Activation of PERK signaling through fluoride-mediated endoplasmic reticulum stress in OS732 cells

Toxicology

Volumn 277, Issue 1-3, 2010, Pages 1-5

  Xu, Hui ^a   Zhou, Yu Lai ^a   Zhang, Xiu Yun ^a   Lu, Peng ^a   Li, Guang Sheng ^a  

^a JILIN UNIVERSITY   (China)

Author keywords

Endoplasmic reticulum stress; Osteoblast; PRK like ER kinase; Skeletal fluorosis

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVATING TRANSCRIPTION FACTOR 6; BINDING IMMUNOGLOBULIN PROTEIN; CARRIER PROTEIN; FLUORIDE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PHOSPHOTRANSFERASE; PRK LIKE ER KINASE; PROTEIN IRE1; TRANSCRIPTION FACTOR NRF2; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1; PERK KINASE; PROTEIN KINASE R;

ARTICLE; BONE TURNOVER; CELL LINE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; COMPARATIVE STUDY; DRUG EFFECTS; ENDOPLASMIC RETICULUM; ENZYMOLOGY; FLUORIDE POISONING; METABOLISM; OSTEOBLAST; OXIDATIVE STRESS; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; TOXICITY; TUMOR CELL LINE;

CELL LINE, TUMOR; EIF-2 KINASE; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; FLUORIDE POISONING; FLUORIDES; HUMANS; OSTEOBLASTS; OXIDATIVE STRESS; SIGNAL TRANSDUCTION;

EID: 77957875161     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2010.08.006     Document Type: Article

References (26)

1. Bertolotti A., Zhang Y., Hendershot L.M., Harding H.P., Ron D. Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat. Cell Biol. 2000, 2:326-333.
2. Boivin G., Chavassieux P., Chapuy M.C., Baud C.A., Meunier P.J. Skeletal fluorosis: histomorphometric analysis of bone changes and bone. Bone 1989, 10:89-99.
3. Boyle W.J., Simonet W.S., Lacey D.L. Osteoclast differentiation and activation. Nature 2003, 423:337-342.
4. Clements C.M., McNally R.S., Conti B.J., Mak T.W., Ting J.P. DJ-1, a cancer and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:15091-15096.
5. Cullinan S.B., Diehl J.A. Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathway. Int. J. Biochem. Cell Biol. 2006, 38:317-332.
6. Cullinan S.B., Diehl J.A. PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress. J. Biol. Chem. 2004, 279:20108-20117.
7. Harding H.P., Zhang Y., Bertolotti A., Zeng H., Ron D. Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol. Cell 2000, 5:897-904.
8. Ito M., Nakagawa H., Okada T., Miyazaki S., Matsuo S. ER-stress caused by accumulated intracistanal granules activates autophagy through a different signal pathway from unfolded protein response in exocrine pancreas cells of rats exposed to fluoride. Arch. Toxicol. 2009, 83:151-159.
9. Karsenty G. Transcriptional control of skeletogenesis. Annu. Rev. Genomics Hum. Genet. 2008, 9:183-196.
10. Kubota K., Lee D.H., Tsuchiya M., Young C.S., Everett E.T., Martinez-Mier E.A., Snead M.L., Nguyen L., Urano F., Bartlett J.D. Fluoride induces endoplasmic reticulum stress in ameloblasts responsible for dental enamel formation. J. Biol. Chem. 2005, 280:23194-23202.
11. Li G.S. Progress in the mechanism studies on dental and skeletal fluorosis and its revelation. Chin. J. Endemiol. 2009, 28:121-122.
12. Li G.S., Jing L., Xu H. Progress of study on endemic fluorosis. Zhonghua Bing Li Xue Za Zhi 2005, 34:632-634.
13. -ΔΔCT. Methods 2001, 25:402-408.
14. Mithal A., Trivedi N., Gupta S.K., Kumar S., Gupta R.K. Radiological spectrum of endemic fluorosis: relationship with calcium intake. Skeletal Radiol. 1993, 22:257-261.
15. Rao R.V., Peel A., Logvinova A., del Rio G., Hermel E., Yokota T., Goldsmith P.C., Ellerby L.M., Ellerby H.M., Bredesen D.E. Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78. FEBS Lett. 2002, 514:122-128.
16. Samali A., Fitzgerald U., Deegan S., Gupta S. Methods for monitoring endoplasmic reticulum stress and the unfolded protein response. Int. J. Cell Biol. 2010, 2010:830307.
17. Sharma R., Tsuchiya M., Bartlett J.D. Fluoride induces endoplasmic reticulum stress and inhibits protein synthesis and secretion. Environ. Health Perspect. 2008, 116:1142-1146.
18. Shen X., Zhang K., Kaufman R.J. The unfolded protein response a stress signaling pathway of the endoplasmic reticulum. J. Chem. Neuroanat. 2004, 28:79-92.
19. Sun J., Li J.Y., Liu X.Y., Wei L., Wang G.C., Meng F.H. Proliferation and gene expression of osteoblasts cultured in DMEM containing the ionic products of dicalcium silicate coating. Biomed. Pharmacother. 2009, 63:650-657.
20. Wei J., Sheng X., Feng D., McGrath B., Cavener D.R. PERK is essential for neonatal skeletal development to regulate osteoblast proliferation and differentiation. J. Cell. Physiol. 2008, 217:693-707.
21. Wu H.L., Lin Y.H., Wang R., Li Y.B., Tie L., Song Q.L., Guo D.A., Yu H.M., Li X.J. Salvianolic acid B protects human endothelial cells from oxidative stress damage: a possible protective role of glucose-regulated protein 78 induction. Cardiovasc. Res. 2009, 81:148-158.
22. Xu H., Jing L., Li G.S. Proteomic analysis of osteoblasts exposed to fluoride in vitro. Biol. Trace Elem. Res. 2008, 123:91-97.
23. Xu H., Wang C.H., Zhao Z.T., Zhang W.B., Li G.S. Role of oxidative stress in osteoblasts exposed to sodium fluoride. Biol. Trace Elem. Res. 2008, 123:109-115.
24. Xuan B.Q., Qian Z.K., Torigoi E., Yu D. Human cytomegalovirus protein pUL38 induces ATF4 expression, inhibits persistent JNK phosphorylation, and suppresses endoplasmic reticulum stress-induced cell death. J. Virol. 2009, 83:3463-3474.
25. Yang X., Matsuda K., Bialek P., Jacquot S., Masuoka H.C., Schinke T., Li L., Brancorsini S., Sassone-Corsi P., Townes T.M., Hanauer A., Karsenty G. ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology. Cell 2004, 117:387-398.
26. Yoshida H., Matsui T., Yamamoto A., Okada T., Mori K. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER. Cell 2001, 107:881-891.