Structural and mechanistic paradigm of Leptin receptor activation revealed by complexes with wild-type and antagonist Leptins

Structure

Volumn 22, Issue 6, 2014, Pages 866-877

  Moharana, Kedar ^a   Zabeau, Lennart ^a   Peelman, Frank ^a   Ringler, Philippe ^b   Stahlberg, Henning ^b   Tavernier, Jan ^a   Savvides, Savvas N ^a  

^a GHENT UNIVERSITY   (Belgium)

^b UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CYSTEINE; HORMONE ANTAGONIST; IMMUNOGLOBULIN F(AB) FRAGMENT; LEPTIN RECEPTOR; LEPTIN; LEPTIN RECEPTOR, HUMAN; MULTIPROTEIN COMPLEX; RECOMBINANT PROTEIN;

ARTICLE; CELL SURFACE; CONTROLLED STUDY; EMBRYO; FIELD FLOW FRACTIONATION; GEL PERMEATION CHROMATOGRAPHY; HUMAN; IMMOBILIZED METAL AFFINITY CHROMATOGRAPHY; IMMUNOPRECIPITATION; ISOTHERMAL TITRATION CALORIMETRY; LIGHT SCATTERING; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; STOICHIOMETRY; X RAY CRYSTALLOGRAPHY; BIOPHYSICS; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; METABOLISM; PROTEIN DOMAIN; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE; SMALL ANGLE SCATTERING; X RAY DIFFRACTION;

BIOPHYSICAL PHENOMENA; CYSTEINE; HUMANS; LEPTIN; MODELS, MOLECULAR; MULTIPROTEIN COMPLEXES; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; RECEPTORS, LEPTIN; RECOMBINANT PROTEINS; SCATTERING, SMALL ANGLE; X-RAY DIFFRACTION;

EID: 84902334438     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2014.04.012     Document Type: Article

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