-
1
-
-
77952956961
-
Evidence for leptin receptor isoforms heteromerization at the cell surface
-
Bacart J, Leloire A, Levoye A, Froguel P, Jockers R & Couturier C 2010 Evidence for leptin receptor isoforms heteromerization at the cell surface. FEBS Letters 584 2213-2217. (doi:10.1016/j.febslet.2010.03.033)
-
(2010)
FEBS Letters
, vol.584
, pp. 2213-2217
-
-
Bacart, J.1
Leloire, A.2
Levoye, A.3
Froguel, P.4
Jockers, R.5
Couturier, C.6
-
2
-
-
0036219070
-
Identification of the critical sequence elements in the cytoplasmic domain of leptin receptor isoforms required for Janus kinase/signal transducer and activator of transcription activation by receptor heterodimers
-
Bahrenberg G, Behrmann I, Barthel A, Hekerman P, Heinrich PC, Joost H-G & Becker W 2002 Identification of the critical sequence elements in the cytoplasmic domain of leptin receptor isoforms required for Janus kinase/signal transducer and activator of transcription activation by receptor heterodimers. Molecular Endocrinology 16 859-872. (doi:10.1210/mend.16.4.0800)
-
(2002)
Molecular Endocrinology
, vol.16
, pp. 859-872
-
-
Bahrenberg, G.1
Behrmann, I.2
Barthel, A.3
Hekerman, P.4
Heinrich, P.C.5
Joost, H.-G.6
Becker, W.7
-
3
-
-
84877040289
-
Designer peptide antagonist of the leptin receptor with peripheral antineoplastic activity
-
Beccari S, Kovalszky I, Wade JD, Otvos L Jr & Surmacz E 2013 Designer peptide antagonist of the leptin receptor with peripheral antineoplastic activity. Peptides 44 1-8. (doi:10.1016/j.peptides.2013.03.02)
-
(2013)
Peptides
, vol.44
, pp. 1-8
-
-
Beccari, S.1
Kovalszky, I.2
Wade, J.D.3
Otvos, L.4
Surmacz, E.5
-
4
-
-
27444441450
-
Quantitative FRET imaging of leptin receptor oligomerization kinetics in single cells
-
Biener E, Charlier M, Ramanujan VK, Daniel N, Eisenberg A, Bjørbaek C, Herman B, Gertler A & Djiane J 2005 Quantitative FRET imaging of leptin receptor oligomerization kinetics in single cells. Biology of the Cell 97 905-919. (doi:10.1042/BC20040511)
-
(2005)
Biology of the Cell
, vol.97
, pp. 905-919
-
-
Biener, E.1
Charlier, M.2
Ramanujan, V.K.3
Daniel, N.4
Eisenberg, A.5
Bjørbaek, C.6
Herman, B.7
Gertler, A.8
Djiane, J.9
-
5
-
-
0038609651
-
Hexameric structure and assembly of the interleukin-6/IL-6 α-receptor/gp130 complex
-
Boulanger MJ, Chow D, Brevnova EE & Garcia KC 2003 Hexameric structure and assembly of the interleukin-6/IL-6 α-receptor/gp130 complex. Science 300 2101-2104. (doi:10.1126/science.1083901)
-
(2003)
Science
, vol.300
, pp. 2101-2104
-
-
Boulanger, M.J.1
Chow, D.2
Brevnova, E.E.3
Garcia, K.C.4
-
6
-
-
26944493862
-
Model for growth hormone receptor activation based on subunit rotation within a receptor dimer
-
Brown RJ, Adams JJ, Pelekanos RA, Wan Y, McKinstry WJ, Palethorpe K, Seeber RM, Monks TA, Eidne KA, Parker MW et al. 2005 Model for growth hormone receptor activation based on subunit rotation within a receptor dimer. Nature Structural & Molecular Biology 12 814-821. (doi:10.1038/nsmb977)
-
(2005)
Nature Structural & Molecular Biology
, vol.12
, pp. 814-821
-
-
Brown, R.J.1
Adams, J.J.2
Pelekanos, R.A.3
Wan, Y.4
McKinstry, W.J.5
Palethorpe, K.6
Seeber, R.M.7
Monks, T.A.8
Eidne, K.A.9
Parker, M.W.10
-
7
-
-
84857978585
-
Structure of the human obesity receptor leptin-binding domain reveals the mechanism of leptin antagonism by a monoclonal antibody
-
Carpenter B, Hemsworth GR, Wu Z, Maamra M, Strasburger CJ, Ross RJ & Artymiuk PJ 2012 Structure of the human obesity receptor leptin-binding domain reveals the mechanism of leptin antagonism by a monoclonal antibody. Structure 20 487-497. (doi:10.1016/j.str.2012.01.019)
-
(2012)
Structure
, vol.20
, pp. 487-497
-
-
Carpenter, B.1
Hemsworth, G.R.2
Wu, Z.3
Maamra, M.4
Strasburger, C.J.5
Ross, R.J.6
Artymiuk, P.J.7
-
8
-
-
0030010388
-
Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin
-
Chehab FF, Lim ME & Lu R 1996 Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nature Genetics 12 318-320. (doi:10.1038/ng0396-318)
-
(1996)
Nature Genetics
, vol.12
, pp. 318-320
-
-
Chehab, F.F.1
Lim, M.E.2
Lu, R.3
-
9
-
-
0035896394
-
Structure of an extracellular gp130 cytokine receptor signaling complex
-
Chow D, He X, Snow AL, Rose-John S & Garcia KC 2001 Structure of an extracellular gp130 cytokine receptor signaling complex. Science 291 2150-2155. (doi:10.1126/science.1058308)
-
(2001)
Science
, vol.291
, pp. 2150-2155
-
-
Chow, D.1
He, X.2
Snow, A.L.3
Rose-John, S.4
