-
1
-
-
0028139089
-
Positional cloning of the mouse obese gene and its human homologue
-
DOI 10.1038/372425a0
-
Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425-432 (Pubitemid 24365442)
-
(1994)
Nature
, vol.372
, Issue.6505
, pp. 425-432
-
-
Zhang, Y.1
Proenca, R.2
Maffei, M.3
Barone, M.4
Leopold, L.5
Friedman, J.M.6
-
2
-
-
0028845877
-
Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
-
Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1995;1:1155-1161
-
(1995)
Nat Med
, vol.1
, pp. 1155-1161
-
-
Maffei, M.1
Halaas, J.2
Ravussin, E.3
Pratley, R.E.4
Lee, G.H.5
Zhang, Y.6
Fei, H.7
Kim, S.8
Lallone, R.9
Ranganathan, S.10
-
3
-
-
0018139377
-
Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice
-
Coleman DL. Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 1978;14:141-148
-
(1978)
Diabetologia
, vol.14
, pp. 141-148
-
-
Coleman, D.L.1
-
4
-
-
0022515702
-
Age effects on glycosylated blood proteins in lean and obese hyperglycaemic (ob/ob) mice
-
Flatt PR, Bailey CJ, Cameron AM, Gould BJ. Age effects on glycosylated blood proteins in lean and obese hyperglycaemic (ob/ob) mice. Diabetes Res 1986;3:241-243
-
(1986)
Diabetes Res
, vol.3
, pp. 241-243
-
-
Flatt, P.R.1
Bailey, C.J.2
Cameron, A.M.3
Gould, B.J.4
-
5
-
-
0016289615
-
Hyperinsulinemia in pre-weaning diabetes (db) mice
-
Coleman DL, Hummel KP. Hyperinsulinemia in pre-weaning diabetes (db) mice. Diabetologia 1974;10(Suppl.):607-610
-
(1974)
Diabetologia
, vol.10
, Issue.SUPPL.
, pp. 607-610
-
-
Coleman, D.L.1
Hummel, K.P.2
-
7
-
-
73049107663
-
Antidiabetic effects of IGFBP2, a leptin-regulated gene
-
Hedbacker K, Birsoy K, Wysocki RW, Asilmaz E, Ahima RS, Farooqi IS, Friedman JM. Antidiabetic effects of IGFBP2, a leptin-regulated gene. Cell Metab 2010;11:11-22
-
(2010)
Cell Metab
, vol.11
, pp. 11-22
-
-
Hedbacker, K.1
Birsoy, K.2
Wysocki, R.W.3
Asilmaz, E.4
Ahima, R.S.5
Farooqi, I.S.6
Friedman, J.M.7
-
9
-
-
0037148928
-
Leptin-replacement therapy for lipodystrophy
-
Oral EA, Simha V, Ruiz E, Andewelt A, Premkumar A, Snell P, Wagner AJ, DePaoli AM, Reitman ML, Taylor SI, Gorden P, Garg A. Leptin-replacement therapy for lipodystrophy. N Engl J Med 2002;346:570-578
-
(2002)
N Engl J Med
, vol.346
, pp. 570-578
-
-
Oral, E.A.1
Simha, V.2
Ruiz, E.3
Andewelt, A.4
Premkumar, A.5
Snell, P.6
Wagner, A.J.7
DePaoli, A.M.8
Reitman, M.L.9
Taylor, S.I.10
Gorden, P.11
Garg, A.12
-
10
-
-
0032558725
-
Leptin and the regulation of body weight in mammals
-
DOI 10.1038/27376
-
Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature 1998;395:763-770 (Pubitemid 28485436)
-
(1998)
Nature
, vol.395
, Issue.6704
, pp. 763-770
-
-
Friedman, J.M.1
Halaas, J.L.2
-
11
-
-
66049133685
-
Leptin-dependent control of glucose balance and locomotor activity by POMC neurons
-
Huo L, Gamber K, Greeley S, Silva J, Huntoon N, Leng XH, Bjørbaek C. Leptin-dependent control of glucose balance and locomotor activity by POMC neurons. Cell Metab 2009;9:537-547
-
(2009)
Cell Metab
, vol.9
