Genetic variants of the FADS gene cluster and ELOVL gene family, colostrums LC-PUFA levels, breastfeeding, and child cognition

PLoS ONE

Volumn 6, Issue 2, 2011, Pages

  Morales, Eva ^a,b,c   Bustamante, Mariona ^a,b,c,d   Gonzalez, Juan Ramon ^a,b,c   Guxens, Monica ^a,b,c   Torrent, Maties ^e   Mendez, Michelle ^a,b,c   Garcia Esteban, Raquel ^a,b,c   Julvez, Jordi ^a,b,c   Forns, Joan ^a,b,c   Vrijheid, Martine ^a,b,c   Molto Puigmarti, Carolina ^c,f   Lopez Sabater, Carmen ^c,f   Estivill, Xavier ^c,d,g   Sunyer, Jordi ^a,b,c,g  

^a CENTRE FOR RESEARCH IN ENVIRONMENTAL EPIDEMIOLOGY CREAL   (Spain)

^b HOSPITAL DEL MAR   (Spain)

^c CIBER EPIDEMIOLOGÍA Y SALUD PÚBLICA CIBERESP   (Spain)

^d CENTRE FOR GENOMIC REGULATION CRG   (Spain)

^e IB SALUT ^*  (Spain)

^f UNIVERSITY OF BARCELONA   (Spain)

^g UNIVERSITAT POMPEU FABRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DESATURASE 1; ARACHIDONIC ACID; DOCOSAHEXAENOIC ACID; ELONGASE 5; FATTY ACID DESATURASE 2; ICOSAPENTAENOIC ACID; LONG CHAIN POLYUNSATURATED FATTY ACID; OXYGENASE; POLYUNSATURATED FATTY ACID; PROTEIN KINASE; UNCLASSIFIED DRUG; ACYL COENZYME A DESATURASE; ACYLTRANSFERASE; FATTY ACID ELONGASES; UNSATURATED FATTY ACID;

ARTICLE; BREAST FEEDING; CHILD; CHILD COGNITION; COGNITION; COHORT ANALYSIS; COLOSTRUM; ELOVL GENE; ENZYME ACTIVITY; FADS GENE; FATTY ACID ANALYSIS; FATTY ACID SYNTHESIS; FEMALE; GENE; GENE CLUSTER; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOTE; HUMAN; MULTIGENE FAMILY; PRESCHOOL CHILD; ADULT; CHEMISTRY; CHILD DEVELOPMENT; COGNITIVE DEFECT; GENETICS; INFANT; MALE; METABOLISM; NEWBORN; PATHOPHYSIOLOGY; PHYSIOLOGY;

ACETYLTRANSFERASES; ADULT; BREAST FEEDING; CHILD DEVELOPMENT; CHILD, PRESCHOOL; COGNITION; COGNITION DISORDERS; COHORT STUDIES; COLOSTRUM; FATTY ACID DESATURASES; FATTY ACIDS, UNSATURATED; FEMALE; GENETIC VARIATION; HUMANS; INFANT; INFANT, NEWBORN; MALE; MULTIGENE FAMILY;

EID: 79952010953     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0017181     Document Type: Article

References (50)

