메뉴 건너뛰기




Volumn 154, Issue 7, 2013, Pages 2434-2445

Neither Signal Transducer and Activator of Transcription 3 (STAT3) or STAT5 signaling pathways are required for leptin's effects on fertility in mice

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; LEPTIN; LEPTIN RECEPTOR; STAT3 PROTEIN; STAT5 PROTEIN;

EID: 84879304955     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2013-1109     Document Type: Article
Times cited : (47)

References (66)
  • 1
    • 33744490873 scopus 로고    scopus 로고
    • Physiology of the GnRH neuronal network
    • Neill JD, ed. San Diego: Elsevier
    • Herbison AE. Physiology of the GnRH neuronal network. In: Neill JD, ed. Knobil and Neill's Physiology of Reproduction. San Diego: Elsevier; 2006;1415-1481.
    • (2006) Knobil and Neill's Physiology of Reproduction , pp. 1415-1481
    • Herbison, A.E.1
  • 2
    • 84883975740 scopus 로고    scopus 로고
    • 2006 Neuroendocrine control of the ovarian cycle of the rat
    • Neill JD, ed. San Diego: Elsevier
    • Freeman ME. 2006 Neuroendocrine control of the ovarian cycle of the rat. In: Neill JD, ed. Knobil and Neill's Physiology of Reproduction. San Diego: Elsevier; 2006;2327-2387.
    • (2006) Knobil and Neill's Physiology of Reproduction , pp. 2327-2387
    • Freeman, M.E.1
  • 3
    • 0018139377 scopus 로고
    • Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice
    • Coleman D. Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia. 1978;14:141-148. (Pubitemid 8286141)
    • (1978) Diabetologia , vol.14 , Issue.3 , pp. 141-148
    • Coleman, D.L.1
  • 4
    • 0030010388 scopus 로고    scopus 로고
    • Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin
    • DOI 10.1038/ng0396-318
    • Chehab FF, Lim ME, Lu R. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nature Genet. 1996;12:318-320. (Pubitemid 26080094)
    • (1996) Nature Genetics , vol.12 , Issue.3 , pp. 318-320
    • Chehab, F.F.1    Lim, M.E.2    Lu, R.3
  • 6
    • 0032558725 scopus 로고    scopus 로고
    • Leptin and the regulation of body weight in mammals
    • DOI 10.1038/27376
    • Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature. 1998;395:763-770. (Pubitemid 28485436)
    • (1998) Nature , vol.395 , Issue.6704 , pp. 763-770
    • Friedman, J.M.1    Halaas, J.L.2
  • 7
    • 8644268830 scopus 로고    scopus 로고
    • Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism
    • Zhang EE, Chapeau E, Hagihara K, Feng GS. Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism. Proc Natl Acad Sci USA. 2004;101:16064.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 16064
    • Zhang, E.E.1    Chapeau, E.2    Hagihara, K.3    Feng, G.S.4
  • 9
    • 0029073613 scopus 로고
    • Weight-reducing effects of the plasma protein encoded by the obese gene
    • Halaas JL, Gajiwala KS, Maffei M, et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science. 1995;269: 543-546.
    • (1995) Science , vol.269 , pp. 543-546
    • Halaas, J.L.1    Gajiwala, K.S.2    Maffei, M.3
  • 10
    • 0031051499 scopus 로고    scopus 로고
    • Leptin treatment rescues the sterility of genetically obese ob/ob males
    • DOI 10.1210/en.138.3.1190
    • Mounzih K, Lu R, Chehab FF. Leptin treatment rescues the sterility of genetically obese ob/ob males. Endocrinology. 1997;138:1190-1193. (Pubitemid 27089777)
    • (1997) Endocrinology , vol.138 , Issue.3 , pp. 1190-1193
    • Mounzih, K.1    Lu, R.2    Chehab, F.F.3
  • 11
    • 30044434035 scopus 로고    scopus 로고
    • Intracellular signalling pathways activated by leptin
    • Fruhbeck G. Intracellular signalling pathways activated by leptin. Biochem J. 2006;393:7.