Garcia, K.C.5
-
10
-
-
0035836645
-
Ligand-independent oligomerization of cell-surface erythropoietin receptor is mediated by the transmembrane domain
-
Constantinescu SN, Keren T, Socolovsky M, Nam H, Henis YI & Lodish HF 2001 Ligand-independent oligomerization of cell-surface erythropoietin receptor is mediated by the transmembrane domain. PNAS 98 4379-4384. (doi:10.1073/pnas.081069198)
-
(2001)
PNAS
, vol.98
, pp. 4379-4384
-
-
Constantinescu, S.N.1
Keren, T.2
Socolovsky, M.3
Nam, H.4
Henis, Y.I.5
Lodish, H.F.6
-
11
-
-
0038374250
-
Activation of the leptin receptor by a ligand-induced conformational change of constitutive receptor dimers
-
Couturier C & Jockers R 2003 Activation of the leptin receptor by a ligand-induced conformational change of constitutive receptor dimers. Journal of Biological Chemistry 278 26604-26611. (doi:10.1074/jbc.M302002200)
-
(2003)
Journal of Biological Chemistry
, vol.278
, pp. 26604-26611
-
-
Couturier, C.1
Jockers, R.2
-
12
-
-
32444449415
-
Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis
-
De Rosa V, Procaccini C, La Cava A, Chieffi P, Nicoletti GF, Fontana S, Zappacosta S & Matarese G 2006 Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis. Journal of Clinical Investigation 116 447-455. (doi:10.1172/JCI26523)
-
(2006)
Journal of Clinical Investigation
, vol.116
, pp. 447-455
-
-
De Rosa, V.1
Procaccini, C.2
La Cava, A.3
Chieffi, P.4
Nicoletti, G.F.5
Fontana, S.6
Zappacosta, S.7
Matarese, G.8
-
13
-
-
0030793449
-
Ligand-independent dimerization of the extracellular domain of the leptin receptor and determination of the stoichiometry of leptin binding
-
Devos R, Guisez Y, Van der Heyden J, White DW, Kalai M, Fountoulakis M & Plaetinck G 1997 Ligand-independent dimerization of the extracellular domain of the leptin receptor and determination of the stoichiometry of leptin binding. Journal of Biological Chemistry 272 18304-18310. (doi:10.1074/jbc.272.29.18304)
-
(1997)
Journal of Biological Chemistry
, vol.272
, pp. 18304-18310
-
-
Devos, R.1
Guisez, Y.2
Van der Heyden, J.3
White, D.W.4
Kalai, M.5
Fountoulakis, M.6
Plaetinck, G.7
-
14
-
-
33746126567
-
p.Q223R leptin receptor polymorphism associated with obesity in Brazilian multiethnic subjects
-
Duarte SF, Francischetti EA, Genelhu-Abreu V, Barroso SG, Braga JU, Cabello PH & Pimentel MM 2006 p.Q223R leptin receptor polymorphism associated with obesity in Brazilian multiethnic subjects. American Journal of Human Biology 18 448-453. (doi:10.1002/ajhb.20519)
-
(2006)
American Journal of Human Biology
, vol.18
, pp. 448-453
-
-
Duarte, S.F.1
Francischetti, E.A.2
Genelhu-Abreu, V.3
Barroso, S.G.4
Braga, J.U.5
Cabello, P.H.6
Pimentel, M.M.7
-
15
-
-
0141737573
-
Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass
-
Ducy P, Amling M, Takeda S, Priemel M, Schilling AF, Beil FT, Shen J, Vinson C, Rueger JM & Karsenty G 2000 Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 100 197-207. (doi:10.1016/S0092-8674(00)81558-5)
-
(2000)
Cell
, vol.100
, pp. 197-207
-
-
Ducy, P.1
Amling, M.2
Takeda, S.3
Priemel, M.4
Schilling, A.F.5
Beil, F.T.6
Shen, J.7
Vinson, C.8
Rueger, J.M.9
Karsenty, G.10
-
16
-
-
79952209777
-
A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children
-
Duggal P, Guo X, Haque R, Peterson KM, Ricklefs S, Mondal D, Alam F, Noor Z, Verkerke HP, Marie C et al. 2011 A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children. Journal of Clinical Investigation 121 1191-1198. (doi:10.1172/JCI45294)
-
(2011)
Journal of Clinical Investigation
, vol.121
, pp. 1191-1198
-
-
Duggal, P.1
Guo, X.2
Haque, R.3
Peterson, K.M.4
Ricklefs, S.5
Mondal, D.6
Alam, F.7
Noor, Z.8
Verkerke, H.P.9
Marie, C.10
-
17
-
-
67649665611
-
Pegylated leptin antagonist is a potent orexigenic agent: preparation and mechanism of activity
-
Elinav E, Niv-Spector L, Katz M, Price TO, Ali M, Yacobovitz M, Solomon G, Reicher S, Lynch JL, Halpern Z et al. 2009 Pegylated leptin antagonist is a potent orexigenic agent: preparation and mechanism of activity. Endocrinology 150 3083-3091. (doi:10.1210/en.2008-1706)
-
(2009)
Endocrinology
, vol.150
, pp. 3083-3091
-
-
Elinav, E.1
Niv-Spector, L.2
Katz, M.3
Price, T.O.4
Ali, M.5
Yacobovitz, M.6
Solomon, G.7
Reicher, S.8
Lynch, J.L.9
Halpern, Z.10
-
18
-
-
33747050687
-
Identification of a monoclonal antibody against the leptin receptor that acts as an antagonist and blocks human monocyte and T cell activation
-