, pp. 537-547
-
-
Huo, L.1
Gamber, K.2
Greeley, S.3
Silva, J.4
Huntoon, N.5
Leng, X.H.6
Bjørbaek, C.7
-
12
-
-
70349337472
-
Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve
-
German J, Kim F, Schwartz GJ, Havel PJ, Rhodes CJ, Schwartz MW, Morton GJ. Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve. Endocrinology 2009;150:4502-4511
-
(2009)
Endocrinology
, vol.150
, pp. 4502-4511
-
-
German, J.1
Kim, F.2
Schwartz, G.J.3
Havel, P.J.4
Rhodes, C.J.5
Schwartz, M.W.6
Morton, G.J.7
-
13
-
-
0032553418
-
Intracerebroventricular leptin regulates hepatic but not peripheral glucose fluxes
-
Liu L, Karkanias GB, Morales JC, Hawkins M, Barzilai N, Wang J, Rossetti L. Intracerebroventricular leptin regulates hepatic but not peripheral glucose fluxes. J Biol Chem 1998;273:31160-31167
-
(1998)
J Biol Chem
, vol.273
, pp. 31160-31167
-
-
Liu, L.1
Karkanias, G.B.2
Morales, J.C.3
Hawkins, M.4
Barzilai, N.5
Wang, J.6
Rossetti, L.7
-
14
-
-
2442654859
-
Identification and expression cloning of a leptin receptor, OB-R
-
Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J, Muir C, Sanker S, Moriarty A, Moore KJ, Smutko JS, Mays GG, Wool EA, Monroe CA, Tepper RI. Identification and expression cloning of a leptin receptor, OB-R. Cell 1995;83:1263-1271
-
(1995)
Cell
, vol.83
, pp. 1263-1271
-
-
Tartaglia, L.A.1
Dembski, M.2
Weng, X.3
Deng, N.4
Culpepper, J.5
Devos, R.6
Richards, G.J.7
Campfield, L.A.8
Clark, F.T.9
Deeds, J.10
Muir, C.11
Sanker, S.12
Moriarty, A.13
Moore, K.J.14
Smutko, J.S.15
Mays, G.G.16
Wool, E.A.17
Monroe, C.A.18
Tepper, R.I.19
-
15
-
-
0030015417
-
Defective STAT signaling by the leptin receptor in diabetic mice
-
Ghilardi N, Ziegler S, Wiestner A, Stoffel R, Heim MH, Skoda RC. Defective STAT signaling by the leptin receptor in diabetic mice. Proc Natl Acad Sci U S A 1996;93:6231-6235
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 6231-6235
-
-
Ghilardi, N.1
Ziegler, S.2
Wiestner, A.3
Stoffel, R.4
Heim, M.H.5
Skoda, R.C.6
-
16
-
-
0031010408
-
Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues
-
DOI 10.1073/pnas.94.13.7001
-
Fei H, Okano HJ, Li C, Lee GH, Zhao C, Darnell R, Friedman JM. Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc Natl Acad Sci U S A 1997;94:7001-7005 (Pubitemid 27281980)
-
(1997)
Proceedings of the National Academy of Sciences of the United States of America
, vol.94
, Issue.13
, pp. 7001-7005
-
-
Fei, H.1
Okano, H.J.2
Li, C.3
Lee, G.-H.4
Zhao, C.5
Darnell, R.6
Friedman, J.M.7
-
17
-
-
0029860791
-
Modulation of insulin activities by leptin
-
Cohen B, Novick D, Rubinstein M. Modulation of insulin activities by leptin. Science 1996;274:1185-1188
-
(1996)
Science
, vol.274
, pp. 1185-1188
-
-
Cohen, B.1
Novick, D.2
Rubinstein, M.3
-
19
-
-
2342616185
-
Leptin reduces glucose transport and cellular ATP levels in INS-1 β-cells
-
Lam NT, Cheung AT, Riedel MJ, Light PE, Cheeseman CI, Kieffer TJ. Leptin reduces glucose transport and cellular ATP levels in INS-1 β-cells. J Mol Endocrinol 2004;32:415-424
