Sulforaphane induces apoptosis in T24 human urinary bladder cancer cells through a reactive oxygen species-mediated mitochondrial pathway: The involvement of endoplasmic reticulum stress and the Nrf2 signaling pathway

International Journal of Oncology

Volumn 45, Issue 4, 2014, Pages 1497-1506

  Jo, Guk Heui ^a   Kim, Gi Young ^b   Kim, Wun Jae ^c   Park, Kun Young ^d   Choi, Yung Hyun ^a  

^a Dong Eui University   (South Korea)

^b Jeju National University   (South Korea)

^c Chungbuk National University College of Medicine   (South Korea)

^d Pusan National University   (South Korea)

Author keywords

Apoptosis; Endoplasmic reticulum stress; Nuclear factor E2 related factor 2; Reactive oxygen species; Sulforaphane

Indexed keywords

ACETYLCYSTEINE; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; GLUCOSE REGULATED PROTEIN 78; HEME OXYGENASE 1; KELCH LIKE ECH ASSOCIATED PROTEIN 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SULFORAPHANE; TRANSCRIPTION FACTOR NRF2; ANTINEOPLASTIC AGENT; ISOTHIOCYANIC ACID DERIVATIVE; NFE2L2 PROTEIN, HUMAN; SULFORAFAN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BLADDER CANCER CELL LINE; CELL NUCLEUS; CELL PROLIFERATION; CELL STRUCTURE; CELL VACUOLE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA CONTENT; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; ENZYME RELEASE; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION; DRUG EFFECTS; GENE EXPRESSION REGULATION; METABOLISM; MITOCHONDRION; PATHOLOGY; TUMOR CELL LINE; URINARY BLADDER NEOPLASMS;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; ISOTHIOCYANATES; MITOCHONDRIA; NF-E2-RELATED FACTOR 2; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; URINARY BLADDER NEOPLASMS;

EID: 84907459133     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2014.2536     Document Type: Article

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