Fazeli M, Zarkesh-Esfahani H, Wu Z, Maamra M, Bidlingmaier M, Pockley AG, Watson P, Matarese G, Strasburger CJ & Ross RJ 2006 Identification of a monoclonal antibody against the leptin receptor that acts as an antagonist and blocks human monocyte and T cell activation. Journal of Immunological Methods 312 190-200. (doi:10.1016/j.jim.2006.03.011)
-
(2006)
Journal of Immunological Methods
, vol.312
, pp. 190-200
-
-
Fazeli, M.1
Zarkesh-Esfahani, H.2
Wu, Z.3
Maamra, M.4
Bidlingmaier, M.5
Pockley, A.G.6
Watson, P.7
Matarese, G.8
Strasburger, C.J.9
Ross, R.J.10
-
19
-
-
0031010408
-
Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues
-
Fei H, Okano HJ, Li C, Lee GH, Zhao C, Darnell R & Friedman JM 1997 Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. PNAS 94 7001-7005. (doi:10.1073/pnas.94.13.7001)
-
(1997)
PNAS
, vol.94
, pp. 7001-7005
-
-
Fei, H.1
Okano, H.J.2
Li, C.3
Lee, G.H.4
Zhao, C.5
Darnell, R.6
Friedman, J.M.7
-
20
-
-
0031886385
-
Localization of leptin binding domain in the leptin receptor
-
Fong TM, Huang RR, Tota MR, Mao C, Smith T, Varnerin J, Karpitskiy VV, Krause JE & Van der Ploeg LH 1998 Localization of leptin binding domain in the leptin receptor. Molecular Pharmacology 53 234-240. (doi:10.1124/mol.53.2.234)
-
(1998)
Molecular Pharmacology
, vol.53
, pp. 234-240
-
-
Fong, T.M.1
Huang, R.R.2
Tota, M.R.3
Mao, C.4
Smith, T.5
Varnerin, J.6
Karpitskiy, V.V.7
Krause, J.E.8
Van der Ploeg, L.H.9
-
21
-
-
0037195916
-
Generation of soluble leptin receptor by ectodomain shedding of membrane-spanning receptors in vitro and in vivo
-
Ge H, Huang L, Pourbahrami T & Li C 2002 Generation of soluble leptin receptor by ectodomain shedding of membrane-spanning receptors in vitro and in vivo. Journal of Biological Chemistry 277 45898-45903. (doi:10.1074/jbc.M205825200)
-
(2002)
Journal of Biological Chemistry
, vol.277
, pp. 45898-45903
-
-
Ge, H.1
Huang, L.2
Pourbahrami, T.3
Li, C.4
-
22
-
-
0037162458
-
Ligand-independent growth hormone receptor dimerization occurs in the endoplasmic reticulum and is required for ubiquitin system-dependent endocytosis
-
Gent J, van Kerkhof P, Roza M, Bu G & Strous GJ 2002 Ligand-independent growth hormone receptor dimerization occurs in the endoplasmic reticulum and is required for ubiquitin system-dependent endocytosis. PNAS 99 9858-9863. (doi:10.1073/pnas.152294299)
-
(2002)
PNAS
, vol.99
, pp. 9858-9863
-
-
Gent, J.1
van Kerkhof, P.2
Roza, M.3
Bu, G.4
Strous, G.J.5
-
23
-
-
33750043782
-
Development of leptin antagonists and their potential use in experimental biology and medicine
-
Gertler A 2006 Development of leptin antagonists and their potential use in experimental biology and medicine. Trends in Endocrinology and Metabolism 17 372-378. (doi:10.1016/j.tem.2006.09.006)
-
(2006)
Trends in Endocrinology and Metabolism
, vol.17
, pp. 372-378
-
-
Gertler, A.1
-
24
-
-
0042706427
-
A peptide derived from the human leptin molecule is a potent inhibitor of the leptin receptor function in rabbit endometrial cells
-
Gonzalez RR & Leavis PC 2003 A peptide derived from the human leptin molecule is a potent inhibitor of the leptin receptor function in rabbit endometrial cells. Endocrine 21 185-195. (doi:10.1385/ENDO:21:2:185)
-
(2003)
Endocrine
, vol.21
, pp. 185-195
-
-
Gonzalez, R.R.1
Leavis, P.C.2
-
25
-
-
84866659220
-
The unique cysteine knot regulates the pleotropic hormone leptin
-
Haglund E, Sulkowska JI, He Z, Feng G-S, Jennings PA & Onuchic JN 2012 The unique cysteine knot regulates the pleotropic hormone leptin. PLoS ONE 7 e45654. (doi:10.1371/journal.pone.0045654)
-
(2012)
PLoS ONE
, vol.7
, pp. e45654
-
-
Haglund, E.1
Sulkowska, J.I.2
He, Z.3
Feng, G.-S.4
Jennings, P.A.5
Onuchic, J.N.6
-
26
-
-
0032582687
-
Human leptin receptor. Determination of disulfide structure andN-glycosylation sites of the extracellulardomain
-
Haniu M, Arakawa T, Bures EJ, Young Y, Hui JO, Rohde MF, Welcher AA & Horan T 1998 Human leptin receptor. Determination of disulfide structure andN-glycosylation sites of the extracellulardomain. Journal of Biological Chemistry 273 28691-28699. (doi:10.1074/jbc.273.44.28691)
-
(1998)
Journal of Biological Chemistry
, vol.273
, pp. 28691-28699
-
-
Haniu, M.1
Arakawa, T.2
Bures, E.J.3
Young, Y.4
Hui, J.O.5
Rohde, M.F.6
Welcher, A.A.7
Horan, T.8
-
27
-
-
17744388106
-
Transcellular transport of leptin by the short leptin receptor isoform ObRa in Madin-Darby Canine Kidney cells
-
