate and heart rate variability in the 19-year-old offspring

British Journal of Nutrition

Volumn 108, Issue 8, 2012, Pages 1475-1483

  Rytter, Dorte ^a   Christensen, Jeppe H ^b   Bech, Bodil H ^a   Schmidt, Erik B ^b   Henriksen, Tine B ^c   Olsen, Sjurdur F ^d  

^a AARHUS UNIVERSITY   (Denmark)

^b AALBORG UNIVERSITY HOSPITAL   (Denmark)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

^d STATENS SERUM INSTITUT   (Denmark)

Author keywords

Blood pressure; Developmental programming; Fish oil; Heart rate variability

Indexed keywords

FISH OIL; OLIVE OIL; OMEGA 3 FATTY ACID;

ADULT; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; FEMALE; FISH; FOLLOW UP; HEART RATE; HEART RATE VARIABILITY; HUMAN; PHYSICAL EXAMINATION; PREGNANT WOMAN; RANDOMIZED CONTROLLED TRIAL (TOPIC); SYSTOLIC BLOOD PRESSURE; THIRD TRIMESTER PREGNANCY;

BLOOD PRESSURE; DIETARY FATS; DIETARY SUPPLEMENTS; FEMALE; FISH OILS; FOLLOW-UP STUDIES; HEART RATE; HUMANS; LINEAR MODELS; MALE; PHYSICAL EXAMINATION; PREGNANCY; PREGNANCY TRIMESTERS; PRENATAL EXPOSURE DELAYED EFFECTS; PRENATAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; YOUNG ADULT;

EID: 84867706318     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114511006799     Document Type: Article

References (33)