-
(2004)
J Mol Endocrinol
, vol.32
, pp. 415-424
-
-
Lam, N.T.1
Cheung, A.T.2
Riedel, M.J.3
Light, P.E.4
Cheeseman, C.I.5
Kieffer, T.J.6
-
20
-
-
0034776770
-
Selective deletion of leptin receptor in neurons leads to obesity
-
Cohen P, Zhao C, Cai X, Montez JM, Rohani SC, Feinstein P, Mombaerts P, Friedman JM. Selective deletion of leptin receptor in neurons leads to obesity. J Clin Invest 2001;108:1113-1121
-
(2001)
J Clin Invest
, vol.108
, pp. 1113-1121
-
-
Cohen, P.1
Zhao, C.2
Cai, X.3
Montez, J.M.4
Rohani, S.C.5
Feinstein, P.6
Mombaerts, P.7
Friedman, J.M.8
-
21
-
-
16644371686
-
Quantitative body composition analysis in awake mice and rats by magnetic resonance relaxometry
-
Künnecke B, Verry P, Bénardeau A, von Kienlin M. Quantitative body composition analysis in awake mice and rats by magnetic resonance relaxometry. Obes Res 2004;12:1604-1615
-
(2004)
Obes Res
, vol.12
, pp. 1604-1615
-
-
Künnecke, B.1
Verry, P.2
Bénardeau, A.3
Von Kienlin, M.4
-
22
-
-
0035145780
-
Lipotoxicity of the pancreatic β-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids
-
Briaud I, Harmon JS, Kelpe CL, Segu VB, Poitout V. Lipotoxicity of the pancreatic β-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids. Diabetes 2001;50:315-321
-
(2001)
Diabetes
, vol.50
, pp. 315-321
-
-
Briaud, I.1
Harmon, J.S.2
Kelpe, C.L.3
Segu, V.B.4
Poitout, V.5
-
23
-
-
0035514162
-
In muscle-specific lipoprotein lipase-overexpressing mice, muscle triglyceride content is increased without inhibition of insulin-stimulated whole-body and muscle-specific glucose uptake
-
Voshol PJ, Jong MC, Dahlmans VE, Kratky D, Levak-Frank S, Zechner R, Romijn JA, Havekes LM. In muscle-specific lipoprotein lipase-overexpressing mice, muscle triglyceride content is increased without inhibition of insulin-stimulated whole-body and muscle-specific glucose uptake. Diabetes 2001;50:2585-2590
-
(2001)
Diabetes
, vol.50
, pp. 2585-2590
-
-
Voshol, P.J.1
Jong, M.C.2
Dahlmans, V.E.3
Kratky, D.4
Levak-Frank, S.5
Zechner, R.6
Romijn, J.A.7
Havekes, L.M.8
-
24
-
-
2942733252
-
Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
-
DOI 10.1016/j.neuron.2004.06.004, PII S089662730400354X
-
Balthasar N, Coppari R, McMinn J, Liu SM, Lee CE, Tang V, Kenny CD, McGovern RA, Chua SC Jr, Elmquist JK, Lowell BB. Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron 2004;42:983-991 (Pubitemid 38798236)
-
(2004)
Neuron
, vol.42
, Issue.6
, pp. 983-991
-
-
Balthasar, N.1
Coppari, R.2
McMinn, J.3
Liu, S.M.4
Lee, C.E.5
Tang, V.6
Kenny, C.D.7
McGovern, R.A.8
Chua Jr., S.C.9
Elmquist, J.K.10
Lowell, B.B.11
-
25
-
-
4344713706
-
An allelic series for the leptin receptor gene generated by CRE and FLP recombinase
-
DOI 10.1007/s00335-004-2340-1
-
McMinn JE, Liu SM, Dragatsis I, Dietrich P, Ludwig T, Eiden S, Chua SC Jr. An allelic series for the leptin receptor gene generated by CRE and FLP recombinase. Mamm Genome 2004;15:677-685 (Pubitemid 39159192)
-
(2004)
Mammalian Genome
, vol.15