Hileman SM, Tornoe J, Flier JS & Bjorbaek C 2000 Transcellular transport of leptin by the short leptin receptor isoform ObRa in Madin-Darby Canine Kidney cells. Endocrinology 141 1955-1961. (doi:10.1210/endo.141.6.7450)
-
(2000)
Endocrinology
, vol.141
, pp. 1955-1961
-
-
Hileman, S.M.1
Tornoe, J.2
Flier, J.S.3
Bjorbaek, C.4
-
28
-
-
34547866498
-
An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor
-
Huyton T, Zhang J-G, Luo CS, Lou M-Z, Hilton DJ, Nicola NA & Garrett TPJ 2007 An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor. PNAS 104 12737-12742. (doi:10.1073/pnas.0705577104)
-
(2007)
PNAS
, vol.104
, pp. 12737-12742
-
-
Huyton, T.1
Zhang, J.-G.2
Luo, C.S.3
Lou, M.-Z.4
Hilton, D.J.5
Nicola, N.A.6
Garrett, T.P.J.7
-
29
-
-
21044451449
-
Mapping of the interface between leptin and the leptin receptor CRH2 domain
-
Iserentant H, Peelman F, Defeau D, Vandekerckhove J, Zabeau L & Tavernier J 2005 Mapping of the interface between leptin and the leptin receptor CRH2 domain. Journal of Cell Science 118 2519-2527. (doi:10.1242/jcs.02386)
-
(2005)
Journal of Cell Science
, vol.118
, pp. 2519-2527
-
-
Iserentant, H.1
Peelman, F.2
Defeau, D.3
Vandekerckhove, J.4
Zabeau, L.5
Tavernier, J.6
-
30
-
-
41149116148
-
Contribution of leptin receptor N-linked glycans to leptin binding
-
Kamikubo Y, Dellas C, Loskutoff DJ, Quigley JP & Ruggeri ZM 2008 Contribution of leptin receptor N-linked glycans to leptin binding. Biochemical Journal 410 595-604. (doi:10.1042/BJ20071137)
-
(2008)
Biochemical Journal
, vol.410
, pp. 595-604
-
-
Kamikubo, Y.1
Dellas, C.2
Loskutoff, D.J.3
Quigley, J.P.4
Ruggeri, Z.M.5
-
31
-
-
57349101727
-
Functional characterization of naturally occurring pathogenic mutations in the human leptin receptor
-
Kimber W, Peelman F, Prieur X, Wangensteen T, O'Rahilly S, Tavernier J & Farooqi IS 2008 Functional characterization of naturally occurring pathogenic mutations in the human leptin receptor. Endocrinology 149 6043-6052. (doi:10.1210/en.2008-0544)
-
(2008)
Endocrinology
, vol.149
, pp. 6043-6052
-
-
Kimber, W.1
Peelman, F.2
Prieur, X.3
Wangensteen, T.4
O'Rahilly, S.5
Tavernier, J.6
Farooqi, I.S.7
-
32
-
-
0036828842
-
Regulation of Jak kinases by intracellular leptin receptor sequences
-
Kloek C, Haq AK, Dunn SL, Lavery HJ, Banks AS & Myers MG 2002 Regulation of Jak kinases by intracellular leptin receptor sequences. Journal of Biological Chemistry 277 41547-41555. (doi:10.1074/jbc.M205148200)
-
(2002)
Journal of Biological Chemistry
, vol.277
, pp. 41547-41555
-
-
Kloek, C.1
Haq, A.K.2
Dunn, S.L.3
Lavery, H.J.4
Banks, A.S.5
Myers, M.G.6
-
33
-
-
2442618838
-
The weight of leptin in immunity. Nature Reviews
-
La Cava A & Matarese G 2004 The weight of leptin in immunity. Nature Reviews. Immunology 4 371-379. (doi:10.1038/nri1350)
-
(2004)
Immunology
, vol.4
, pp. 371-379
-
-
La Cava, A.1
Matarese, G.2
-
34
-
-
0030039272
-
Abnormal splicing of the leptin receptor in diabetic mice
-
Lee GH, Proenca R, Montez JM, Carroll KM, Darvishzadeh JG, Lee JI & Friedman JM 1996 Abnormal splicing of the leptin receptor in diabetic mice. Nature 379 632-635. (doi:10.1038/379632a0)
-
(1996)
Nature
, vol.379
, pp. 632-635
-
-
Lee, G.H.1
Proenca, R.2
Montez, J.M.3
Carroll, K.M.4
Darvishzadeh, J.G.5
Lee, J.I.6
Friedman, J.M.7
-
35
-
-
0030841741
-
Expression and characterization of a putative high affinity human soluble leptin receptor
-
Liu C, Liu XJ, Barry G, Ling N, Maki RA & De Souza EB 1997 Expression and characterization of a putative high affinity human soluble leptin receptor. Endocrinology 138 3548-3554. (doi:10.1210/endo.138.8.5343)
-
(1997)
Endocrinology
, vol.138
, pp. 3548-3554
-
-
Liu, C.1
Liu, X.J.2
Barry, G.3
Ling, N.4
Maki, R.A.5
De Souza, E.B.6
-
36
-
-
0033548259
-
Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation
-
Livnah O, Stura EA, Middleton SA, Johnson DL, Jolliffe LK & Wilson IA 1999 Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation. Science 283 987-990. (doi:10.1126/science.283.5404.987)
-
(1999)
Science
, vol.283
, pp. 987-990
-
-
Livnah, O.1
Stura, E.A.2
Middleton, S.A.3
Johnson, D.L.4
Jolliffe, L.K.5
Wilson, I.A.6
-
37
-
-
0029086473
-
Threading analysis suggests that the obese gene product may be a helical cytokine
-
Madej T, Boguski MS & Bryant SH 1995 Threading analysis suggests that the obese gene product may be a helical cytokine. FEBS Letters 373 13-18. (doi:10.1016/0014-5793(95)00977-H)
-
(1995)
FEBS Letters
, vol.373
, pp. 13-18
-