1. Schmidt EB, Arnesen H, Christensen JH, et al. (2005) Marine n-3 polyunsaturated fatty acids and coronary heart disease: part II. Clinical trials and recommendations. Thromb Res 115, 257-262.
2. Calder PC (2004) n-3 Fatty acids and cardiovascular disease: evidence explained and mechanisms explored. Clin Sci (Lond) 107, 1-11.
3. Dahl L, Bjorkkjaer T, Graff IE, et al. (2006) Fish-more than just omega 3. Tidsskr Nor Laegeforen 126, 309-311.
4. Mori TA (2010) Omega-3 fatty acids and blood pressure. Cell Mol Biol (Noisy-le-grand) 56, 83-92.
5. Geleijnse JM, Giltay EJ, Grobbee DE, et al. (2002) Blood pressure response to fish oil supplementation: metaregression analysis of randomized trials. J Hypertens 20, 1493-1499.
6. Mozaffarian D, Geelen A, Brouwer IA, et al. (2005) Effect of fish oil on heart rate in humans: a meta-analysis of randomized controlled trials. Circulation 112, 1945-1952.
7. Christensen JH & Schmidt EB (2007) Autonomic nervous system, heart rate variability and n-3 fatty acids. J Cardiovasc Med (Hagerstown) 8, Suppl. 1, S19-S22.
8. Christensen JH, Svensson M, Strandhave C, et al. (2010) n-3 Fatty acids and cardiac autonomic function in humans. Cell Mol Biol (Noisy-le-grand) 56, 131-139.
9. Holguin F, Tellez-Rojo MM, Lazo M, et al. (2005) Cardiac autonomic changes associated with fish oil vs soy oil supplementation in the elderly. Chest 127, 1102-1107.
10. Tsuji H, Larson MG, Venditti FJ Jr, et al. (1996) Impact of reduced heart rate variability on risk for cardiac events. The Framingham Heart Study. Circulation 94, 2850-2855.
11. Barker DJ (2008) Human growth and cardiovascular disease. Nestle Nutr Workshop Ser Pediatr Program 61, 21-38.
12. Uauy R, Peirano P, Hoffman D, et al. (1996) Role of essential fatty acids in the function of the developing nervous system. Lipids 31, S167-S176.
13. Armitage JA, Pearce AD, Sinclair AJ, et al. (2003) Increased blood pressure later in life may be associated with perinatal n-3 fatty acid deficiency. Lipids 38, 459-464.
14. Weisinger HS, Armitage JA, Sinclair AJ, et al. (2001) Perinatal omega-3 fatty acid deficiency affects blood pressure later in life. Nat Med 7, 258-259.
15. Massin M & von Bernuth G (1997) Normal ranges of heart rate variability during infancy and childhood. Pediatr Cardiol 18, 297-302.
16. Lauritzen L, Christensen JH, Damsgaard CT, et al. (2008) The effect of fish oil supplementation on heart rate in healthy Danish infants. Pediatr Res 64, 610-614.
17. Damsgaard CT, Schack-Nielsen L, Michaelsen KF, et al. (2005) Fish oil affects blood pressure and the plasma lipid profile in healthy Danish infants. J Nutr 136, 94-99.
18. Forsyth JS, Willatts P, Agostoni C, et al. (2003) Long chain polyunsaturated fatty acid supplementation in infant formula and blood pressure in later childhood: follow up of a randomised controlled trial. BMJ 326, 953.
19. Larnkjaer A, Christensen JH, Michaelsen KF, et al. (2006) Maternal fish oil supplementation during lactation does not affect blood pressure, pulse wave velocity, or heart rate variability in 2·5-y-old children. J Nutr 136, 1539-1544.
20. Asserhoj M, Nehammer S, Matthiessen J, et al. (2009) Maternal fish oil supplementation during lactation may adversely affect long-term blood pressure, energy intake, and physical activity of 7-year-old boys. J Nutr 139, 298-304.
21. Ayer JG, Harmer JA, Xuan W, et al. (2009) Dietary supplementation with n-3 polyunsaturated fatty acids in early childhood: effects on blood pressure and arterial structure and function at age 8 y. Am J Clin Nutr 90, 438-446.
22. Olsen SF, Sorensen JD, Secher NJ, et al. (1992) Randomised controlled trial of effect of fish-oil supplementation on pregnancy duration. Lancet 339, 1003-1007.
23. Ejskjaer N, Fleischer J, Fleischer J, et al. (2008) A pocket-size device to detect autonomic neuropathy. J Diabetes Sci Technol 2, 692-696.
24. Fleischer J, Nielsen R, Laugesen E, et al. (2011) Self-monitoring of cardiac autonomic function at home is feasible. J Diabetes Sci Technol 5, 107-112.
25. Salvig JD, Olsen SF & Secher NJ (1996) Effects of fish oil supplementation in late pregnancy on blood pressure: a randomised controlled trial. Br J Obstet Gynaecol 103, 529-533.
26. Kennedy K, Ross S, Isaacs EB, et al. (2010) The 10-year follow-up of a randomised trial of long-chain polyunsaturated fatty acid supplementation in preterm infants: effects on growth and blood pressure. Arch Dis Child 95, 588-595.
27. Wilson AC, Forsyth JS, Greene SA, et al. (1998) Relation of infant diet to childhood health: seven year follow up of cohort of children in Dundee infant feeding study. BMJ 316, 21-25.
28. Singhal A, Cole TJ & Lucas A (2001) Early nutrition in preterm infants and later blood pressure: two cohorts after randomised trials. Lancet 357, 413-419.
29. Singhal A & Lucas A (2004) Early origins of cardiovascular disease: is there a unifying hypothesis? Lancet 363, 1642-1645.
30. Dirix CE, Kester AD & Hornstra G (2009) Associations between neonatal birth dimensions and maternal essential and trans fatty acid contents during pregnancy and at delivery. Br J Nutr 101, 399-407.
31. Bonnemeier H, Richardt G, Potratz J, et al. (2003) Circadian profile of cardiac autonomic nervous modulation in healthy subjects: differing effects of aging and gender on heart rate variability. J Cardiovasc Electrophysiol 14, 791-799.
32. Rytter D, Bech BH, Christensen JH, et al. (2011) Intake of fish oil during pregnancy and adiposity in 19-y-old offspring: follow-up on a randomized controlled trial. Am J Clin Nutr 94, 701-708.
33. Rytter D, Schmidt EB, Bech BH, et al. (2011) Fish oil supplementation during late pregnancy does not influence plasma lipids or lipoprotein levels in young adult offspring. Lipids 46, 1091-1099.