, Issue.9
, pp. 677-685
-
-
McMinn, J.E.1
Liu, S.-M.2
Dragatsis, I.3
Dietrich, P.4
Ludwig, T.5
Eiden, S.6
Chua Jr., S.C.7
-
26
-
-
0034640508
-
Activation of downstream signals by the long form of the leptin receptor
-
Banks AS, Davis SM, Bates SH, Myers MG Jr. Activation of downstream signals by the long form of the leptin receptor. J Biol Chem 2000;275:14563-14572
-
(2000)
J Biol Chem
, vol.275
, pp. 14563-14572
-
-
Banks, A.S.1
Davis, S.M.2
Bates, S.H.3
Myers Jr., M.G.4
-
27
-
-
17844389670
-
The hypothalamic arcuate nucleus: A key site for mediating leptin's effects on glucose homeostasis and locomotor activity
-
DOI 10.1016/j.cmet.2004.12.004, PII S1550413104000105
-
Coppari R, Ichinose M, Lee CE, Pullen AE, Kenny CD, McGovern RA, Tang V, Liu SM, Ludwig T, Chua SC Jr, Lowell BB, Elmquist JK. The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity. Cell Metab 2005;1:63-72 (Pubitemid 43960588)
-
(2005)
Cell Metabolism
, vol.1
, Issue.1
, pp. 63-72
-
-
Coppari, R.1
Ichinose, M.2
Lee, C.E.3
Pullen, A.E.4
Kenny, C.D.5
McGovern, R.A.6
Tang, V.7
Liu, S.M.8
Ludwig, T.9
Chua Jr., S.C.10
Lowell, B.B.11
Elmquist, J.K.12
-
28
-
-
30644473109
-
Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis
-
Dhillon H, Zigman JM, Ye C, Lee CE, McGovern RA, Tang V, Kenny CD, Christiansen LM, White RD, Edelstein EA, Coppari R, Balthasar N, Cowley MA, Chua S Jr, Elmquist JK, Lowell BB. Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron 2006;49:191-203
-
(2006)
Neuron
, vol.49
, pp. 191-203
-
-
Dhillon, H.1
Zigman, J.M.2
Ye, C.3
Lee, C.E.4
McGovern, R.A.5
Tang, V.6
Kenny, C.D.7
Christiansen, L.M.8
White, R.D.9
Edelstein, E.A.10
Coppari, R.11
Balthasar, N.12
Cowley, M.A.13
Chua Jr., S.14
Elmquist, J.K.15
Lowell, B.B.16
-
29
-
-
0032898369
-
Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic β-cell-specific gene knock-outs using Cre recombinase
-
Postic C, Shiota M, Niswender KD, Jetton TL, Chen Y, Moates JM, Shelton KD, Lindner J, Cherrington AD, Magnuson MA. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic β-cell-specific gene knock-outs using Cre recombinase. J Biol Chem 1999;274:305-315
-
(1999)
J Biol Chem
, vol.274
, pp. 305-315
-
-
Postic, C.1
Shiota, M.2
Niswender, K.D.3
Jetton, T.L.4
Chen, Y.5
Moates, J.M.6
Shelton, K.D.7
Lindner, J.8
Cherrington, A.D.9
Magnuson, M.A.10
-
30
-
-
33646384957
-
RIP-Cre revisited, evidence for impairments of pancreatic β-cell function
-
Lee JY, Ristow M, Lin X, White MF, Magnuson MA, Hennighausen L. RIP-Cre revisited, evidence for impairments of pancreatic β-cell function. J Biol Chem 2006;281:2649-2653
-
(2006)
J Biol Chem
, vol.281
, pp. 2649-2653
-
-
Lee, J.Y.1
Ristow, M.2
Lin, X.3
White, M.F.4
Magnuson, M.A.5
Hennighausen, L.6
-
31
-
-
0035937174
-
Liporegulation in diet-induced obesity: The antisteatotic role of hyperleptinemia
-
Lee Y, Wang MY, Kakuma T, Wang ZW, Babcock E, McCorkle K, Higa M, Zhou YT, Unger RH. Liporegulation in diet-induced obesity: the antisteatotic role of hyperleptinemia. J Biol Chem 2001;276:5629-5635
