Leptin action via LepR-b Tyr1077 contributes to the control of energy balance and female reproduction

Molecular Metabolism

Volumn 1, Issue 1-2, 2012, Pages 61-69

  Patterson, Christa M ^a   Villanueva, Eneida C ^a   Greenwald Yarnell, Megan ^a   Rajala, Michael ^a   Gonzalez, Ian E ^a   Saini, Natinder ^a   Jones, Justin ^a   Myers, Martin G ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Estrus; Leptin; Obesity; Reproduction; STAT5; Tyrosine phosphorylation

Indexed keywords

LEPTIN; LEPTIN RECEPTOR; MUTANT PROTEIN; TYROSINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DISEASE ASSOCIATION; ENERGY BALANCE; ESTRUS CYCLE; FEMALE; FEMALE FERTILITY; GENE TARGETING; GLUCOSE HOMEOSTASIS; HORMONAL REGULATION; HORMONE ACTION; MALE; METABOLIC REGULATION; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

MUS;

EID: 84869058775     PISSN: 22128778     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmet.2012.05.001     Document Type: Article

References (39)

1. Ahima R.S., Prabakaran D., Mantzoros C., Qu D., Lowell B., Maratos-Flier E., et al. Role of leptin in the neuroendocrine response to fasting. Nature 1996, 382:250-252.
2. Myers M.G., Munzberg H., Leinninger G.M., Leshan R.L. The geometry of leptin action in the brain: more complicated than a simple ARC. Cell metabolism 2009, 9:117-123.
3. Chua S.C., Chung W.K., Wu-Peng X.S., Zhang Y., Liu S.M., Tartaglia L., et al. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science (New York, NY) 1996, 271:994-996.
4. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., Friedman J.M. Positional cloning of the mouse obese gene and its human homologue. Nature 1994, 372:425-432.
5. Cohen P., Zhao C., Cai X., Montez J.M., Rohani S.C., Feinstein P., et al. Selective deletion of leptin receptor in neurons leads to obesity. The Journal of Clinical Investigation 2001, 108:1113-1121.
6. de Luca C., Kowalski T.J., Zhang Y., Elmquist J.K., Lee C., Kilimann M.W., et al. Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes. The Journal of Clinical Investigation 2005, 115:3484-3493.
7. Chua S.C., Koutras I.K., Han L., Liu S.M., Kay J., Young S.J., et al. Fine structure of the murine leptin receptor gene: Splice site suppression is required to form two alternatively spliced transcripts. Genomics 1997, 45:264-270.
8. Robertson S.A., Leinninger G.M., Myers M.G. Molecular and neural mediators of leptin action. Physiology and Behavior 2008, 94:637-642.
9. Kloek C., Haq A.K., Dunn S.L., Lavery H.J., Banks A.S., Myers M.G. Regulation of Jak kinases by intracellular leptin receptor sequences. The Journal of Biological Chemistry 2002, 277:41547-41555.
10. Gong Y., Ishida-Takahashi R., Villanueva E.C., Fingar D.C., Munzberg H., Myers M.G. The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms. The Journal of Biological Chemistry 2007, 282:31019-31027.
11. Robertson S., Ishida-Takahashi R., Tawara I., Hu J., Patterson C.M., Jones J.C., et al. Insufficiency of Janus kinase 2-autonomous leptin receptor signals for most physiologic leptin actions. Diabetes 2010, 59:782-790.
12. Banks A.S., Davis S.M., Bates S.H., Myers M.G. Activation of downstream signals by the long form of the leptin receptor. The Journal of Biological Chemistry 2000, 275:14563-14572.
13. Bjorbaek C., Lavery H.J., Bates S.H., Olson R.K., Davis S.M., Flier J.S., et al. SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985. The Journal of Biological Chemistry 2000, 275:40649-40657.
14. Bjornholm M., Munzberg H., Leshan R.L., Villanueva E.C., Bates S.H., Louis G.W., et al. Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function. The Journal of Clinical Investigation 2007, 117:1354-1360.
15. You J., Yu Y., Jiang L., Li W., Yu X., Gonzalez L., et al. Signaling through Tyr985 of leptin receptor as an age/diet-dependent switch in the regulation of energy balance. Molecular and Cellular Biology 2010, 30:1650-1659.
16. Hekerman P., Zeidler J., Bamberg-Lemper S., Knobelspies H., Lavens D., Tavernier J., et al. Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines. The FEBS Journal 2005, 272:109-119.
17. Bates S.H., Stearns W.H., Schubert M., Tso A.W.K., Wang Y., Banks A.S., et al. STAT3 signaling is required for leptin regulation of energy balance but not reproduction. Nature 2003, 421:856-859.
18. Bates S.H., Dundon T.A., Seifert M., Carlson M., Maratos-Flier E., Myers M.G. LRb-STAT3 signaling is required for the neuroendocrine regulation of energy expenditure by leptin. Diabetes 2004, 53:3067-3073.