-
Madej, T.1
Boguski, M.S.2
Bryant, S.H.3
-
38
-
-
84870388146
-
Ligand-induced architecture of the leptin receptor signaling complex
-
Mancour L, Daghestani H & Dutta S 2012 Ligand-induced architecture of the leptin receptor signaling complex. Molecular Cell 48 1-7. (doi:10.1016/j.molcel.2012.09.003)
-
(2012)
Molecular Cell
, vol.48
, pp. 1-7
-
-
Mancour, L.1
Daghestani, H.2
Dutta, S.3
-
39
-
-
0029895233
-
Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization
-
Mercer JG, Hoggard N, Williams LM, Lawrence CB, Hannah LT & Trayhurn P 1996 Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Letters 387 113-116. (doi:10.1016/0014-5793(96)00473-5)
-
(1996)
FEBS Letters
, vol.387
, pp. 113-116
-
-
Mercer, J.G.1
Hoggard, N.2
Williams, L.M.3
Lawrence, C.B.4
Hannah, L.T.5
Trayhurn, P.6
-
40
-
-
1642462147
-
BiaCore analysis of leptin-leptin receptor interaction: evidence for 1:1 stoichiometry
-
Mistrík P, Moreau F & Allen JM 2004 BiaCore analysis of leptin-leptin receptor interaction: evidence for 1:1 stoichiometry. Analytical Biochemistry 327 271-277. (doi:10.1016/j.ab.2004.01.022)
-
(2004)
Analytical Biochemistry
, vol.327
, pp. 271-277
-
-
Mistrík, P.1
Moreau, F.2
Allen, J.M.3
-
41
-
-
84902334438
-
Structural andmechanistic paradigm of leptin receptor activation revealed by complexes with wild-type and antagonist leptins
-
Moharana K, Zabeau L, Peelman F, Ringler P, Stahlberg H, Tavernier J & Savvides SN 2014 Structural andmechanistic paradigm of leptin receptor activation revealed by complexes with wild-type and antagonist leptins. Structure 22 866-877. (doi:10.1016/j.str.2014.04.012)
-
(2014)
Structure
, vol.22
, pp. 866-877
-
-
Moharana, K.1
Zabeau, L.2
Peelman, F.3
Ringler, P.4
Stahlberg, H.5
Tavernier, J.6
Savvides, S.N.7
-
42
-
-
0031056665
-
Leptin receptor (OB-R) oligomerizes with itself but not with its closely related cytokine signal transducer gp130
-
Nakashima K, Narazaki M & Taga T 1997 Leptin receptor (OB-R) oligomerizes with itself but not with its closely related cytokine signal transducer gp130. FEBS Letters 403 79-82. (doi:10.1016/S0014-5793(97)00013-6)
-
(1997)
FEBS Letters
, vol.403
, pp. 79-82
-
-
Nakashima, K.1
Narazaki, M.2
Taga, T.3
-
43
-
-
25144509422
-
Mapping leptin-interacting sites in recombinant leptin-binding domain (LBD) subcloned from chicken leptin receptor
-
Niv-Spector L, Raver N, Friedman-Einat M, Grosclaude J, Gussakovsky EE, Livnah O & Gertler A 2005a Mapping leptin-interacting sites in recombinant leptin-binding domain (LBD) subcloned from chicken leptin receptor. Biochemical Journal 390 475-484. (doi:10.1042/BJ20050233)
-
(2005)
Biochemical Journal
, vol.390
, pp. 475-484
-
-
Niv-Spector, L.1
Raver, N.2
Friedman-Einat, M.3
Grosclaude, J.4
Gussakovsky, E.E.5
Livnah, O.6
Gertler, A.7
-
44
-
-
25144489423
-
Identification of the hydrophobic strand in the A-B loop of leptin as major binding site III: implications for large-scale preparation of potent recombinant human and ovine leptin antagonists
-
Niv-Spector L, Gonen-Berger D, Gourdou I, Biener E, Gussakovsky EE, Benomar Y, Ramanujan KV, Taouis M, Herman B, Callebaut I et al.2005b Identification of the hydrophobic strand in the A-B loop of leptin as major binding site III: implications for large-scale preparation of potent recombinant human and ovine leptin antagonists. Biochemical Journal 391 221-230. (doi:10.1042/BJ20050457)
-
(2005)
Biochemical Journal
, vol.391
, pp. 221-230
-
-
Niv-Spector, L.1
Gonen-Berger, D.2
Gourdou, I.3
Biener, E.4
Gussakovsky, E.E.5
Benomar, Y.6
Ramanujan, K.V.7
Taouis, M.8
Herman, B.9
Callebaut, I.10
-
45
-
-
50849130228
-
Development of a pharmacologically improved peptide agonist of the leptin receptor
-
Otvos L, Terrasi M, Cascio S, Cassone M, Abbadessa G, De Pascali F, Scolaro L, Knappe D, Stawikowski M, Cudic P et al. 2008 Development of a pharmacologically improved peptide agonist of the leptin receptor. Biochimica et Biophysica Acta 1783 1745-1754. (doi:10.1016/j.bbamcr.2008.05.007)
-
(2008)
Biochimica et Biophysica Acta
, vol.1783
, pp. 1745-1754
-
-
Otvos, L.1
Terrasi, M.2
Cascio, S.3
Cassone, M.4
Abbadessa, G.5
De Pascali, F.6
Scolaro, L.7
Knappe, D.8
Stawikowski, M.9
Cudic, P.10
-
46
-
-
4644358139
-
Mapping of the leptin binding sites and design of a leptin antagonist
-
Peelman F, Van Beneden K, Zabeau L, Iserentant H, Ulrichts P, Defeau D, Verhee A, Catteeuw D, Elewaut D & Tavernier J 2004 Mapping of the leptin binding sites and design of a leptin antagonist. Journal of Biological Chemistry 279 41038-41046. (doi:10.1074/jbc.M404962200)