1. Haag M, (2003) Essential fatty acids and the brain. Can J Psychiatry 48: 195-203.
2. Uauy R, Hoffman DR, Peirano P, Birch DG, Birch EE, (2001) Essential fatty acids in visual and brain development. Lipids 36: 885-895.
3. Innis SM, (2000) The role of dietary n-6 and n-3 fatty acids in the developing brain. Dev Neurosci 22: 474-480.
4. He C, Qu X, Cui L, Wang J, Kang JX, (2009) Improved spatial learning performance of fat-1 mice is associated with enhanced neurogenesis and neuritogenesis by docosahexaenoic acid. Proc Natl Acad Sci U S A 106: 11370-11375.
5. Robson LG, Dyall S, Sidloff D, Michael-Titus AT, (2010) Omega-3 polyunsaturated fatty acids increase the neurite outgrowth of rat sensory neurones throughout development and in aged animals. Neurobiol Aging 31: 678-687.
6. Salvati S, Natali F, Attorri L, Di Benedetto R, Leonardi F, et al. (2008) Eicosapentaenoic acid stimulates the expression of myelin proteins in rat brain. J Neurosci Res 86: 776-784.
7. Marza E, Lesa GM, (2006) Polyunsaturated fatty acids and neurotransmission in Caenorhabditis elegans. Biochem Soc Trans 34: 77-80.
8. Schuchardt JP, Huss M, Stauss-Grabo M, Hahn A, (2010) Significance of long-chain polyunsaturated fatty acids (PUFAs) for the development and behaviour of children. Eur J Pediatr 169: 149-164.
9. Sauerwald TU, Demmelmair H, Koletzko B, (2001) Polyunsaturated fatty acid supply with human milk. Lipids 36: 991-996.
10. Makrides M, Neumann MA, Byard RW, Simmer K, Gibson RA, (1994) Fatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infants. Am J Clin Nutr 60: 189-194.
11. Anderson JW, Johnstone BM, Remley DT, (1999) Breast-feeding and cognitive development: a meta-analysis. Am J Clin Nutr 70: 525-535.
12. Mortensen EL, Michaelsen KF, Sanders SA, Reinisch JM, (2002) The association between duration of breastfeeding and adult intelligence. JAMA 287: 2365-2371.
13. Der G, Batty GD, Deary IJ, (2006) Effect of breast feeding on intelligence in children: prospective study, sibling pairs analysis, and meta-analysis. BMJ 333: 945.
14. Simmer K, Patole SK, Rao SC, (2008) Longchain polyunsaturated fatty acid supplementation in infants born at term. Cochrane Database Syst Rev.
15. Marquardt A, Stöhr H, White K, Weber BH, (2000) cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family. Genomics 66: 175-183.
16. Sprecher H, (2000) Metabolism of highly unsaturated n-3 and n-6 fatty acids. Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids 1486: 219-231.
17. Jakobsson A, Westerberg R, Jacobsson A, (2006) Fatty acid elongases in mammals: their regulation and roles in metabolism. Prog Lipid Res 45: 237-249.
18. Tanaka T, Shen J, Abecasis GR, Kisialiou A, Ordovas JM, et al. (2009) Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study. PLoS Genet 5: e1000338.
19. Schaeffer L, Gohlke H, Müller M, Heid IM, Palmer LJ, et al. (2006) Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids. Hum Mol Genet 15: 1745-1756.
20. Xie L, Innis SM, (2008) Genetic variants of the FADS1 FADS2 gene cluster are associated with altered (n-6) and (n-3) essential fatty acids in plasma and erythrocyte phospholipids in women during pregnancy and in breast milk during lactation. J Nutr 138: 2222-2228.
21. Martinelli N, Girelli D, Malerba G, Guarini P, Illig T, et al. (2008) FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease. Am J Clin Nutr 88: 941-949.
22. Moltó-Puigmartí C, Plat J, Mensink RP, Müller A, Jansen E, et al. (2010) FADS1 FADS2 gene variants modify the association between fish intake and the docosahexaenoic acid proportions in human milk. Am J Clin Nutr 91: 1368-1376.
23. Heird WC, Lapillonne A, (2005) The role of essential fatty acids in development. Annu Rev Nutr 25: 549-571.
24. Smith GD, Ebrahim S, (2004) Mendelian randomization: prospects, potentials, and limitations. Int J Epidemiol 33: 30-42.
25. Ribas-Fitó N, Ramón R, Ballester F, Grimalt J, Marco A, et al. (2006) Child health and the environment: the INMA Spanish Study. Paediatr Perinat Epidemiol 20: 403-410.
26. World Health Organization (2008) Indicators for assessing infant and young child feeding practices: Part 1 Definitions. Geneva, Switzerland.
27. Bayley N, (1977) Escalas Bayley de Desarrollo Infantil. Madrid TEA Ediciones.
28. Vrijheid M, Martinez D, Forns J, Guxens M, Julvez J, et al. (2010) Prenatal exposure to cell phone use and neurodevelopment at 14 months. Epidemiology 21: 259-262.