-
(2001)
J Biol Chem
, vol.276
, pp. 5629-5635
-
-
Lee, Y.1
Wang, M.Y.2
Kakuma, T.3
Wang, Z.W.4
Babcock, E.5
McCorkle, K.6
Higa, M.7
Zhou, Y.T.8
Unger, R.H.9
-
32
-
-
0033598749
-
Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes
-
Shimomura I, Bashmakov Y, Ikemoto S, Horton JD, Brown MS, Goldstein JL. Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes. Proc Natl Acad Sci U S A 1999;96:13656-13661
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 13656-13661
-
-
Shimomura, I.1
Bashmakov, Y.2
Ikemoto, S.3
Horton, J.D.4
Brown, M.S.5
Goldstein, J.L.6
-
33
-
-
24044512596
-
Acute hepatic steatosis in mice by blocking β-oxidation does not reduce insulin sensitivity of very-low-density lipoprotein production
-
DOI 10.1152/ajpgi.00063.2005
-
Grefhorst A, Hoekstra J, Derks TG, Ouwens DM, Baller JF, Havinga R, Havekes LM, Romijn JA, Kuipers F. Acute hepatic steatosis in mice by blocking β-oxidation does not reduce insulin sensitivity of very-low-density lipoprotein production. Am J Physiol Gastrointest Liver Physiol 2005;289:G592-G598 (Pubitemid 41216398)
-
(2005)
American Journal of Physiology - Gastrointestinal and Liver Physiology
, vol.289
, Issue.3
-
-
Grefhorst, A.1
Hoekstra, J.2
Derks, T.G.J.3
Ouwens, D.M.4
Baller, J.F.W.5
Havinga, R.6
Havekes, L.M.7
Romijn, J.A.8
Kuipers, F.9
-
34
-
-
0018355535
-
Obesity genes: Beneficial effects in heterozygous mice
-
Coleman DL. Obesity genes: beneficial effects in heterozygous mice. Science 1979;203:663-665
-
(1979)
Science
, vol.203
, pp. 663-665
-
-
Coleman, D.L.1
-
35
-
-
0032948090
-
The obese gene is expressed in lean littermates of the genetically obese mouse (C57BL/6J ob/ob)
-
Haller EW, Wittmers LE Jr, Haller IV, Regal RR. The obese gene is expressed in lean littermates of the genetically obese mouse (C57BL/6J ob/ob). Am J Physiol 1999;276:E762-E765
-
(1999)
Am J Physiol
, vol.276
-
-
Haller, E.W.1
Wittmers Jr., L.E.2
Haller, I.V.3
Regal, R.R.4
-
36
-
-
0033517284
-
Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
-
DOI 10.1038/43448
-
Shimomura I, Hammer RE, Ikemoto S, Brown MS, Goldstein JL. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature 1999;401:73-76 (Pubitemid 29418444)
-
(1999)
Nature
, vol.401
, Issue.6748
, pp. 73-76
-
-
Shimomura, I.1
Hammer, R.E.2
Ikemoto, S.3
Brown, M.S.4
Goldstein, J.L.5
-
37
-
-
56749171368
-
Regulation of pancreatic β-cell mass by neuronal signals from the liver
-
Imai J, Katagiri H, Yamada T, Ishigaki Y, Suzuki T, Kudo H, Uno K, Hasegawa Y, Gao J, Kaneko K, Ishihara H, Niijima A, Nakazato M, Asano T, Minokoshi Y, Oka Y. Regulation of pancreatic β-cell mass by neuronal signals from the liver. Science 2008;322:1250-1254
-
(2008)
Science
, vol.322
, pp. 1250-1254
-
-
Imai, J.1
Katagiri, H.2
Yamada, T.3
Ishigaki, Y.4
Suzuki, T.5
Kudo, H.6
Uno, K.7
Hasegawa, Y.8
Gao, J.9
Kaneko, K.10
Ishihara, H.11
Niijima, A.12
Nakazato, M.13
Asano, T.14
Minokoshi, Y.15
Oka, Y.16
-
38
-
-
77950899850
-