    • (2006) Biochem J , vol.393 , pp. 7
    • Fruhbeck, G.1
  • 12
    • 79959375716 scopus 로고    scopus 로고
    • Intracellular leptin-signaling pathways in hypothalamic neurons: The emerging role of phosphatidylinositol-3 kinase-phosphodiesterase-3B-cAMP pathway
    • Sahu A. Intracellular leptin-signaling pathways in hypothalamic neurons: the emerging role of phosphatidylinositol-3 kinase-phosphodiesterase-3B-cAMP pathway. Neuroendocrinology. 2011;93:201-210.
    • (2011) Neuroendocrinology , vol.93 , pp. 201-210
    • Sahu, A.1
  • 13
    • 0000430395 scopus 로고    scopus 로고
    • Divergent roles of SHP-2 in ERK activation by leptin receptors
    • Bj[b]ørbaek C, Buchholz RM, Davis SM, et al. Divergent roles of SHP-2 in ERK activation by leptin receptors. J Biol Chem. 2001;276:4747-4755.
    • (2001) J Biol Chem , vol.276 , pp. 4747-4755
    • Bjbørbaek, C.1    Buchholz, R.M.2    Davis, S.M.3
  • 14
    • 33646582664 scopus 로고    scopus 로고
    • Hypothalamic mTOR signaling regulates food intake
    • Cota D, Proulx K, Smith KAB, et al. Hypothalamic mTOR signaling regulates food intake. Science. 2006;312:927.
    • (2006) Science , vol.312 , pp. 927
    • Cota, D.1    Proulx, K.2    Smith, K.A.B.3
  • 15
    • 2342444310 scopus 로고    scopus 로고
    • Leptin receptor signaling and the regulation of mammalian physiology
    • Myers MG Jr. Leptin receptor signaling and the regulation of mammalian physiology. Recent Prog Horm Res. 2004;59:287-304.
    • (2004) Recent Prog Horm Res , vol.59 , pp. 287-304
    • Myers Jr., M.G.1
  • 17
    • 0029900899 scopus 로고    scopus 로고
    • Reflections on STAT3, STAT5, and STAT6 as fat STATs
    • Darnell JE Jr. Reflections on STAT3, STAT5, and STAT6 as fat STATs. Proc Natl Acad Sci USA. 1996;93:6221.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 6221
    • Darnell Jr., J.E.1
  • 18
    • 34247102713 scopus 로고    scopus 로고
    • Nuclear translocation of the transcription factor STAT5 in the rat brain after systemic leptin administration
    • DOI 10.1016/j.neulet.2007.02.074, PII S0304394007002431
    • Mütze J, Roth J, Gerstberger R, Hübschle T. Nuclear translocation of the transcription factor STAT5 in the rat brain after systemic leptin administration. Neurosci Lett. 2007;417:286-291. (Pubitemid 46589788)
    • (2007) Neuroscience Letters , vol.417 , Issue.3 , pp. 286-291
    • Mutze, J.1    Roth, J.2    Gerstberger, R.3    Hubschle, T.4
  • 20
    • 0031768207 scopus 로고    scopus 로고
    • Leptin signaling in the hypothalamus of normal rats in vivo
    • DOI 10.1210/en.139.11.4442
    • McCowen KC, Chow JC, Smith RJ. Leptin signaling in the hypothalamus of normal rats in vivo. Endocrinology. 1998;139:4442-4447. (Pubitemid 28487757)
    • (1998) Endocrinology , vol.139 , Issue.11 , pp. 4442-4447
    • Mccowen, K.C.1    Chow, J.C.2    Smith, R.J.3
  • 21
    • 0034984796 scopus 로고    scopus 로고
    • Leptin and tumor necrosis factor-alpha induce the tyrosine phosphorylation of signal transducer and activator of transcription proteins in the hypothalamus of normal rats in vivo
    • DOI 10.1210/en.142.7.3027
    • Rizk NM, Stammsen D, Preibisch G, Eckel J. Leptin and tumor necrosis factor-alpha induce the tyrosine phosphorylation of signal transducer and activator of transcription proteins in the hypothalamus of normal rats in vivo. Endocrinology. 2001;142:3027-3032. (Pubitemid 32575540)
    • (2001) Endocrinology , vol.142 , Issue.7 , pp. 3027-3032
    • Rizkt, N.M.1    Stammsen, D.2    Preibisch, G.3    Eckel, J.4
  • 22
    • 84863204371 scopus 로고    scopus 로고
    • Suppression of leptin-induced hypothalamic JAK/STAT signalling and feeding response during pregnancy in the mouse
    • Ladyman SR, Fieldwick DM, Grattan DR. Suppression of leptin-induced hypothalamic JAK/STAT signalling and feeding response during pregnancy in the mouse. Reproduction. 2012;144:83-90.
