Effects of high-dose fish oil supplementation during early infancy on neurodevelopment and language: A randomised controlled trial

British Journal of Nutrition

Volumn 108, Issue 8, 2012, Pages 1443-1454

  Meldrum, Suzanne J ^a,b   D'Vaz, Nina ^a   Simmer, Karen ^a,b   Dunstan, Janet A ^a   Hird, Kathryn ^a,c   Prescott, Susan L ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c UNIVERSITY OF NOTRE DAME   (Australia)

Author keywords

Infant supplementation; Language; n 3 Long chain PUFA; Neurodevelopment

Indexed keywords

DOCOSAHEXAENOIC ACID; FISH OIL; ICOSAPENTAENOIC ACID; OLIVE OIL; PHOSPHOLIPID; PLACEBO;

ARTICLE; BAYLEY SCALE OF INFANT AND TODDLER DEVELOPMENT; CHILD BEHAVIOR CHECKLIST; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DRUG MEGADOSE; ERYTHROCYTE; GESTURE; HUMAN; HUMAN EXPERIMENT; INFANT NUTRITION; INTERPERSONAL COMMUNICATION; LANGUAGE ABILITY; LANGUAGE DEVELOPMENT; MACARTHUR BATES COMMUNICATIVE DEVELOPMENT INVENTORY; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; NERVOUS SYSTEM DEVELOPMENT; NORMAL HUMAN; PATIENT COMPLIANCE; PERINATAL PERIOD; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

CENTRAL NERVOUS SYSTEM; CHILD DEVELOPMENT; COGNITION; DIETARY FATS; DIETARY SUPPLEMENTS; DOCOSAHEXAENOIC ACIDS; DOUBLE-BLIND METHOD; EICOSAPENTAENOIC ACID; FATTY ACIDS, OMEGA-3; FISH OILS; HUMANS; INFANT; INFANT NUTRITIONAL PHYSIOLOGICAL PHENOMENA; LANGUAGE; PHOSPHOLIPIDS;

EID: 84867727809     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114511006878     Document Type: Article

References (61)