-
(2004)
Journal of Biological Chemistry
, vol.279
, pp. 41038-41046
-
-
Peelman, F.1
Van Beneden, K.2
Zabeau, L.3
Iserentant, H.4
Ulrichts, P.5
Defeau, D.6
Verhee, A.7
Catteeuw, D.8
Elewaut, D.9
Tavernier, J.10
-
47
-
-
33646493330
-
Techniques: new pharmacological perspectives for the leptin receptor
-
Peelman F, Couturier C, Dam J, Zabeau L, Tavernier J & Jockers R 2006a Techniques: new pharmacological perspectives for the leptin receptor. Trends in Pharmacological Sciences 27 218-225. (doi:10.1016/j.tips.2006.02.009)
-
(2006)
Trends in Pharmacological Sciences
, vol.27
, pp. 218-225
-
-
Peelman, F.1
Couturier, C.2
Dam, J.3
Zabeau, L.4
Tavernier, J.5
Jockers, R.6
-
48
-
-
33744959239
-
Mapping of binding site III in the leptin receptor and modeling of a hexameric leptin-leptin receptor complex
-
Peelman F, Iserentant H, De Smet AS, Vandekerckhove J, Zabeau L & Tavernier J 2006b Mapping of binding site III in the leptin receptor and modeling of a hexameric leptin-leptin receptor complex. Journal of Biological Chemistry 281 15496-15504. (doi:10.1074/jbc.M512622200)
-
(2006)
Journal of Biological Chemistry
, vol.281
, pp. 15496-15504
-
-
Peelman, F.1
Iserentant, H.2
De Smet, A.S.3
Vandekerckhove, J.4
Zabeau, L.5
Tavernier, J.6
-
49
-
-
0033548048
-
Erythropoietin receptor activation by a ligand-induced conformation change
-
Remy I, Wilson IA & Michnick SW 1999 Erythropoietin receptor activation by a ligand-induced conformation change. Science 283 990-993. (doi:10.1126/science.283.5404.990)
-
(1999)
Science
, vol.283
, pp. 990-993
-
-
Remy, I.1
Wilson, I.A.2
Michnick, S.W.3
-
50
-
-
0030455390
-
The leptin haemopoietic cytokine fold is stabilized by an intrachain disulfide bond
-
Rock FL, Altmann SW, van Heek M, Kastelein RA & Bazan JF 1996a The leptin haemopoietic cytokine fold is stabilized by an intrachain disulfide bond. Hormone and Metabolic Research 28 649-652. (doi:10.1055/s-2007-979871)
-
(1996)
Hormone and Metabolic Research
, vol.28
, pp. 649-652
-
-
Rock, F.L.1
Altmann, S.W.2
van Heek, M.3
Kastelein, R.A.4
Bazan, J.F.5
-
51
-
-
0030453705
-
Binding of leptin to the soluble ectodomain of recombinant leptin receptor: a kinetic analysis by surface plasmon resonance
-
Rock FL, Peterson D, Weig BC, Kastelein RA & Bazan JF 1996b Binding of leptin to the soluble ectodomain of recombinant leptin receptor: a kinetic analysis by surface plasmon resonance. Hormone and Metabolic Research 28 748-750. (doi:10.1055/s-2007-979892)
-
(1996)
Hormone and Metabolic Research
, vol.28
, pp. 748-750
-
-
Rock, F.L.1
Peterson, D.2
Weig, B.C.3
Kastelein, R.A.4
Bazan, J.F.5
-
52
-
-
0038361120
-
Subcloning, expression, purification, and characterization of recombinant human leptinbinding domain
-
Sandowski Y, Raver N, Gussakovsky EE, Shochat S, Dym O, Livnah O, Rubinstein M, Krishna R & Gertler A 2002 Subcloning, expression, purification, and characterization of recombinant human leptinbinding domain. Journal of Biological Chemistry 277 46304-46309. (doi:10.1074/jbc.M207556200)
-
(2002)
Journal of Biological Chemistry
, vol.277
, pp. 46304-46309
-
-
Sandowski, Y.1
Raver, N.2
Gussakovsky, E.E.3
Shochat, S.4
Dym, O.5
Livnah, O.6
Rubinstein, M.7
Krishna, R.8
Gertler, A.9
-
53
-
-
0037434888
-
The human interleukin-6 (IL-6) receptor exists as a preformed dimer in the plasma membrane
-
Schuster B, Meinert W, Rose-John S & Kallen K-J 2003 The human interleukin-6 (IL-6) receptor exists as a preformed dimer in the plasma membrane. FEBS Letters 538 113-116. (doi:10.1016/S0014-5793(03)00154-6)
-
(2003)
FEBS Letters
, vol.538
, pp. 113-116
-
-
Schuster, B.1
Meinert, W.2
Rose-John, S.3
Kallen, K.-J.4
-
54
-
-
0029739970
-
Identification of targets of leptin action in rat hypothalamus
-
Schwartz MW, Seeley RJ, Campfield LA, Burn P & Baskin DG 1996 Identification of targets of leptin action in rat hypothalamus. Journal of Clinical Investigation 98 1101-1106. (doi:10.1172/JCI118891)
-
(1996)
Journal of Clinical Investigation
, vol.98
, pp. 1101-1106
-
-
Schwartz, M.W.1
Seeley, R.J.2
Campfield, L.A.3
Burn, P.4
Baskin, D.G.5
-
55
-
-
79952999216
-
Development and characterization of high affinity leptins and leptin antagonists
-