    • (2012) Reproduction , vol.144 , pp. 83-90
    • Ladyman, S.R.1    Fieldwick, D.M.2    Grattan, D.R.3
  • 24
    • 79953705077 scopus 로고    scopus 로고
    • Estrogen receptor alpha pathway is involved in leptin-induced ovarian cancer cell growth
    • Choi JH, Lee KT, Leung PC. Estrogen receptor alpha pathway is involved in leptin-induced ovarian cancer cell growth. Carcinogenesis. 2011;32:589-596.
    • (2011) Carcinogenesis , vol.32 , pp. 589-596
    • Choi, J.H.1    Lee, K.T.2    Leung, P.C.3
  • 25
    • 79959815001 scopus 로고    scopus 로고
    • Activation of the signal transducer and activator of transcription 3 pathway up-regulates estrogen receptor-beta expression in lung adenocarcinoma cells
    • Wang HC, Yeh HH, Huang WL, et al. Activation of the signal transducer and activator of transcription 3 pathway up-regulates estrogen receptor-beta expression in lung adenocarcinoma cells. Mol Endocrinol. 2011;25:1145-1158.
    • (2011) Mol Endocrinol , vol.25 , pp. 1145-1158
    • Wang, H.C.1    Yeh, H.H.2    Huang, W.L.3
  • 26
    • 1842584949 scopus 로고    scopus 로고
    • Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation
    • Gao Q, Wolfgang MJ, Neschen S, et al. Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. Proc Natl Acad Sci USA. 2004;101:4661.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 4661
    • Gao, Q.1    Wolfgang, M.J.2    Neschen, S.3
  • 28
    • 45749150715 scopus 로고    scopus 로고
    • Loss of cytokine-STAT5 signaling in the CNS and pituitary gland alters energy balance and leads to obesity
    • Lee JY, Munzberg H, Gavrilova O, et al. Loss of cytokine-STAT5 signaling in the CNS and pituitary gland alters energy balance and leads to obesity. PLoS One. 2008;3:e1639.
    • (2008) PLoS One , vol.3
    • Lee, J.Y.1    Munzberg, H.2    Gavrilova, O.3
  • 29
  • 33
    • 4444268818 scopus 로고    scopus 로고
    • Inactivation of stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation
    • DOI 10.1128/MCB.24.18.8037-8047.2004
    • Cui Y, Riedlinger G, Miyoshi K, et al. Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation. Mol Cell Biol. 2004;24:8037-8047. (Pubitemid 39167454)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.18 , pp. 8037-8047
    • Cui, Y.1    Riedlinger, G.2    Miyoshi, K.3    Tang, W.4    Li, C.5    Deng, C.-X.6    Robinson, G.W.7    Hennighausen, L.8
  • 34
    • 33748746590 scopus 로고    scopus 로고
    • Suppression of prolactin-induced signal transducer and activator of transcription 5b signaling and induction of suppressors of cytokine signaling messenger ribonucleic acid in the hypothalamic arcuate nucleus of the rat during late pregnancy and lactation
    • DOI 10.1210/en.2005-0755
    • Anderson GM, Beijer P, Bang AS, Fenwick MA, Bunn SJ, Grattan DR. Suppression of prolactin-induced signal transducer and activator of transcription 5b signaling and induction of suppressors of cytokine signaling messenger ribonucleic acid in the hypothalamic arcuate nucleus of the rat during late pregnancy and lactation. Endocrinology. 2006;147:4996-5005. (Pubitemid 44402207)
    • (2006) Endocrinology , vol.147 , Issue.10 , pp. 4996-5005
    • Anderson, G.M.1    Beijer, P.2    Bang, A.S.3    Fenwick, M.A.4    Bunn, S.J.5    Grattan, D.R.6
  • 35
    • 0025916432 scopus 로고
    • Increased sperm production in adult rats after transient neonatal hypothyroidism
    • Cooke PS, Hess RA, Porcelli J, Meisami E. Increased sperm production in adult rats after transient neonatal hypothyroidism. Endocrinology. 1991;129:244-248.
