Dietary long-chain polyunsaturated fatty acid supplementation in infants with phenylketonuria: A randomized controlled trial

Journal of Inherited Metabolic Disease

Volumn 30, Issue 3, 2007, Pages 326-332

  Koletzko, Berthold ^a,f   Sauerwald, T ^a   Demmelmair, H ^a   Herzog, M ^a   von Schenck, U ^b   Bohles H ^c   Wendel, U ^d   Seidel, J ^e  

^a UNIVERSITY OF MUNICH   (Germany)

^b HUMBOLDT UNIVERSITY   (Germany)

^c GOETHE UNIVERSITY   (Germany)

^d HEINRICH HEINE UNIVERSITY   (Germany)

^e FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^f LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; DOCOSAHEXAENOIC ACID; PHENYLALANINE; POLYUNSATURATED FATTY ACID;

ARTICLE; BREAST FEEDING; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DIETARY INTAKE; DOUBLE BLIND PROCEDURE; FATTY ACID BLOOD LEVEL; FEMALE; FOLLOW UP; HUMAN; HUMAN CELL; INFANT; MALE; MULTICENTER STUDY; PHENYLKETONURIA; PHOSPHOLIPID BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL;

BIRTH WEIGHT; BODY SIZE; BODY WEIGHT; DIETARY SUPPLEMENTS; FATTY ACIDS, UNSATURATED; FOOD ANALYSIS; GESTATIONAL AGE; HUMANS; INFANT; INFANT FOOD; INFANT, NEWBORN; PHENYLKETONURIAS;

EID: 34250017342     PISSN: 01418955     EISSN: 15732665     Source Type: Journal    
DOI: 10.1007/s10545-007-0491-4     Document Type: Article

References (32)