Shpilman M, Niv-Spector L, Katz M, Varol C, Solomon G, Ayalon-Soffer M, Boder E, Halpern Z, Elinav E & Gertler A 2011 Development and characterization of high affinity leptins and leptin antagonists. The Journal of Biological Chemistry 286 4429-4442. (doi:10.1074/jbc.M110.196402)
-
(2011)
The Journal of Biological Chemistry
, vol.286
, pp. 4429-4442
-
-
Shpilman, M.1
Niv-Spector, L.2
Katz, M.3
Varol, C.4
Solomon, G.5
Ayalon-Soffer, M.6
Boder, E.7
Halpern, Z.8
Elinav, E.9
Gertler, A.10
-
56
-
-
0030570741
-
Molecular cloning of rat leptin receptor isoform complementary DNAs - identification of a missense mutation in Zucker fatty (fa/fa) rats
-
Takaya K, Ogawa Y, Isse N, Okazaki T, Satoh N, Masuzaki H, Mori K, Tamura N, Hosoda K & Nakao K 1996 Molecular cloning of rat leptin receptor isoform complementary DNAs - identification of a missense mutation in Zucker fatty (fa/fa) rats. Biochemical and Biophysical Research Communications 225 75-83. (doi:10.1006/bbrc.1996.1133)
-
(1996)
Biochemical and Biophysical Research Communications
, vol.225
, pp. 75-83
-
-
Takaya, K.1
Ogawa, Y.2
Isse, N.3
Okazaki, T.4
Satoh, N.5
Masuzaki, H.6
Mori, K.7
Tamura, N.8
Hosoda, K.9
Nakao, K.10
-
57
-
-
33644761881
-
Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex
-
Tamada T, Honjo E, Maeda Y, Okamoto T, Ishibashi M, Tokunaga M & Kuroki R 2006 Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex. PNAS 103 3135-3140. (doi:10.1073/pnas.0511264103)
-
(2006)
PNAS
, vol.103
, pp. 3135-3140
-
-
Tamada, T.1
Honjo, E.2
Maeda, Y.3
Okamoto, T.4
Ishibashi, M.5
Tokunaga, M.6
Kuroki, R.7
-
58
-
-
2442654859
-
Identification and expression cloning of a leptin receptor, OB-R
-
Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J et al. 1995 Identification and expression cloning of a leptin receptor, OB-R. Cell 83 1263-1271. (doi:10.1016/0092-8674(95)90151-5)
-
(1995)
Cell
, vol.83
, pp. 1263-1271
-
-
Tartaglia, L.A.1
Dembski, M.2
Weng, X.3
Deng, N.4
Culpepper, J.5
Devos, R.6
Richards, G.J.7
Campfield, L.A.8
Clark, F.T.9
Deeds, J.10
-
59
-
-
0033008075
-
Functional properties of leptin receptor isoforms: internalization and degradation of leptin and ligand-induced receptor downregulation
-
Uotani S, Bjørbaek C, Tornøe J & Flier JS 1999 Functional properties of leptin receptor isoforms: internalization and degradation of leptin and ligand-induced receptor downregulation. Diabetes 48 279-286. (doi:10.2337/diabetes.48.2.279)
-
(1999)
Diabetes
, vol.48
, pp. 279-286
-
-
Uotani, S.1
Bjørbaek, C.2
Tornøe, J.3
Flier, J.S.4
-
60
-
-
0029739826
-
Leptinactivationof Stat3inthehypothalamusofwild-type andob/obmice but not db/dbmice
-
Vaisse C, Halaas JL, Horvath CM, Darnell JE, Stoffel M & Friedman JM 1996 Leptinactivationof Stat3inthehypothalamusofwild-type andob/obmice but not db/dbmice. Nature Genetics 14 95-97. (doi:10.1038/ng0996-95)
-
(1996)
Nature Genetics
, vol.14
, pp. 95-97
-
-
Vaisse, C.1
Halaas, J.L.2
Horvath, C.M.3
Darnell, J.E.4
Stoffel, M.5
Friedman, J.M.6
-
61
-
-
84875196370
-
Design and validation of a homogeneous time-resolved fluorescence-based leptin receptor binding assay
-
Vauthier V, Derviaux C, Douayry N, Roux T, Trinquet E, Jockers R & Dam J 2013 Design and validation of a homogeneous time-resolved fluorescence-based leptin receptor binding assay. Analytical Biochemistry 436 1-9. (doi:10.1016/j.ab.2012.12.013)
-
(2013)
Analytical Biochemistry
, vol.436
, pp. 1-9
-
-
Vauthier, V.1
Derviaux, C.2
Douayry, N.3
Roux, T.4
Trinquet, E.5
Jockers, R.6
Dam, J.7
-
62
-
-
0030992071
-
A human leptin mutant induces weight gain in normal mice
-
Verploegen SA, Plaetinck G, Devos R, Van der Heyden J & Guisez Y 1997 A human leptin mutant induces weight gain in normal mice. FEBS Letters 405 237-240. (doi:10.1016/S0014-5793(97)00192-0)
-
(1997)
FEBS Letters
, vol.405
, pp. 237-240
-
-
Verploegen, S.A.1
Plaetinck, G.2
Devos, R.3
Van der Heyden, J.4
Guisez, Y.5
-
63
-
-
79952811396
-
RNF41 (Nrdp1) controls type 1 cytokine receptor degradation and ectodomain shedding
-
Wauman J, De Ceuninck L, Vanderroost N, Lievens S & Tavernier J 2011 RNF41 (Nrdp1) controls type 1 cytokine receptor degradation and ectodomain shedding. Journal of Cell Science 124 921-932. (doi:10.1242/jcs.078055)
-
(2011)
Journal of Cell Science
, vol.124
, pp. 921-932
-
-
Wauman, J.1
De Ceuninck, L.2
Vanderroost, N.3
Lievens, S.4
Tavernier, J.5
-
64
-
-
0033135272
-
Evidence for ligand-independent homooligomerization of leptin receptor (OB-R) isoforms: a proposed mechanism permitting productive long-form signaling in the presence of excess short-form expression