    • (1991) Endocrinology , vol.129 , pp. 244-248
    • Cooke, P.S.1    Hess, R.A.2    Porcelli, J.3    Meisami, E.4
  • 36
    • 0018088898 scopus 로고
    • Daily sperm production and epididymal sperm reserves of pubertal and adult rats
    • Robb GW, Amann RP, Killian GJ. Daily sperm production and epididymal sperm reserves of pubertal and adult rats. J Reproduc Fertil. 1978;54:103-107. (Pubitemid 9016166)
    • (1978) Journal of Reproduction and Fertility , vol.54 , Issue.1 , pp. 103-107
    • Robb, G.W.1    Amann, R.P.2    Killian, G.J.3
  • 37
    • 0027140989 scopus 로고
    • Neonatal goitrogen treatment increases adult testis size and sperm production in the mouse
    • Joyce KL, Porcelli J, Cooke PS. Neonatal goitrogen treatment increases adult testis size and sperm production in the mouse. J Androl. 1993;14:448.
    • (1993) J Androl , vol.14 , pp. 448
    • Joyce, K.L.1    Porcelli, J.2    Cooke, P.S.3
  • 39
    • 40849124301 scopus 로고    scopus 로고
    • Specific physiological roles for signal transducer and activator of transcription 3 in leptin receptor-expressing neurons
    • DOI 10.1210/me.2007-0389
    • Piper ML, Unger EK, Myers MG Jr, Xu AW. Specific physiological roles for signal transducer and activator of transcription 3 in leptin receptor-expressing neurons. Mol Endocrinol. 2008;22:751-759. (Pubitemid 351397800)
    • (2008) Molecular Endocrinology , vol.22 , Issue.3 , pp. 751-759
    • Piper, M.L.1    Unger, E.K.2    Myers Jr., M.G.3    Xu, A.W.4
  • 40
    • 0034457883 scopus 로고    scopus 로고
    • In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: Overlapping but distinct pathways from insulin
    • DOI 10.1210/en.141.7.2328
    • Kim YB, Uotani S, Pierroz DD, Flier JS, Kahn BB. In vivo administration of leptin activates signal transduction directly in insulinsensitive tissues: overlapping but distinct pathways from insulin. Endocrinology. 2000;141:2328-2339. (Pubitemid 32269051)
    • (2000) Endocrinology , vol.141 , Issue.7 , pp. 2328-2339
    • Kim, Y.-B.1    Uotani, S.2    Pierroz, D.D.3    Flier, J.S.4    Kahn, B.B.5
  • 43
    • 34447116951 scopus 로고    scopus 로고
    • Role of signal transducer and activator of transcription-3 in estradiol-mediated neuroprotection
    • DOI 10.1523/JNEUROSCI.1558-07.2007
    • Dziennis S, Jia T, R[b]ønnekleiv OK, Hurn PD, Alkayed NJ. Role of signal transducer and activator of transcription-3 in estradiol-mediated neuroprotection. J Neurosci. 2007;27:7268-7274. (Pubitemid 47037568)
    • (2007) Journal of Neuroscience , vol.27 , Issue.27 , pp. 7268-7274
    • Dziennis, S.1    Jia, T.2    Ronnekleiv, O.K.3    Hurn, P.D.4    Alkayed, N.J.5
  • 46
    • 0028848026 scopus 로고
    • In vivo growth hormone treatment rapidly stimulates the tyrosine phosphorylation and activation of Stat3
    • Gronowski AM, Zhong Z, Wen Z, Thomas MJ, Darnell JE Jr, Rotwein P. In vivo growth hormone treatment rapidly stimulates the tyrosine phosphorylation and activation of Stat3. Mol Endocrinol. 1995;9:171-177.