Attenuation of age- and sucrose-induced insulin resistance and syndrome X by a synergistic antioxidant cocktail: The AMIS syndrome and HISS hypothesis
-
Lautt WW, Ming Z, Legare DJ. Attenuation of age- and sucrose-induced insulin resistance and syndrome X by a synergistic antioxidant cocktail: the AMIS syndrome and HISS hypothesis. Can J Physiol Pharmacol 2010;88:313-323
-
Can J Physiol Pharmacol
, vol.2010
, Issue.88
, pp. 313-323
-
-
Lautt, W.W.1
Ming, Z.2
Legare, D.J.3
-
39
-
-
0036328381
-
Analysis of paradoxical observations on the association between leptin and insulin resistance
-
Ceddia RB, Koistinen HA, Zierath JR, Sweeney G. Analysis of paradoxical observations on the association between leptin and insulin resistance. FASEB J 2002;16:1163-1176
-
(2002)
FASEB J
, vol.16
, pp. 1163-1176
-
-
Ceddia, R.B.1
Koistinen, H.A.2
Zierath, J.R.3
Sweeney, G.4
-
40
-
-
25844471008
-
In vivo leptin infusion impairs insulin and leptin signalling in liver and hypothalamus
-
Benomar Y, Wetzler S, Larue-Achagiotis C, Djiane J, Tomé D, Taouis M. In vivo leptin infusion impairs insulin and leptin signalling in liver and hypothalamus. Mol Cell Endocrinol 2005;242:59-66
-
(2005)
Mol Cell Endocrinol
, vol.242
, pp. 59-66
-
-
Benomar, Y.1
Wetzler, S.2
Larue-Achagiotis, C.3
Djiane, J.4
Tomé, D.5
Taouis, M.6
-
41
-
-
2542499538
-
Leptin increases hepatic insulin sensitivity and protein tyrosine phosphatase 1B expression
-
Lam NT, Lewis JT, Cheung AT, Luk CT, Tse J, Wang J, Bryer-Ash M, Kolls JK, Kieffer TJ. Leptin increases hepatic insulin sensitivity and protein tyrosine phosphatase 1B expression. Mol Endocrinol 2004;18:1333-1345
-
(2004)
Mol Endocrinol
, vol.18
, pp. 1333-1345
-
-
Lam, N.T.1
Lewis, J.T.2
Cheung, A.T.3
Luk, C.T.4
Tse, J.5
Wang, J.6
Bryer-Ash, M.7
Kolls, J.K.8
Kieffer, T.J.9
-
42
-
-
85047683106
-
Short-term leptin-dependent inhibition of hepatic gluconeogenesis is mediated by insulin receptor substrate-2
-
Anderwald C, Müller G, Koca G, Fürnsinn C, Waldhäusl W, Roden M. Short-term leptin-dependent inhibition of hepatic gluconeogenesis is mediated by insulin receptor substrate-2. Mol Endocrinol 2002;16:1612-1628
-
(2002)
Mol Endocrinol
, vol.16
, pp. 1612-1628
-
-
Anderwald, C.1
Müller, G.2
Koca, G.3
Fürnsinn, C.4
Waldhäusl, W.5
Roden, M.6
-
43
-
-
33846105545
-
Resistance to leptin action is the major determinant of hepatic triglyceride accumulation in vivo
-
Fishman S, Muzumdar RH, Atzmon G, Ma X, Yang X, Einstein FH, Barzilai N. Resistance to leptin action is the major determinant of hepatic triglyceride accumulation in vivo. FASEB J 2007;21:53-60
-
(2007)
FASEB J
, vol.21
, pp. 53-60
-
-
Fishman, S.1
Muzumdar, R.H.2
Atzmon, G.3
Ma, X.4
Yang, X.5
Einstein, F.H.6
Barzilai, N.7
-
44
-
-
0033525870
-
Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene
-
Elchebly M, Payette P, Michaliszyn E, Cromlish W, Collins S, Loy AL, Normandin D, Cheng A, Himms-Hagen J, Chan CC, Ramachandran C, Gresser MJ, Tremblay ML, Kennedy BP. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science 1999;283:1544-1548