-
White DW & Tartaglia L 1999 Evidence for ligand-independent homooligomerization of leptin receptor (OB-R) isoforms: a proposed mechanism permitting productive long-form signaling in the presence of excess short-form expression. Journal of Cellular Biochemistry 73 278-288. (doi:10.1002/(SICI)1097-4644(19990501)73:2<278::AIDJCB13>3.0.CO;2-W)
-
(1999)
Journal of Cellular Biochemistry
, vol.73
, pp. 278-288
-
-
White, D.W.1
Tartaglia, L.2
-
65
-
-
77954368725
-
Crystal structure of the entire ectodomain of gp130: insights into the molecular assembly of the tall cytokine receptor complexes
-
Xu Y, Kershaw NJ, Luo CS, Soo P, Pocock MJ, Czabotar PE, Hilton DJ, Nicola NA, Garrett TPJ & Zhang J-G 2010 Crystal structure of the entire ectodomain of gp130: insights into the molecular assembly of the tall cytokine receptor complexes. Journal of Biological Chemistry 285 21214-21218. (doi:10.1074/jbc.C110.129502)
-
(2010)
Journal of Biological Chemistry
, vol.285
, pp. 21214-21218
-
-
Xu, Y.1
Kershaw, N.J.2
Luo, C.S.3
Soo, P.4
Pocock, M.J.5
Czabotar, P.E.6
Hilton, D.J.7
Nicola, N.A.8
Garrett, T.P.J.9
Zhang, J.-G.10
-
66
-
-
0037862102
-
The ins and outs of leptin receptor activation
-
Zabeau L, Lavens D, Peelman F, Eyckerman S, Vandekerckhove J & Tavernier J 2003 The ins and outs of leptin receptor activation. FEBS Letters 546 45-50. (doi:10.1016/S0014-5793(03)00440-X)
-
(2003)
FEBS Letters
, vol.546
, pp. 45-50
-
-
Zabeau, L.1
Lavens, D.2
Peelman, F.3
Eyckerman, S.4
Vandekerckhove, J.5
Tavernier, J.6
-
67
-
-
0347286631
-
Functional analysis of leptin receptor activation using a Janus kinase/signal transducer and activator of transcription complementation assay
-
Zabeau L, Defeau D, Van der Heyden J, Iserentant H, Vandekerckhove J & Tavernier J 2004 Functional analysis of leptin receptor activation using a Janus kinase/signal transducer and activator of transcription complementation assay. Molecular Endocrinology 18 150-161. (doi:10.1210/me.2003-0078)
-
(2004)
Molecular Endocrinology
, vol.18
, pp. 150-161
-
-
Zabeau, L.1
Defeau, D.2
Van der Heyden, J.3
Iserentant, H.4
Vandekerckhove, J.5
Tavernier, J.6
-
68
-
-
20744460050
-
Leptin receptor activation depends on critical cysteine residues in its fibronectin type III subdomains
-
Zabeau L, Defeau D, Iserentant H, Vandekerckhove J, Peelman F & Tavernier J 2005 Leptin receptor activation depends on critical cysteine residues in its fibronectin type III subdomains. Journal of Biological Chemistry 280 22632-22640. (doi:10.1074/jbc.M413308200)
-
(2005)
Journal of Biological Chemistry
, vol.280
, pp. 22632-22640
-
-
Zabeau, L.1
Defeau, D.2
Iserentant, H.3
Vandekerckhove, J.4
Peelman, F.5
Tavernier, J.6
-
69
-
-
84055223513
-
Selection of non-competitive leptin antagonists using a random nanobody-based approach
-
Zabeau L, Verhee A, Catteeuw D, Faes L, Seeuws S, Decruy T, Elewaut D, Peelman F & Tavernier J 2012 Selection of non-competitive leptin antagonists using a random nanobody-based approach. Biochemical Journal 441 425-434. (doi:10.1042/BJ20110438)
-
(2012)
Biochemical Journal
, vol.441
, pp. 425-434
-
-
Zabeau, L.1
Verhee, A.2
Catteeuw, D.3
Faes, L.4
Seeuws, S.5
Decruy, T.6
Elewaut, D.7
Peelman, F.8
Tavernier, J.9
-
70
-
-
84900866393
-
Antagonising leptin: current status and future directions
-
Zabeau L, Peelman F & Tavernier J 2014 Antagonising leptin: current status and future directions. Biological Chemistry 395 499-514. (doi:10.1515/hsz-2013-0283)
-
(2014)
Biological Chemistry
, vol.395
, pp. 499-514
-
-
Zabeau, L.1
Peelman, F.2
Tavernier, J.3
-
71
-
-
0028139089
-
Positional cloning of the mouse obese gene and its human homologue
-
Zhang Y, Proenca R, Maffei M, Barone M, Leopold L & Friedman JM 1994 Positional cloning of the mouse obese gene and its human homologue. Nature 372 425-432. (doi:10.1038/372425a0)
-
(1994)
Nature
, vol.372
, pp. 425-432
-
-
Zhang, Y.1
Proenca, R.2
Maffei, M.3
Barone, M.4
Leopold, L.5
Friedman, J.M.6
-
72
-
-
0030977992
-
Crystal structure of the obese protein leptin-E100
-
Zhang F, Basinski MB, Beals JM, Briggs SL, Churgay LM, Clawson DK, DiMarchi RD, Furman TC, Hale JE, Hsiung HM et al. 1997 Crystal structure of the obese protein leptin-E100. Nature 387 206-209. (doi:10.1038/387206a0)
-
(1997)
Nature
, vol.387
, pp. 206-209
-
-
Zhang, F.1
Basinski, M.B.2
Beals, J.M.3
Briggs, S.L.4
Churgay, L.M.5
Clawson, D.K.6
DiMarchi, R.D.7
Furman, T.C.8
Hale, J.E.9
Hsiung, H.M.10
|