1. Agostoni C, Riva E, Biasucci G, et al (1995a) The effects of n-3 and n-6 polyunsaturated fatty acids on plasma lipids and fatty acids of treated phenylketonuric children. Prostaglandins Leukot Essent Fatty Acids 53: 401-404.
2. Agostoni C, Trojan S, Bellu R, Riva E, Giovannini M (1995b) Neurodevelopmental quotient of healthy term infants at 4 months and feeding practice: The role of long-chain polyunsaturated fatty acids. Pediatr Res 38: 262-266.
3. Agostoni C, Massetto N, Biasucci G, et al (2000) Effects of long-chain polyunsaturated fatty acid supplementation on fatty acid status and visual function in treated children with hyperphenylalaninemia. J Pediatr 137: 504-509.
4. Beblo S, Reinhardt H, Muntau AC, Mueller-Felber W, Roscher AA, Koletzko B (2001) Fish oil supplementation improves visual evoked potentials in children with phenylketonuria. Neurology 57: 1488-1491.
5. Beblo S, Reinhardt H, Demmelmair H, Muntau A, Koletzko B (2007) Effect of fish oil supplementation on fatty acid status, coordination and fine motor skills in children with phenylketonuria. J Pediatr, in press.
6. Birch EE, Hoffman DR, Uauy R, Birch DG, Prestidge C (1998) Visual acuity and the essentiality of docosahexaenoic acid and arachidonic acid in the diet of term infants. Pediatr Res 44: 201-209.
7. Birch EE, Garfield S, Hoffman DR, Uauy R, Birch DG (2000) A randomized controlled trial of early dietary supply of long-chain polyunsaturated fatty acids and mental development in term infants. Dev Med Child Neurol 42: 174-181.
8. Carlson SE, Werkman SH, Rhodes PG, Tolley EA (1993) Visual-acuity development in healthy preterm infants: Effect of marine-oil supplementation. Am J Clin Nutr 58: 35-42.
9. Cleary MA, Feillet F, White FJ, et al (2006) Randomised controlled trial of essential fatty acid supplementation in phenylketonuria. Eur J Clin Nutr 60(7): 915-920.
10. Emken EA, Adlof RO, Gulley RM (1994) Dietary linoleic acid influences desaturation and acylation of deuterium-labeled linoleic and linolenic acids in young adult males. Biochim Biophys Acta 1213(3): 277-288.
11. Galli C, Agostoni C, Mosconi C, Riva E, Salari PC, Giovannini M (1991) Reduced plasma C-20 and C-22 polyunsaturated fatty acids in children with phenylketonuria during dietary intervention. J Pediatr 119: 562-567.
12. Geppert J, Kraft V, Demmelmair H, Koletzko B (2006) Microalgal docosahexaenoic acid decreases plasma triacylglycerol in normolipidaemic vegetarians: A randomised trial. Br J Nutr 95: 1-5.
13. Gibson RA, Makrides M (1999) Polyunsaturated fatty acids and infant visual development: A critical appraisal of randomized clinical trials. Lipids 34: 179-184.
14. Innis SM (1992) Plasma and red blood cell fatty acid values as indexes of essential fatty acids in the developing organs of infants fed with milk or formulas. J Pediatr 120: S78-S86.
15. Innis SM, Nelson CM, Rioux FM, King DJ (1994) Development of visual acuity in relation to plasma and erythrocyte ω-6 and ω-3 fatty acids in healthy term gestation infants. Am J Clin Nutr 60: 347-352.
16. Innis SM, Auestad N, Siegman JS (1996) Blood lipid docosahexaenoic and arachidonic acid in term gestation infants fed formulas with high docosahexaenoic acid, low eicosapentaenoic acid fish oil. Lipids 31: 617-625.
17. Koletzko B, Rodriguez-Palmero M (1999) Polyunsaturated fatty acids in human milk and their role in early infant development. J Mammary Gland Biol Neoplasia 4: 269-284.
18. Koletzko B, Sinclair AJ (1999) Long-chain polyunsaturated fatty acids in diets for infants: Choices for recommending and regulating bodies and for manufacturers of dietary products. Lipids 34: 215-220.
19. Koletzko B, Edenhofer S, Lipowsky G, Reinhardt D (1995) Effects of a low birth weight infant formula containing human milk levels of docosahexaenoic and arachidonic acids. J Pediatr Gastroenterol Nutr 21: 200-208.
20. Koletzko B, Agostoni C, Carlson SE, et al (2001) Long chain polyunsaturated fatty acids (LC-PUFA) and perinatal development. Acta Paediatr 90: 460-464.
21. Koletzko B, Baker S, Cleghorn G, et al (2005) Global standard for the composition of infant formula: Recommendations of an ESPGHAN coordinated international expert group. J Pediatr Gastroenterol Nutr 41(5): 584-599.
22. Luukkainen P, Salo MK, Visakorpi JK, Räihä NCR, Nikkari T (1996) Impact of solid food on plasma arachidonic and docosahexaenoic acid status of term infants at 8 months of age. J Pediatr Gastroenterol Nutr 23: 229-234.
23. Ma J, Folsom AR, Eckfeldt JH, Lewis L, Chambless LE (1995) Short- and long-term repeatability of fatty acid composition of human plasma phospholipids and cholesterol esters. The Atherosclerosis Risk in Communities (ARIC) Study Investigators. Am J Clin Nutr 62: 572-578.
24. Makrides M, Simmer K, Goggin M, Gibson RA (1993) Erythrocyte docosahexaenoic acid correlates with the visual response of healthy, term infants. Pediatr Res 34: 425-427.
25. Martinez M (1992) Tissue levels of polyunsaturated fatty acids during early human development. J Pediatr 120: S129-S138.
26. Phinney SD, Odin RS, Johnson SB, Holman RT (1990) Reduced arachidonate in serum phospholipids and cholesteryl esters associated with vegetarian diets in humans. Am J Clin Nutr 51: 385-392.
27. Pöge AP, Bäumann K, Müller E, Leichsenring M, Schmidt H, Bremer HJ (1998) Long-chain polyunsaturated fatty acids in plasma and erythrocyte membrane lipids of children with phenylketonuria after controlled linoleic acid intake. J Inherit Metab Dis 21: 373-381.
28. SanGiovanni JP, Parra-Cabrera S, Colditz GA, Berkey CS, Dwyer JT (2000) Meta-analysis of dietary essential fatty acids and long-chain polyunsaturated fatty acids as they relate to visual resolution acuity in healthy preterm infants. Pediatrics 105: 1292-1298.
29. Sanjurjo P, Perteagudo L, Rodriguez Soriano J, Vilaseca A, Campistol J (1994) Polyunsaturated fatty acid status in patients with phenylketonuria. J Inherit Metab Dis 17: 704-709.
30. Scriver CR, Kaufman S, Woo SLC (2001) The hyperphenylalaninemias. In: Scriver CR, Beaudet AL, Sly WS, Valle D, eds. The Metabolic Basis of Inherited Disease, 6th edn. New York: McGraw-Hill Information Services Company, 495-546.
31. van Gool CJAW, van Houwelingen AC, Hornstra G (2000) The essential fatty acid status in phenylketonuria patients under treatment. J Nutr Biochem 11: 543-547.
32. Willatts P, Forsyth JS, DiModugno MK, Varma S, Colvin M (1998) Effect of long-chain polyunsaturated fatty acids in infant formula on problem solving at 10 months of age. Lancet 352: 688-691.