19. Bates S.H., Kulkarni R.N., Seifert M., Myers M.G. Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis. Cell Metabolism 2005, 1:169-178.
20. Jiang L., You J., Yu X., Gonzalez L., Yu Y., Wang Q., et al. Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis. Proceedings of the National Academy of Sciences of the United States of America 2008, 105:18619-18624.
21. Patterson C.M., Leshan R.L., Jones J.C., Myers M.G. Molecular mapping of mouse brain regions innervated by leptin receptor-expressing cells. Brain Research 2011.
22. Soliman G.A., Ishida-Takahashi R., Gong Y., Jones J.C., Leshan R.L., Saunders T.L., et al. A simple qPCR-based method to detect correct insertion of homologous targeting vectors in murine ES cells. Transgenic Research 2007, 16:665-670.
23. Munzberg H., Jobst E.E., Bates S.H., Jones J., Villanueva E., Leshan R., et al. Appropriate inhibition of orexigenic hypothalamic arcuate nucleus neurons independently of leptin receptor/STAT3 signaling. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience 2007, 27:69-74.
24. Morton G.J., Cummings D.E., Baskin D.G., Barsh G.S., Schwartz M.W. Central nervous system control of food intake and body weight. Nature 2006, 443:289-295.
25. Gautron L., Elmquist J.K. Sixteen years and counting: an update on leptin in energy balance. The Journal of Clinical Investigation 2011, 121:2087-2093.
26. Roa J., Castellano J.M., Navarro V.M., Handelsman D.J., Pinilla L., Tena-Sempere M. Kisspeptins and the control of gonadotropin secretion in male and female rodents. Peptides 2009, 30:57-66.
27. Kauffman A.S., Clifton D.K., Steiner R.A. Emerging ideas about kisspeptin- GPR54 signaling in the neuroendocrine regulation of reproduction. Trends In Neurosciences 2007, 30:504-511.
28. Donato J., Cravo R.M., Frazao R., Gautron L., Scott M.M., Lachey J., et al. Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons. The Journal of Clinical Investigation 2011, 121:355-368.
29. Louis G.W., Greenwald-Yarnell M., Phillips R., Coolen L.M., Lehman M.N., Myers M.G. Molecular mapping of the neural pathways linking leptin to the neuroendocrine reproductive axis. Endocrinology 2011, 152:2302-2310.
30. Lee J.Y., Muenzberg H., Gavrilova O., Reed J.A., Berryman D., Villanueva E.C., et al. Loss of Cytokine-STAT5 signaling in the CNS and pituitary gland alters energy balance and leads to obesity. PLoS.ONE 2008, 3:e1639.
31. Reed J.A., Clegg D.J., Smith K.B., Tolod-Richer E.G., Matter E.K., Picard L.S., et al. GM-CSF action in the CNS decreases food intake and body weight. Journal of Clinical Investigation 2005, 115:3035-3044.
32. True C., Kirigiti M.A., Kievit P., Grove K.L., Smith M.S. Leptin is not the critical signal for kisspeptin or luteinising hormone restoration during exit from negative energy balance. Journal of Neuroendocrinology 2011, 23:1099-1112.
33. Balthasar N., Coppari R., McMinn J., Liu S.M., Lee C.E., Tang V., Kenny C.D., McGovern R.A., Chua S.C., Elmquist J.K, et al. Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron 2004, 42:983-991.
34. van de Wall, E., Leshan, R., Xu, A.W., Balthasar, N., Coppari, R., Liu, S.M., Jo, Y.H., MacKenzie, R.G., Allison, D.B., Dun, N.J., et al., 2008. Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion. Endocrinology 149:1773-1785.
35. Leshan R.L., Louis G.W., Jo Y.H., Rhodes C.J., Munzberg H., Myers M.G. Direct innervation of GnRH neurons by metabolic- and sexual odorant-sensing leptin receptor neurons in the hypothalamic ventral premammillary nucleus. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience 2009, 29:3138-3147.
36. Donato J., Cravo R.M., Frazao R., Elias C.F. Hypothalamic sites of leptin action linking metabolism and reproduction. Neuroendocrinology 2011, 93:9-18.
37. Cravo R.M., Margatho L.O., Osborne-Lawrence S., Donato J., Atkin S., Bookout A.L., et al. Characterization of Kiss1 neurons using transgenic mouse models. Neuroscience 2011, 173:37-56.
38. Donato J., Silva R.J., Sita L.V., Lee S., Lee C., Lacchini S., et al. The ventral premammillary nucleus links fasting-induced changes in leptin levels and coordinated luteinizing hormone secretion. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience 2009, 29:5240-5250.
39. Leshan, RL, Greenwald-Yarnell, M, Patterson, CM, Gonzalez, IE, Myers, MG, Jr., 2012. Leptin action via hypothalamic nitric oxide synthase-1 neurons controls energy balance. Nature Medicine 18:820-823.