1. Salem N Jr, Litman B, Kim HY, et al. (2001) Mechanisms of action of docosahexaenoic acid in the nervous system. Lipids 36, 945-959.
2. Innis SM (2007) Dietary (n-3) fatty acids and brain development. J Nutr 137, 855-859.
3. Innis SM (2003) Perinatal biochemistry and physiology of long-chain polyunsaturated fatty acids. J Pediatr 143, S1-S8.
4. Hornstra G (2000) Essential fatty acids in mothers and their neonates. Am J Clin Nutr 71, 1262S-1269S.
5. Simopoulos AP (1991) Omega-3 fatty acids in health and disease and in growth and development. Am J Clin Nutr 54, 438-463.
6. Drover J, Hoffman DR, Castaneda YS, et al. (2009) Three randomized controlled trials of early long-chain polyunsaturated fatty acid supplementation on means-end problem solving in 9-month-olds. Child Dev 80, 1376-1384.
7. Willatts P, Forsyth JS, DiModugno MK, et al. (1998) Effect of long-chain polyunsaturated fatty acids in infant formula on problem solving at 10 months of age. Lancet 352, 688-691.
8. Willatts P, Forsyth JS, DiModugno MK, et al. (1998) Influence of long-chain polyunsaturated fatty acids on infant cognitive function. Lipids 33, 973-980.
9. Scott DT, Janowsky JS, Carroll RE, et al. (1998) Formula supplementation with long-chain polyunsaturated fatty acids: are there developmental benefits? Pediatrics 102, E59.
10. Makrides M, Neumann M, Simmer K, et al. (1995) Are longchain polyunsaturated fatty acids essential nutrients in infancy? Lancet 345, 1463-1468.
11. de Jong C, Kikkert HK, Fidler V, et al. (2010) The Groningen LCPUFA study: no effect of postnatal long-chain polyunsaturated fatty acids in healthy term infants on neurological condition at 9 years. Br J Nutr 104, 566-572.
12. Bouwstra H, Dijck-Brouwer DA, Wildeman JA, et al. (2003) Long-chain polyunsaturated fatty acids have a positive effect on the quality of general movements of healthy term infants. Am J Clin Nutr 78, 313-318.
13. Birch EE, Hoffman DR, Castaneda YS, et al. (2002) A randomized controlled trial of long-chain polyunsaturated fatty acid supplementation of formula in term infants after weaning at 6 wk of age. Am J Clin Nutr 75, 570-580.
14. Birch EE, Garfield S, Hoffman DR, et al. (2000) A randomized controlled trial of early dietary supply of long-chain polyunsaturated fatty acids and mental development in term infants. Dev Med Child Neurol 42, 174-181.
15. Ben XM, Zhou XY, Zhao WH, et al. (2004) Growth and development of term infants fed with milk with long-chain polyunsaturated fatty acid supplementation. Chin Med J (Engl) 117, 1268-1270.
16. Auestad N, Scott DT, Janowsky JS, et al. (2003) Visual, cognitive, and language assessments at 39 months: a follow-up study of children fed formulas containing long-chain polyunsaturated fatty acids to 1 year of age. Pediatrics 112, e177-e183.
17. Auestad N, Halter R, Hall RT, et al. (2001) Growth and development in term infants fed long-chain polyunsaturated fatty acids: a double-masked, randomized, parallel, prospective, multivariate study. Pediatrics 108, 372-381.
18. Agostoni C, Trojan S, Bellu R, et al. (1997) Developmental quotient at 24 months and fatty acid composition of diet in early infants: a follow up study. Arch Dis Child 76, 421-424.
19. Agostoni C, Riva E, Trojan S, et al. (1995) Docosahexaenoic acid status and developmental quotient of healthy term infants. Lancet 346, 638.
20. Agostoni C, Zuccotti GV, Radaelli G, et al. (2009) Docosahexaenoic acid supplementation and time at achievement of gross motor milestones in healthy infants: a randomized, prospective, double-blind, placebo-controlled trial. Am J Clin Nutr 89, 64-70.
21. Auestad N, Montalto MB, Hall RT, et al. (1997) Visual acuity, erythrocyte fatty acid composition, and growth in term infants fed formulas with long chain polyunsaturated fatty acids for one year. Ross Pediatric Lipid Study. Pediatr Res 41, 1-10.
22. Birch EE, Castaneda YS, Wheaton DH, et al. (2005) Visual maturation of term infants fed long-chain polyunsaturated fatty acid-supplemented or control formula for 12 mo. Am J Clin Nutr 81, 871-879.
23. Birch EE, Carlson SE, Hoffman DR, et al. (2010) The DIAMOND (DHA Intake And Measurement Of Neural Development) Study: a double-masked, randomized controlled clinical trial of the maturation of infant visual acuity as a function of the dietary level of docosahexaenoic acid. Am J Clin Nutr 91, 848-859.
24. Bouwstra H, Dijck-Brouwer DA, Boehm G, et al. (2005) Long-chain polyunsaturated fatty acids and neurological developmental outcome at 18 months in healthy term infants. Acta Paediatr 94, 26-32.
25. Carlson SE, Ford AJ, Werkman SH, et al. (1996) Visual acuity and fatty acid status of term infants fed human milk and formulas with and without docosahexaenoate and arachidonate from egg yolk lecithin. Pediatr Res 39, 882-888.
26. Makrides M, Neumann MA, Simmer K, et al. (2000) A critical appraisal of the role of dietary long-chain polyunsaturated fatty acids on neural indices of term infants: a randomized, controlled trial. Pediatrics 105, 32-38.
27. Lucas A, Stafford M, Morley R, et al. (1999) Efficacy and safety of long-chain polyunsaturated fatty acid supplementation of infant-formula milk: a randomised trial. Lancet 354, 1948-1954.
28. Beyerlein A, Hadders-Algra M, Kennedy K, et al. (2010) Infant formula supplementation with long-chain polyunsaturated fatty acids has no effect on Bayley developmental scores at 18 months of age-IPD meta-analysis of 4 large clinical trials. J Pediatr Gastroenterol Nutr 50, 79-84.
29. Helland IB, Smith L, Saarem K, et al. (2003) Maternal supplementation with very-long-chain n-3 fatty acids during pregnancy and lactation augments children's IQ at 4 years of age. Pediatrics 111, e39-e44.
30. Gibson RA, Neumann MA & Makrides M (1997) Effect of increasing breast milk docosahexaenoic acid on plasma and erythrocyte phospholipid fatty acids and neural indices of exclusively breast fed infants. Eur J Clin Nutr 51, 578-584.