-
(1999)
Science
, vol.283
, pp. 1544-1548
-
-
Elchebly, M.1
Payette, P.2
Michaliszyn, E.3
Cromlish, W.4
Collins, S.5
Loy, A.L.6
Normandin, D.7
Cheng, A.8
Himms-Hagen, J.9
Chan, C.C.10
Ramachandran, C.11
Gresser, M.J.12
Tremblay, M.L.13
Kennedy, B.P.14
-
45
-
-
0037228018
-
Interaction between leptin and insulin signaling pathways differentially affects JAKSTAT and PI 3-kinase-mediated signaling in rat liver
-
Carvalheira JB, Ribeiro EB, Folli F, Velloso LA, Saad MJ. Interaction between leptin and insulin signaling pathways differentially affects JAKSTAT and PI 3-kinase-mediated signaling in rat liver. Biol Chem 2003;384:151-159
-
(2003)
Biol Chem
, vol.384
, pp. 151-159
-
-
Carvalheira, J.B.1
Ribeiro, E.B.2
Folli, F.3
Velloso, L.A.4
Saad, M.J.5
-
46
-
-
0030948734
-
Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic β-cells
-
Kieffer TJ, Heller RS, Leech CA, Holz GG, Habener JF. Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic β-cells. Diabetes 1997;46:1087-1093
-
(1997)
Diabetes
, vol.46
, pp. 1087-1093
-
-
Kieffer, T.J.1
Heller, R.S.2
Leech, C.A.3
Holz, G.G.4
Habener, J.F.5
-
47
-
-
33748920365
-
The pancreatic β-cell is a key site for mediating the effects of leptin on glucose homeostasis
-
Covey SD, Wideman RD, McDonald C, Unniappan S, Huynh F, Asadi A, Speck M, Webber T, Chua SC, Kieffer TJ. The pancreatic β-cell is a key site for mediating the effects of leptin on glucose homeostasis. Cell Metab 2006;4:291-302
-
(2006)
Cell Metab
, vol.4
, pp. 291-302
-
-
Covey, S.D.1
Wideman, R.D.2
McDonald, C.3
Unniappan, S.4
Huynh, F.5
Asadi, A.6
Speck, M.7
Webber, T.8
Chua, S.C.9
Kieffer, T.J.10
-
48
-
-
34948825485
-
Disruption of leptin receptor expression in the pancreas directly affects β-cell growth and function in mice
-
Morioka T, Asilmaz E, Hu J, Dishinger JF, Kurpad AJ, Elias CF, Li H, Elmquist JK, Kennedy RT, Kulkarni RN. Disruption of leptin receptor expression in the pancreas directly affects β-cell growth and function in mice. J Clin Invest 2007;117:2860-2868
-
(2007)
J Clin Invest
, vol.117
, pp. 2860-2868
-
-
Morioka, T.1
Asilmaz, E.2
Hu, J.3
Dishinger, J.F.4
Kurpad, A.J.5
Elias, C.F.6
Li, H.7
Elmquist, J.K.8
Kennedy, R.T.9
Kulkarni, R.N.10
-
49
-
-
43149112800
-
Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome
-
Wang MY, Grayburn P, Chen S, Ravazzola M, Orci L, Unger RH. Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome. Proc Natl Acad Sci U S A 2008;105:6139-6144
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 6139-6144
-
-
Wang, M.Y.1
Grayburn, P.2
Chen, S.3
Ravazzola, M.4
Orci, L.5
Unger, R.H.6
-
50
-
-
0040381066
-
Leptin impairs metabolic actions of insulin in isolated rat adipocytes
-
Müller G, Ertl J, Gerl M, Preibisch G. Leptin impairs metabolic actions of insulin in isolated rat adipocytes. J Biol Chem 1997;272:10585-10593
-
(1997)
J Biol Chem
, vol.272
, pp. 10585-10593
-
-
Müller, G.1
Ertl, J.2
Gerl, M.3
Preibisch, G.4
|