    • (1995) Mol Endocrinol , vol.9 , pp. 171-177
    • Gronowski, A.M.1    Zhong, Z.2    Wen, Z.3    Thomas, M.J.4    Darnell Jr., J.E.5    Rotwein, P.6
  • 47
    • 0029968831 scopus 로고    scopus 로고
    • The role of the growth hormone (GH) receptor and JAK1 and JAK2 kinases in the activation of Stats 1, 3, and 5 by GH
    • DOI 10.1210/me.10.5.519
    • Smit LS, Meyer DJ, Billestrup N, Norstedt G, Schwartz J, Carter-Su C. The role of the growth hormone (GH) receptor and JAK1 and JAK2 kinases in the activation of Stats 1, 3, and 5 by GH. Mol Endocrinol. 1996;10:519-533. (Pubitemid 26142578)
    • (1996) Molecular Endocrinology , vol.10 , Issue.5 , pp. 519-533
    • Smit, L.S.1    Meyer, D.J.2    Billestrup, N.3    Norstedt, G.4    Schwartz, J.5    Carter-Su, C.6
  • 48
    • 0034871775 scopus 로고    scopus 로고
    • Feedback regulation of PRL secretion is mediated by the transcription factor, signal transducer, and activator of transcription 5b
    • Grattan DR,XuJ, McLachlan MJ, et al. Feedback regulation of PRL secretion is mediated by the transcription factor, signal transducer, and activator of transcription 5b. Endocrinology. 2001;142:3935-3940.
    • (2001) Endocrinology , vol.142 , pp. 3935-3940
    • Grattan, D.R.1    Xu, J.2    McLachlan, M.J.3
  • 49
    • 27744479381 scopus 로고    scopus 로고
    • Prolactin-induced activation of STAT5 within the hypothalamic arcuate nucleus
    • DOI 10.1097/01.wnr.0000176516.19347.6f
    • Cave BJ, NormanM,Flynn A, Townsend J, Wakerley JB, Tortonese DJ. Prolactin-induced activation of STAT5 within the hypothalamic arcuate nucleus. Neuroreport. 2005;16:1423-1426. (Pubitemid 41805655)
    • (2005) NeuroReport , vol.16 , Issue.13 , pp. 1423-1426
    • Cave, B.J.1    Norman, M.2    Flynn, A.3    Townsend, J.4    Wakerley, J.B.5    Tortonese, D.J.6
  • 51
    • 0037108268 scopus 로고    scopus 로고
    • N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation
    • Knoepfler PS, Cheng PF, Eisenman RN. N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation. Genes Dev. 2002;16:2699-2712.
    • (2002) Genes Dev , vol.16 , pp. 2699-2712
    • Knoepfler, P.S.1    Cheng, P.F.2    Eisenman, R.N.3
  • 54
    • 0029895233 scopus 로고    scopus 로고
    • Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization
    • Mercer JG, Hoggard N, Williams LM, Lawrence CB, Hannah LT, Trayhurn P. Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett. 1996;387:113-116.
    • (1996) FEBS Lett , vol.387 , pp. 113-116
    • Mercer, J.G.1    Hoggard, N.2    Williams, L.M.3    Lawrence, C.B.4    Hannah, L.T.5    Trayhurn, P.6
  • 55
    • 34047271043 scopus 로고    scopus 로고
    • 125I]leptin binding in the rat forebrain
    • DOI 10.1016/j.jchemneu.2007.02.007, PII S0891061807000439
    • Carlo AS, Meyerhof W, Williams LM. Early developmental expression of leptin receptor gene and [125I]leptin binding in the rat forebrain. J Chem Neuroanat. 2007;33:155-163. (Pubitemid 46546521)
    • (2007) Journal of Chemical Neuroanatomy , vol.33 , Issue.3 , pp. 155-163
    • Carlo, A.-S.1    Meyerhof, W.2    Williams, L.M.3
  • 56
    • 65949099104 scopus 로고    scopus 로고
    • Developmental changes in hypothalamic leptin receptor: Relationship with the postnatal leptin surge and energy balance neuropeptides in the postnatal rat
    • Cottrell EC, Cripps RL, Duncan JS, et al. Developmental changes in hypothalamic leptin receptor: relationship with the postnatal leptin surge and energy balance neuropeptides in the postnatal rat. Am J Physiol Regul Integr Comp Physiol. 2009;296:R631-R639.