29. Polk S, Sunyer J, Muñoz-Ortiz L, Barnes M, Torrent M, et al. (2004) A prospective study of Fel d1 and Der p1 exposure in infancy and childhood wheezing. Am J Respir Crit Care Med 170: 273-278.
30. Ribas-Fitó N, Júlvez J, Torrent M, Grimalt JO, Sunyer J, (2007) Beneficial effects of breastfeeding on cognition regardless of DDT concentrations at birth. Am J Epidemiol 166: 1198-1202.
31. McCarthy D, (1972) Manual for the McCarthy Scales of Children's Abilities. 1996) New York Psychological Corporation (Spanish adaptation: Madrid: TEA Ediciones;.
32. Julvez J, Ribas-Fitó N, Torrent M, Forns M, Garcia-Esteban R, et al. (2007) Maternal smoking habits and cognitive development of children at age 4 years in a population-based birth cohort. Int J Epidemiol 36: 825-832.
33. Morales E, Julvez J, Torrent M, de Cid R, Guxens M, et al. (2009) Association of early-life exposure to household gas appliances and indoor nitrogen dioxide with cognition and attention behavior in preschoolers. Am J Epidemiol 169: 1327-1336.
34. Moltó-Puigmartí C, Castellote AI, López-Sabater MC, (2007) Conjugated linoleic acid determination in human milk by fast-gas chromatography. Anal Chim Acta 602: 122-130.
35. Gieger C, Geistlinger L, Altmaier E, Hrabé de Angelis M, Kronenberg F, et al. (2008) Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum. PLoS Genet 4: e1000282.
36. Warensjö E, Rosell M, Hellenius ML, Vessby B, De Faire U, et al. (2009) Associations between estimated fatty acid desaturase activities in serum lipids and adipose tissue in humans: links to obesity and insulin resistance. Lipids Health Dis 8.
37. Bokor S, Dumont J, Spinneker A, Gonzalez-Gross M, Nova E, et al. (2010) Single nucleotide polymorphisms in the FADS gene cluster are associated with delta-5 and delta-6 desaturase activities estimated by serum fatty acid ratios. J Lipid Res 51: 2325-2333.
38. Ribas-Fitó N, Cardo E, Sala M, Eulàlia de Muga M, Mazón C, et al. (2003) Breastfeeding, exposure to organochlorine compounds, and neurodevelopment in infants. Pediatrics 111: e580-585.
39. González JR, Armengol L, Solé X, Guinó E, Mercader JM, et al. (2007) SNPassoc: an R package to perform whole genome association studies. Bioinformatics 23: 654-655.
40. Rodriguez-Cruz M, Tovar AR, Palacios-González B, Del Prado M, Torres N, (2006) Synthesis of long-chain polyunsaturated fatty acids in lactating mammary gland: role of Delta5 and Delta6 desaturases, SREBP-1, PPARalpha, and PGC-1. J Lipid Res 47: 553-560.
41. Xiang M, Alfven G, Blennow M, Trygg M, Zetterstrom R, (2000) Longchain polyunsaturated fatty acids in human milk and brain growth during early infancy. Acta Paediatr 89: 142-147.
42. Lattka E, Eggers S, Moeller G, Heim K, Weber M, et al. (2010) A common FADS2 promoter polymorphism increases promoter activity and facilitates binding of transcription factor ELK1. J Lipid Res 51: 182-191.
43. Koletzko B, Lien E, Agostoni C, Böhles H, Campoy C, et al. (2008) The roles of long-chain polyunsaturated fatty acids in pregnancy, lactation and infancy: review of current knowledge and consensus recommendations. J Perinat Med 36: 5-14.
44. Caspi A, Williams B, Kim-Cohen J, Craig IW, Milne BJ, et al. (2007) Moderation of breastfeeding effects on the IQ by genetic variation in fatty acid metabolism. Proc Natl Acad Sci U S A 104: 18860-18865.
45. Leonard AE, Kelder B, Bobik EG, Chuang LT, Lewis CJ, et al. (2002) Identification and expression of mammalian long-chain PUFA elongation enzymes. Lipids 37: 733-740.
46. Kothapalli KS, Anthony JC, Pan BS, Hsieh AT, Nathanielsz PW, et al. (2007) Differential cerebral cortex transcriptomes of baboon neonates consuming moderate and high docosahexaenoic acid formulas. PLoS One 2: e370.
47. Posthuma D, Luciano M, Geus EJ, Wright MJ, Slagboom PE, et al. (2005) A genomewide scan for intelligence identifies quantitative trait loci on 2q and 6p. Am J Hum Genet 77: 318-326.
48. Thomas D, (2010) Gene-environment-wide association studies: emerging approaches. Nat Rev Genet 11: 259-272.
49. Sorgi PJ, Hallowell EM, Hutchins HL, Sears B, (2007) Effects of an open-label pilot study with high-dose EPA/DHA concentrates on plasma phospholipids and behavior in children with attention deficit hyperactivity disorder. Nutr J 6: 16.
50. Brookes KJ, Chen W, Xu X, Taylor E, Asherson P, (2006) Association of fatty acid desaturase genes with attention-deficit/hyperactivity disorder. Biol Psychiatry 60: 1053-1061.