31. Lauritzen L, Jorgensen MH, Olsen SF, et al. (2005) Maternal fish oil supplementation in lactation: effect on developmental outcome in breast-fed infants. Reprod Nutr Dev 45, 535-547.
32. Jensen CL, Voigt RG, Prager TC, et al. (2005) Effects of maternal docosahexaenoic acid intake on visual function and neurodevelopment in breastfed term infants. Am J Clin Nutr 82, 125-132.
33. Simmer K & Patole SK (2008) Longchain polyunsaturated fatty acid supplementation in infants born at term. The Cochrane Database Systematic Reviews issue 1, CD000376.
34. Hoffman DR, Boettcher JA & Diersen-Schade DA (2009) Toward optimizing vision and cognition in term infants by dietary docosahexaenoic and arachidonic acid supplementation: a review of randomized controlled trials. Prostaglandins Leukot Essent Fatty Acids 81, 151-158.
35. Brenna JT, Varamini B, Jensen RG, et al. (2007) Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. Am J Clin Nutr 85, 1457-1464.
36. Carlson SE (2000) Behavioral methods used in the study of long-chain polyunsaturated fatty acid nutrition in primate infants. Am J Clin Nutr 71, 268S-274S.
37. Meldrum SJ, D'Vaz N, Dunstan J, et al. (2011) The Infant Fish Oil Supplementation Study (IFOS): design and research protocol of a double-blind, randomised controlled n-3 LCPUFA intervention trial in term infants. Contemp Clin Trials 32, 771-778.
38. Litonjua AA, Carey VJ, Burge HA, et al. (1998) Parental history and the risk for childhood asthma. Does mother confer more risk than father? Am J Respir Crit Care Med 158, 176-181.
39. Fekete K, Marosvolgyi T, Jakobik V, et al. (2009) Methods of assessment of n-3 long-chain polyunsaturated fatty acid status in humans: a systematic review. Am J Clin Nutr 89, 2070S-2084S.
40. Mori TA, Burke V, Puddey IB, et al. (2000) Purified eicosapentaenoic and docosahexaenoic acids have differential effects on serum lipids and lipoproteins, LDL particle size, glucose, and insulin in mildly hyperlipidemic men. Am J Clin Nutr 71, 1085-1094.
41. Dunstan JA, Roper J, Mitoulas L, et al. (2004) The effect of supplementation with fish oil during pregnancy on breast milk immunoglobulin A, soluble CD14, cytokine levels and fatty acid composition. Clin Exp Allergy 34, 1237-1242.
42. Makrides M, Neumann MA, Simmer K, et al. (1995) Erythrocyte fatty acids of term infants fed either breast milk, standard formula, or formula supplemented with long-chain polyunsaturates. Lipids 30, 941-948.
43. Fenson L, Dale PS, Reznik JS, et al. (1993) The MacArthur Communicative Development Inventories: User's Guide and Technical Manual. San Diego, CA: Singular Publishing Group.
44. Bayley N (2006) Bayley Scales of Infant and Toddler Development, 3rd ed. San Antonio, TX: Harcourt Assessment.
45. Achenbach TM & Rescola LA (2000) Manual for the ASEBA Preschool Forms and Profiles. Burlington, VT: University of Vermont Department of Psychiatry.
46. Makrides M, Neumann MA, Simmer K, et al. (1999) Dietary long-chain polyunsaturated fatty acids do not influence growth of term infants: a randomized clinical trial. Pediatrics 104, 468-475.
47. Dunstan JA, Mitoulas LR, Dixon G, et al. (2007) The effects of fish oil supplementation in pregnancy on breast milk fatty acid composition over the course of lactation: a randomized controlled trial. Pediatr Res 62, 689-694.
48. Goodwyn SW & Acredolo LP (1998) Encouraging symbolic gestures: a new perspective on the relationship between gesture and speech. New Dir Child Dev 61-73.
49. Innis SM, Gilley J & Werker J (2001) Are human milk longchain polyunsaturated fatty acids related to visual and neural development in breast-fed term infants? J Pediatr 139, 532-538.
50. Hallahan B & Garland MR (2005) Essential fatty acids and mental health. Br J Psychiatry 186, 275-277.
51. Peet M & Stokes C (2005) Omega-3 fatty acids in the treatment of psychiatric disorders. Drugs 65, 1051-1059.
52. Neisworth JT & Bagnato SJ (2004) The mismeasure of young children: the authentic assessment alternative. Infant Young Child 17, 198-212.
53. Cheatham CL, Colombo J & Carlson SE (2006) n-3 Fatty acids and cognitive and visual acuity development: methodologic and conceptual considerations. Am J Clin Nutr 83, 1458S-1466S.
54. Prescott SL, Macaubas C, Holt BJ, et al. (1998) Transplacental priming of the human immune system to environmental allergens: universal skewing of initial T cell responses toward the Th2 cytokine profile. J Immunol 160, 4730-4737.
55. Chida Y, Hamer M & Steptoe A (2008) A bidirectional relationship between psychosocial factors and atopic disorders: a systematic review and meta-analysis. Psychosom Med 70, 102-116.
56. Liu CC, Carlson SE, Rhodes PG, et al. (1987) Increase in plasma phospholipid docosahexaenoic and eicosapentaenoic acids as a reflection of their intake and mode of administration. Pediatr Res 22, 292-296.
57. Nordoy A, Barstad L, Connor WE, et al. (1991) Absorption of the n-3 eicosapentaenoic and docosahexaenoic acids as ethyl esters and triglycerides by humans. Am J Clin Nutr 53, 1185-1190.
58. Sala-Vila A, Castellote AI, Campoy C, et al. (2004) The source of long-chain PUFA in formula supplements does not affect the fatty acid composition of plasma lipids in full-term infants. J Nutr 134, 868-873.
59. Commonwealth Scientific and Industrial Research Organisation (1996) CSIRO Australian Food and Nutrition Surveys 1988 and 1993: Results from the CSIRO Australian Food and Nutrition Surveys 1988 and 1993. Adelaide, SA: CSIRO Division of Human Nutrition.
60. Cramer JA, Scheyer RD & Mattson RH (1990) Compliance declines between clinic visits. Arch Intern Med 150, 1509-1510.
61. Bacchetti P (2002) Peer review of statistics in medical research: the other problem. BMJ 324, 1271-1273.