    • (2009) Am J Physiol Regul Integr Comp Physiol , vol.296
    • Cottrell, E.C.1    Cripps, R.L.2    Duncan, J.S.3
  • 57
    • 18344376775 scopus 로고    scopus 로고
    • Stimulation of appetite by ghrelin is regulated by leptin restraint: Peripheral and central sites of action
    • Kalra SP, Ueno N, Kalra PS. Stimulation of appetite by ghrelin is regulated by leptin restraint: peripheral and central sites of action. J Nutr. 2005;135:1331-1335. (Pubitemid 40638359)
    • (2005) Journal of Nutrition , vol.135 , Issue.5 , pp. 1331-1335
    • Kalra, S.P.1    Ueno, N.2    Kalra, P.S.3
  • 58
    • 0035800015 scopus 로고    scopus 로고
    • Hypothalamic leptin resistance is associated with impaired leptin signal transduction in aged obese rats
    • DOI 10.1016/S0306-4522(01)00142-7, PII S0306452201001427
    • Scarpace PJ, Matheny M, Tümer N. Hypothalamic leptin resistance is associated with impaired leptin signal transduction in aged obese rats. Neuroscience. 2001;104:1111-1117. (Pubitemid 32701970)
    • (2001) Neuroscience , vol.104 , Issue.4 , pp. 1111-1117
    • Scarpace, P.J.1    Matheny, M.2    Tumer, N.3
  • 61
    • 80052935067 scopus 로고    scopus 로고
    • The acute effects of leptin require PI3K signaling in the hypothalamic ventral premammillary nucleus
    • Williams KW, Sohn JW, Donato J Jr, et al. The acute effects of leptin require PI3K signaling in the hypothalamic ventral premammillary nucleus. J Neurosci. 2011;31:13147-13156.
    • (2011) J Neurosci , vol.31 , pp. 13147-13156
    • Williams, K.W.1    Sohn, J.W.2    Donato Jr., J.3
  • 62
    • 65549098301 scopus 로고    scopus 로고
    • The ventral premammillary nucleus links fasting-induced changes in leptin levels and coordinated luteinizing hormone secretion
    • Donato J Jr, Silva RJ, Sita LV, et al. The ventral premammillary nucleus links fasting-induced changes in leptin levels and coordinated luteinizing hormone secretion. J Neurosci. 2009;29:5240-5250.
    • (2009) J Neurosci , vol.29 , pp. 5240-5250
    • Donato Jr., J.1    Silva, R.J.2    Sita, L.V.3
  • 63
    • 84855220278 scopus 로고    scopus 로고
    • Leptin action in pubertal development: Recent advances and unanswered questions
    • Elias CF. Leptin action in pubertal development: recent advances and unanswered questions. Trends Endocrinol Metab. 2012;23:9-15.
    • (2012) Trends Endocrinol Metab , vol.23 , pp. 9-15
    • Elias, C.F.1
  • 64
    • 70350266820 scopus 로고    scopus 로고
    • The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system
    • Roa J, Garcia-Galiano D, Varela L, et al. The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system. Endocrinology. 2009;150:5016-5026.
    • (2009) Endocrinology , vol.150 , pp. 5016-5026
    • Roa, J.1    Garcia-Galiano, D.2    Varela, L.3
  • 65
    • 53549133638 scopus 로고    scopus 로고
    • The Creb1 coactivator Crtc1 is required for energy balance and fertility
    • Altarejos JY, Goebel N, Conkright MD, et al. The Creb1 coactivator Crtc1 is required for energy balance and fertility. Nat Med. 2008;14:1112-1117.
    • (2008) Nat Med , vol.14 , pp. 1112-1117
    • Altarejos, J.Y.1    Goebel, N.2    Conkright, M.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.